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Also known as: 91374-20-8, Ropinirole hcl, Requip, 4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride, Skf 101468 hydrochloride, Requip xl
Molecular Formula
C16H25ClN2O
Molecular Weight
296.83  g/mol
InChI Key
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
FDA UNII
D7ZD41RZI9

Ropinirole Hydrochloride
Ropinirole Hydrochloride is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property. Acting as a substitute for dopamine, ropinirole hydrochloride binds to and activates dopamine D2 and D3 receptors within the caudate putamen in the brain, thereby improving motor function.
1 2D Structure

Ropinirole Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride
2.1.2 InChI
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
2.1.3 InChI Key
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl
2.2 Other Identifiers
2.2.1 UNII
D7ZD41RZI9
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(2-(di-n-propylamino)ethyl)-2(3h)-indolone

2. Requip

3. Ropinirol

4. Ropinirole

5. Sk And F 101468

6. Sk And F-101,468

7. Skf 101468

2.3.2 Depositor-Supplied Synonyms

1. 91374-20-8

2. Ropinirole Hcl

3. Requip

4. 4-(2-(dipropylamino)ethyl)indolin-2-one Hydrochloride

5. Skf 101468 Hydrochloride

6. Requip Xl

7. Sk&f 101468-a

8. Ropinirole (hydrochloride)

9. 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride

10. D7zd41rzi9

11. Ropinirole (as Hydrochloride)

12. 4-(2-(dipropylamino)ethyl)-2-indolinone Monohydrochloride

13. 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2h-indol-2-one Hydrochloride

14. Sk&f-101468a

15. Sk&f-101468-a

16. Ropinirolhydrochloride

17. Ropinirolehydrochloride

18. Ropinirole Hydrochloride [usan]

19. Sr-01000076215

20. Ropinirole Hydrochloride [usan:usp]

21. Unii-d7zd41rzi9

22. C16h24n2o.hcl

23. Adartrel

24. Repreve

25. Requi

26. Requip Cr

27. Requip Lp

28. Requip Pr

29. Requip Xr

30. Skf-101468a

31. Mfcd01754173

32. Requip (tn)

33. 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-one Monohydrochloride

34. Jzp-7

35. Schembl40760

36. Mls003899234

37. Chebi:8889

38. Chembl1200411

39. Hy-b0623a

40. Dtxsid50238533

41. Nvd-434

42. 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one Hydrochloride

43. Act02690

44. Bcp02130

45. Ex-a4943

46. Ropinirole For Peak Identification 1

47. Ropinirole For Peak Identification 2

48. Ropinirole For Peak Identification 3

49. Ropinirole Hydrochloride (jan/usp)

50. Tox21_501101

51. Ac-735

52. Ac-736

53. Np-201

54. Ropinirole Hydrochloride [mi]

55. S3189

56. Ropinirole Hydrochloride [jan]

57. Akos015844988

58. Bs-1020

59. Ccg-213346

60. Hp-3000

61. Lp01101

62. 2(h)-indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, Monohydrochloride

63. Ropinirole Hydrochloride [mart.]

64. Ropinirole Hydrochloride [vandf]

65. Ncgc00094373-01

66. Ncgc00261786-01

67. Ropinirole Hydrochloride [usp-rs]

68. Ropinirole Hydrochloride [who-dd]

69. Smr001456484

70. Eu-0101101

71. Ft-0642200

72. Sw199044-2

73. Ropinirole Hydrochloride [orange Book]

74. D00784

75. R 4152

76. Ropinirole Hydrochloride [ep Monograph]

77. Ropinirole Hydrochloride [usp Monograph]

78. 374r208

79. A843815

80. Ropinirole Hydrochloride, Powder, >=98% (hplc)

81. Sr-01000076215-2

82. Sr-01000076215-5

83. 4-(2-dipropylamino-ethyl)-1,3-dihydro-indol-2-one

84. Q27276228

85. 4-(2-di-n-propylaminoethyl)-2(3h)indolone Hydrochloride

86. Z1695926158

87. 4-(2-di-n-propylaminoethyl)-2(3h)-indolone Hydrochloride

88. 4-[2-(dipropylamino)ethyl]-1,3-dihy Dro-2h-indol-2-one Hydrochloride

89. 4-[2-(dipropylamino)ethyl]-2,3-dihydro-1h-indol-2-one Hydrochloride

90. Ropinirole Hydrochloride, Europepharmacopoeia (ep) Reference Standard

91. 2h-indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, Monohydrochloride

92. 4-(2-(dipropylamino)ethyl)-1,3-dihydro-2h-indol-2-one Monohydrochloride

93. Ropinirole For Peak Identification 1, Europepharmacopoeia (ep) Reference Standard

94. Ropinirole For Peak Identification 2, Europepharmacopoeia (ep) Reference Standard

95. Ropinirole Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

96. Ropinirole Hydrochloride, United States Pharmacopeia (usp) Reference Standard

97. Skf 101468; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2h-indol-2-one Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 296.83 g/mol
Molecular Formula C16H25ClN2O
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count7
Exact Mass296.1655411 g/mol
Monoisotopic Mass296.1655411 g/mol
Topological Polar Surface Area32.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity287
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameRopinirole hydrochloride
Drug LabelRopinirole hydrochloride is an orally administered non-ergoline dopamine agonist. It is the hydrochloride salt of 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one monohydrochloride and has an molecular formula of C16H24N2OHCl. The molecular w...
Active IngredientRopinirole hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strengtheq 4mg base; eq 5mg base; eq 0.5mg base; eq 2mg base; eq 0.25mg base; eq 6mg base; eq 1mg base; eq 12mg base; eq 3mg base; eq 8mg base
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Alembic; Teva; Apotex; Sandoz; Prinston; Roxane; Watson Labs; Glenmark Generics; Actavis Elizabeth; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan

2 of 2  
Drug NameRopinirole hydrochloride
Drug LabelRopinirole hydrochloride is an orally administered non-ergoline dopamine agonist. It is the hydrochloride salt of 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one monohydrochloride and has an molecular formula of C16H24N2OHCl. The molecular w...
Active IngredientRopinirole hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strengtheq 4mg base; eq 5mg base; eq 0.5mg base; eq 2mg base; eq 0.25mg base; eq 6mg base; eq 1mg base; eq 12mg base; eq 3mg base; eq 8mg base
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Alembic; Teva; Apotex; Sandoz; Prinston; Roxane; Watson Labs; Glenmark Generics; Actavis Elizabeth; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan

4.2 Drug Indication

Induction of vomiting in dogs.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Nonergot Dopamine Agonist [EPC]; Dopamine Agonists [MoA]
5.3 ATC Code

QN04BC04


API Reference Price

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05-Jan-2021
09-Sep-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 0.25MG BASE **Feder...DOSAGE - TABLET;ORAL - EQ 0.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 0.5MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 0.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 1MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 1MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 2MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 2MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 3MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 3MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 4MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 4MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20658

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 12MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22008

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