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    Chemistry

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    Also known as: Lee011 succinate, 1374639-75-4, Lee-011 succinate, Lee011-bba, Ribociclib succinate [usan], Kisqali
    Molecular Formula
    C27H36N8O5
    Molecular Weight
    552.6  g/mol
    InChI Key
    NHANOMFABJQAAH-UHFFFAOYSA-N
    FDA UNII
    BG7HLX2919
    Ribociclib
    1 2D Structure

    Ribociclib

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid;7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
    2.1.2 InChI
    InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    NHANOMFABJQAAH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    BG7HLX2919
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Kisqali

    2. Lee011

    3. Ribociclib

    2.3.2 Depositor-Supplied Synonyms

    1. Lee011 Succinate

    2. 1374639-75-4

    3. Lee-011 Succinate

    4. Lee011-bba

    5. Ribociclib Succinate [usan]

    6. Kisqali

    7. Lee-011-bba

    8. Bg7hlx2919

    9. 7-cyclopentyl-n,n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate

    10. Butanedioic Acid;7-cyclopentyl-n,n-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide

    11. Ribociclib Succinate (usan)

    12. Butanedioic Acid, Compd. With 7-cyclopentyl-n,n-dimethyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-7h-pyrrolo(2,3-d)pyrimidine-6-carboxamide (1:1)

    13. Butanedioic Acid, Compd. With 7-cyclopentyl-n,n-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1)

    14. Unii-bg7hlx2919

    15. Kisqali (tn)

    16. Lee011 (succinate)

    17. Birociclib [who-dd]

    18. Schembl2684999

    19. Chembl3707266

    20. Ribociclib Succinate [mi]

    21. Dtxsid301027923

    22. Amy25508

    23. Bcp12715

    24. Ex-a1586

    25. Zec63975

    26. Lee011 Succinatelee011 Succinate

    27. Hy-15777b

    28. S5188

    29. Ribociclib Succinate [who-dd]

    30. Sb18482

    31. Ac-30654

    32. As-75241

    33. Ribociclib Succinate [orange Book]

    34. D10979

    35. Lee-011 Succinate Salt, Ribociclib Succinate Salt

    36. J-007026

    37. Q27274660

    38. Kisqali Femara Co-pack Component Ribociclib Succinate

    39. Ribociclib Succinate Component Of Kisqali Femara Co-pack

    40. 7-cyclopentyl-n,n-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Butanedioic Acid

    2.4 Create Date
    2012-06-20
    3 Chemical and Physical Properties
    Molecular Weight 552.6 g/mol
    Molecular Formula C27H36N8O5
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count8
    Exact Mass552.28086628 g/mol
    Monoisotopic Mass552.28086628 g/mol
    Topological Polar Surface Area166 Ų
    Heavy Atom Count40
    Formal Charge0
    Complexity728
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameKISQALI
    Active IngredientRIBOCICLIB SUCCINATE
    CompanyNOVARTIS PHARMS CORP (Application Number: N209092. Patents: 8324225, 8415355, 8685980, 8962630, 9193732, 9416136, 9868739)

    2 of 2  
    Drug NameKISQALI FEMARA CO-PACK (COPACKAGED)
    Active IngredientLETROZOLE; RIBOCICLIB SUCCINATE
    CompanyNOVARTIS PHARMS CORP (Application Number: N209935. Patents: 8324225, 8415355, 8685980, 8962630, 9193732, 9416136, 9868739)

    4.2 Drug Indication

    Kisqali is indicated for the treatment of women with hormone receptor (HR)positive, human epidermal growth factor receptor 2 (HER2)negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy.

    In pre or perimenopausal women, the endocrine therapy should be combined with a luteinising hormonereleasing hormone (LHRH) agonist.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    L01XE

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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1670524200,"product":"RIBOCICLIB SUCCINATE (LEE011) DRUG","address":"INSPIRE BKC PART OF 601 AND 701,BA NDRAKURLA COMPLEX BANDRA EAST","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"SWITZERLAND","quantity":"0.00","actualQuantity":"2","unit":"GMS","unitRateFc":"25.3","totalValueFC":"48.5","currency":"CHF","unitRateINR":2000,"date":"09-Dec-2022","totalValueINR":"4000","totalValueInUsd":"48.5","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"6032768","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"INSPIRE BKC PART OF 601 AND 701,BA NDRAKURLA COMPLEX BANDRA EAST, MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723055400,"product":"RIBOCICLIB SUCCINATE,BATCH NO:RIBA24004P2 & RIBA24006P1","address":"N0 116\/117, KIADB INDUSTRIAL AREA,","city":"BANGALORE","supplier":"CDYMAX (INDIA) PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"M\/S R-OPRA LLC","customerCountry":"RUSSIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"668000","totalValueFC":"23891.7","currency":"INR","unitRateINR":668000,"date":"08-Aug-2024","totalValueINR":"2004000","totalValueInUsd":"23891.7","indian_port":"Bangalore Air","hs_no":"29335990","bill_no":"3055518","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0 116\/117, KIADB INDUSTRIAL AREA,, BANGALORE","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678732200,"product":"RIBOCICLIB SUCCINATE (LEE)-51000171 -H10507-03 (2X1000 MG) FOC","address":"KALWE MIDC PLOT NO.8-A\/2 8\/B,TTC I NDUSTRIAL AREA KALWE BLOCK","city":"VILLAGE DIGHE NAVI MUMBAI THANE,MAH","supplier":"SANDOZ B2B","supplierCountry":"SLOVENIA","foreign_port":"NA","customer":"SANDOZ B2B","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"2","unit":"GMS","unitRateFc":"265.8","totalValueFC":"539.8","currency":"USD","unitRateINR":"22198.1","date":"14-Mar-2023","totalValueINR":"44396.12","totalValueInUsd":"539.8","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"5034164","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVENIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"KALWE MIDC PLOT NO.8-A\/2 8\/B,TTC I NDUSTRIAL AREA KALWE BLOCK"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1689532200,"product":"RIBOCICLIB SUCCINATE\/DS 04.(FREE OF COST.THIS MATERIAL IS SENT FOR ANALYTICAL PURPOSE ONLY AND HAS NO COMMERCIAL VALUE.)","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"CHINA","foreign_port":"CHANGI","customer":"DIVIS LABORATORIES","customerCountry":"INDIA","quantity":"0.72","actualQuantity":"715","unit":"GMS","unitRateFc":"30.7","totalValueFC":"22216.2","currency":"USD","unitRateINR":"2553.8","date":"17-Jul-2023","totalValueINR":"1825942","totalValueInUsd":"22216.2","indian_port":"Vizag-DLL SEZ","hs_no":"29335990","bill_no":"1000606","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHANGI","supplierAddress":"N\/A","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722277800,"product":"RIBOCICLIB SUCCINATE (LEE001)","address":"SANDOZ HOUSE,8TH FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"M\/S.NOVARTIS PHARMACEUTICALS MANUFACTURING LLC","supplierCountry":"SLOVENIA","foreign_port":"LJUBLJANA - BRNIK","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"274","totalValueFC":"1662.4","currency":"EUR","unitRateINR":"27792.8","date":"30-Jul-2024","totalValueINR":"138963.79","totalValueInUsd":"1662.4","indian_port":"Hyderabad Air","hs_no":"29335990","bill_no":"4778555","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVENIA","selfForZScoreResived":"Pharma Grade","supplierPort":"LJUBLJANA - BRNIK","supplierAddress":"VEROVSKOVA ULICA 571000 LJUBLJANASLOVENIA SI","customerAddress":"SANDOZ HOUSE,8TH FLOOR,"}]
    09-Dec-2022
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    (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin...

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    RLD :

    TE Code :

    RIBOCICLIB

    Brand Name : RIBOCICLIB

    Dosage Form : TABLET; ORAL

    Dosage Strength : 200MG

    Approval Date :

    Application Number : 215677

    RX/OTC/DISCN :

    RLD :

    TE Code :

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    RLD : Yes

    TE Code :

    RIBOCICLIB SUCCINATE

    Brand Name : KISQALI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 200MG BASE

    Approval Date : 2017-03-13

    Application Number : 209092

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code :

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    03

    NOVARTIS

    Switzerland
    SupplySide West 2024
    Not Confirmed
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    NOVARTIS

    Switzerland
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Digital Content Digital Content

    RLD : Yes

    TE Code :

    LETROZOLE; RIBOCICLIB SUCCINATE

    Brand Name : KISQALI FEMARA CO-PACK (COPACKAGED)

    Dosage Form : TABLET;ORAL

    Dosage Strength : 2.5MG;EQ 200MG BASE

    Approval Date : 2017-05-04

    Application Number : 209935

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code :

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