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Chemistry

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Also known as: 811803-05-1, Rivoceranib, Apatinib free base, Yn968d1, N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
Molecular Formula
C24H23N5O
Molecular Weight
397.5  g/mol
InChI Key
WPEWQEMJFLWMLV-UHFFFAOYSA-N
FDA UNII
5S371K6132

Rivoceranib
Rivoceranib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Upon administration, rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.
1 2D Structure

Rivoceranib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
2.1.2 InChI
InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)
2.1.3 InChI Key
WPEWQEMJFLWMLV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
2.2 Other Identifiers
2.2.1 UNII
5S371K6132
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apatinib Mesylate

2. Rivoceranib

3. Rivoceranib Mesylate

4. Yn-968d1

5. Yn968d1

2.3.2 Depositor-Supplied Synonyms

1. 811803-05-1

2. Rivoceranib

3. Apatinib Free Base

4. Yn968d1

5. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

6. N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide

7. 5s371k6132

8. N-(4-(1-cyanocyclopentyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide

9. 3-pyridinecarboxamide, N-(4-(1-cyanocyclopentyl)phenyl)-2-((4-pyridinylmethyl)amino)-

10. Unii-5s371k6132

11. Apatinib (in China)

12. Rivoceranib [inn]

13. Rivoceranib (usan/inn)

14. Rivoceranib [usan]

15. Rivoceranib [who-dd]

16. Gtpl7648

17. Schembl1814966

18. Chembl3186534

19. Apatinib Free Base; Yn-968d1

20. Dtxsid601024366

21. Amy21302

22. Bcp02840

23. Ex-a1794

24. Hy-13342a

25. Mfcd21648511

26. Nsc772886

27. Nsc799333

28. S5248

29. Zinc70466461

30. Akos024464453

31. Ccg-268625

32. Db14765

33. Ds-7455

34. Nsc-772886

35. Nsc-799333

36. Sb16590

37. N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

38. Ncgc00249393-01

39. Ncgc00249393-08

40. Ac-27461

41. Ba175030

42. Da-35324

43. Cs-0003200

44. C76598

45. D11288

46. Ab01274807-01

47. Ab01274807_02

48. Q27262801

49. N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]nicotinamide

50. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 397.5 g/mol
Molecular Formula C24H23N5O
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass397.19026037 g/mol
Monoisotopic Mass397.19026037 g/mol
Topological Polar Surface Area90.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity608
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Rivoceranib Manufacturers

A Rivoceranib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rivoceranib, including repackagers and relabelers. The FDA regulates Rivoceranib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rivoceranib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rivoceranib Suppliers

A Rivoceranib supplier is an individual or a company that provides Rivoceranib active pharmaceutical ingredient (API) or Rivoceranib finished formulations upon request. The Rivoceranib suppliers may include Rivoceranib API manufacturers, exporters, distributors and traders.

click here to find a list of Rivoceranib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rivoceranib USDMF

A Rivoceranib DMF (Drug Master File) is a document detailing the whole manufacturing process of Rivoceranib active pharmaceutical ingredient (API) in detail. Different forms of Rivoceranib DMFs exist exist since differing nations have different regulations, such as Rivoceranib USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rivoceranib DMF submitted to regulatory agencies in the US is known as a USDMF. Rivoceranib USDMF includes data on Rivoceranib's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rivoceranib USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rivoceranib suppliers with USDMF on PharmaCompass.

Rivoceranib GMP

Rivoceranib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rivoceranib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rivoceranib GMP manufacturer or Rivoceranib GMP API supplier for your needs.

Rivoceranib CoA

A Rivoceranib CoA (Certificate of Analysis) is a formal document that attests to Rivoceranib's compliance with Rivoceranib specifications and serves as a tool for batch-level quality control.

Rivoceranib CoA mostly includes findings from lab analyses of a specific batch. For each Rivoceranib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rivoceranib may be tested according to a variety of international standards, such as European Pharmacopoeia (Rivoceranib EP), Rivoceranib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rivoceranib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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