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Rilmenidine Phosphate

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ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 2 CEP/COS, 4 Listed Suppliers

6 API Suppliers
2 CEP/COS
4 Listed Suppliers

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 85409-38-7, Rilmenidine dihydrogen phosphate, Rilmenidine (phosphate), S 3341-3, 2-oxazolamine, n-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1), N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid

Molecular Formula

C₁₀H₁₉N₂O₅P

Molecular Weight

278.24 g/mol

InChI Key

ZJCOWRFWZOAVFY-UHFFFAOYSA-N

FDA UNII

59QD64Q32M

Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.

1 2D Structure

Rilmenidine Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid

2.1.2 InChI

InChI=1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4)

2.1.3 InChI Key

ZJCOWRFWZOAVFY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC1C(C2CC2)NC3=NCCO3.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

59QD64Q32M

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(n-(dicyclopropylmethyl)amino)oxazoline

2. 2-(n-(dicyclopropylmethyl)amino)oxazoline Phosphate Salt

3. Hyperium

4. Oxaminozoline

5. Rilmenidine

6. S 3341

7. S 3341 3

8. S-3341

9. S-3341-3

10. S3341

11. S33413

2.3.2 Depositor-Supplied Synonyms

1. 85409-38-7

2. Rilmenidine Dihydrogen Phosphate

3. Rilmenidine (phosphate)

4. S 3341-3

5. 2-oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, Phosphate (1:1)

6. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric Acid

7. 59qd64q32m

8. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine Phosphate

9. Rilmenidinephosphate

10. Einecs 287-106-2

11. Unii-59qd64q32m

12. 4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamine Phosphate (1:1)

13. 2-oxazolamine, 4,5-dihydro-n-(dicyclopropylmethyl)-, Phosphate (1:1)

14. (dicyclopropylmethyl)(4,5-dihydro-2-oxazolyl)ammonium Dihydrogen Phosphate

15. Schembl1231349

16. Dtxsid50234616

17. Rilmenidine For System Suitability

18. Rilmenidine Phosphate [mi]

19. Bcp13443

20. Mfcd00875846

21. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine; Phosphoric Acid

22. Rilmenidine Hydrogen Phosphate

23. S7548

24. Rilmenidine Phosphate [mart.]

25. Akos015900521

26. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric Acid

27. Rilmenidine Phosphate [who-dd]

28. Ccg-267224

29. Hy-100490b

30. As-15125

31. Cs-0020190

32. Ft-0656776

33. A14256

34. S-3341

35. 409r387

36. A841323

37. S-3341-3

38. W-104082

39. Q27261715

40. Rilmenidine Dihydrogen Phosphate [ep Monograph]

41. (5-methylpyridin-2-yl)piperidin-4-yl-aminedihydrochloride

42. 2-((dicyclopropylmethyl)amino)-2-oxazoline Phosphate

43. Dicyclopropylmethyl-(4,5-dihydrooxazol-2-yl)ammonium Phosphate

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₉N₂O₅P
Molecular Weight	278.24 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	278.10315871 g/mol
Monoisotopic Mass	278.10315871 g/mol
Topological Polar Surface Area	111 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

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ABOUT THIS PAGE

Rilmenidine Phosphate Manufacturers

A Rilmenidine Phosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rilmenidine Phosphate, including repackagers and relabelers. The FDA regulates Rilmenidine Phosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rilmenidine Phosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Rilmenidine Phosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Rilmenidine Phosphate Suppliers

A Rilmenidine Phosphate supplier is an individual or a company that provides Rilmenidine Phosphate active pharmaceutical ingredient (API) or Rilmenidine Phosphate finished formulations upon request. The Rilmenidine Phosphate suppliers may include Rilmenidine Phosphate API manufacturers, exporters, distributors and traders.

click here to find a list of Rilmenidine Phosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rilmenidine Phosphate CEP

A Rilmenidine Phosphate CEP of the European Pharmacopoeia monograph is often referred to as a Rilmenidine Phosphate Certificate of Suitability (COS). The purpose of a Rilmenidine Phosphate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Rilmenidine Phosphate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Rilmenidine Phosphate to their clients by showing that a Rilmenidine Phosphate CEP has been issued for it. The manufacturer submits a Rilmenidine Phosphate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Rilmenidine Phosphate CEP holder for the record. Additionally, the data presented in the Rilmenidine Phosphate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Rilmenidine Phosphate DMF.

A Rilmenidine Phosphate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Rilmenidine Phosphate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Rilmenidine Phosphate suppliers with CEP (COS) on PharmaCompass.

Rilmenidine Phosphate GMP

Rilmenidine Phosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rilmenidine Phosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rilmenidine Phosphate GMP manufacturer or Rilmenidine Phosphate GMP API supplier for your needs.

Rilmenidine Phosphate CoA

A Rilmenidine Phosphate CoA (Certificate of Analysis) is a formal document that attests to Rilmenidine Phosphate's compliance with Rilmenidine Phosphate specifications and serves as a tool for batch-level quality control.

Rilmenidine Phosphate CoA mostly includes findings from lab analyses of a specific batch. For each Rilmenidine Phosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rilmenidine Phosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Rilmenidine Phosphate EP), Rilmenidine Phosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rilmenidine Phosphate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.