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Rilmenidine Phosphate

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Chemistry

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Also known as: 85409-38-7, Rilmenidine dihydrogen phosphate, Rilmenidine (phosphate), S 3341-3, 2-oxazolamine, n-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1), N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid

Molecular Formula

C₁₀H₁₉N₂O₅P

Molecular Weight

278.24 g/mol

InChI Key

ZJCOWRFWZOAVFY-UHFFFAOYSA-N

FDA UNII

59QD64Q32M

Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.

1 2D Structure

Rilmenidine Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric acid

2.1.2 InChI

InChI=1S/C10H16N2O.H3O4P/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10;1-5(2,3)4/h7-9H,1-6H2,(H,11,12);(H3,1,2,3,4)

2.1.3 InChI Key

ZJCOWRFWZOAVFY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC1C(C2CC2)NC3=NCCO3.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

59QD64Q32M

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(n-(dicyclopropylmethyl)amino)oxazoline

2. 2-(n-(dicyclopropylmethyl)amino)oxazoline Phosphate Salt

3. Hyperium

4. Oxaminozoline

5. Rilmenidine

6. S 3341

7. S 3341 3

8. S-3341

9. S-3341-3

10. S3341

11. S33413

2.3.2 Depositor-Supplied Synonyms

1. 85409-38-7

2. Rilmenidine Dihydrogen Phosphate

3. Rilmenidine (phosphate)

4. S 3341-3

5. 2-oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, Phosphate (1:1)

6. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine;phosphoric Acid

7. 59qd64q32m

8. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine Phosphate

9. Rilmenidinephosphate

10. Einecs 287-106-2

11. Unii-59qd64q32m

12. 4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamine Phosphate (1:1)

13. 2-oxazolamine, 4,5-dihydro-n-(dicyclopropylmethyl)-, Phosphate (1:1)

14. (dicyclopropylmethyl)(4,5-dihydro-2-oxazolyl)ammonium Dihydrogen Phosphate

15. Schembl1231349

16. Dtxsid50234616

17. Rilmenidine For System Suitability

18. Rilmenidine Phosphate [mi]

19. Bcp13443

20. Mfcd00875846

21. N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine; Phosphoric Acid

22. Rilmenidine Hydrogen Phosphate

23. S7548

24. Rilmenidine Phosphate [mart.]

25. Akos015900521

26. N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric Acid

27. Rilmenidine Phosphate [who-dd]

28. Ccg-267224

29. Hy-100490b

30. As-15125

31. Cs-0020190

32. Ft-0656776

33. A14256

34. S-3341

35. 409r387

36. A841323

37. S-3341-3

38. W-104082

39. Q27261715

40. Rilmenidine Dihydrogen Phosphate [ep Monograph]

41. (5-methylpyridin-2-yl)piperidin-4-yl-aminedihydrochloride

42. 2-((dicyclopropylmethyl)amino)-2-oxazoline Phosphate

43. Dicyclopropylmethyl-(4,5-dihydrooxazol-2-yl)ammonium Phosphate

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₉N₂O₅P
Molecular Weight	278.24 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	278.10315871 g/mol
Monoisotopic Mass	278.10315871 g/mol
Topological Polar Surface Area	111 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

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