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Synopsis

Synopsis

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Chemistry

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Also known as: 592542-59-1, On-01910, On 01910, Rigosertib [usan], 67dow7f9gl, Rigosertib (usan)
Molecular Formula
C21H25NO8S
Molecular Weight
451.5  g/mol
InChI Key
OWBFCJROIKNMGD-BQYQJAHWSA-N
FDA UNII
67DOW7F9GL

Rigosertib
Rigosertib is a synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic activity. Upon administration, rigosertib targets and binds to Ras-binding domain (RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol 3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and inhibits proliferation in a variety of susceptible tumor cells.
1 2D Structure

Rigosertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetic acid
2.1.2 InChI
InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11,22H,12-13H2,1-4H3,(H,23,24)/b8-7+
2.1.3 InChI Key
OWBFCJROIKNMGD-BQYQJAHWSA-N
2.1.4 Canonical SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
2.1.5 Isomeric SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
67DOW7F9GL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetic Acid

2. N-(2-methoxy-5-((((e)-2-(2,4,6-trimethoxyphenyl)vinyl)sulfonyl)methyl)phenyl)glycine

3. On 01910

4. On 01910.na

5. On-01910

6. On01910

7. Rigosertib Sodium

8. Sodium (n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetate

2.3.2 Depositor-Supplied Synonyms

1. 592542-59-1

2. On-01910

3. On 01910

4. Rigosertib [usan]

5. 67dow7f9gl

6. Rigosertib (usan)

7. 2-[2-methoxy-5-[[(e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetic Acid

8. (e)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic Acid

9. N-[2-methoxy-5-({[(e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine

10. N-[2-methoxy-5-[[[(1e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine

11. Rigosertib [usan:inn]

12. Unii-67dow7f9gl

13. Rigosertibum

14. 6fs

15. N-(2-methoxy-5-((((1e)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)phenyl)glycine

16. Rigosertib [inn]

17. Rigosertib [who-dd]

18. Estybon (proposed Trade Name)

19. Schembl498623

20. Schembl498624

21. Gtpl7833

22. Chembl1241855

23. On01910.na

24. Dtxsid30207984

25. 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethenylsulfonylmethyl]anilino]acetic Acid

26. Chebi:124939

27. Chebi:145417

28. Bcp08296

29. Ex-a4346

30. Zinc3942646

31. Bdbm50060917

32. Akos015966442

33. Db12146

34. Glycine, N-[2-methoxy-5-[[[(1e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-

35. (e)-on 01910

36. 2-[[2-methoxy-5-[[(e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl]amino]acetic Acid

37. Ac-32479

38. As-35249

39. On-01910on-01910

40. D10154

41. On-01910;on01910;on 01910

42. Brd-k55187425-236-01-1

43. Q21099552

44. (e)-2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)acetic Acid

45. [2-methoxy-5-({[(e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetic Acid

46. [2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetic Acid

47. N-(2-methoxy-5-((((1e)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl) Phenyl)glycine

48. N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine

49. Glycine, N-(2-methoxy-5-((((1e)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl) Methyl)phenyl)-

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 451.5 g/mol
Molecular Formula C21H25NO8S
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count11
Exact Mass451.13008793 g/mol
Monoisotopic Mass451.13008793 g/mol
Topological Polar Surface Area129 Ų
Heavy Atom Count31
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Looking for 592542-59-1 / Rigosertib API manufacturers, exporters & distributors?

Rigosertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Rigosertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rigosertib manufacturer or Rigosertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rigosertib manufacturer or Rigosertib supplier.

PharmaCompass also assists you with knowing the Rigosertib API Price utilized in the formulation of products. Rigosertib API Price is not always fixed or binding as the Rigosertib Price is obtained through a variety of data sources. The Rigosertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rigosertib

Synonyms

592542-59-1, On-01910, On 01910, Rigosertib [usan], 67dow7f9gl, Rigosertib (usan)

Cas Number

592542-59-1

Unique Ingredient Identifier (UNII)

67DOW7F9GL

About Rigosertib

Rigosertib is a synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic activity. Upon administration, rigosertib targets and binds to Ras-binding domain (RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol 3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and inhibits proliferation in a variety of susceptible tumor cells.

Rigosertib Manufacturers

A Rigosertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rigosertib, including repackagers and relabelers. The FDA regulates Rigosertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rigosertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rigosertib Suppliers

A Rigosertib supplier is an individual or a company that provides Rigosertib active pharmaceutical ingredient (API) or Rigosertib finished formulations upon request. The Rigosertib suppliers may include Rigosertib API manufacturers, exporters, distributors and traders.

Rigosertib GMP

Rigosertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rigosertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rigosertib GMP manufacturer or Rigosertib GMP API supplier for your needs.

Rigosertib CoA

A Rigosertib CoA (Certificate of Analysis) is a formal document that attests to Rigosertib's compliance with Rigosertib specifications and serves as a tool for batch-level quality control.

Rigosertib CoA mostly includes findings from lab analyses of a specific batch. For each Rigosertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rigosertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Rigosertib EP), Rigosertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rigosertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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