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Chemistry

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Also known as: Ribitol, Adonitol, Xylite, 488-81-3, 87-99-0, D-xylitol

Molecular Formula

C₅H₁₂O₅

Molecular Weight

152.15 g/mol

InChI Key

HEBKCHPVOIAQTA-NGQZWQHPSA-N

FDA UNII

353ZQ9TVDA

A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

1 2D Structure

Ribitol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,4R)-pentane-1,2,3,4,5-pentol

2.1.2 InChI

InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5?

2.1.3 InChI Key

HEBKCHPVOIAQTA-NGQZWQHPSA-N

2.1.4 Canonical SMILES

C(C(C(C(CO)O)O)O)O

2.1.5 Isomeric SMILES

C([C@H](C([C@H](CO)O)O)O)O

2.2 Other Identifiers

2.2.1 UNII

353ZQ9TVDA

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Ribitol

2. Adonitol

3. Xylite

4. 488-81-3

5. 87-99-0

6. D-xylitol

7. Adonite

8. Adonit

9. D-ribitol

10. Xyliton

11. Eutrit

12. Klinit

13. Xylite (sugar)

14. Kannit

15. Xylit

16. Newtol

17. 1,2,3,4,5-pentanepentol

18. Pentitol

19. Fluorette

20. Xylisorb

21. Kylit

22. Meso-ribitol

23. Xylo-pentitol

24. L-ribitol

25. (2r,3r,4s)-pentane-1,2,3,4,5-pentaol

26. (2r,3s,4s)-pentane-1,2,3,4,5-pentol

27. Xylitab 300

28. Meso-xylitol

29. L-xylitol

30. D-adonitol

31. (2s,4r)-pentane-1,2,3,4,5-pentol

32. Nsc 25283

33. Xylitol, D-

34. Xylitol Cm 90

35. Brn 1720523

36. 16277-71-7

37. Chebi:15963

38. Chebi:17151

39. Xylo-pentane-1,2,3,4,5-pentol

40. 2,3-dihydro Acrivastine

41. C-xylidex Cr 16055

42. 353zq9tvda

43. Vcq006kq1e

44. Ins No.967

45. (2r,3s,4s)-pentane-1,2,3,4,5-pentaol

46. Xylooligosaccharide

47. Ins-967

48. Nsc-25283

49. 87849-01-2

50. 1,2,3,4,5-pentahydroxypentane

51. E-967

52. (2r,3r,4s)-pentane-1,2,3,4,5-pentol

53. 4-01-00-02832 (beilstein Handbook Reference)

54. Mfcd00064291

55. Einecs 201-788-0

56. Unii-353zq9tvda

57. Unii-vcq006kq1e

58. Adonito

59. Xylitol [inn:ban:jan:nf]

60. Nsc-16868

61. Dl-arabinit

62. Xylitol C

63. Hsdb 7967

64. Xylitab Dc

65. Wood Sugar Alcohol

66. Rb0

67. Xylitol,(s)

68. Einecs 207-685-7

69. Ribitol (adonitol)

70. Adonitol (7ci)

71. Xylisorb 300

72. Xylisorb 700

73. Mfcd00064292

74. Nsc 16868

75. Xylitab 100

76. Ribo-pentitol

77. Brn 1720524

78. D-ribitol (incorrect)

79. L-ribitol (incorrect)

80. Adonitol, >=99%

81. Xylitol [vandf]

82. Xylitol [inci]

83. Xylitol, >=99%

84. Adonitol [mi]

85. Xylitol [fcc]

86. Xylitol [jan]

87. Xylitol [ii]

88. Xylitol [mi]

89. Xylitol [mart.]

90. Xylitol [usp-rs]

91. Xylitol [who-dd]

92. Bmse000062

93. Bmse000129

94. Bmse000886

95. Epitope Id:114702

96. Epitope Id:114703

97. Ec 201-788-0

98. Schembl4250

99. Xylitol, Analytical Standard

100. Dsstox_cid_22514

101. Dsstox_rid_80046

102. Dsstox_gsid_42514

103. Schembl15318

104. Mls002695898

105. Chembl96783

106. Ribitol (6ci,8ci,9ci)

107. Xylitol [ep Impurity]

108. Xylitol [ep Monograph]

109. Qspl 191

110. Schembl1924966

111. Chembl1865120

112. Chembl3137744

113. Dtxsid601032335

114. Hy-n0538

115. Tox21_201056

116. S2612

117. S4546

118. Zinc18068098

119. Akos015903403

120. Akos015915193

121. Zinc100014205

122. Zinc100018612

123. Ccg-214167

124. Ccg-266218

125. Cs-6043

126. Db01904

127. Db11195

128. Db14704

129. Cas-87-99-0

130. Ncgc00165982-01

131. Ncgc00165982-02

132. Ncgc00258609-01

133. Ncgc00390798-01

134. Adonitol, Bioxtra, >=99.0% (hplc)

135. As-55964

136. Ds-11416

137. E967

138. Smr001562099

139. Hy-100582

140. Xylitol, Vetec(tm) Reagent Grade, >=99%

141. A0171

142. N1725

143. Sw220290-1

144. X0018

145. Xylite 1000 Microg/ml In Acetonitrile:water

146. A-3000

147. Adonitol, Bioreagent, Suitable For Cell Culture

148. C00379

149. C00474

150. X-7000

151. Wurcs=2.0/1,1,0/[h212h]/1/

152. Wurcs=2.0/1,1,0/[h222h]/1/

153. A842433

154. Q212093

155. Q416534

156. Xylitol, European Pharmacopoeia (ep) Reference Standard

157. 5dcf4f57-e023-469a-b4f3-91e8349a6705

158. Xylitol, United States Pharmacopeia (usp) Reference Standard

159. 6684f574-c267-40cb-8828-12f2550e58d0

160. Xylitol, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₅H₁₂O₅
Molecular Weight	152.15 g/mol
XLogP3	-2.5
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	152.06847348 g/mol
Monoisotopic Mass	152.06847348 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	76.1
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Sweetening Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)

4.2 Drug Indication

Indicated for use as a sugar substitute, and oral hygiene active ingredient.

5 Pharmacology and Biochemistry

5.1 Pharmacology

There has been evidence of xylitol in dental hygiene in reducing dental caries disease and also reversing the process of early caries. Xylitol increases salivary flow and pH, reduces the levels of _Streptococcus mutans_ in plaque and saliva and reduces the adhesion on the microorganism to the teeth surface. _Streptococcus mutans_ is the main target plaque microorganism, but xylitol may potentially have inhibitory actions against several other bacterial species. It prevents a shift of the bacterial community towards a more cariogenic microflora in oral environment. Oral ingestion of xylitol causes a smaller rise in plasma glucose and insulin concentrations than does the ingestion of glucose in healthy men and diabetics.

5.2 MeSH Pharmacological Classification

Sweetening Agents

Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed) (See all compounds classified as Sweetening Agents.)

5.3 Absorption, Distribution and Excretion

Absorption

Xylitol is absorbed in the small intestine via passive diffusion with a slow absorption rate.

Route of Elimination

No pharmacokinetic data available.

Volume of Distribution

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Five healthy human volunteers (two males and three females) received an orange flavored drink containing 30 g xylitol with breakfast. Before dosing, urine was collected for 24 hr and collections were continued 24 hr after the dose of xylitol. During the collection period no foods rich in oxalate were permitted. No significant changes in urinary oxalate excretion could be detected.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 18: Xylitol (87-99-0) (1983). Available from, as of July 11, 2011: https://www.inchem.org/pages/jecfa.html

Diets containing 20% of xylitol or one of the following carbohydrates: glucose, fructose, sucrose, xylose, sorbitol or mannitol were fed to groups of five Wistar rats for seven days. The rats were fasted for 12 hr and given a 5 uCi dose of U(14)C-oxalic acid mixed with 0.625 g/kg of xylitol or respective carbohydrate. Urine and feces were collected for 72 hr and counted for recovery of activity. Ten rats were gradually adapted to 20% xylitol diets. After a 12-hr fast these rats and 20 controls received 5 uCi of U(14)C-oxalic acid mixed with water only or together with 0.625 g/kg xylitol/body weight. Urine and feces were collected from five rats/group; tail vein blood from the other rats at intervals up to 24 hours. Urinary excretion of the label was virtually identical in all groups. The mean excretion of label in feces of control rats receiving oxalic acid was significantly lower (P <0.001) than in control rats receiving oxalate alone, or xylitol adapted rats receiving oxalate with xylitol (fecal recoveries were 77.8 and 83% respectively). The urinary excretion of label was also significantly higher among control rats receiving oxalate with xylitol when compared to control rats receiving oxalate alone. However, xylitol adapted rats excreted a significantly smaller proportion of oxalate in urine compared to controls receiving oxalate alone. The mean plasma levels of radioactivity in control rats receiving oxalic acid with xylitol were significantly higher (P <0.05) immediately after the start of the study when compared to controls receiving oxalic acid with water only or xylitol adapted rats. When samples of plasma, urine and feces were analyzed by use of thin layer chromatography, the major part of the radioactivity was recovered as oxalic acid.

Male (30) and female (20) CD-1 mice were either gradually adapted to 20% xylitol diets or fed a control diet. After a 12-hour fast the mice received a single oral dose of 2 uCi of U(14)C-oxalic acid in water or in an xylitol solution (a total dose of 0.625 g/kg bw). For five xylitol adapted male mice the oxalic acid dose was given with sorbitol (0.625 g/kg bw) and for another group of five with mannitol (0.625 g/kg bw). Urine and feces were collected at intervals for 72 hours to monitor the excretion of the label. ... Adaptation of male mice to 20% dietary xylitol increased the urinary excretion of the label fourfold (4.5 versus 20%). No major changes were seen in fecal excretion. Both sorbitol and mannitol increased the urinary excretion of the label while only sorbitol also affected fecal excretion of the label. Urinary excretion of oxalic acid was significantly higher in xylitol adapted mice when compared to controls receiving oxalic acid only. Even greater urinary recovery of label was observed in control mice receiving oxalic acid with xylitol. In female mice xylitol appeared to induce an even more pronounced increase in oxalic acid excretion.

Six groups of three Sprague-Dawley male weanling rats received semi-synthetic diets for 28 days; four of the groups were pyridoxine deficient. Diets contained either 50% glucose by weight or 30% glucose and 20% fructose. On day 28 the rats were injected three times at spaced intervals with either 15% glucose; 10% xylitol + 5% glucose; 15% fructose; or 10% xylitol + 5% fructose. Urine was collected on days 28 and 29 and rats were sacrificed and livers collected 30 minutes after a final injection on day 30. The final body weights for the rats show that the group with the best growth received fructose + xylitol injections and was pyridoxine adequate (mean weight 216.6 g) versus the group receiving fructose + fructose injection (15%) and were pyridoxine deficient (119.7 g). The poorest growing groups received glucose diets only and either xylitol or glucose and glucose injections, and were pyridoxine deficient (107.1 g, 103.1 g). The rats on the pyridoxine deficient diets tended to excrete more oxalate and have higher liver oxalate levels. Within the pyridoxine deficient group only, rats injected with xylitol tended to excrete more oxalate and have higher liver oxalate levels, but these differences were not significant. Fructose had no effect on oxalate excretion or liver oxalate levels in the rats injected with xylitol.

For more Absorption, Distribution and Excretion (Complete) data for Xylitol (10 total), please visit the HSDB record page.

5.4 Metabolism/Metabolites

In mammals, xylitol is mainly metabolized in the liver where it is oxidized to D-xylulose by xylitol dehydrogenase and cofactor NAD. D-xyluose is further phosphorylated and metabolized by xylulose kinase to xylulose 5-phosphate (Xu5P), an intermediate of the nonoxidative branch of the pentose phosphate pathway. Xu5P is reported to activate nuclear transport and the DNA-binding activities of carbohydrate response element binding protein (ChREBP) via activation of activation of protein phosphatase 2A (PP2A) _in vitro_. Activation of ChREBP thereby upregulates the gene transcription of lipogenic enzymes in vitro, which may stimulate lipogenesis in the liver.

The biochemical pathways for formation of oxalate after intravenous injection of xylitol in humans were studied using enzymes derived from human liver. It was concluded that metabolic pathways based on a combination of the transketolase, fructokinase, and aldolase reactions can account for the production of glucose, lactate, tertronates (D-threonic and D-erythronic acids) and oxalate (precursors) during the metabolism of xylitol administered parenterally.

After xylitol ingestion increase of serum lactate concentration and lactate-pyruvate ratio was observed, but to a degree less than after glucose. /Investigators/ also found a marked increase of alpha-dihydroxybutyrate. Complete metabolism of xylitol produces 35 equivalents of ATP compared to 32 from glucose.

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives Series 12: Xylitol (87-99-0) (1977). Available from, as of July 6, 2011: https://www.inchem.org/pages/jecfa.html

/In humans/ exogenous xylitol enters the pathway by conversion to D-xylulose by a nonspecific cytoplasmic polyol dehydrogenase. Phosphorylation then yields D-xylulose phosphate, the link between the glucuronic acid and the pentose phosphate pathways; the latter leads to the formation of glyceraldehyde-3-phosphate and fructose-6-phosphate, intermediate metabolites of the Embden-Meyerhof (glycolytic) pathway. Thus xylitol can be metabolized via glucose-6-phosphate to glycogen and pyruvate or lactate via the citric acid cycle to CO2. Xylitol is mainly metabolized in the liver (80% to glucose only 20%) but a small amount also in kidney, myocardium, erythrocytes, adrenal, brain, lungs and adipose tissue. Exogenous xylitol can be metabolized in large quantities, intravenously 0.4 gm/kg/hour or 40 g/day orally raises the plasma level to a maximum of 1.5-16 mg/100 mL. The metabolic rate for xylitol is identical in both healthy and diabetic or uraemic patients and patients who suffered from liver diseases.

In /human/ studies with (14)C-xylitol 90% of C-atoms taken up could be recovered in products and intermediates of the glycolytic and pentose phosphate pathway.

For more Metabolism/Metabolites (Complete) data for Xylitol (8 total), please visit the HSDB record page.

5.5 Biological Half-Life

No pharmacokinetic data available.

/In humans/ the initial fast distribution phase /for xylitol/ had a half life of about four minutes, while the apparent half life of elimination was approximately 20 minutes.

(14)C-xylitol disappeared extremely rapidly and the calculated half life is 165 seconds. ...

The half-life of exhalation of (14)CO2 after feeding with xylitol in unadapted /rats/ is 295 minutes, whereas rats which were adapted for 14 days to xylitol had a half-life of 237 minutes...

...Rats were administered (14)C-xylitol (250 mg) by intubation, the half-live of the resorption of xylitol was about 7 to 8 hr. The resorption rate is about 15-20% of that of glucose. After the animals had been fed xylitol for 14 days the half-life fell to 4.5 hr. ...

WHO/FAO: Expert Committee on Food Additives. Summary of Toxicological Data of Certain Food Additives: Xylitol (87-99-0) (1977). Available from, as of July 6, 2011: https://www.inchem.org/pages/jecfa.html

5.6 Mechanism of Action

Xylitol is initially taken up by the microorganism and accumulates intracellularly. Accumulated xylitol is transported into an energy-consuming cycle, or the inducible fructose transport system. It is converted to non-metabolizable, toxic xylitol-5-phosphate via phosphoenolpyruvate: a constitutive fructose phosphotransferase system by _S. mutans_. This metabolic process of xylitol, without the gain of any energy molecules, results in the development of intracellular vacuoles and cell membrane degradation. _S. mutans_ dephosphorylates xylitol-5-phosphate and expels it from the cell, in which requires energy consumption. This ultimately leading to starving of microorganism and growth inhibition. Long-term exposure to xylitol can cause microorganisms to develop resistance to xylitol. This clinically beneficial selection process creates xylitol-resistant mutans strains that are less virulent and less cariogenic than their parent strains. Xylitol also increases the concentrations of ammonia and amino acids in plaque, thereby neutralizing plaque acids. A study suggests that xylitol may also promote remineralization of deeper layers of demineralized enamel by facilitating Ca2+ and phosphate movement and accessibility.

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Mitsubishi Corporation

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Bussan Food Science Co., Ltd.

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Medlab Asia & Asia Health

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Mitsubishi Corporation Life Science...

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Medlab Asia & Asia Health

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Drugs in Development

01 BridgeBio Pharma

U.S.A

Medlab Asia & Asia Health

Not Confirmed

02 BridgeBio Pharma

U.S.A

Medlab Asia & Asia Health

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03 BridgeBio Pharma

U.S.A

Medlab Asia & Asia Health

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South Korea

Medlab Asia & Asia Health

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U.S.A

Medlab Asia & Asia Health

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Medlab Asia & Asia Health

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Pannon

Hungary

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PHYTOPHARM KLEKA S.A

Poland

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PHYTOPHARM KLEKA S.A

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Rochem International Inc

U.S.A

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Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

Dosage Form : Capsule, Cream / Lotion / Ointment, Emulsion, Suspension, Tablet

Grade : Topical, Oral

Category : Coating Systems & Additives, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Thickeners and Stabilizers

Brand Name : Carboxymethyl Cellulose

Application : Coating Systems & Additives, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Thickeners and Stabilizers

Excipient Details : Carboxymethylcellulose serves as a disintegrant, binder, coating agent & thickener in oral formulations, also as a stabilizer in topical formulations.

Pharmacopoeia Ref : NA

Technical Specs : NA

Ingredient(s) : Carboxymethyl cellulose excipient

02

SPI Pharma

U.S.A

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SPI Pharma has been solving formulation challenges using superior functional materials.

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Grade : Oral

Category : Chewable & Orodispersible Aids, Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Taste Masking

Brand Name : Compressol SM

Application : Chewable & Orodispersible Aids, Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Taste Masking

Excipient Details : Compressol® SM, co-processed polyol, is a DC excipient of mannitol & sorbitol with superior compactibility, lower disintegration time & hygroscopicity

Pharmacopoeia Ref : NA

Technical Specs : NA

Ingredient(s) : Mannitol

03

Faran Shimi Pharmaceutical

Iran

Antibody Engineering

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Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Dosage Form : Tablet

Grade : Oral

Category : Fillers, Diluents & Binders

Brand Name : Pregelatinized Corn Starch

Application : Fillers, Diluents & Binders

Excipient Details : Corn starch is used as a filler and binder in pharmaceutical oral solid dosage forms, including tablets.

Pharmacopoeia Ref : BP/USP

Technical Specs : NA

Ingredient(s) : Corn Starch, Pregelatinized

04

Faran Shimi Pharmaceutical

Iran

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Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Dosage Form : Tablet

Grade : Oral

Category : Fillers, Diluents & Binders

Brand Name : Lactose Monohydrate

Application : Fillers, Diluents & Binders

Excipient Details : Lactose monohydrate is widely used as a filler and diluent in solid dosage forms such as tablets.

Pharmacopoeia Ref : NA

Technical Specs : NA

Ingredient(s) : Lactose Monohydrate

05

Gangwal Healthcare

India

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Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

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Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Brand Name : STARLOSE®

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Excipient Details : STARLOSE is used as a diluent, binder, directly compressible (DC), and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : IP/EP/USP-NF/IH

Technical Specs : NA

Ingredient(s) : Lactose Monohydrate

06

Nanjing Well Pharmaceutical

China

Antibody Engineering

Not Confirmed

Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

Dosage Form : Injectable / Parenteral

Grade : Parenteral

Category : Parenteral

Brand Name : Lactose Monohydrate

Application : Parenteral

Excipient Details : Lactose monohydrate is used as a diluent in inhalation and lyophilized preparations.

Pharmacopoeia Ref : ChP/USP/EP/JP

Technical Specs : NA

Ingredient(s) : Lactose Monohydrate

07

Pluviaendo

Turkey

Antibody Engineering

Not Confirmed

08

Gangwal Healthcare

India

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Brand Name : DiCOM-DC® S-Star

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Excipient Details : DiCOM-DC S-Star (Maize Starch) is used as a filler, binder, and directly compressible co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : In-house

Technical Specs : NA

Ingredient(s) : Maize Starch

09

Gangwal Healthcare

India

Antibody Engineering

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Brand Name : DiCOM-DC® PL009 P60

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Excipient Details : DiCOM-DC PL009 P60 is used as a filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : IH

Technical Specs : NA

Ingredient(s) : Maize Starch

10

Gangwal Healthcare

India

Antibody Engineering

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

Brand Name : DiCOM-DC® SP204

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

Excipient Details : DiCOM-DC SP204 is used as a stabilizer, filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : In-house

Technical Specs : NA

Ingredient(s) : Corn Starch, Pregelatinized

Only 10 entries up to this point, click to access all

Direct Compression

Film Formers & Plasticizers

Solubilizers

Parenteral

Thickeners and Stabilizers

Co-Processed Excipients

Coating Systems & Additives

Taste Masking

Granulation

Topical

Rheology Modifiers

Emulsifying Agents

Controlled & Modified Release

Chewable & Orodispersible Aids

Lubricants & Glidants

Disintegrants & Superdisintegrants

Surfactant & Foaming Agents

API Stability Enhancers

Soft Gelatin

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DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

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APIs

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EXCIPIENTS

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REF. STANDARDS & IMPURITIES

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USP

Others

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ANALYTICAL

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Analytical Methods

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Market Place

Find Ribitol manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

5 API Suppliers

2 USDMF

2 JDMF

1 NDC API

1 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers

5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc

5 SPI Pharma

2 DKSH

3 Faran Shimi Pharmaceutical

9 Gangwal Healthcare

5 Nanjing Well Pharmaceutical

4 Actylis

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

7 BASF

1 Bioplus Life Sciences

1 Clariant

2 DFE Pharma

4 Gangwal Chemicals

2 Ingredion Pharma Solutions

16 Kerry

1 Kima Chemical

5 Microlex e.U

1 Nanjing Bold Chemical

4 Pluviaendo

17 Roquette

7 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

4 Sigachi Industries

1 The Dow Chemical Company

1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

41 Fillers, Diluents & Binders

20 Direct Compression

14 Film Formers & Plasticizers

13 Solubilizers

12 Parenteral

11 Thickeners and Stabilizers

11 Co-Processed Excipients

10 Coating Systems & Additives

10 Taste Masking

9 Granulation

7 Topical

5 Rheology Modifiers

5 Emulsifying Agents

5 Controlled & Modified Release

5 Chewable & Orodispersible Aids

5 Lubricants & Glidants

5 Disintegrants & Superdisintegrants

3 Surfactant & Foaming Agents

2 API Stability Enhancers

1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

2 NEWS #PharmaBuzz

MARKET PLACE

8 APIs

1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 USP

1 Others

ANALYTICAL

1 Analytical Methods

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 256

MARKET PLACE