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Chemistry

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Also known as: 147098-20-2, Crestor, Rosuvastatin hemicalcium, Fortius, Rostar, Rosuvastatin calcium salt
Molecular Formula
C44H54CaF2N6O12S2
Molecular Weight
1001.1  g/mol
InChI Key
LALFOYNTGMUKGG-BGRFNVSISA-L
FDA UNII
83MVU38M7Q

Rosuvastatin Calcium
A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.
1 2D Structure

Rosuvastatin Calcium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium;(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
2.1.2 InChI
InChI=1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1
2.1.3 InChI Key
LALFOYNTGMUKGG-BGRFNVSISA-L
2.1.4 Canonical SMILES
CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.[Ca+2]
2.1.5 Isomeric SMILES
CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]
2.2 Other Identifiers
2.2.1 UNII
83MVU38M7Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Calcium, Rosuvastatin

2. Crestor

3. Rosuvastatin

4. Zd 4522

5. Zd4522

2.3.2 Depositor-Supplied Synonyms

1. 147098-20-2

2. Crestor

3. Rosuvastatin Hemicalcium

4. Fortius

5. Rostar

6. Rosuvastatin Calcium Salt

7. Rosuvastatin Calcium [usan]

8. Rozavel

9. Suvikan

10. Zd4522

11. S-4522

12. Zd 4522

13. Rosuvastatin (as Calcium)

14. Zd4522 (calcium Salt)

15. Zd4522 Calcium

16. Zd-4522 Calcium

17. 83mvu38m7q

18. Chebi:77249

19. Nsc-747274

20. Nsc-758930

21. Rosuvastatincalcium

22. Crestor (tn)

23. Calcium (3r,5s,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(n-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

24. Rovista

25. Zd 4522, Calcium Salt

26. Calcium;(e,3r,5s)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

27. S 4522

28. Unii-83mvu38m7q

29. Provisacor

30. Shufutan

31. Ezallor

32. Zd 4522 Calcium

33. Rosuvastatin Calcium- Bio-x

34. Zd-4522 (calcium Salt)

35. Schembl150740

36. Schembl429217

37. Chembl1744447

38. Dtxsid9045928

39. Rosuvastatin Calcium (jan/usan)

40. Rosuvastatin Calcium [jan]

41. Azd-4522

42. Bcp04131

43. Rosuvastatin Calcium [mart.]

44. S2169

45. Rosuvastatin Calcium [usp-rs]

46. Rosuvastatin Calcium [who-dd]

47. Akos005145896

48. Akos017343682

49. Rosuvastatin Calcium Salt [mi]

50. Ccg-270606

51. Ks-1109

52. Nsc 747274

53. Nsc 758930

54. (s-((r*,s*-(e)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) Amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

55. (s-(r*,s*-(e)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

56. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (3r,5s,6e)

57. As-12488

58. Br164378

59. Rosuvastatin Calcium [orange Book]

60. Rosuvastatin Calcium [ep Monograph]

61. Rosuvastatin Calcium [usp Monograph]

62. Roszet Component Rosuvastatin Calcium

63. R0180

64. D01915

65. Rosuvastatin Calcium Component Of Roszet

66. Q-201685

67. Q27146836

68. (s-((r*,s*-(e)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) Amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

69. (s-(r*,s*-(e)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt

70. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (3r,5s,6e)-

71. Bis((e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)-pyrimide-5-yl)-(3r,5s)3,5-dihydroxylhept-6-enoic Acid) Calcium

72. Calcium Bis[(3r,5s,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate]

73. Calcium(3r,5s,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(n-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

74. Monocalcium Bis((3r,5s,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methanesulfonyl (methyl) Amino] Pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate)

2.4 Create Date
2005-10-11
3 Chemical and Physical Properties
Molecular Weight 1001.1 g/mol
Molecular Formula C44H54CaF2N6O12S2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count20
Rotatable Bond Count18
Exact Mass1000.2835107 g/mol
Monoisotopic Mass1000.2835107 g/mol
Topological Polar Surface Area304 Ų
Heavy Atom Count67
Formal Charge0
Complexity761
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameCrestor
Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
Active IngredientRosuvastatin calcium
Dosage FormTablet
RouteOral
Strength5mg; 10mg; 40mg; 20mg
Market StatusPrescription
CompanyIpr

2 of 4  
Drug NameRosuvastatin calcium
PubMed HealthRosuvastatin (By mouth)
Drug ClassesAntihyperlipidemic
Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
Active IngredientRosuvastatin calcium
Dosage FormTablet
Routeoral; Oral
Strength5mg; 10mg; 40mg; 20mg
Market StatusTentative Approval
CompanyMylan Pharma; Apotex; Aurobindo Pharma; Sandoz; Sun Pharma Global; Par Pharm; Watson Labs; Glenmark Generics; Teva Pharms

3 of 4  
Drug NameCrestor
Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
Active IngredientRosuvastatin calcium
Dosage FormTablet
RouteOral
Strength5mg; 10mg; 40mg; 20mg
Market StatusPrescription
CompanyIpr

4 of 4  
Drug NameRosuvastatin calcium
PubMed HealthRosuvastatin (By mouth)
Drug ClassesAntihyperlipidemic
Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
Active IngredientRosuvastatin calcium
Dosage FormTablet
Routeoral; Oral
Strength5mg; 10mg; 40mg; 20mg
Market StatusTentative Approval
CompanyMylan Pharma; Apotex; Aurobindo Pharma; Sandoz; Sun Pharma Global; Par Pharm; Watson Labs; Glenmark Generics; Teva Pharms

4.2 Drug Indication

Homozygous Familial Hypercholesterolaemia, Prevention of cardiovascular events, Primary combined (mixed) dyslipidaemia, Primary hypercholesterolaemia


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anticholesteremic Agents

Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)


Hydroxymethylglutaryl-CoA Reductase Inhibitors

Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]; HMG-CoA Reductase Inhibitor [EPC]

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PU DONG","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"900.00","actualQuantity":"900","unit":"KGS","unitRateFc":"550","totalValueFC":"499865.7","currency":"USD","unitRateINR":"46365","date":"19-Jun-2024","totalValueINR":"41728500","totalValueInUsd":"499865.7","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"4072848","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO.518 LAODONG EAST ROAD, CHANGZHOU, JIANGSU PROVINCE CHINA.SDNF China","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"RE-IMPORT OF ROSUVASTATIN CALCIUM USP.-HARMLESS BULK DRUG.LUT ARN NO.AD240421002115Z.(SB.7641216 DT.21.01.2022).","address":"PLOT NO. 221, G.I.D.C.,","city":"GUJARAT","supplier":"ACINO PHARMACEUTICALS FZ LLC.","supplierCountry":"INDIA","foreign_port":"JEBEL ALI","customer":"AMOLI ORGANICS","customerCountry":"INDIA","quantity":"1.58","actualQuantity":"1.58","unit":"KGS","unitRateFc":"995","totalValueFC":"1587.6","currency":"USD","unitRateINR":"83878.5","date":"27-Jun-2024","totalValueINR":"132528.03","totalValueInUsd":"1587.6","indian_port":"JNPT","hs_no":"29420090","bill_no":"4217437","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JEBEL ALI","supplierAddress":"Dubai Science Park, Umm Suqueim Street, Dubai 478893. U.A.E.SDNF United Arab Emirates","customerAddress":"PLOT NO. 221, G.I.D.C.,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"RE-IMPORT OF ROSUVASTATIN CALCIUM USP.-HARMLESS BULK DRUG.LUT ARN NO.AD240421002115Z.(SB.7641216 DT.21.01.2022).","address":"PLOT NO. 221, G.I.D.C.,","city":"GUJARAT","supplier":"ACINO PHARMACEUTICALS FZ LLC.","supplierCountry":"INDIA","foreign_port":"JEBEL ALI","customer":"AMOLI ORGANICS","customerCountry":"INDIA","quantity":"38.08","actualQuantity":"38.079","unit":"KGS","unitRateFc":"995","totalValueFC":"38261","currency":"USD","unitRateINR":"83878.5","date":"27-Jun-2024","totalValueINR":"3194009.4","totalValueInUsd":"38261","indian_port":"JNPT","hs_no":"29420090","bill_no":"4217437","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JEBEL ALI","supplierAddress":"Dubai Science Park, Umm Suqueim Street, Dubai 478893. U.A.E.SDNF United Arab Emirates","customerAddress":"PLOT NO. 221, G.I.D.C.,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725474600,"product":"ROSUVASTATIN CALCIUM PH.EUR (RE-IMPORT GOODS VIDE SB NO:1754819 DT:18.06.2024, BATCH NO: RTM0210923)","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"KUHNIL PHARMACEUTICAL, CO. LTD","supplierCountry":"REPUBLIC OF KOREA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1150","totalValueFC":"5887.5","currency":"USD","unitRateINR":"98675.2","date":"05-Sep-2024","totalValueINR":"493376.23","totalValueInUsd":"5887.5","indian_port":"Hyderabad Air","hs_no":"29359090","bill_no":"5439409","productDescription":"API","marketType":"","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"14, JEONGDONG-GIL JUNG-GU SEOUL SDNF SDNF Korea, Republic of","customerAddress":"MSN HOUSE, PLOT NO. C-24,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"ROSUVASTATIN CALCIUM USP","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"CHANGZHOU PHARMACEUTICAL FACTORY","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"1250.00","actualQuantity":"1250","unit":"KGS","unitRateFc":"540","totalValueFC":"682418.2","currency":"USD","unitRateINR":"45873","date":"28-Oct-2024","totalValueINR":"57341250","totalValueInUsd":"682418.2","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"6380176","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"NO.518 LAODONG EAST ROAD, CHANGZHOU , JIANGSU PROVINCE CHINA China SDNF China","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]
01-Jan-2021
29-Nov-2024
KGS
overview
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Average Price (USD/KGS)

648.5

Number of Transactions

> 200

Total Quantity (KGS)

223.4k

Total Value (USD)

144.9M

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions
PAKISTAN4,876.88278.651 - 200
BRAZIL16,734.20622.751 - 200
EGYPT10,390.08394.751 - 200
BANGLADESH4,424.67690.851 - 200
POLAND19,664.66749.051 - 200
KOREA,REPUBLIC OF5,687.601,355.651 - 200
RUSSIA8,445.31617.551 - 200
NEPAL924.15255.351 - 200
TURKEY6,270.80754.251 - 200

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