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Chemistry

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Also known as: Rifamycin sv, Rifocin, Rifamicine sv, Rifomycin sv, Rifamicina, Rifamycine
Molecular Formula
C37H47NO12
Molecular Weight
697.8  g/mol
InChI Key
HJYYPODYNSCCOU-ODRIEIDWSA-N
FDA UNII
DU69T8ZZPA

Rifamycin
A group of ANTI-BACTERIAL AGENTS characterized by a chromophoric naphthohydroquinone group spanned by an aliphatic bridge not previously found in other known ANTI-BACTERIAL AGENTS. They have been isolated from fermentation broths of Streptomyces mediterranei.
Rifamycin is a Rifamycin Antibacterial.
1 2D Structure

Rifamycin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
2.1.2 InChI
InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
2.1.3 InChI Key
HJYYPODYNSCCOU-ODRIEIDWSA-N
2.1.4 Canonical SMILES
CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C
2.1.5 Isomeric SMILES
C[C@H]1/C=C/C=C(\C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C
2.2 Other Identifiers
2.2.1 UNII
DU69T8ZZPA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Rifamycins

2. Rifomycin

3. Rifomycins

2.3.2 Depositor-Supplied Synonyms

1. Rifamycin Sv

2. Rifocin

3. Rifamicine Sv

4. Rifomycin Sv

5. Rifamicina

6. Rifamycine

7. Rifamycinum

8. Rifocyn

9. 6998-60-3

10. Cb-01-11

11. Aemcolo

12. Du69t8zzpa

13. M-14

14. Chebi:29673

15. 6998-60-3 (free Acid)

16. 15105-92-7

17. Rifamycin Sv, An Antibiotic Produced By Certain Strains Of Streptomyces Mediterranei, Or The Same Substance Produced By Any Other Means

18. Rifamycine [inn-french]

19. Rifamycinum [inn-latin]

20. Rifamicina [inn-spanish]

21. (7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl Acetate

22. [(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] Acetate

23. Rifomycin

24. Einecs 230-273-3

25. Unii-du69t8zzpa

26. Tuborin

27. Rifamycin-sv

28. Nsc133100

29. Rifamycin [usan:inn:ban:dcf]

30. Rifamycin [inn]

31. Rifamycin (usan/inn)

32. Rifamycin [usan]

33. Rifamycin Sv [mi]

34. Rifamycin [who-dd]

35. Schembl151824

36. Chembl437765

37. Gtpl4570

38. Dtxsid1032014

39. Rifamycin Sv [ep Impurity]

40. Bdbm50391000

41. Lmpk05000005

42. Akos024281286

43. Zinc169633673

44. Db11753

45. 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2h)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate

46. Rifaximin Impurity C [ep Impurity]

47. D02549

48. Sr-01000872597

49. Sr-01000872597-1

50. (pentahydroxy-methoxy-heptamethyl-dioxo-[?]yl) Acetate

51. Q26270990

52. (2s,12z,14e,16s,17s,18r,19r,20r,21s,22r,23s,24e)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl Acetate

53. (7s,11s,12r,13s,14r,15r,16r,17s,18s,19z,21z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl Acetate

54. (7s,11s,13s,17s,18s,12r,14r,15r,16r)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7 ,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1<4, 7>.0<5,28>]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl Acetate

55. 2,7-(epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-1,11(2h)-dione, 21-(acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, (2s,16s,17s,18r,19r,20r,21s,22r,23s)-

56. 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2h)-dione 21-acetate

2.4 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 697.8 g/mol
Molecular Formula C37H47NO12
XLogP34.9
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count12
Rotatable Bond Count3
Exact Mass697.30982593 g/mol
Monoisotopic Mass697.30982593 g/mol
Topological Polar Surface Area201 Ų
Heavy Atom Count50
Formal Charge0
Complexity1330
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Rifamycin is indicated for the treatment of adult patients with travelers' diarrhea caused by noninvasive strains of _E. coli_. The status of the disease should not be complicated by fever or blood in the stool. To prevent drug-resistant bacteria, it is important to mention that the use of rifamycin for this indication should be only done in cases where the infection is proven or strongly suspected to be caused by bacteria. Travallers' diarrhea is very common problem affecting 20-60% of the travellers and it is defined as an increase in frequency of bowel movements to three or more loose stools per day during a trip abroad. This condition is rarely life threatening but in severe cases it can produce dehydration and sepsis. The most common cause of travellers' diarrhea is a pathogen and from the pathogens identified, bacteria is the most common cause followed by norovirus, rotavirus and similar viruses.


FDA Label


Treatment of acute infectious diarrhoea


Treatment of acute infectious diarrhoea


5 Pharmacology and Biochemistry
5.1 Pharmacology

Rifamycin is known to be effective against Gram-positive and Gram-negative pathogens and mycobacteria. It is very effective against _E. coli_ reporting a MIC90 of 64-128 mcg/ml without showing cross-resistance with other antimicrobial agents. The specific indication of rifamycin is extremely important as ther were previous reports that indicated a high risk factor in the generation of resistant _E. coli_ strains in patients with inflammatory bowel disease. In clinical trials, rifamycin was tested in a randomized clinical trial of travellers' coming from Mexico and Guatemala. In this trial, rifamycin was proven to significantly reduce the symptoms of travellers' diarrhea.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
RIFAMYCIN
5.3.2 FDA UNII
DU69T8ZZPA
5.3.3 Pharmacological Classes
Rifamycins [CS]; Rifamycin Antibacterial [EPC]
5.4 ATC Code

J04AB03

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07A - Intestinal antiinfectives

A07AA - Antibiotics

A07AA13 - Rifamycin


D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AX - Other antibiotics for topical use

D06AX15 - Rifamycin


J - Antiinfectives for systemic use

J04 - Antimycobacterials

J04A - Drugs for treatment of tuberculosis

J04AB - Antibiotics

J04AB03 - Rifamycin


S - Sensory organs

S01 - Ophthalmologicals

S01A - Antiinfectives

S01AA - Antibiotics

S01AA16 - Rifamycin


S - Sensory organs

S02 - Otologicals

S02A - Antiinfectives

S02AA - Antiinfectives

S02AA12 - Rifamycin


5.5 Absorption, Distribution and Excretion

Absorption

Rifamycin has a very poor absorption and thus, the generation of an oral modified-release formulation using the technology of the multi-matrix structure was required for the generation of the FDA approved product. This preparation allows the delivery of the active ingredient in the distal small bowel and colon without interfering with the flora in the upper gastrointestinal tract. The multi-matrix is made by a lipophiic matrix surrounded in a hydrophilic matrix which allows for the protection of the active ingredient from dissolution in the intestinal aqueous fluids before it arrives in the cecum. All this matrix is surrounded by a gastro-resistant polymer that only desintegrate in a pH lower than 7. All this administration-customed formulation allows for a bioavailability of <0.1% and the plasma concentrations are reported to be of <2 ng/ml in patients receiving a dose of 400 mg. This confirms that the site of action of rifamycin stays in the small intestine and colon which prevents the need for dose adjustments in special populations as well as systemic drug interactions. The reported Cmax, tmax, AUC and mean residence time after a dosage of 250 mg of rifamycin is 36 mg/L, 5 min, 11.84 mg.h/L and 0.49 h respectively.


Route of Elimination

From the administered dose, 18%, 50% and 21% is recovered in feces during the first 24, 48 and 72h after administration. This will represent about 90% of the administered dose eliminated by the feces while the urinary secretion is negligible.


Volume of Distribution

The reported volume of distribution after measured after a dosage of 250 mg of rifamycin is 101.8 L.


Clearance

The reported clearance when a dose of 250 mg of rifamycin was administered is 23.3 L/h.


5.6 Metabolism/Metabolites

When absorbed, rifamycin is mainly metabolzied in hepatocytes and intestinal microsomes to a 25-deacetyl metabolite.


5.7 Biological Half-Life

The reported half-life when a dose of 250 mg of rifamycin was administered is 3 h.


5.8 Mechanism of Action

Rifamycins, as well as all the other members of this group, present an antibacterial mechanism of action related to the inhibition of RNA synthesis. This mechanism of action is done by the strong binding to the DNA-dependent RNA polymerase of prokaryotes. The inhibition of the RNA synthesis is thought to be related with the initiation phase of the process and to involve stacking interactions between the naphthalene ring and the aromatic moiety in the polymerase. As well, it has been suggested that the presence of zinc atoms in the polymerase allows for the binding of phenolic -OH groups of the naphthalene ring. In eukaryotic cells, the binding is significantly reduced making them at least 100 to 10,000 times less sensitive to the action of rifamycins. The members of the rifamycin family present the same mechanism of action and the structural modifications are usually related to pharmacokinetic properties as well as to the interaction with eukaryotic cells.


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LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"MACLEODS PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"2500.00","actualQuantity":"2500","unit":"KGS","unitRateFc":"94.7","totalValueFC":"237722.4","currency":"USD","unitRateINR":"8199.4","date":"09-Jan-2025","totalValueINR":"20498612.09","totalValueInUsd":"237722.4","indian_port":"Bombay Air","hs_no":"29419013","bill_no":"7696602","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"UNIT 106 ON 1\/F,WAYSON COMMERCIAL BUILDING, 28 CANNAUGHT ROAD WEST,SHEUNG WAN, CHINA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736706600,"product":"RIFAMYCINS AS PER INVOICE RIFAMYCINS AS PER INVOICE","address":"RANJIT HOUSE, OPP- SUN RESIDENCY","city":"SHILAJ ROAD,THALTEJ,AHMEDABAD","supplier":"SUZHOU BIOSYNERGY PHARMACEUTICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"BILLS BIOTECH","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"97","totalValueFC":"48708.6","currency":"USD","unitRateINR":"8400.2","date":"13-Jan-2025","totalValueINR":"4200100","totalValueInUsd":"48708.6","indian_port":"Ahmedabad Air","hs_no":"29329990","bill_no":"7754830","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOM 202, BUILDING 15, SUZHOU NANO CITY, 99 JINJI LAKE AVENUE, SUZHOU INDUSTRIAL PARK, JIANGSU CHINA","customerAddress":"RANJIT HOUSE, OPP- SUN RESIDENCY"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736706600,"product":"SODIUM RIFAMYCIN S SODIUM RIFAMYCIN S","address":"159, C.S.T. ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"HEBEI XINGANG PHARMACEUTICAL CO","supplierCountry":"CHINA","foreign_port":"XINGANG","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"6000.00","actualQuantity":"6000","unit":"KGS","unitRateFc":"68.7","totalValueFC":"413769.4","currency":"N\/A","unitRateINR":"5946.5","date":"13-Jan-2025","totalValueINR":"35679000","totalValueInUsd":"413769.4","indian_port":"JNPT","hs_no":"29419013","bill_no":"7768942","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XINGANG","supplierAddress":"TDNO.2, FUQIANG STREET, ZHAOYUAN RO AD, ZHAO COUNTY SHIJIZHUANG, HEBEI PROVINCE-051530, China","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737052200,"product":"4-O-CARBOXYMETHYL-1-DEOXY-1,4-DIHYDRO-4-HYDROXY-1-OXORIFAMYCIN Y-LACTONE (RIFAMYCIN-O)CHEMICAL","address":"PLOT NO.131,3RD FLOOR,NARMADA","city":"HYDERABAD. AP","supplier":"UBERONE LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"OPTIMUS DRUGS PRIVATE ","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"84","totalValueFC":"42424.1","currency":"USD","unitRateINR":"7316.4","date":"17-Jan-2025","totalValueINR":"3658200","totalValueInUsd":"42424.1","indian_port":"Madras Sea","hs_no":"29420090","bill_no":"7838553","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"7001 CORPORATE DR STE 100, HOUSTON, TX,77036 SDNF CN","customerAddress":"PLOT NO.131,3RD FLOOR,NARMADA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737052200,"product":"4-O-CARBOXYMETHYL-1-DEOXY-1,4-DIHYDRO-4-HYDROXY-1-OXORIFAMYCIN Y-LACTONE (RIFAMYCIN-O)CHEMICAL","address":"PLOT NO.131,3RD FLOOR,NARMADA","city":"HYDERABAD. AP","supplier":"UBERONE LLC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"OPTIMUS DRUGS PRIVATE ","customerCountry":"INDIA","quantity":"2500.00","actualQuantity":"2500","unit":"KGS","unitRateFc":"84","totalValueFC":"212120.7","currency":"USD","unitRateINR":"7316.4","date":"17-Jan-2025","totalValueINR":"18291000","totalValueInUsd":"212120.7","indian_port":"Madras Sea","hs_no":"29420090","bill_no":"7838553","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"7001 CORPORATE DR STE 100, HOUSTON, TX,77036 SDNF CN","customerAddress":"PLOT NO.131,3RD FLOOR,NARMADA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737397800,"product":"RIFAMYCIN-O RIFAMYCIN-O","address":"NO.13-1-183\/1, PLOT NO.69,","city":"HYDERABAD, AP.","supplier":"HISUN PHARMACEUTICAL (HANGZHOU) CO.,LTD.","supplierCountry":"CHINA","foreign_port":"NINGBO","customer":"BENOVA LABS PRIVATE ","customerCountry":"INDIA","quantity":"2400.00","actualQuantity":"2400","unit":"KGS","unitRateFc":"82","totalValueFC":"198787.4","currency":"USD","unitRateINR":"7142.2","date":"21-Jan-2025","totalValueINR":"17141280","totalValueInUsd":"198787.4","indian_port":"Madras Sea","hs_no":"29419011","bill_no":"7905880","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NINGBO","supplierAddress":"NO 1,HAIZHENG ROAD, XUKOU TOWN,FUYA NG DISTRICT, HANGZHOU CITY,ZHEJIANG PROVINCE,311404 China","customerAddress":"NO.13-1-183\/1, PLOT NO.69,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738002600,"product":"RIFAMYCIN S RIFAMYCIN S","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"HIGH HOPE PBC HK CO. LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"MACLEODS PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"94.7","totalValueFC":"57382.1","currency":"USD","unitRateINR":"8246.7","date":"28-Jan-2025","totalValueINR":"4948013.76","totalValueInUsd":"57382.1","indian_port":"Bombay Air","hs_no":"29419013","bill_no":"8040624","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"UNIT 106 ON 1\/F,WAYSON COMMERCIAL BUILDING, 28 CANNAUGHT ROAD WEST,SHEUNG WAN,","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738089000,"product":"4-O-CARBOXYMETHYL-1-DEOXY-1,4-DIHYDRO-4- HYDROXY-1-OXORIFAMYCIN Y-LACTONE4-O-CARBOXYMETHYL-1-DEOXY-1,4-DIHYDRO-4- HYDROXY-1-OXORIFAMY","address":"PLOT NO.131,3RD FLOOR,NARMADA","city":"HYDERABAD. AP","supplier":"UBERONE LLC","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"OPTIMUS DRUGS PRIVATE ","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"87.5","totalValueFC":"265150.9","currency":"N\/A","unitRateINR":"7621.3","date":"29-Jan-2025","totalValueINR":"22863750","totalValueInUsd":"265150.9","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"8062583","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"7001 Corporate Dr Ste100,Houston,TX ,77036 SDNF","customerAddress":"PLOT NO.131,3RD FLOOR,NARMADA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738521000,"product":"RIFAMYCIN S RIFAMYCIN S","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"HEBEI XINGANG PHARMACEUTICAL CO","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MACLEODS PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"5510.00","actualQuantity":"5510","unit":"KGS","unitRateFc":"94.1","totalValueFC":"519076.3","currency":"USD","unitRateINR":"8192.6","date":"03-Feb-2025","totalValueINR":"45140997.2","totalValueInUsd":"519076.3","indian_port":"JNPT","hs_no":"29419013","bill_no":"8138065","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO. 2 FUQIANG STREET, ZHAOYUAN ROAD , ZHAO COUNTRY, SHIJIAZHUANG SDNF CHINA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738866600,"product":"RIFAMYCIN O RIFAMYCIN O","address":"13, KAILASH DARSHAN, 4TH FLOOR,","city":"MUMBAI, MAHARASHTRA.","supplier":"SHANGHAI HUIRUI MEDICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ORBIT LIFESCIENCE","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"84","totalValueFC":"170773.9","currency":"USD","unitRateINR":"7425.6","date":"07-Feb-2025","totalValueINR":"14851200","totalValueInUsd":"170773.9","indian_port":"JNPT","hs_no":"29419011","bill_no":"8218617","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"1001,CUBE EDIFICE,NO.58,CHANGLIU RO AD,PUDONG NEW DISTRICT,SHANGHAI 200 135,CHINA CHINA","customerAddress":"13, KAILASH DARSHAN, 4TH FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739125800,"product":"RIFAMYCIN S RIFAMYCIN S","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"HEBEI XINGANG PHARMACEUTICAL CO","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"MACLEODS PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"7000.00","actualQuantity":"7000","unit":"KGS","unitRateFc":"96.1","totalValueFC":"683713","currency":"USD","unitRateINR":"8494.1","date":"10-Feb-2025","totalValueINR":"59458477.36","totalValueInUsd":"683713","indian_port":"Bombay Air","hs_no":"29419013","bill_no":"8275028","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"D. NO.2 FUQIANG STREET, ZHAOYUAN RO AD, ZHAO COUTY, SHIJIAZHUANG CHINA SDNF CHINA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739730600,"product":"REIMPORT OF RIFAMYCIN-S (BATCH NO.2080000598,2080000599, 2080000600)(FOC)(RE-ASSESS BOE WITH IGST) REIMPORT OF RIFAMYCIN-S","address":"UNIT NO. 3B - 38, 39 AND 40,,3RD F","city":"LBS MARG KURLA WEST,MAHARASHTRA","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"RICERCA BIOSCIENCES LLC","customerCountry":"INDIA","quantity":"477.50","actualQuantity":"477.5","unit":"KGA","unitRateFc":"139.1","totalValueFC":"67514.8","currency":"N\/A","unitRateINR":"12296","date":"17-Feb-2025","totalValueINR":"5871360.24","totalValueInUsd":"67514.8","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"8394533","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"SEDE LEGALE - STRADA RIVOLTANA KM 6\/7 20053 RODANO MILAN , ITALY","customerAddress":"UNIT NO. 3B - 38, 39 AND 40,,3RD F"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740162600,"product":"RIFAMYCIN-O RIFAMYCIN-O","address":"NO.13-1-183\/1, PLOT NO.69,","city":"HYDERABAD, AP.","supplier":"HISUN PHARMACEUTICAL (HANGZHOU) CO.,LTD.","supplierCountry":"CHINA","foreign_port":"NINGBO","customer":"BENOVA LABS PRIVATE ","customerCountry":"INDIA","quantity":"3200.00","actualQuantity":"3200","unit":"KGS","unitRateFc":"82","totalValueFC":"264771.4","currency":"N\/A","unitRateINR":"7195.5","date":"22-Feb-2025","totalValueINR":"23025600","totalValueInUsd":"264771.4","indian_port":"Madras Sea","hs_no":"29419011","bill_no":"8515067","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NINGBO","supplierAddress":"NO 1,HAIZHENG ROAD, XUKOU TOWN,FUYA NG DISTRICT, HANGZHOU CITY,ZHEJIANG PROVINCE,311404 China China","customerAddress":"NO.13-1-183\/1, PLOT NO.69,"}]
13-Jan-2021
27-Feb-2025
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INTERMEDIATE SUPPLIERS

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01

EUROAPI

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

CAS Number : 13553-79-2

End Use API : Rifamycin

About The Company : EUROAPI is focused on reinventing active ingredient solutions to meet the needs of customers and patients worldwide sustainably. We are a leading player in APIs...

EUROAPI Compnay Banner
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FDF Dossiers

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01

Country
World Vaccine Conference
Not Confirmed
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Country
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World Vaccine Conference
Not Confirmed

Rifamycin Sv

Brand Name : Rifocin

Dosage Form :

Dosage Strength : 1 Ampoule Im 250 Mg 3 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

Country
World Vaccine Conference
Not Confirmed
arrow

Country
arrow
World Vaccine Conference
Not Confirmed

Rifamycin Sv

Brand Name : Rifocin

Dosage Form :

Dosage Strength : 1 Ampoule Intralesional Cutaneous/90 Mg 1.8 Ml + 1 Ampoule 16.2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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NEWS #PharmaBuzz

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https://www.biospace.com/article/releases/redhill-biopharma-announces-36-million-strategic-investment-by-cosmo-pharmaceuticals-and-u-s-rights-to-approved-travelers-diarrhea-drug-aemcolo/?s=95

BIOSPACE
19 Oct 2019
2018 Drug Approvals: A Closer Look
2018 Drug Approvals: A Closer Look

05 Feb 2019

// Derek Lowe SCIENCE MAG BLOG

https://blogs.sciencemag.org/pipeline/archives/2019/02/04/2018-drug-approvals-a-closer-look?r3f_986=https://www.google.com/

Derek Lowe SCIENCE MAG BLOG
05 Feb 2019

https://www.fiercepharma.com/marketing/cosmo-to-give-bausch-health-sales-a-run-latest-fda-nod-for-xifaxan-rival

Angus Liu FIERCE PHARMA
21 Nov 2018

https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm626121.htm?utm_campaign=FDA%20approves%20new%20treatment%20of%20travelers%E2%80%99%20diarrhea%20caused%20by%20noninvasive%20strains%20of%20Escherichia%20coli&utm_medium=email&utm_source=Eloqua

FDA
17 Nov 2018

https://www.prnewswire.com/news-releases/fda-accepts-new-drug-application-for-aemcolo-rifamycin-sv-mmx-and-sets-pdufa-date-for-november-16-2018-300651877.html

PR NEWSWIRE
21 May 2018

https://seekingalpha.com/article/4158489-valeant-rifamycin-threat-devastating

SEEKINGALPHA
23 Mar 2018

Global Sales Information

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Annual Reports

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01

Brand Name : Aemcolo

Rifamycin

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MAGHREB PHARMA
Not Confirmed

Brand Name : Aemcolo

Ireland
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MAGHREB PHARMA
Not Confirmed

Rifamycin

Main Therapeutic Indication : Gastrointestinal Disorders

Currency : USD

2020 Revenue in Millions : 0

2019 Revenue in Millions : 1

Growth (%) : -100

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02

Brand Name : Aemcolo/Relafalk

Rifamycin

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MAGHREB PHARMA
Not Confirmed

Brand Name : Aemcolo/Relafalk

Ireland
arrow
MAGHREB PHARMA
Not Confirmed

Rifamycin

Main Therapeutic Indication : Gastrointestinal Diseases

Currency : USD

2022 Revenue in Millions : 0

2021 Revenue in Millions : 2

Growth (%) : -93

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03

Brand Name : Aemcolo/Relafalk

Rifamycin

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MAGHREB PHARMA
Not Confirmed

Brand Name : Aemcolo/Relafalk

Ireland
arrow
MAGHREB PHARMA
Not Confirmed

Rifamycin

Main Therapeutic Indication : Gastrointestinal Diseases

Currency : USD

2023 Revenue in Millions : 1

2022 Revenue in Millions : 0

Growth (%) : 435

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Looking for 6998-60-3 / Rifamycin API manufacturers, exporters & distributors?

Rifamycin manufacturers, exporters & distributors 1

85

PharmaCompass offers a list of Rifamycin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rifamycin manufacturer or Rifamycin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rifamycin manufacturer or Rifamycin supplier.

PharmaCompass also assists you with knowing the Rifamycin API Price utilized in the formulation of products. Rifamycin API Price is not always fixed or binding as the Rifamycin Price is obtained through a variety of data sources. The Rifamycin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rifamycin

Synonyms

Rifamycin sv, Rifocin, Rifamicine sv, Rifomycin sv, Rifamicina, Rifamycine

Cas Number

6998-60-3

Unique Ingredient Identifier (UNII)

DU69T8ZZPA

About Rifamycin

A group of ANTI-BACTERIAL AGENTS characterized by a chromophoric naphthohydroquinone group spanned by an aliphatic bridge not previously found in other known ANTI-BACTERIAL AGENTS. They have been isolated from fermentation broths of Streptomyces mediterranei.

Rifamycin Manufacturers

A Rifamycin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rifamycin, including repackagers and relabelers. The FDA regulates Rifamycin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rifamycin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Rifamycin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Rifamycin Suppliers

A Rifamycin supplier is an individual or a company that provides Rifamycin active pharmaceutical ingredient (API) or Rifamycin finished formulations upon request. The Rifamycin suppliers may include Rifamycin API manufacturers, exporters, distributors and traders.

click here to find a list of Rifamycin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rifamycin USDMF

A Rifamycin DMF (Drug Master File) is a document detailing the whole manufacturing process of Rifamycin active pharmaceutical ingredient (API) in detail. Different forms of Rifamycin DMFs exist exist since differing nations have different regulations, such as Rifamycin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rifamycin DMF submitted to regulatory agencies in the US is known as a USDMF. Rifamycin USDMF includes data on Rifamycin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rifamycin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rifamycin suppliers with USDMF on PharmaCompass.

Rifamycin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Rifamycin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Rifamycin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Rifamycin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Rifamycin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Rifamycin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Rifamycin suppliers with NDC on PharmaCompass.

Rifamycin GMP

Rifamycin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rifamycin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rifamycin GMP manufacturer or Rifamycin GMP API supplier for your needs.

Rifamycin CoA

A Rifamycin CoA (Certificate of Analysis) is a formal document that attests to Rifamycin's compliance with Rifamycin specifications and serves as a tool for batch-level quality control.

Rifamycin CoA mostly includes findings from lab analyses of a specific batch. For each Rifamycin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rifamycin may be tested according to a variety of international standards, such as European Pharmacopoeia (Rifamycin EP), Rifamycin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rifamycin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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