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    Chemistry

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    Also known as: 91374-20-8, Ropinirole hcl, Requip, 4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride, Skf 101468 hydrochloride, Requip xl
    Molecular Formula
    C16H25ClN2O
    Molecular Weight
    296.83  g/mol
    InChI Key
    XDXHAEQXIBQUEZ-UHFFFAOYSA-N
    FDA UNII
    D7ZD41RZI9
    Ropinirole Hydrochloride
    Ropinirole Hydrochloride is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property. Acting as a substitute for dopamine, ropinirole hydrochloride binds to and activates dopamine D2 and D3 receptors within the caudate putamen in the brain, thereby improving motor function.
    1 2D Structure

    Ropinirole Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
    2.1.3 InChI Key
    XDXHAEQXIBQUEZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    D7ZD41RZI9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-(2-(di-n-propylamino)ethyl)-2(3h)-indolone

    2. Requip

    3. Ropinirol

    4. Ropinirole

    5. Sk And F 101468

    6. Sk And F-101,468

    7. Skf 101468

    2.3.2 Depositor-Supplied Synonyms

    1. 91374-20-8

    2. Ropinirole Hcl

    3. Requip

    4. 4-(2-(dipropylamino)ethyl)indolin-2-one Hydrochloride

    5. Skf 101468 Hydrochloride

    6. Requip Xl

    7. Sk&f 101468-a

    8. Ropinirole (hydrochloride)

    9. 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride

    10. D7zd41rzi9

    11. Ropinirole (as Hydrochloride)

    12. 4-(2-(dipropylamino)ethyl)-2-indolinone Monohydrochloride

    13. 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2h-indol-2-one Hydrochloride

    14. Sk&f-101468a

    15. Sk&f-101468-a

    16. Ropinirolhydrochloride

    17. Ropinirolehydrochloride

    18. Ropinirole Hydrochloride [usan]

    19. Sr-01000076215

    20. Ropinirole Hydrochloride [usan:usp]

    21. Unii-d7zd41rzi9

    22. C16h24n2o.hcl

    23. Adartrel

    24. Repreve

    25. Requi

    26. Requip Cr

    27. Requip Lp

    28. Requip Pr

    29. Requip Xr

    30. Skf-101468a

    31. Mfcd01754173

    32. Requip (tn)

    33. 1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-one Monohydrochloride

    34. Jzp-7

    35. Schembl40760

    36. Mls003899234

    37. Chebi:8889

    38. Chembl1200411

    39. Hy-b0623a

    40. Dtxsid50238533

    41. Nvd-434

    42. 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one Hydrochloride

    43. Act02690

    44. Bcp02130

    45. Ex-a4943

    46. Ropinirole For Peak Identification 1

    47. Ropinirole For Peak Identification 2

    48. Ropinirole For Peak Identification 3

    49. Ropinirole Hydrochloride (jan/usp)

    50. Tox21_501101

    51. Ac-735

    52. Ac-736

    53. Np-201

    54. Ropinirole Hydrochloride [mi]

    55. S3189

    56. Ropinirole Hydrochloride [jan]

    57. Akos015844988

    58. Bs-1020

    59. Ccg-213346

    60. Hp-3000

    61. Lp01101

    62. 2(h)-indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, Monohydrochloride

    63. Ropinirole Hydrochloride [mart.]

    64. Ropinirole Hydrochloride [vandf]

    65. Ncgc00094373-01

    66. Ncgc00261786-01

    67. Ropinirole Hydrochloride [usp-rs]

    68. Ropinirole Hydrochloride [who-dd]

    69. Smr001456484

    70. Eu-0101101

    71. Ft-0642200

    72. Sw199044-2

    73. Ropinirole Hydrochloride [orange Book]

    74. D00784

    75. R 4152

    76. Ropinirole Hydrochloride [ep Monograph]

    77. Ropinirole Hydrochloride [usp Monograph]

    78. 374r208

    79. A843815

    80. Ropinirole Hydrochloride, Powder, >=98% (hplc)

    81. Sr-01000076215-2

    82. Sr-01000076215-5

    83. 4-(2-dipropylamino-ethyl)-1,3-dihydro-indol-2-one

    84. Q27276228

    85. 4-(2-di-n-propylaminoethyl)-2(3h)indolone Hydrochloride

    86. Z1695926158

    87. 4-(2-di-n-propylaminoethyl)-2(3h)-indolone Hydrochloride

    88. 4-[2-(dipropylamino)ethyl]-1,3-dihy Dro-2h-indol-2-one Hydrochloride

    89. 4-[2-(dipropylamino)ethyl]-2,3-dihydro-1h-indol-2-one Hydrochloride

    90. Ropinirole Hydrochloride, Europepharmacopoeia (ep) Reference Standard

    91. 2h-indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, Monohydrochloride

    92. 4-(2-(dipropylamino)ethyl)-1,3-dihydro-2h-indol-2-one Monohydrochloride

    93. Ropinirole For Peak Identification 1, Europepharmacopoeia (ep) Reference Standard

    94. Ropinirole For Peak Identification 2, Europepharmacopoeia (ep) Reference Standard

    95. Ropinirole Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    96. Ropinirole Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    97. Skf 101468; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2h-indol-2-one Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 296.83 g/mol
    Molecular Formula C16H25ClN2O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count7
    Exact Mass296.1655411 g/mol
    Monoisotopic Mass296.1655411 g/mol
    Topological Polar Surface Area32.3 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity287
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameRopinirole hydrochloride
    Drug LabelRopinirole hydrochloride is an orally administered non-ergoline dopamine agonist. It is the hydrochloride salt of 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one monohydrochloride and has an molecular formula of C16H24N2OHCl. The molecular w...
    Active IngredientRopinirole hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strengtheq 4mg base; eq 5mg base; eq 0.5mg base; eq 2mg base; eq 0.25mg base; eq 6mg base; eq 1mg base; eq 12mg base; eq 3mg base; eq 8mg base
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Alembic; Teva; Apotex; Sandoz; Prinston; Roxane; Watson Labs; Glenmark Generics; Actavis Elizabeth; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan

    2 of 2  
    Drug NameRopinirole hydrochloride
    Drug LabelRopinirole hydrochloride is an orally administered non-ergoline dopamine agonist. It is the hydrochloride salt of 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one monohydrochloride and has an molecular formula of C16H24N2OHCl. The molecular w...
    Active IngredientRopinirole hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strengtheq 4mg base; eq 5mg base; eq 0.5mg base; eq 2mg base; eq 0.25mg base; eq 6mg base; eq 1mg base; eq 12mg base; eq 3mg base; eq 8mg base
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Alembic; Teva; Apotex; Sandoz; Prinston; Roxane; Watson Labs; Glenmark Generics; Actavis Elizabeth; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan

    4.2 Drug Indication

    Induction of vomiting in dogs.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Nonergot Dopamine Agonist [EPC]; Dopamine Agonists [MoA]
    5.3 ATC Code

    QN04BC04

    API Reference Price

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    05-Jan-2021
    16-Sep-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
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    USFDA APPLICATION NUMBER - 22008

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 4MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22008

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 6MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 8MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22008

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