Kisqali is indicated for the treatment of women with hormone receptor (HR)positive, human epidermal growth factor receptor 2 (HER2)negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy.

In pre or perimenopausal women, the endocrine therapy should be combined with a luteinising hormonereleasing hormone (LHRH) agonist.

Molecular Formula	C₂₇H₃₆N₈O₅
Molecular Weight	552.6 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	8
Exact Mass	552.28086628 g/mol
Monoisotopic Mass	552.28086628 g/mol
Topological Polar Surface Area	166 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	728
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

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Drug Name	KISQALI
Active Ingredient	RIBOCICLIB SUCCINATE
Company	NOVARTIS PHARMS CORP (Application Number: N209092. Patents: 8324225, 8415355, 8685980, 8962630, 9193732, 9416136, 9868739)

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Drug Name	KISQALI FEMARA CO-PACK (COPACKAGED)
Active Ingredient	LETROZOLE; RIBOCICLIB SUCCINATE
Company	NOVARTIS PHARMS CORP (Application Number: N209935. Patents: 8324225, 8415355, 8685980, 8962630, 9193732, 9416136, 9868739)

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