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Chemistry

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Also known as: Sodium risedronate, 115436-72-1, Actonel, Atelvia, Risedronate (sodium), Ne 58095
Molecular Formula
C7H10NNaO7P2
Molecular Weight
305.09  g/mol
InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
FDA UNII
OFG5EXG60L

Risedronate Sodium
A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
1 2D Structure

Risedronate Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate
2.1.2 InChI
InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
2.1.3 InChI Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
OFG5EXG60L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-hydroxy-2-(3-pyridyl)ethylidene Diphosphonate

2. 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate

3. 2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate

4. Actonel

5. Atelvia

6. Bisphosphonate Risedronate Sodium

7. Risedronate

8. Risedronate Sodium, Bisphosphonate

9. Risedronic Acid

10. Risedronic Acid, Monosodium Salt

11. Sodium, Bisphosphonate Risedronate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Risedronate

2. 115436-72-1

3. Actonel

4. Atelvia

5. Risedronate (sodium)

6. Ne 58095

7. Risedronic Acid Monosodium Salt

8. Risedronate Monosodium

9. Ofg5exg60l

10. Risedronate Sodium Anhydrous

11. Ne-58095 Anhydrous

12. Sodium Trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate

13. 115436-72-1 (sodium)

14. Risedronic Acid Sodium

15. Benet

16. Nsc-722598

17. Nsc-759280

18. Actonel (tn)

19. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Monosodium Salt

20. Sodium Hydrogen (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

21. Risedronate Sodium [usan]

22. Risedronic Acid Sodium Salt

23. Mfcd00867080

24. 122458-82-6

25. Unii-ofg5exg60l

26. Optinate

27. Acrel

28. Risedronate Sodium [usan:usp]

29. Sodium Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate

30. Optinate Septimum

31. Monosodium Risedronate

32. Monosodium (1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate

33. Ne 58095 Sodium

34. Risedronate Sodium (usp)

35. Chembl1654

36. Schembl18377

37. Risedronate Sodium, Min 97%

38. Chebi:8868

39. Dtxsid20924178

40. Risedronate Sodium [vandf]

41. Risedronate Sodium [mart.]

42. Act03362

43. Bcp22742

44. Hy-b0119

45. Risedronate Sodium [usp-rs]

46. Risedronate Sodium [who-dd]

47. Ac-732

48. Mfcd01706268

49. S1428

50. Akos015833432

51. Ab09807

52. Ccg-213235

53. Cs-1883

54. Nsc 722598

55. Nsc 759280

56. Risedronate Sodium [orange Book]

57. Ncgc00346521-01

58. Ac-20120

59. As-13309

60. Risedronate Sodium [usp Monograph]

61. Ft-0631078

62. M2289

63. Risedronic Acid Monosodium Salt [mi]

64. D00942

65. H11438

66. Ab01274790-01

67. Q-201723

68. Q27285633

69. 2-(3-pyridinyl)-2-hydroxyethylidene-1,1-bisphosphonate

70. Monosodium 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonate

71. 1-hydroxy-2-(3-pyridinyl) Ethylidene Bis-phosphonic Acid Monosodium Salt

72. Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (na+)

73. P,p'-[1-hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic Acid Sodium Salt

74. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

75. Phosphonic Acid, (2-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

76. Risedronate Sodium, United States Pharmacopeia (usp) Reference Standard

77. Risedronate Sodium;risedronic Acid Sodium;ne-58095; Ne 58095; Ne58095

78. Sodium Hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate

79. Sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

80. (1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic Acid) Sodium Salt

81. Risedronate Sodium 2.5-hydrate, European Pharmacopoeia (ep) Reference Standard

82. Risedronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

83. 934544-85-1

2.4 Create Date
2005-09-13
3 Chemical and Physical Properties
Molecular Weight 305.09 g/mol
Molecular Formula C7H10NNaO7P2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass304.98301994 g/mol
Monoisotopic Mass304.98301994 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count18
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameActonel
PubMed HealthAntacid, Calcium Containing (By mouth)
Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
RouteOral
Strength5mg; 30mg; 150mg; 35mg
Market StatusPrescription
CompanyWarner Chilcott

2 of 6  
Drug NameAtelvia
Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
Active IngredientRisedronate sodium
Dosage FormTablet, delayed release
RouteOral
Strength35mg
Market StatusPrescription
CompanyWarner Chilcott

3 of 6  
Drug NameRisedronate sodium
PubMed HealthRisedronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
Routeoral; Oral
Strength30mg; 150mg; 75mg; 5mg; 35mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

4 of 6  
Drug NameActonel
PubMed HealthAntacid, Calcium Containing (By mouth)
Drug ClassesAntacid, Aluminum Containing, Antacid, Aluminum/Calcium/Magnesium Containing, Antacid, Calcium Containing, Antacid, Magnesium Containing, Antiflatulent, Calcium Supplement
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
RouteOral
Strength5mg; 30mg; 150mg; 35mg
Market StatusPrescription
CompanyWarner Chilcott

5 of 6  
Drug NameAtelvia
Drug LabelAtelvia (risedronate sodium) delayed-release tablets contain a pH-sensitive enteric coating and a chelating agent (EDTA). Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each...
Active IngredientRisedronate sodium
Dosage FormTablet, delayed release
RouteOral
Strength35mg
Market StatusPrescription
CompanyWarner Chilcott

6 of 6  
Drug NameRisedronate sodium
PubMed HealthRisedronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelACTONEL (risedronate sodium) tablets is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism. Each ACTONEL tablet for oral administration contains the equivalent of 5, 30, 35, 75, or 150 mg of anh...
Active IngredientRisedronate sodium
Dosage FormTablet
Routeoral; Oral
Strength30mg; 150mg; 75mg; 5mg; 35mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Aurobindo Pharma; Teva Pharms Usa; Sun Pharma Global; Teva Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Bisphosphonate [EPC]; Diphosphonates [CS]; Bisphosphonate [EPC]

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04-Jan-2021
25-Feb-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 150MG

USFDA APPLICATION NUMBER - 20835

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DOSAGE - TABLET;ORAL - 30MG

USFDA APPLICATION NUMBER - 20835

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DOSAGE - TABLET;ORAL - 35MG

USFDA APPLICATION NUMBER - 20835

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DOSAGE - TABLET;ORAL - 5MG

USFDA APPLICATION NUMBER - 20835

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DOSAGE - TABLET;ORAL - 75MG **Federal Registe...DOSAGE - TABLET;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20835

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DOSAGE - TABLET, DELAYED RELEASE;ORAL - 35MG

USFDA APPLICATION NUMBER - 22560

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ABOUT THIS PAGE

Looking for 115436-72-1 / Risedronate Sodium API manufacturers, exporters & distributors?

Risedronate Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Risedronate Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Risedronate Sodium manufacturer or Risedronate Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Risedronate Sodium manufacturer or Risedronate Sodium supplier.

PharmaCompass also assists you with knowing the Risedronate Sodium API Price utilized in the formulation of products. Risedronate Sodium API Price is not always fixed or binding as the Risedronate Sodium Price is obtained through a variety of data sources. The Risedronate Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Risedronate Sodium

Synonyms

Sodium risedronate, 115436-72-1, Actonel, Atelvia, Risedronate (sodium), Ne 58095

Cas Number

115436-72-1

Unique Ingredient Identifier (UNII)

OFG5EXG60L

About Risedronate Sodium

A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.

Risedronate Sodium Hydrate Manufacturers

A Risedronate Sodium Hydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Risedronate Sodium Hydrate, including repackagers and relabelers. The FDA regulates Risedronate Sodium Hydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Risedronate Sodium Hydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Risedronate Sodium Hydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Risedronate Sodium Hydrate Suppliers

A Risedronate Sodium Hydrate supplier is an individual or a company that provides Risedronate Sodium Hydrate active pharmaceutical ingredient (API) or Risedronate Sodium Hydrate finished formulations upon request. The Risedronate Sodium Hydrate suppliers may include Risedronate Sodium Hydrate API manufacturers, exporters, distributors and traders.

click here to find a list of Risedronate Sodium Hydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Risedronate Sodium Hydrate USDMF

A Risedronate Sodium Hydrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Risedronate Sodium Hydrate active pharmaceutical ingredient (API) in detail. Different forms of Risedronate Sodium Hydrate DMFs exist exist since differing nations have different regulations, such as Risedronate Sodium Hydrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Risedronate Sodium Hydrate DMF submitted to regulatory agencies in the US is known as a USDMF. Risedronate Sodium Hydrate USDMF includes data on Risedronate Sodium Hydrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Risedronate Sodium Hydrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Risedronate Sodium Hydrate suppliers with USDMF on PharmaCompass.

Risedronate Sodium Hydrate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Risedronate Sodium Hydrate Drug Master File in Japan (Risedronate Sodium Hydrate JDMF) empowers Risedronate Sodium Hydrate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Risedronate Sodium Hydrate JDMF during the approval evaluation for pharmaceutical products. At the time of Risedronate Sodium Hydrate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Risedronate Sodium Hydrate suppliers with JDMF on PharmaCompass.

Risedronate Sodium Hydrate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Risedronate Sodium Hydrate Drug Master File in Korea (Risedronate Sodium Hydrate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Risedronate Sodium Hydrate. The MFDS reviews the Risedronate Sodium Hydrate KDMF as part of the drug registration process and uses the information provided in the Risedronate Sodium Hydrate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Risedronate Sodium Hydrate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Risedronate Sodium Hydrate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Risedronate Sodium Hydrate suppliers with KDMF on PharmaCompass.

Risedronate Sodium Hydrate CEP

A Risedronate Sodium Hydrate CEP of the European Pharmacopoeia monograph is often referred to as a Risedronate Sodium Hydrate Certificate of Suitability (COS). The purpose of a Risedronate Sodium Hydrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Risedronate Sodium Hydrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Risedronate Sodium Hydrate to their clients by showing that a Risedronate Sodium Hydrate CEP has been issued for it. The manufacturer submits a Risedronate Sodium Hydrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Risedronate Sodium Hydrate CEP holder for the record. Additionally, the data presented in the Risedronate Sodium Hydrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Risedronate Sodium Hydrate DMF.

A Risedronate Sodium Hydrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Risedronate Sodium Hydrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Risedronate Sodium Hydrate suppliers with CEP (COS) on PharmaCompass.

Risedronate Sodium Hydrate WC

A Risedronate Sodium Hydrate written confirmation (Risedronate Sodium Hydrate WC) is an official document issued by a regulatory agency to a Risedronate Sodium Hydrate manufacturer, verifying that the manufacturing facility of a Risedronate Sodium Hydrate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Risedronate Sodium Hydrate APIs or Risedronate Sodium Hydrate finished pharmaceutical products to another nation, regulatory agencies frequently require a Risedronate Sodium Hydrate WC (written confirmation) as part of the regulatory process.

click here to find a list of Risedronate Sodium Hydrate suppliers with Written Confirmation (WC) on PharmaCompass.

Risedronate Sodium Hydrate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Risedronate Sodium Hydrate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Risedronate Sodium Hydrate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Risedronate Sodium Hydrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Risedronate Sodium Hydrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Risedronate Sodium Hydrate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Risedronate Sodium Hydrate suppliers with NDC on PharmaCompass.

Risedronate Sodium Hydrate GMP

Risedronate Sodium Hydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Risedronate Sodium Hydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Risedronate Sodium Hydrate GMP manufacturer or Risedronate Sodium Hydrate GMP API supplier for your needs.

Risedronate Sodium Hydrate CoA

A Risedronate Sodium Hydrate CoA (Certificate of Analysis) is a formal document that attests to Risedronate Sodium Hydrate's compliance with Risedronate Sodium Hydrate specifications and serves as a tool for batch-level quality control.

Risedronate Sodium Hydrate CoA mostly includes findings from lab analyses of a specific batch. For each Risedronate Sodium Hydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Risedronate Sodium Hydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Risedronate Sodium Hydrate EP), Risedronate Sodium Hydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Risedronate Sodium Hydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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