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Romifidine

Romifidine

Synopsis, Chemistry

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Also known as: 65896-16-4, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1h-imidazol-2-amine, Romifidinum, Sedivet, 2-(2-bromo-6-fluoroanilino)-2-imidazoline, Romifidine (inn)

Molecular Formula

C₉H₉BrFN₃

Molecular Weight

258.09 g/mol

InChI Key

KDPNLRQZHDJRFU-UHFFFAOYSA-N

FDA UNII

876351L05K

Romifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. It is also used less commonly in a wide variety of other animal species. This drug's chemical structure closely resembles that of clonidine, however, romifidine is not approved for use in humans.

1 2D Structure

Romifidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine

2.1.2 InChI

InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)

2.1.3 InChI Key

KDPNLRQZHDJRFU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN=C(N1)NC2=C(C=CC=C2Br)F

2.2 Other Identifiers

2.2.1 UNII

876351L05K

2.3 Synonyms

2.3.1 MeSH Synonyms

1. N-(2-bromo-6-fluorophenyl)-4,5-dihydro-(1h)-imidazol-2-amine

2. Romifidine Monohydrochloride

3. Sedivet

4. Sth 2130

2.3.2 Depositor-Supplied Synonyms

1. 65896-16-4

2. N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1h-imidazol-2-amine

3. Romifidinum

4. Sedivet

5. 2-(2-bromo-6-fluoroanilino)-2-imidazoline

6. Romifidine (inn)

7. Romifidine [inn]

8. 876351l05k

9. Romifidinum [latin]

10. Romifidina [spanish]

11. Romifidina

12. Romifidine [inn:ban]

13. Unii-876351l05k

14. Sedivet (tn)

15. Romifidine [mi]

16. Romifidine [mart.]

17. Mls006010405

18. Schembl246009

19. Chembl2105424

20. Dtxsid40216103

21. Mfcd00868606

22. Zinc56898821

23. Akos026348206

24. Db11543

25. Ncgc00532499-01

26. Smr004701406

27. Hy-119456

28. Cs-0068423

29. R0120

30. 2-(2-bromo-6-fluorophenylamino)-2-imidazoline

31. D08487

32. Methyl4-chloro-3-cyclohexene-1-carboxylate

33. Q747850

34. Sr-01000945279

35. Sr-01000945279-1

36. Z1849014130

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₉H₉BrFN₃
Molecular Weight	258.09 g/mol
XLogP3	1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	256.99639 g/mol
Monoisotopic Mass	256.99639 g/mol
Topological Polar Surface Area	36.4 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	234
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

Anesthetics

Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site. (See all compounds classified as Anesthetics.)