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Chemistry

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Also known as: 308362-25-6, Ridinilazole [inn], Smt19969, Smt-19969, Ridinilazole [usan], Chembl3753858
Molecular Formula
C24H16N6
Molecular Weight
388.4  g/mol
InChI Key
UHQFBTAJFNVZIV-UHFFFAOYSA-N
FDA UNII
06DX01190R

Ridinilazole
Ridinilazole is a narrow-spectrum antibiotic with potential activity against Clostridioides difficile infection (CDI). Upon oral administration, ridinilazole exerts its bactericidal activity against C. difficile through inhibition of cell division. This suppresses bacterial toxin production and inhibits the associated inflammatory response. Compared to other antibiotics that treat C. difficile, ridinilazole does not deplete intestinal bacteria and preserves the intestinal bacterial activity and the associated bile acid metabolome.
1 2D Structure

Ridinilazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-pyridin-4-yl-6-(2-pyridin-4-yl-3H-benzimidazol-5-yl)-1H-benzimidazole
2.1.2 InChI
InChI=1S/C24H16N6/c1-3-19-21(29-23(27-19)15-5-9-25-10-6-15)13-17(1)18-2-4-20-22(14-18)30-24(28-20)16-7-11-26-12-8-16/h1-14H,(H,27,29)(H,28,30)
2.1.3 InChI Key
UHQFBTAJFNVZIV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C=C1C3=CC4=C(C=C3)N=C(N4)C5=CC=NC=C5)NC(=N2)C6=CC=NC=C6
2.2 Other Identifiers
2.2.1 UNII
06DX01190R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2,2' Bis(4-pyridyl) 3h,3'h 5,5' Bibenzimidazole

2. 2,2'-dipyridin-4-yl-1h,1'h-5,5'-bibenzimidazole

3. Smt19969

2.3.2 Depositor-Supplied Synonyms

1. 308362-25-6

2. Ridinilazole [inn]

3. Smt19969

4. Smt-19969

5. Ridinilazole [usan]

6. Chembl3753858

7. 5,5'-bi-1h-benzimidazole, 2,2'-di-4-pyridinyl-

8. 06dx01190r

9. 2,2'-di(pyridin-4-yl)-1h,1'h-5,5'-bibenzo[d]imidazole

10. 2-pyridin-4-yl-6-(2-pyridin-4-yl-3h-benzimidazol-5-yl)-1h-benzimidazole

11. 2,2'-di(pyridin-4-yl)-1h,1'h-5,5'-bi(benzimidazole)

12. P-pyben

13. Unii-06dx01190r

14. Ridinilazole [who-dd]

15. Schembl413723

16. Schembl17867397

17. Schembl19235713

18. Gtpl10853

19. Dtxsid101028337

20. Smt19969smt19969

21. Bdbm50134759

22. Mfcd28963972

23. Who 10075

24. Zinc113778168

25. Cs-6591

26. Db15308

27. Lx-0216

28. Hy-16753

29. D80826

30. Q25102246

31. 2,2'-dipyridin-4-yl-1h,1'h-5,5'-bibenzimidazole

32. 2,2'-bis(4-pyridyl)-3h,3'h-5,5'-bibenzimidazole

33. 2-(pyridin-4-yl)-6-[2-(pyridin-4-yl)-1h-1,3-benzodiazol-5-yl]-1h-1,3-benzodiazole

2.4 Create Date
2007-08-09
3 Chemical and Physical Properties
Molecular Weight 388.4 g/mol
Molecular Formula C24H16N6
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass388.14364454 g/mol
Monoisotopic Mass388.14364454 g/mol
Topological Polar Surface Area83.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity524
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of Clostridium difficile infection


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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ABOUT THIS PAGE

Ridinilazole Manufacturers

A Ridinilazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ridinilazole, including repackagers and relabelers. The FDA regulates Ridinilazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ridinilazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ridinilazole Suppliers

A Ridinilazole supplier is an individual or a company that provides Ridinilazole active pharmaceutical ingredient (API) or Ridinilazole finished formulations upon request. The Ridinilazole suppliers may include Ridinilazole API manufacturers, exporters, distributors and traders.

Ridinilazole GMP

Ridinilazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ridinilazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ridinilazole GMP manufacturer or Ridinilazole GMP API supplier for your needs.

Ridinilazole CoA

A Ridinilazole CoA (Certificate of Analysis) is a formal document that attests to Ridinilazole's compliance with Ridinilazole specifications and serves as a tool for batch-level quality control.

Ridinilazole CoA mostly includes findings from lab analyses of a specific batch. For each Ridinilazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ridinilazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Ridinilazole EP), Ridinilazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ridinilazole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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