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ACTIVE PHARMA INGREDIENTS

18 API Suppliers, 5 USDMF, 8 NDC API, 16 Listed Suppliers, $ API Reference Price

18 API Suppliers
5 USDMF
8 NDC API
16 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

25 Drugs in Development

25 Drugs in Development

INTERMEDIATES

18 Intermediates Suppliers

18 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 1 FDA Orange Book, 3 Europe

4 FDF Dossiers
1 FDA Orange Book
3 Europe

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 37 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
37 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 3 Finished Drug Prices, 2 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
3 Finished Drug Prices
2 Annual Reports

MARKET PLACE

10 APIs

marketPlace
10 APIs

PATENTS & EXCLUSIVITIES

5 US Patents, 2 US Exclusivities

patents
5 US Patents
2 US Exclusivities

Moehs Rimegepant Sulfate

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

JDMF

EU WC

KDMF

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VMF

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API REF. PRICE (USD/KG)

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FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

276,493,155

Annual Reports (USD Million)

1,141

Finished Drug Prices

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Chemistry

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Also known as: Nurtec odt, Rimegepant sulfate [usan], 1374024-48-2, 1383nm3q0h, Rimegepant sulfate (usan), 1-piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1h-imidazo(4,5-b)pyridin-1-yl)-, (5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta(b)pyridin-9-yl ester, sulfate, hydrate (2:1:3)

Molecular Formula

C₅₆H₆₄F₄N₁₂O₁₃S

Molecular Weight

1221.2 g/mol

InChI Key

SOGUOEZRYKUOHR-CQZKMDJHSA-N

FDA UNII

1383NM3Q0H

1 2D Structure

Rimegepant Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;sulfuric acid;trihydrate

2.1.2 InChI

InChI=1S/2C28H28F2N6O3.H2O4S.3H2O/c2*29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37;1-5(2,3)4;;;/h2*1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37);(H2,1,2,3,4);3*1H2/t2*18-,22+,24-;;;;/m00..../s1

2.1.3 InChI Key

SOGUOEZRYKUOHR-CQZKMDJHSA-N

2.1.4 Canonical SMILES

C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.O.O.O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6.O.O.O.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

1383NM3Q0H

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta(b)pyridin-9-yl 4-(2-oxo-2,3-dihydro-1h-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxylate

2. Bms-927711

3. Nurtec Odt

4. Rimegepant

2.3.2 Depositor-Supplied Synonyms

1. Nurtec Odt

2. Rimegepant Sulfate [usan]

3. 1374024-48-2

4. 1383nm3q0h

5. Rimegepant Sulfate (usan)

6. 1-piperidinecarboxylic Acid, 4-(2,3-dihydro-2-oxo-1h-imidazo(4,5-b)pyridin-1-yl)-, (5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta(b)pyridin-9-yl Ester, Sulfate, Hydrate (2:1:3)

7. Di((5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta(b)pyridin-9-yl 4-(2-oxo-2,3-dihydro-1h-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxylate), Monosulfate, Trihydrate

8. Unii-1383nm3q0h

9. Nurtec Odt (tn)

10. Rimegepant Sulfate Dihydrate

11. Chembl2364629

12. Dtxsid60160174

13. Rimegepant Sulfate [who-dd]

14. Rimegepant Sulfate [orange Book]

15. Rimegepant Hemisulfate Sesquihydrate

16. D10663

17. Rimegepant Hemisulfate Sesquihydrate [mi]

18. Q27251488

2.4 Create Date

2013-07-08

3 Chemical and Physical Properties

Molecular Formula	C₅₆H₆₄F₄N₁₂O₁₃S
Molecular Weight	1221.2 g/mol
Hydrogen Bond Donor Count	9
Hydrogen Bond Acceptor Count	23
Rotatable Bond Count	8
Exact Mass	1220.43726396 g/mol
Monoisotopic Mass	1220.43726396 g/mol
Topological Polar Surface Area	313 Å²
Heavy Atom Count	86
Formal Charge	0
Complexity	973
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	6

4 Pharmacology and Biochemistry

4.1 FDA Pharmacological Classification

4.1.1 Pharmacological Classes

Calcitonin Gene-related Peptide Receptor Antagonists [MoA]; Calcitonin Gene-related Peptide Receptor Antagonist [EPC]

API SUPPLIERS

01

Moehs Iberica

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Booth #1A73

Moehs Group, a reference company in the production of pharmaceutical active ingredients.

Contact Supplier

Spain

Virtual Booth

Digital Content

USDMF

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CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

02

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Jinan Tantu Chemicals

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI China

Exhibiting

Jinan Tantu Chemicals offers customized R&D services & production of small molecule APIs & pharmaceutical intermediates.

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China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Medichem S.A

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Medichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

Contact Supplier

Spain

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

05

Porton Pharma Solutions

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Porton Pharma Solutions: Value creation via innovation & discovery through technical platforms.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

06

TAPI Technology & API Services

Israel

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI WW Frankfurt

Booth #6.1A32

TAPI offers customized CDMO Solutions for API development and manufacturing services.

Contact Supplier

Israel

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

07

Aurobindo Pharma Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Not Confirmed

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API Reference Price

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HEATHROW","customer":"CATALENT PHARMA SOLUTIONS","customerCountry":"UNITED KINGDOM","quantity":"225.35","actualQuantity":"225.35","unit":"KGS","unitRateFc":"12910.7","totalValueFC":"2881088.2","currency":"USD","unitRateINR":1061255.8242733525,"date":"01-Sep-2023","totalValueINR":"239154000","totalValueInUsd":"2881088.2","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"3649252","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK, KURLA, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709317800,"product":"RIMEGEPANT SULFATE (RES)","address":"PLOT NO.C-24, MSN HOUSE, INDUSTRIAL","city":"HYDERABAD, AP","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"MERKO PHARMACEUTICAL & ","customerCountry":"TURKEY","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"30000","totalValueFC":"63145.6","currency":"EUR","unitRateINR":2621672.1699999999,"date":"02-Mar-2024","totalValueINR":"5243344.34","totalValueInUsd":"63145.6","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"8001178","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.C-24, MSN HOUSE, INDUSTRIAL, HYDERABAD, AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711737000,"product":"FINE ORGANIC COMPOUND.-WE INTEND TO CLAIM UNDER RODTEP SCHEME .RIMEGEPANT SULFATE.BATCH# A012440060,A012440067,**","address":"PLOT.NO.49,CANARA BANK ROAD,BOMMASANDRA INDL.AREA,","city":"PHASE-I,BANGALORE","supplier":"ANTHEM BIOSCIENCES","supplierCountry":"INDIA","foreign_port":"LONDON METROPOLITAN","customer":"PROJECT MANAGER","customerCountry":"UNITED KINGDOM","quantity":"299.30","actualQuantity":"299.3","unit":"KGS","unitRateFc":"13534.4","totalValueFC":"4012520.6","currency":"USD","unitRateINR":1113206.8676912796,"date":"30-Mar-2024","totalValueINR":"333182815.5","totalValueInUsd":"4012520.6","indian_port":"Bangalore Air","hs_no":"29333100","bill_no":"8784526","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"PLOT.NO.49,CANARA BANK ROAD,BOMMASANDRA INDL.AREA,, PHASE-I,BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714329000,"product":"FINE ORGANIC COMPOUND,WE INTEND TO CLAIMUNDER RODTEP SCHEME, BATCH A062440069 A062440073 A062440077 RIMEGEPANT SULFATE","address":"PLOT.NO.49,CANARA BANK ROAD,BOMMASANDRA INDL.AREA,","city":"PHASE-I,BANGALORE","supplier":"ANTHEM BIOSCIENCES","supplierCountry":"INDIA","foreign_port":"LONDON - 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HEATHROW","customer":"PROJECT MANAGER","customerCountry":"UNITED KINGDOM","quantity":"28.70","actualQuantity":"28.7","unit":"KGS","unitRateFc":"12210","totalValueFC":"347174.4","currency":"USD","unitRateINR":1014651,"date":"31-Aug-2024","totalValueINR":"29120483.7","totalValueInUsd":"347174.4","indian_port":"Bangalore Air","hs_no":"29333100","bill_no":"3662019","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"PLOT.NO.49,CANARA BANK ROAD,BOMMASANDRA INDL.AREA,, PHASE-I,BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"FINE ORGANIC COMPOUND-WE INTEND TO CLAIMTHE BENEFIT UNDER RODTEP SCHEME (BATCHNO:A012440171) RIMEGEPANT SULFATE","address":"PLOT.NO.49,CANARA BANK ROAD,BOMMASANDRA INDL.AREA,","city":"PHASE-I,BANGALORE","supplier":"ANTHEM BIOSCIENCES","supplierCountry":"INDIA","foreign_port":"LONDON - 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HEATHROW","customer":"PROJECT MANAGER","customerCountry":"UNITED KINGDOM","quantity":"177.83","actualQuantity":"177.83","unit":"KGS","unitRateFc":"13010","totalValueFC":"2291959.6","currency":"USD","unitRateINR":1087636.000112467,"date":"29-Nov-2024","totalValueINR":"193414309.9","totalValueInUsd":"2291959.6","indian_port":"Bangalore Air","hs_no":"29333100","bill_no":"6042476","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"PLOT.NO.49,CANARA BANK ROAD,, PHASE-I,BANGALORE","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1687804200,"product":"RIMEGEPANT HEMISULFATE SESQUIHYDRATE CAS: 1374024-48-2 (RIMEGEPANT HEMISULFATE SESQUIHYDRAT)","address":"MED ONE HOUSE, PLOT NO B-75, RD NO ,Z-33, WAGLE INDUSTRIAL ESTATE,","city":"THANE,MAHARASHTRA","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"NA","customer":"RUBICON RESEARCH","customerCountry":"INDIA","quantity":"7.00","actualQuantity":"7","unit":"KGS","unitRateFc":"36500","totalValueFC":"258153.7","currency":"USD","unitRateINR":"3031325.3","date":"27-Jun-2023","totalValueINR":"21219274.73","totalValueInUsd":"258153.7","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"MED ONE HOUSE, PLOT NO B-75, RD NO ,Z-33, WAGLE INDUSTRIAL ESTATE,"}]