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Chemistry

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Also known as: 62669-70-9, 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)xanthylium chloride, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]xanthylium chloride, Rh 123, Chebi:8828, Rh-123
Molecular Formula
C21H17ClN2O3
Molecular Weight
380.8  g/mol
InChI Key
MYFATKRONKHHQL-UHFFFAOYSA-N

Rhodamine 123
A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)
1 2D Structure

Rhodamine 123

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[6-amino-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]azanium;chloride
2.1.2 InChI
InChI=1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
2.1.3 InChI Key
MYFATKRONKHHQL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC(=O)C1=CC=CC=C1C2=C3C=CC(=[NH2+])C=C3OC4=C2C=CC(=C4)N.[Cl-]
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 62669-70-9

2. 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)xanthylium Chloride

3. 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]xanthylium Chloride

4. Rh 123

5. Chebi:8828

6. Rh-123

7. Rhodamin 123 Chloride

8. Schembl37743

9. Chembl245839

10. Schembl18816029

11. Dtxsid00886503

12. Amy40920

13. Hy-d0816

14. Akos015917525

15. Akos015958728

16. Cs-7693

17. R-22420rh-123

18. R-4500

19. R-22420

20. 2-(6-amino-3-imino-3h-xanthen-9-yl)benzoic Acid Methyl Ester

21. 3,6-diamino-9-(2-methoxycarbonyl-phenyl)-xanthenylium; Chloride

22. [6-amino-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]azanium;chloride

23. 6-amino-9-[2-(methoxycarbonyl)phenyl]-3h-xanthen-3-iminium Chloride

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 380.8 g/mol
Molecular Formula C21H17ClN2O3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass380.0927701 g/mol
Monoisotopic Mass380.0927701 g/mol
Topological Polar Surface Area87.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity670
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Fluorescent Dyes

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)


ABOUT THIS PAGE

Rhodamine 123 Manufacturers

A Rhodamine 123 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rhodamine 123, including repackagers and relabelers. The FDA regulates Rhodamine 123 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rhodamine 123 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rhodamine 123 Suppliers

A Rhodamine 123 supplier is an individual or a company that provides Rhodamine 123 active pharmaceutical ingredient (API) or Rhodamine 123 finished formulations upon request. The Rhodamine 123 suppliers may include Rhodamine 123 API manufacturers, exporters, distributors and traders.

click here to find a list of Rhodamine 123 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rhodamine 123 USDMF

A Rhodamine 123 DMF (Drug Master File) is a document detailing the whole manufacturing process of Rhodamine 123 active pharmaceutical ingredient (API) in detail. Different forms of Rhodamine 123 DMFs exist exist since differing nations have different regulations, such as Rhodamine 123 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rhodamine 123 DMF submitted to regulatory agencies in the US is known as a USDMF. Rhodamine 123 USDMF includes data on Rhodamine 123's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rhodamine 123 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rhodamine 123 suppliers with USDMF on PharmaCompass.

Rhodamine 123 GMP

Rhodamine 123 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rhodamine 123 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rhodamine 123 GMP manufacturer or Rhodamine 123 GMP API supplier for your needs.

Rhodamine 123 CoA

A Rhodamine 123 CoA (Certificate of Analysis) is a formal document that attests to Rhodamine 123's compliance with Rhodamine 123 specifications and serves as a tool for batch-level quality control.

Rhodamine 123 CoA mostly includes findings from lab analyses of a specific batch. For each Rhodamine 123 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rhodamine 123 may be tested according to a variety of international standards, such as European Pharmacopoeia (Rhodamine 123 EP), Rhodamine 123 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rhodamine 123 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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