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Chemistry

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Also known as: 93793-83-0, Roxatidine acetate hcl, Altat, Gastralgin, Hoe 760, Tzu-0460
Molecular Formula
C19H29ClN2O4
Molecular Weight
384.9  g/mol
InChI Key
FEWCTJHCXOHWNL-UHFFFAOYSA-N
FDA UNII
60426GOR1E

Roxatidine Acetate Hydrochloride
1 2D Structure

Roxatidine Acetate Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride
2.1.2 InChI
InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
2.1.3 InChI Key
FEWCTJHCXOHWNL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
2.2 Other Identifiers
2.2.1 UNII
60426GOR1E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hoe 760

2. Hoe-760

3. N-(3-(3-(n(1)-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide

4. Tzu 0460

5. Tzu-0460

2.3.2 Depositor-Supplied Synonyms

1. 93793-83-0

2. Roxatidine Acetate Hcl

3. Altat

4. Gastralgin

5. Hoe 760

6. Tzu-0460

7. Hoe-760

8. Roxatidine (acetate Hydrochloride)

9. Pifatidine Hydrochloride

10. Nsc-760384

11. Hoe 062 [roxatidine]

12. 60426gor1e

13. 2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamide Hydrochloride

14. 2-acetoxy-n-[3-[3-(1-piperidinomethylphenoxy]propyl]acetamide Hydrochloride

15. Mfcd00941429

16. 98793-83-0

17. Neo H2

18. Dsstox_cid_26670

19. Dsstox_rid_81809

20. Dsstox_gsid_46670

21. Aceroxatidine Hydrochloride

22. 2-oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethyl Acetate Hydrochloride

23. 2-oxo-2-(3-(3-(piperidin-1-ylmethyl)phenoxy)propylamino)ethyl Acetate Hydrochloride

24. Smr000469144

25. Tzu 0460

26. Cas-93793-83-0

27. Ccris 3347

28. Ncgc00167499-01

29. Xarcin

30. Unii-60426gor1e

31. Sr-01000763240

32. Altat (tn)

33. Roxatidine Acetate Hydrochloride [usan:jan]

34. 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamide Acetate (ester) Hydrochloride

35. Acetamide, 2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-, Monohydrochloride

36. Acetamide, 2-hydroxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)-, Acetate, Hydrochloride

37. N-(3-((alpha-piperidino-m-tolyl)oxy)propyl)glycolamide Acetate (ester), Monohydrochloride

38. Mls001401443

39. Mls002153806

40. Schembl667643

41. Chembl2104871

42. Dtxsid2046670

43. Chebi:32107

44. Hy-b0305a

45. Akp-004

46. Amy8936

47. Pharmakon1600-01502334

48. Bcp10517

49. N-(3-(3-(n(1)-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide

50. Tox21_112500

51. Tox21_112954

52. Nsc760384

53. S1880

54. 2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamidehydrochloride

55. Akos015894912

56. Tox21_112500_1

57. Ab07712

58. Ccg-101016

59. Nc00266

60. Nsc 760384

61. [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] Acetate;hydrochloride

62. 2-(acetyloxy)-n-[3-[3-(1-piperidinyl-methyl)phenoxy]propyl]- Acetamide Monohydrochloride

63. 2-oxo-2-[[3-[3-(1-piperidylmethyl)phenoxy]propyl]amino]ethyl Acetate Hydrochloride

64. Acetamide, 2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl-, Monohydrochloride

65. Ncgc00167499-02

66. Ac-26444

67. Acetamide, 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)-, Acetate (ester), Hydrochloride

68. As-14306

69. Sy111342

70. Ft-0630983

71. R0178

72. Roxatidine Acetate Hydrochloride [mi]

73. Sw197646-3

74. Roxatidine Acetate Hydrochloride (jp17/usan)

75. Roxatidine Acetate Hydrochloride [jan]

76. C90611

77. D01467

78. Roxatidine Acetate Hydrochloride [usan]

79. 2-oxo-2-(3-(3-(piperidin-1-ylmethyl)phenoxy

80. Roxatidine Acetate Hydrochloride [mart.]

81. Roxatidine Acetate Hydrochloride [who-dd]

82. 793r830

83. A844708

84. Sr-01000763240-4

85. Q27263158

86. 2-acetoxy-n-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide Hydrochloride

87. 2-oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethylacetatehydrochloride

88. N-(3-((.alpha.-piperidino-m-tolyl)oxy)propyl)glycolamide Acetate Monohydrochloride

89. [2-oxidanylidene-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] Ethanoate Hydrochloride

90. Acetic Acid [2-oxo-2-[3-[3-(1-piperidinylmethyl)phenoxy]propylamino]ethyl] Ester Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 384.9 g/mol
Molecular Formula C19H29ClN2O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass384.1815851 g/mol
Monoisotopic Mass384.1815851 g/mol
Topological Polar Surface Area67.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histamine H2 Antagonists

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)


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Roxatidine Acetate Hydrochloride

Registration Number : 228MF10110

Registrant's Address : 25, Barangongdan-ro, Hyangnam-eup, Hwaseong-si, Gyeonggi-do, Korea

Initial Date of Registration : 2016-06-08

Latest Date of Registration : 2016-06-08

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Roxatidine acetate hydrochloride (for manufacturing only)

Registration Number : 218MF10789

Registrant's Address : 25, Barangongdan-ro, Hyangnam-eup, Hwaseong-si, Gyeonggi-do, Korea

Initial Date of Registration : 2006-09-22

Latest Date of Registration : 2014-04-02

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Roxatidine Acetate Hydrochloride

Registration Number : 226MF10169

Registrant's Address : 9FL, KyungDong Pharm Bldg, 1926, Nambusunhwan-ro, Gwanak-gu, Seoul, Republic of Korea

Initial Date of Registration : 2014-09-01

Latest Date of Registration : 2014-09-01

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Roxatidine Acetate Hydrochloride

Registration Number : 301MF10100

Registrant's Address : 3F SMART-K Bldg. B, 26, Gwacheon-daero 7-gil, Gwacheon-si, Gyeonggi-do, Republic of K...

Initial Date of Registration : 2019-11-27

Latest Date of Registration : 2019-11-27

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Roxatidine acetate hydrochloride

Registration Number : 217MF10722

Registrant's Address : 1-10-11 Nihonbashi Horidomecho, Chuo-ku, Tokyo

Initial Date of Registration : 2005-10-07

Latest Date of Registration : 2009-01-13

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Roxatidine Acetate Hydrochloride

Registration Number : 219MF10219

Registrant's Address : 3-10-4 Nihonbashi Ningyocho, Chuo-ku, Tokyo

Initial Date of Registration : 2007-07-06

Latest Date of Registration : 2007-07-06

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Listed Dossiers

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Roxatidine Acetate Hydrochloride

Brand Name :

Dosage Form : Injection

Dosage Strength : 75MG

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Registration Country : China

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Dosage : Injection

Dosage Strength : 75MG

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Registration Country : China

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REF. STANDARDS & IMPURITIES

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Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Roxatidine...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test : I/ UV-VIS I/ IR

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DDL Conference
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Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Roxatidine...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test : U/ LC D/ LC

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Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Extended-r...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test : A/ L

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04

DDL Conference
Not Confirmed
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Not Confirmed

Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Roxatidine...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test : U/ LC A/ LC

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05

DDL Conference
Not Confirmed
DDL Conference
Not Confirmed

Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Extended-r...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test :

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06

DDL Conference
Not Confirmed
DDL Conference
Not Confirmed

Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : Roxatidine...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test : A/ LC

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07

DDL Conference
Not Confirmed
DDL Conference
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Roxatidine Acetate Hydrochloride

Monograph in Japanese Pharmacopoeia : for Inject...

Package Size : 300 mg

Price (¥) : 53,486

Storage Temprature °C : 25°C

Assay Test :

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