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Rimantadine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 3 USDMF, 1 NDC API, 4 Listed Suppliers

6 API Suppliers
3 USDMF
1 NDC API
4 Listed Suppliers

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

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5 FDF Dossiers, 5 FDA Orange Book

5 FDF Dossiers
5 FDA Orange Book

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1 SPI Pharma, 2 Seqens, 1 Faran Shimi Pharmaceutical, 7 Gangwal Healthcare, 1 ACG Worldwide, 3 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 8 BASF, 10 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 5 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 15 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 1 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 9 Roquette, 6 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

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GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

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1 US Medicaid Prescriptions

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2 APIs

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2 APIs

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

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1 USP
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Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

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API

FDF

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FDF Dossiers

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Canada

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EDQM

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Chemistry

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Also known as: 1501-84-4, Flumadine, Rimantadine hcl, Meradane, 1-(1-adamantyl)ethylamine hydrochloride, 1-(adamantan-1-yl)ethanamine hydrochloride

Molecular Formula

C₁₂H₂₂ClN

Molecular Weight

215.76 g/mol

InChI Key

OZBDFBJXRJWNAV-UHFFFAOYSA-N

FDA UNII

JEI07OOS8Y

An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

1 2D Structure

Rimantadine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-(1-adamantyl)ethanamine;hydrochloride

2.1.2 InChI

InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H

2.1.3 InChI Key

OZBDFBJXRJWNAV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C12CC3CC(C1)CC(C3)C2)N.Cl

2.2 Other Identifiers

2.2.1 UNII

JEI07OOS8Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Flumadine

2. Hydrochloride, Rimantadine

3. Remantadine

4. Riamantadine

5. Rimantadine

6. Roflual

2.3.2 Depositor-Supplied Synonyms

1. 1501-84-4

2. Flumadine

3. Rimantadine Hcl

4. Meradane

5. 1-(1-adamantyl)ethylamine Hydrochloride

6. 1-(adamantan-1-yl)ethanamine Hydrochloride

7. Rimantadine (hydrochloride)

8. Exp 126

9. Rimantadine, Hcl

10. Alpha-methyl-1-adamantanemethylamine Hydrochloride

11. 1-(1-aminoethyl)adamantane Hydrochloride

12. Algirem

13. Meradan

14. Oclovir

15. Roflual

16. 1-(1-adamantyl)ethanamine Hydrochloride

17. Jp 61

18. C12h22cln

19. Mfcd00072023

20. 1-(1-adamantyl)ethanamine;hydrochloride

21. Exp-126

22. Remantadine Hydrochloride

23. Jei07oos8y

24. Nsc-206764

25. Mls000069661

26. Chebi:8865

27. Dsstox_cid_27790

28. Dsstox_rid_82564

29. Dsstox_gsid_47813

30. .alpha.-methyl-1-adamantanemethylamine Hydrochloride

31. [1-(1-adamantyl)ethyl]amine Hydrochloride

32. 1-(adamantan-1-yl)ethan-1-amine Hydrochloride

33. Tricyclo[3.3.1.13,7]decane-1-methanamine, Alpha-methyl-, Hydrochloride (1:1), (alphas)-

34. Smr000436311

35. Cas-1501-84-4

36. Rimantadine Hydrochloride [usan]

37. Akos016034989

38. Ncgc00159491-02

39. Unii-jei07oos8y

40. Nsc 206764

41. Remantadine

42. Adamantane, 1-(1-aminoethyl)-, Hydrochloride

43. Flumadine (tn)

44. Rimantadine Hydrochloride [usan:usp]

45. Rimantadinehydrochloride

46. Diisopropylsulfide

47. Alpha-methyltricyclo(3.3.1.1(sup 3,7))decane-1-methanamine Hydrochloride

48. Schembl40906

49. Mls000332981

50. Mls002548886

51. Chembl535396

52. Chembl1200355

53. Dtxsid1047813

54. Rimantadine Hydrochloride (usp)

55. 1-(1-aminoethyl)adamantane Hcl

56. Hy-b0338a

57. J05ac02

58. Molport-000-768-308

59. 1-adamantanemethylamine, Alpha-methyl-, Hydrochloride

60. Pharmakon1600-01505460

61. [1-(1-adamantyl)ethyl]amine Hcl

62. Act02687

63. Bcp26342

64. Tox21_111712

65. Ccg-41384

66. Nsc206764

67. Nsc759149

68. S5484

69. 1-adamantanemethylamine, Hydrochloride

70. Rimantadine Hydrochloride [mi]

71. Akos005267193

72. Akos016340560

73. Tox21_111712_1

74. Tricyclo(3.3.1.13,7)decane-1-methanamine, Alpha-methyl-, Hydrochloride

75. Ac-8480

76. Ccg-220606

77. Ks-5232

78. Nc00674

79. Nsc-759149

80. Tricyclo(3.3.1.1(sup 3,7))-decane-1-methanamine, Alpha-methyl-, Hydrochloride

81. Ncgc00159491-04

82. Rimantadine Hydrochloride [mart.]

83. Rimantadine Hydrochloride [vandf]

84. 1-adamantan-1-yl-ethylamine Hydrochloride

85. As-12095

86. Br164342

87. Rimantadine Hydrochloride [usp-rs]

88. Rimantadine Hydrochloride [who-dd]

89. Smr000059215

90. Sy057460

91. Ft-0603562

92. R0070

93. En300-08051

94. Vu0244476-5

95. 1-(1-adamantyl)ethylamine Hydrochloride, 99%

96. C08094

97. D00901

98. Rimantadine Hydrochloride [orange Book]

99. Rimantadine Hydrochloride [usp Monograph]

100. Alpha-methyl-1-adamantane-methanamine Hydrochloride

101. Sr-01000631468

102. J-006455

103. Q-201673

104. Sr-01000631468-1

105. Sr-01000631468-4

106. Q27108162

107. 1-((3r,5r,7r)-adamantan-1-yl)ethanamine Hydrochloride

108. Rimantadine Hcl Pound>>hydrochloride, Rimantadine;flumadine

109. 1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanamine Hydrochloride

110. Alpha-methyl-tricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride (1:1)

111. Rimantadine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

112. Tricyclo(3.3.1.1(sup 3,7))-decane-1-methanamine, .alpha.-methyl-, Hydrochloride

113. Tricyclo[3.3.1.13,7]decane-1-methanamine, Alpha-methyl-, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₂₂ClN
Molecular Weight	215.76 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	215.1440774 g/mol
Monoisotopic Mass	215.1440774 g/mol
Topological Polar Surface Area	26 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	180
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Flumadine
PubMed Health	Rimantadine (By mouth)
Drug Classes	Antiviral
Drug Label	Flumadine (rimantadine hydrochloride) is a synthetic antiviral drug available as a 100 mg film-coated tablet and as a syrup for oral administration. Each film-coated tablet contains 100 mg of rimantadine hydrochloride plus hydroxypropyl methylcellu...
Active Ingredient	Rimantadine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg
Market Status	Prescription
Company	Caraco

2 of 4
Drug Name	Rimantadine hydrochloride
Drug Label	Rimantadine hydrochloride is a synthetic antiviral drug available as a 100 mg film-coated tablet. Each film-coated tablet contains 100 mg of rimantadine hydrochloride. In addition, each tablet contains the following inactive ingredients: hydroxypropy...
Active Ingredient	Rimantadine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg
Market Status	Prescription
Company	Impax Labs

3 of 4
Drug Name	Flumadine
PubMed Health	Rimantadine (By mouth)
Drug Classes	Antiviral
Drug Label	Flumadine (rimantadine hydrochloride) is a synthetic antiviral drug available as a 100 mg film-coated tablet and as a syrup for oral administration. Each film-coated tablet contains 100 mg of rimantadine hydrochloride plus hydroxypropyl methylcellu...
Active Ingredient	Rimantadine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg
Market Status	Prescription
Company	Caraco

4 of 4
Drug Name	Rimantadine hydrochloride
Drug Label	Rimantadine hydrochloride is a synthetic antiviral drug available as a 100 mg film-coated tablet. Each film-coated tablet contains 100 mg of rimantadine hydrochloride. In addition, each tablet contains the following inactive ingredients: hydroxypropy...
Active Ingredient	Rimantadine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg
Market Status	Prescription
Company	Impax Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

Nucleic Acid Synthesis Inhibitors

Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

M2 Protein Inhibitors [MoA]; Influenza A M2 Protein Inhibitor [EPC]

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