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    Chemistry

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    Also known as: 147098-20-2, Crestor, Rosuvastatin hemicalcium, Fortius, Rostar, Rosuvastatin calcium salt
    Molecular Formula
    C44H54CaF2N6O12S2
    Molecular Weight
    1001.1  g/mol
    InChI Key
    LALFOYNTGMUKGG-BGRFNVSISA-L
    FDA UNII
    83MVU38M7Q
    Rosuvastatin Calcium
    A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.
    1 2D Structure

    Rosuvastatin Calcium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    2.1.2 InChI
    InChI=1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1
    2.1.3 InChI Key
    LALFOYNTGMUKGG-BGRFNVSISA-L
    2.1.4 Canonical SMILES
    CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.[Ca+2]
    2.1.5 Isomeric SMILES
    CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    83MVU38M7Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Calcium, Rosuvastatin

    2. Crestor

    3. Rosuvastatin

    4. Zd 4522

    5. Zd4522

    2.3.2 Depositor-Supplied Synonyms

    1. 147098-20-2

    2. Crestor

    3. Rosuvastatin Hemicalcium

    4. Fortius

    5. Rostar

    6. Rosuvastatin Calcium Salt

    7. Rosuvastatin Calcium [usan]

    8. Rozavel

    9. Suvikan

    10. Zd4522

    11. S-4522

    12. Zd 4522

    13. Rosuvastatin (as Calcium)

    14. Zd4522 (calcium Salt)

    15. Zd4522 Calcium

    16. Zd-4522 Calcium

    17. 83mvu38m7q

    18. Chebi:77249

    19. Nsc-747274

    20. Nsc-758930

    21. Rosuvastatincalcium

    22. Crestor (tn)

    23. Calcium (3r,5s,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(n-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

    24. Rovista

    25. Zd 4522, Calcium Salt

    26. Calcium;(e,3r,5s)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

    27. S 4522

    28. Unii-83mvu38m7q

    29. Provisacor

    30. Shufutan

    31. Ezallor

    32. Zd 4522 Calcium

    33. Rosuvastatin Calcium- Bio-x

    34. Zd-4522 (calcium Salt)

    35. Schembl150740

    36. Schembl429217

    37. Chembl1744447

    38. Dtxsid9045928

    39. Rosuvastatin Calcium (jan/usan)

    40. Rosuvastatin Calcium [jan]

    41. Azd-4522

    42. Bcp04131

    43. Rosuvastatin Calcium [mart.]

    44. S2169

    45. Rosuvastatin Calcium [usp-rs]

    46. Rosuvastatin Calcium [who-dd]

    47. Akos005145896

    48. Akos017343682

    49. Rosuvastatin Calcium Salt [mi]

    50. Ccg-270606

    51. Ks-1109

    52. Nsc 747274

    53. Nsc 758930

    54. (s-((r*,s*-(e)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) Amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

    55. (s-(r*,s*-(e)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

    56. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (3r,5s,6e)

    57. As-12488

    58. Br164378

    59. Rosuvastatin Calcium [orange Book]

    60. Rosuvastatin Calcium [ep Monograph]

    61. Rosuvastatin Calcium [usp Monograph]

    62. Roszet Component Rosuvastatin Calcium

    63. R0180

    64. D01915

    65. Rosuvastatin Calcium Component Of Roszet

    66. Q-201685

    67. Q27146836

    68. (s-((r*,s*-(e)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) Amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt (2:1)

    69. (s-(r*,s*-(e)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic Acid, Calcium Salt

    70. 6-heptenoic Acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (3r,5s,6e)-

    71. Bis((e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)-pyrimide-5-yl)-(3r,5s)3,5-dihydroxylhept-6-enoic Acid) Calcium

    72. Calcium Bis[(3r,5s,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate]

    73. Calcium(3r,5s,e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(n-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

    74. Monocalcium Bis((3r,5s,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methanesulfonyl (methyl) Amino] Pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate)

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 1001.1 g/mol
    Molecular Formula C44H54CaF2N6O12S2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count20
    Rotatable Bond Count18
    Exact Mass1000.2835107 g/mol
    Monoisotopic Mass1000.2835107 g/mol
    Topological Polar Surface Area304 Ų
    Heavy Atom Count67
    Formal Charge0
    Complexity761
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameCrestor
    Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
    Active IngredientRosuvastatin calcium
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyIpr

    2 of 4  
    Drug NameRosuvastatin calcium
    PubMed HealthRosuvastatin (By mouth)
    Drug ClassesAntihyperlipidemic
    Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
    Active IngredientRosuvastatin calcium
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 10mg; 40mg; 20mg
    Market StatusTentative Approval
    CompanyMylan Pharma; Apotex; Aurobindo Pharma; Sandoz; Sun Pharma Global; Par Pharm; Watson Labs; Glenmark Generics; Teva Pharms

    3 of 4  
    Drug NameCrestor
    Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
    Active IngredientRosuvastatin calcium
    Dosage FormTablet
    RouteOral
    Strength5mg; 10mg; 40mg; 20mg
    Market StatusPrescription
    CompanyIpr

    4 of 4  
    Drug NameRosuvastatin calcium
    PubMed HealthRosuvastatin (By mouth)
    Drug ClassesAntihyperlipidemic
    Drug LabelCRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent for oral administration. The chemical name for rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhe...
    Active IngredientRosuvastatin calcium
    Dosage FormTablet
    Routeoral; Oral
    Strength5mg; 10mg; 40mg; 20mg
    Market StatusTentative Approval
    CompanyMylan Pharma; Apotex; Aurobindo Pharma; Sandoz; Sun Pharma Global; Par Pharm; Watson Labs; Glenmark Generics; Teva Pharms

    4.2 Drug Indication

    Homozygous Familial Hypercholesterolaemia, Prevention of cardiovascular events, Primary combined (mixed) dyslipidaemia, Primary hypercholesterolaemia

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anticholesteremic Agents

    Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)

    Hydroxymethylglutaryl-CoA Reductase Inhibitors

    Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]; HMG-CoA Reductase Inhibitor [EPC]

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    01-Jan-2021
    30-Sep-2024
    KGS
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