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    Chemistry

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    Also known as: Rifaxidin, Rifacol, 80621-81-4, Rifamycin l 105, Xifaxan, Rifamycin l 105sv
    Molecular Formula
    C43H51N3O11
    Molecular Weight
    785.9  g/mol
    InChI Key
    NZCRJKRKKOLAOJ-XRCRFVBUSA-N
    FDA UNII
    L36O5T016N
    Rifaximin
    A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.
    Rifaximin is a Rifamycin Antibacterial.
    1 2D Structure

    Rifaximin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate
    2.1.2 InChI
    InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1
    2.1.3 InChI Key
    NZCRJKRKKOLAOJ-XRCRFVBUSA-N
    2.1.4 Canonical SMILES
    CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C
    2.1.5 Isomeric SMILES
    C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C
    2.2 Other Identifiers
    2.2.1 UNII
    L36O5T016N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4c)rifamycin

    2. L 105

    3. L-105

    4. L105

    5. Redactiv

    6. Xifaxan

    2.3.2 Depositor-Supplied Synonyms

    1. Rifaxidin

    2. Rifacol

    3. 80621-81-4

    4. Rifamycin L 105

    5. Xifaxan

    6. Rifamycin L 105sv

    7. Fatroximin

    8. Rifaximine

    9. Normix

    10. Rifaximina

    11. Xifaxsan

    12. L-105

    13. Rifamixin

    14. Rifaximine [french]

    15. Rifaximinum [latin]

    16. Rifaximina [spanish]

    17. Ritacol

    18. Chebi:75246

    19. 4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin Sv

    20. L36o5t016n

    21. Rifaximin (xifaxan)

    22. Nsc-758957

    23. Rifaximinum

    24. Brn 3584528

    25. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl Acetate

    26. C43h51n3o11

    27. Rifaxin

    28. Redactiv

    29. Ido[1,2-a]benzimidazol-25-yl Acetate

    30. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2h)-dione

    31. L 105sv

    32. L 105 (ansamacrolide Antibiotic)

    33. L 105

    34. Rifaximinun

    35. Flonorm

    36. Lumenax

    37. Spiraxin

    38. Lormyx

    39. Rifaximin [usan:inn:ban]

    40. Unii-l36o5t016n

    41. 5-yl Acetate

    42. Ncgc00095842-01

    43. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione

    44. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-e]pyr

    45. Xifaxan (tn)

    46. Mfcd00864973

    47. Rifaximin [inn]

    48. Rifaximin [jan]

    49. Rifaximin [mi]

    50. Rifaximin [usan]

    51. Rifaximin [vandf]

    52. Rifaximin [mart.]

    53. Alpha-0817185

    54. Rifaximin [who-dd]

    55. Chembl1617

    56. Dsstox_cid_25998

    57. Dsstox_rid_81280

    58. Dsstox_gsid_45998

    59. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26s,27s,28e)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-acetate

    60. Rifaximin (jan/usan/inn)

    61. Schembl124066

    62. Rifaximin [ep Impurity]

    63. Rifaximin [orange Book]

    64. Dtxsid7045998

    65. Rifaximin [ep Monograph]

    66. Gtpl12012

    67. Hms3715b19

    68. 88747-56-2

    69. Tox21_111529

    70. Bdbm50347620

    71. S1790

    72. Akos015963053

    73. Zinc169621200

    74. Ccg-221129

    75. Db01220

    76. Nsc 758957

    77. Rifaximin 100 Microg/ml In Acetonitrile

    78. 2,7-(epoxy(1,11,13)pentadecatrienoimino)furo(2'',3'':7',8')naphth(1',2':4,5)imidazo(1,2-a)pyridine-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, ( 2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-

    79. 2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, (2s-(2r*,16z,18e,20r*,21r*,22s*,23s*,24s*,25r*,26s*,27r*,28e))-

    80. Ac-19112

    81. Cas-80621-81-4

    82. L/105

    83. D02554

    84. Ab01209738-01

    85. Ab01209738-03

    86. Ab01209738_04

    87. Rifaximin, Antibiotic For Culture Media Use Only

    88. 621r814

    89. Q416073

    90. Q-201671

    91. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,1

    92. (7s,11s,12r,13s,14r,15r,16r,17s,18s)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^{4,7}.0^{5,35}.0^{26,34}.0^{27,32}]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl Acetate

    93. [(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] Acetate

    94. 2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-

    95. 5-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-2

    2.4 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 785.9 g/mol
    Molecular Formula C43H51N3O11
    XLogP36.9
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count3
    Exact Mass785.35235945 g/mol
    Monoisotopic Mass785.35235945 g/mol
    Topological Polar Surface Area198 Ų
    Heavy Atom Count57
    Formal Charge0
    Complexity1590
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count3
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameXifaxan
    PubMed HealthRifaximin (By mouth)
    Drug ClassesAntibiotic
    Drug LabelXIFAXAN tablets contain rifaximin, a non-aminoglycoside semi-synthetic, nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The chemical name for rifaximin is (2 ,16 ,18 ,20 ,21 ,22 ,23 ,24 ,25 ,26 ,27...
    Active IngredientRifaximin
    Dosage FormTablet
    RouteOral
    Strength200mg; 550mg
    Market StatusPrescription
    CompanySalix Pharms

    2 of 2  
    Drug NameXifaxan
    PubMed HealthRifaximin (By mouth)
    Drug ClassesAntibiotic
    Drug LabelXIFAXAN tablets contain rifaximin, a non-aminoglycoside semi-synthetic, nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The chemical name for rifaximin is (2 ,16 ,18 ,20 ,21 ,22 ,23 ,24 ,25 ,26 ,27...
    Active IngredientRifaximin
    Dosage FormTablet
    RouteOral
    Strength200mg; 550mg
    Market StatusPrescription
    CompanySalix Pharms

    4.2 Drug Indication

    Rifaximin has multiple indications by the FDA: for the treatment of patients (12 years of age) with traveller's diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients 18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Rifaximin is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis and contributes to restore intestinal microflora imbalance. Other studies have also shown rifaximin to be an pregnane X receptor (PXR) activator. As PXR is responsible for inhibiting the proinflammatory transcription factor NF-kappa B (NF-B) and is inhibited in inflammatory bowel disease (IBD), rifaximin was proven to be effective for the treatment of IBS-D.

    5.2 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Gastrointestinal Agents

    Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    RIFAXIMIN
    5.3.2 FDA UNII
    L36O5T016N
    5.3.3 Pharmacological Classes
    Rifamycins [CS]; Rifamycin Antibacterial [EPC]
    5.4 ATC Code

    A07AA11

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    A - Alimentary tract and metabolism

    A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

    A07A - Intestinal antiinfectives

    A07AA - Antibiotics

    A07AA11 - Rifaximin

    D - Dermatologicals

    D06 - Antibiotics and chemotherapeutics for dermatological use

    D06A - Antibiotics for topical use

    D06AX - Other antibiotics for topical use

    D06AX11 - Rifaximin

    5.5 Absorption, Distribution and Excretion

    Absorption

    Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.

    Route of Elimination

    In a mass balance study, after administration of 400 mg 14C-rifaximin orally to healthy volunteers, of the 96.94% total recovery, 96.62% of the administered radioactivity was recovered in feces almost exclusively as the unchanged drug and 0.32% was recovered in urine mostly as metabolites with 0.03% as the unchanged drug.Rifaximin accounted for 18% of radioactivity in plasma. This suggests that the absorbed rifaximin undergoes metabolism with minimal renal excretion of the unchanged drug

    5.6 Metabolism/Metabolites

    In vitro drug interactions studies have shown that rifaximin, at concentrations ranging from 2 to 200 ng/mL, did not inhibit human hepatic cytochrome P450 isoenzymes: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4. In an in vitro hepa-tocyte induction model, rifaximin was shown to induce cytochrome P450 3A4 (CYP3A4), an isoenzyme which rifampin is known to induce.

    5.7 Biological Half-Life

    Approximately 6 hours.

    5.8 Mechanism of Action

    Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks translocation, which stops transcription.

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AP","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1656700200,"product":"RIFAXIMIN (RE IMPORT VIDE SB NO: 9080438 DT:03.03.2021) (BATCH NO\\'S:OP-40\/12\/20\/068 & OP-40\/12\/20\/070)","address":"H.NO.4-7-101, SCIENTIST COLONY, HABSIGUDA, NACHARAM, Contact No: 91","city":"HYDERABAD","supplier":"LABORATORIOS BERNABOSOCIEDAD ANONIMA","supplierCountry":"ARGENTINA","foreign_port":"NA","customer":"OPTIMUS DRUGS PRIVATE LTD","customerCountry":"INDIA","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"260","totalValueFC":"93804.4","currency":"USD","unitRateINR":"24863.3","date":"02-Jul-2022","totalValueINR":"7458998.63","totalValueInUsd":"93804.4","indian_port":"HYDERABAD AIR","hs_no":"29419090","bill_no":"9386699","productDescription":"API","marketType":"","country":"ARGENTINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"H.NO.4-7-101, SCIENTIST COLONY, HABSIGUDA, NACHARAM, Contact No: 91"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682533800,"product":"(REJECTED & RE-IMPORT) BATCH:2280001087 RIFAXIMIN (N.C.V.)(S\/B NO:1496775 DT.19.05.2022)","address":"UNIT NO.38, 39 & 40, 3RD FLOOR, PHO PHOENIX MARKET CITY, L.B.S.MARG, KU","city":"MUMBAI","supplier":"ALFASIGMA S P A","supplierCountry":"INDIA","foreign_port":"NA","customer":"OLON ACTIVE PHARMACEUTICAL INGREDIENTS INDIA PRIVA","customerCountry":"INDIA","quantity":"553.73","actualQuantity":"553.73","unit":"KGS","unitRateFc":"215","totalValueFC":"135276.5","currency":"EURO","unitRateINR":"20021.4","date":"27-Apr-2023","totalValueINR":"11086422.56","totalValueInUsd":"135276.5","indian_port":"JNPT","hs_no":"29419090","bill_no":"5705748","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"UNIT NO.38, 39 & 40, 3RD FLOOR, PHO PHOENIX MARKET CITY, L.B.S.MARG, KU"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1686681000,"product":"RIFAXIMIN","address":"236 OKHLA INDUSTRIAL ESTATE, PHASE-3","city":"NEW DELHI","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"ANM PHARMA PRIVATE LTD","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"127","totalValueFC":"128859.8","currency":"USD","unitRateINR":"10591.6","date":"14-Jun-2023","totalValueINR":"10591799.92","totalValueInUsd":"128859.8","indian_port":"JNPT","hs_no":"29419090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"236 OKHLA INDUSTRIAL ESTATE, PHASE-3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690914600,"product":"RIFAXIMIN","address":"236 OKHLA INDUSTRIAL ESTATE, ,PHASE-3 ,","city":"NEW DELHI","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"ANM PHARMA PRIVATE LTD","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"127","totalValueFC":"128145.2","currency":"USD","unitRateINR":"10508.9","date":"02-Aug-2023","totalValueINR":"10615076.56","totalValueInUsd":"128145.2","indian_port":"JNPT\/ NHAVA SHEVA SEA","hs_no":"29419090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"236 OKHLA INDUSTRIAL ESTATE, ,PHASE-3 ,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702665000,"product":"RIFAXIMIN BP\/EP","address":"236 OKHLA INDUSTRIAL ESTATE,","city":"NEW DELHI","supplier":"LUOHE CHAMP GROWING TRADING COLTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ANM PHARMA PRIVATE LTD","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"129","totalValueFC":"130760.5","currency":"USD","unitRateINR":"10884.9","date":"16-Dec-2023","totalValueINR":"10884916.57","totalValueInUsd":"130760.5","indian_port":"JNPT","hs_no":"29419090","bill_no":"9262069","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 408-410, GONGSHANGLIAN BUILDING, NENJIANG ROAD,YANCHENG DIST-LUOHE CITY, HENAN PROVINCE,P.R.CHINA ., CHINA","customerAddress":"236 OKHLA INDUSTRIAL ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726425000,"product":"RIFAXIMIN","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"MACLEODS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"263.00","actualQuantity":"263","unit":"KGS","unitRateFc":"137","totalValueFC":"37055","currency":"USD","unitRateINR":"11807.1","date":"16-Sep-2024","totalValueINR":"3105257.06","totalValueInUsd":"37055","indian_port":"Bombay Air","hs_no":"29419019","bill_no":"5621959","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"NO.168 LONGJIANG ROAD YANCHENG DISTRICT LUOHE CITY HENAN PROVINCE CHINA CHINA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728325800,"product":"RIFAXIMIN, CAS NO. 80621-81-4, BATCH NO. F003-240909, F003-240910, F003-240911, F003-241001, F003-241002","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"SUN PHARMA LABORATORIES LTD","customerCountry":"INDIA","quantity":"1500.00","actualQuantity":"1500","unit":"KGS","unitRateFc":"120","totalValueFC":"181764","currency":"USD","unitRateINR":"10182","date":"08-Oct-2024","totalValueINR":"15273000","totalValueInUsd":"181764","indian_port":"Delhi Air","hs_no":"29419090","bill_no":"6020092","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":".NO.168, LONGJIANG ROAD YANCHENGDIS TRICT, LUOHE CITY HENAN PROVINCECHI NA CHINA","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"RIFAXIMIN, CAS NO. 80621-81-4, BATCH NO. F003-241003, F003-241004, F003-241005, F003-241006, F003-241007","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"SUN PHARMA LABORATORIES LTD","customerCountry":"INDIA","quantity":"1500.00","actualQuantity":"1500","unit":"KGS","unitRateFc":"120","totalValueFC":"181764","currency":"USD","unitRateINR":"10182","date":"15-Oct-2024","totalValueINR":"15273000","totalValueInUsd":"181764","indian_port":"Delhi Air","hs_no":"29419090","bill_no":"6135446","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":".NO.168, LONGJIANG ROAD YANCHENGDIS TRICT, LUOHE CITY HENAN PROVINCECHI NA CHINA","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742409000,"product":"RIFAXIMIN RIFAXIMIN","address":"ACME PLAZA , ANDHERI KURLA ROAD","city":"MUMBAI","supplier":"LUOHE CHIEF PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"CHANGSHA","customer":"SUN PHARMA LABORATORIES LTD","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"122","totalValueFC":"494661.7","currency":"USD","unitRateINR":"10711.6","date":"20-Mar-2025","totalValueINR":"42846400","totalValueInUsd":"494661.7","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"8999481","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHANGSHA","supplierAddress":"NO.168, LONGJIANG RD., YANCHENG DISTRICT LUOHE CITY HENAN PROVINCE CN","customerAddress":"ACME PLAZA , ANDHERI KURLA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751913000,"product":"RIFAXIMIN RIFAXIMIN","address":"21-22, KALPATARU SQUARE, KONDIVITA","city":"ANDHERI (E), MUMBAI,MAHARASHTRA","supplier":"CAMBREX PROFARMACO MILANO SRL","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"WATSON PHARMA PRIVATE LTD","customerCountry":"INDIA","quantity":"170.80","actualQuantity":"170.8","unit":"KGS","unitRateFc":"800","totalValueFC":"136852.9","currency":"USD","unitRateINR":"68960","date":"08-Jul-2025","totalValueINR":"11778368","totalValueInUsd":"136852.9","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"3137823","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA E. CURIEL, 34 - 20067 PAULLO MI ., , Italy SDNF Italy","customerAddress":"21-22, KALPATARU SQUARE, KONDIVITA"}]
    25-Jan-2022
    31-Jul-2025
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    Drugs in Development

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    Zydus gets USFDA nod for generic IBS-D treatment drug

    Details:

    Xifaxan-Generic (rifaximin) is a rifamycin antibacterial indicated for the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Gastroenterology Brand Name: Xifaxan-Generic

    Study Phase: Approved FDFProduct Type: Antibiotic

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 02, 2025

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    01

    Zydus Lifesciences

    India
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    ESCRS
    Not Confirmed

    Zydus Lifesciences

    India
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Gastroenterology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Zydus gets USFDA nod for generic IBS-D treatment drug

    Details : Xifaxan-Generic (rifaximin) is a rifamycin antibacterial indicated for the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults.

    Product Name : Xifaxan-Generic

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    June 02, 2025

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    Rifaximin SSD in Dementia Trial

    Details:

    Undisclosed


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase I/ Phase IIProduct Type: Antibiotic

    Sponsor: Bausch Health

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable December 05, 2024

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    02

    Jasmohan Bajaj

    Country
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    ESCRS
    Not Confirmed

    Jasmohan Bajaj

    Country
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I/ Phase II

    Partner/Sponsor/Collaborator : Bausch Health

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Rifaximin SSD in Dementia Trial

    Details : Undisclosed

    Product Name : Undisclosed

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    December 05, 2024

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    A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis

    Details:

    Undisclosed


    Lead Product(s): Vedolizumab,Ciprofloxacin,Metronidazole,Vancomycin Hydrochloride,Amoxicillin Clavulanate,Rifaximin

    Therapeutic Area: Trauma (Emergency, Injury, Surgery) Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Antibody

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 05, 2024

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    03

    Takeda Pharmaceutical

    Japan
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    ESCRS
    Not Confirmed

    Takeda Pharmaceutical

    Japan
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Vedolizumab,Ciprofloxacin,Metronidazole,Vancomycin Hydrochloride,Amoxicillin Clavulanate,Rifaximin

    Therapeutic Area : Trauma (Emergency, Injury, Surgery)

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers W...

    Details : Undisclosed

    Product Name : Undisclosed

    Product Type : Antibody

    Upfront Cash : Inapplicable

    June 05, 2024

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    Rifaximin for the Secondary Prevention of Recurrent Pouchitis

    Details:

    Undisclosed


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Trauma (Emergency, Injury, Surgery) Brand Name: Undisclosed

    Study Phase: Phase IVProduct Type: Antibiotic

    Sponsor: Bausch Health

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 15, 2024

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    04

    University of North Carolina, Chapel Hill

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    ESCRS
    Not Confirmed

    University of North Carolina, Chapel Hill

    Country
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Trauma (Emergency, Injury, Surgery)

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : Bausch Health

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Rifaximin for the Secondary Prevention of Recurrent Pouchitis

    Details : Undisclosed

    Product Name : Undisclosed

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    March 15, 2024

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    Privately Held Alvogen Announces Favorable Ruling on Patents Related to the Company’s Proposed Generic to Xifaxan® for IBS-D

    Details:

    XIFAXAN (rifaximin) is a 2 week prescription treatment that provided up to 6 months of relief from IBS-D symptoms of abdominal pain and diarrhea in a clinical trial.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Gastroenterology Brand Name: Xifaxan-Generic

    Study Phase: UndisclosedProduct Type: Antibiotic

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable November 08, 2022

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    05

    Alvogen

    U.S.A
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    ESCRS
    Not Confirmed

    Alvogen

    U.S.A
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Gastroenterology

    Highest Development Status : Undisclosed

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Privately Held Alvogen Announces Favorable Ruling on Patents Related to the Company’s Proposed G...

    Details : XIFAXAN (rifaximin) is a 2 week prescription treatment that provided up to 6 months of relief from IBS-D symptoms of abdominal pain and diarrhea in a clinical trial.

    Product Name : Xifaxan-Generic

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    November 08, 2022

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    Bausch Health Responds to Norwich Pharmaceuticals Tentative FDA Approval for a 200 mg Rifaximin

    Details:

    XIFAXAN (rifaximin) 200 mg tablets are indicated for travelers diarrhea. XIFAXAN (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea in adults.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Gastroenterology Brand Name: Xifaxan-Generic

    Study Phase: Approved FDFProduct Type: Antibiotic

    Sponsor: Bausch Health

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable September 09, 2022

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    06

    Alvogen

    U.S.A
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    ESCRS
    Not Confirmed

    Alvogen

    U.S.A
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Gastroenterology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Bausch Health

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Bausch Health Responds to Norwich Pharmaceuticals Tentative FDA Approval for a 200 mg Rifaximin

    Details : XIFAXAN (rifaximin) 200 mg tablets are indicated for travelers diarrhea. XIFAXAN (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy recurrence in adults and for the treatment of irritable bowel syndrome with di...

    Product Name : Xifaxan-Generic

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    September 09, 2022

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    Fecal Microbiota Transplantation With Immune Checkpoint Inhibitors in Lung Cancer

    Details:

    Undisclosed


    Lead Product(s): Rifaximin,Fecal Microbiota

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase IIProduct Type: Antibiotic

    Sponsor: Biotax Labs | Israel Cancer Association

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable August 16, 2022

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    07

    Soroka University Medical Center

    Country
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    ESCRS
    Not Confirmed

    Soroka University Medical Center

    Country
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    ESCRS
    Not Confirmed
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    Lead Product(s) : Rifaximin,Fecal Microbiota

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Biotax Labs | Israel Cancer Association

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Fecal Microbiota Transplantation With Immune Checkpoint Inhibitors in Lung Cancer

    Details : Undisclosed

    Product Name : Undisclosed

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    August 16, 2022

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    Bausch Health Provides Update Following Oral Order in XIFAXAN® Patent Litigation

    Details:

    XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Neurology Brand Name: Xifaxan

    Study Phase: Approved FDFProduct Type: Antibiotic

    Sponsor: Salix Pharmaceuticals

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 28, 2022

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    08

    Bausch Health

    Canada
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    ESCRS
    Not Confirmed

    Bausch Health

    Canada
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    ESCRS
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Salix Pharmaceuticals

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Bausch Health Provides Update Following Oral Order in XIFAXAN® Patent Litigation

    Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

    Product Name : Xifaxan

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    July 28, 2022

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    • WHO-GMP
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    Salix Pharmaceuticals Will Present Scientific Data At The Society Of Hospital Medicine Converge 2022

    Details:

    XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Neurology Brand Name: Xifaxan

    Study Phase: Approved FDFProduct Type: Antibiotic

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 04, 2022

    blank

    09

    Salix Pharmaceuticals

    U.S.A
    arrow
    ESCRS
    Not Confirmed

    Salix Pharmaceuticals

    U.S.A
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    ESCRS
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Salix Pharmaceuticals Will Present Scientific Data At The Society Of Hospital Medicine Converge 20...

    Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

    Product Name : Xifaxan

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    July 04, 2022

    blank

    Stock Recap
    #PipelineProspector

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    #PharmaFlow

    Virtual Booth

    • Development Update
    • fda
    • EDQM
    • WHO-GMP
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    Salix to Share New Data from XIFAXAN® (Rifaximin) Clinical Research at EASL's International Liver Congress™ 2022

    Details:

    XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


    Lead Product(s): Rifaximin,Inapplicable

    Therapeutic Area: Neurology Brand Name: Xifaxan

    Study Phase: Approved FDFProduct Type: Antibiotic

    Sponsor: Bausch Health

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 20, 2022

    blank

    10

    Salix Pharmaceuticals

    U.S.A
    arrow
    ESCRS
    Not Confirmed

    Salix Pharmaceuticals

    U.S.A
    arrow
    ESCRS
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Rifaximin,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Bausch Health

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Salix to Share New Data from XIFAXAN® (Rifaximin) Clinical Research at EASL's International Liver...

    Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

    Product Name : Xifaxan

    Product Type : Antibiotic

    Upfront Cash : Inapplicable

    June 20, 2022

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 200MG

    USFDA APPLICATION NUMBER - 21361

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    DOSAGE - TABLET;ORAL - 550MG

    USFDA APPLICATION NUMBER - 21361

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    ABOUT THIS PAGE

    Looking for 80621-81-4 / Rifaximin API manufacturers, exporters & distributors?

    Rifaximin manufacturers, exporters & distributors 1

    82

    PharmaCompass offers a list of Rifaximin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rifaximin manufacturer or Rifaximin supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rifaximin manufacturer or Rifaximin supplier.

    PharmaCompass also assists you with knowing the Rifaximin API Price utilized in the formulation of products. Rifaximin API Price is not always fixed or binding as the Rifaximin Price is obtained through a variety of data sources. The Rifaximin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Rifaximin

    Synonyms

    Rifaxidin, Rifacol, 80621-81-4, Rifamycin l 105, Xifaxan, Rifamycin l 105sv

    Cas Number

    80621-81-4

    Unique Ingredient Identifier (UNII)

    L36O5T016N

    About Rifaximin

    A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.

    Rifaximin Manufacturers

    A Rifaximin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rifaximin, including repackagers and relabelers. The FDA regulates Rifaximin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rifaximin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Rifaximin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Rifaximin Suppliers

    A Rifaximin supplier is an individual or a company that provides Rifaximin active pharmaceutical ingredient (API) or Rifaximin finished formulations upon request. The Rifaximin suppliers may include Rifaximin API manufacturers, exporters, distributors and traders.

    click here to find a list of Rifaximin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Rifaximin USDMF

    A Rifaximin DMF (Drug Master File) is a document detailing the whole manufacturing process of Rifaximin active pharmaceutical ingredient (API) in detail. Different forms of Rifaximin DMFs exist exist since differing nations have different regulations, such as Rifaximin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Rifaximin DMF submitted to regulatory agencies in the US is known as a USDMF. Rifaximin USDMF includes data on Rifaximin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rifaximin USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Rifaximin suppliers with USDMF on PharmaCompass.

    Rifaximin JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Rifaximin Drug Master File in Japan (Rifaximin JDMF) empowers Rifaximin API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Rifaximin JDMF during the approval evaluation for pharmaceutical products. At the time of Rifaximin JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Rifaximin suppliers with JDMF on PharmaCompass.

    Rifaximin KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Rifaximin Drug Master File in Korea (Rifaximin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Rifaximin. The MFDS reviews the Rifaximin KDMF as part of the drug registration process and uses the information provided in the Rifaximin KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Rifaximin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Rifaximin API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Rifaximin suppliers with KDMF on PharmaCompass.

    Rifaximin CEP

    A Rifaximin CEP of the European Pharmacopoeia monograph is often referred to as a Rifaximin Certificate of Suitability (COS). The purpose of a Rifaximin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Rifaximin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Rifaximin to their clients by showing that a Rifaximin CEP has been issued for it. The manufacturer submits a Rifaximin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Rifaximin CEP holder for the record. Additionally, the data presented in the Rifaximin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Rifaximin DMF.

    A Rifaximin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Rifaximin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Rifaximin suppliers with CEP (COS) on PharmaCompass.

    Rifaximin WC

    A Rifaximin written confirmation (Rifaximin WC) is an official document issued by a regulatory agency to a Rifaximin manufacturer, verifying that the manufacturing facility of a Rifaximin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Rifaximin APIs or Rifaximin finished pharmaceutical products to another nation, regulatory agencies frequently require a Rifaximin WC (written confirmation) as part of the regulatory process.

    click here to find a list of Rifaximin suppliers with Written Confirmation (WC) on PharmaCompass.

    Rifaximin NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Rifaximin as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Rifaximin API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Rifaximin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Rifaximin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Rifaximin NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Rifaximin suppliers with NDC on PharmaCompass.

    Rifaximin GMP

    Rifaximin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Rifaximin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rifaximin GMP manufacturer or Rifaximin GMP API supplier for your needs.

    Rifaximin CoA

    A Rifaximin CoA (Certificate of Analysis) is a formal document that attests to Rifaximin's compliance with Rifaximin specifications and serves as a tool for batch-level quality control.

    Rifaximin CoA mostly includes findings from lab analyses of a specific batch. For each Rifaximin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Rifaximin may be tested according to a variety of international standards, such as European Pharmacopoeia (Rifaximin EP), Rifaximin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rifaximin USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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