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Granules Ruxolitinib Phosphate

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Fishfa Biogenics: Renowned Manufacturer, & Exporter of Tacrolimus & Mupirocin API.

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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ACTIVE PHARMA INGREDIENTS

40 API Suppliers, 9 USDMF, 2 EU WC, 1 KDMF, 17 NDC API, 32 Listed Suppliers, $ API Reference Price

40 API Suppliers
9 USDMF
2 EU WC
1 KDMF
17 NDC API
32 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

60 Drugs in Development

60 Drugs in Development

INTERMEDIATES

21 Intermediates Suppliers

21 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

43 FDF Dossiers, 6 FDA Orange Book, 7 Europe, 18 Australia, 3 South Africa, 9 Listed Dossiers

43 FDF Dossiers
6 FDA Orange Book
7 Europe
18 Australia
3 South Africa
9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 DKSH, 1 Boai NKY Pharmaceuticals Ltd, 10 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 BASF, 5 DFE Pharma, 5 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 17 Kerry, 10 Microlex e.U, 1 Novo Excipients, 3 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 9 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 1 Ulanqab Kema New Material, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

47 Fillers, Diluents & Binders, 24 Direct Compression, 16 Disintegrants & Superdisintegrants, 14 Granulation, 13 Thickeners and Stabilizers, 12 Lubricants & Glidants, 12 Co-Processed Excipients, 7 Controlled & Modified Release, 7 Solubilizers, 3 Emulsifying Agents, 3 Coating Systems & Additives, 3 Parenteral, 2 Chewable & Orodispersible Aids, 2 Film Formers & Plasticizers, 2 Taste Masking, 1 Rheology Modifiers, 1 API Stability Enhancers

excipientsByApplications
47 Fillers, Diluents & Binders
24 Direct Compression
16 Disintegrants & Superdisintegrants
14 Granulation
13 Thickeners and Stabilizers
12 Lubricants & Glidants
12 Co-Processed Excipients
7 Controlled & Modified Release
7 Solubilizers
3 Emulsifying Agents
3 Coating Systems & Additives
3 Parenteral
2 Chewable & Orodispersible Aids
2 Film Formers & Plasticizers
2 Taste Masking
1 Rheology Modifiers
1 API Stability Enhancers

DIGITAL CONTENT

5 DATA COMPILATION #PharmaFlow, 144 NEWS #PharmaBuzz

media
5 DATA COMPILATION #PharmaFlow
144 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 7 Finished Drug Prices, 10 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
7 Finished Drug Prices
10 Annual Reports

MARKET PLACE

23 APIs, 3 FDF Dossiers

marketPlace
23 APIs
3 FDF Dossiers

PATENTS & EXCLUSIVITIES

179 US Patents, 38 US Exclusivities, 8 Health Canada Patents

patents
179 US Patents
38 US Exclusivities
8 Health Canada Patents

Granules Ruxolitinib Phosphate

Synopsis

ACTIVE PHARMA INGREDIENTS

40

API Suppliers

9

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

2

EU WC

1

KDMF

17

NDC API

0

VMF

32

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 27,362

MARKET PLACE

23

API

3

FDF

21INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

43

FDF Dossiers

6

FDA Orange Book

FDA (Orange Book)

7

Europe

0

Canada

18

Australia

3

South Africa

9

Listed Dossiers

60DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

179

US Patents

38

US Exclusivities

8

Health Canada Patents

DIGITAL CONTENT

5

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

144

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,780,659,798

Annual Reports (USD Million)

10,014

Finished Drug Prices

102 RELATED EXCIPIENT COMPANIES

169EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1092939-17-7, Jakafi, (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate, Jakavi, Ruxolitinib (phosphate), Ruxolitinib monophosphate

Molecular Formula

C₁₇H₂₁N₆O₄P

Molecular Weight

404.4 g/mol

InChI Key

JFMWPOCYMYGEDM-XFULWGLBSA-N

FDA UNII

436LRU32H5

Ruxolitinib Phosphate

Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

1 2D Structure

Ruxolitinib Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid

2.1.2 InChI

InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

2.1.3 InChI Key

JFMWPOCYMYGEDM-XFULWGLBSA-N

2.1.4 Canonical SMILES

C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

2.1.5 Isomeric SMILES

C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

436LRU32H5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3r)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile

2. Inc-424

3. Inc424

4. Inca24

5. Incb-018424

6. Incb-018424 Phosphate

7. Incb-018424 Salt

8. Incb-18424

9. Incb-18424 Phosphate

10. Incb018424

11. Incb018424 Phosphate

12. Jakafi

13. Jakavi

14. Opzelura

15. Ruxolitinib

16. Ruxolitinib (as Phosphate)

17. Ruxolitinib Monophosphate

2.3.2 Depositor-Supplied Synonyms

1. 1092939-17-7

2. Jakafi

3. (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile Phosphate

4. Jakavi

5. Ruxolitinib (phosphate)

6. Ruxolitinib Monophosphate

7. Incb018424 Phosphate

8. Ruxolitinib (as Phosphate)

9. Incb-018424 Phosphate

10. Incb-018424 Salt

11. Ruxolitinib Phosphate [usan]

12. Incb-18424 Phosphate

13. Incb018424 Salt

14. Chebi:66917

15. 436lru32h5

16. 1092939-17-7 (phosphate)

17. (betar)-beta-cyclopentyl-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazole-1-propanenitrile Phosphate

18. Incb-18424

19. Ruxolitinib Phosphate Salt

20. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile Phosphate

21. (3r)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)propanenitrile Phosphate (1:1)

22. Phosphenoperoxoic Acid Compound With (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)- 1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile And Dihydrogen (1:1:1)

23. Opzelura

24. Unii-436lru32h5

25. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrilephosphoricacid

26. Jakafi (tn)

27. Jakavi (tn)

28. Ruxolitinib Phosphate(incb018424)

29. Inc 424 Phosphate

30. Incb 018424 Phosphate

31. Incb-424

32. Schembl1369365

33. Chembl1795071

34. Amy5620

35. Dtxsid00911086

36. Ruxolitinib Phosphate (jan/usan)

37. Ruxolitinib Phosphate [mi]

38. Ruxolitinib Phosphate [jan]

39. Ex-a2660

40. Cs1956

41. Mfcd18452860

42. S5243

43. Akos024464417

44. Ruxolitinib (incb-18424) Phosphate

45. Ruxolitinib Phosphate [who-dd]

46. Bcp9000783

47. Ccg-268687

48. Cs-0326

49. 1h-pyrazole-1-propanenitrile, Beta-cyclopentyl-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betar)-, Phosphate (1:1)

50. Ac-30901

51. As-74723

52. Hy-50858

53. Ruxolitinib Phosphate [orange Book]

54. Ruxolitinib (as Phosphate) [ema Epar]

55. D09960

56. J-501793

57. Q27135517

58. (3r)-3-cyclopentyl-3-(4-{7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)propanenitrile; Phosphoric Acid

59. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric Acid

60. (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrilephosphate

61. 1h-pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-,(.beta.r)-,phosphate (1:1)

62. Phosphoric Acid--3-cyclopentyl-3-[4-(1h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile (1/1)

2.4 Create Date

2009-01-19

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₁N₆O₄P
Molecular Weight	404.4 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	404.13619017 g/mol
Monoisotopic Mass	404.13619017 g/mol
Topological Polar Surface Area	161 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	503
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Jakafi
PubMed Health	Ruxolitinib (By mouth)
Drug Classes	Antineoplastic Agent
Active Ingredient	Ruxolitinib phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 5mg base; eq 20mg base; eq 15mg base; eq 10mg base; eq 25mg base
Market Status	Prescription
Company	Incyte

2 of 2
Drug Name	Jakafi
PubMed Health	Ruxolitinib (By mouth)
Drug Classes	Antineoplastic Agent
Active Ingredient	Ruxolitinib phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 5mg base; eq 20mg base; eq 15mg base; eq 10mg base; eq 25mg base
Market Status	Prescription
Company	Incyte

4.2 Drug Indication

* Myelofibrosis (MF):

Jakavi is indicated for the treatment of disease related splenomegaly or symptoms in adult patients with primary myelofibrosis (also known as chronic idiopathic myelofibrosis), post polycythaemia vera myelofibrosis or post essential thrombocythaemia myelofibrosis.

* Polycythaemia vera (PV):

Jakavi is indicated for the treatment of adult patients with polycythaemia vera who are resistant to or intolerant of hydroxyurea.

* Graft versus host disease (GvHD):

Jakavi is indicated for the treatment of patients aged 12 years and older with acute graft versus host disease or chronic graft versus host disease who have inadequate response to corticosteroids or other systemic therapies (see section 5. 1).

Treatment of chronic Graft versus Host Disease (cGvHD)

Treatment of acute graft-versus-host disease (aGvHD)

Treatment of vitiligo

5 Pharmacology and Biochemistry

5.1 ATC Code

L01EJ01

API SUPPLIERS

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USDMF

01

Changzhou Pharmaceutical Factory

China

SupplySide West 2024

Not Confirmed

02

Chongqing Huapont Shengchem Pharmace...

China

SupplySide West 2024

Not Confirmed

03

Chongqing Huapont Pharmaceutical Co ...

China

SupplySide West 2024

Not Confirmed

04

Cipla Ltd

India

SupplySide West 2024

Not Confirmed

05

Intas Pharmaceuticals Ltd

India

SupplySide West 2024

Not Confirmed

06

Msn Laboratories Private Ltd

India

SupplySide West 2024

Not Confirmed

07

Msn Laboratories Private Ltd

India

SupplySide West 2024

Not Confirmed

08

Msn Laboratories Private Ltd

India

SupplySide West 2024

Not Confirmed

09

Msn Laboratories Private Ltd

India

SupplySide West 2024

Not Confirmed

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Listed Suppliers

01

Granules India Limited

India

CPhI India 2024

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

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India

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Ruxolitinib Phosphate

About the Company : Granules is a vertically integrated fast-growing Pharmaceutical company headquartered in Hyderabad with best-in-class facilities & a commitment to operational excellence, quality, ...

Granules is a vertically integrated fast-growing Pharmaceutical company headquartered in Hyderabad with best-in-class facilities & a commitment to operational excellence, quality, & customer service. The company is present in the manufacturing of the entire value chain – from APIs, Formulation Intermediates, & Formulations. Their products are being distributed to over 300+ customers with a global presence extending to over 80+ countries with offices across India, US & UK.

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02

Transo-Pharm USA LLC

U.S.A

SupplySide West 2024

Not Confirmed

TransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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U.S.A

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Ruxolitinib Phosphate

About the Company : Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout...

Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout the entire API life cycle, from product development through sales. Transo-Pharm serves as a sourcing and regulatory marketing agent for API manufacturers. It aids clients in establishing DMFs and provides GMP consulting. With a dedicated regulatory department, a warehouse, proprietary IPs for API processes, and partnerships with laboratories, Transo-Pharm offers a wide range of services. It operates from its offices in Shanghai, Hong Kong, Singapore, and the US.

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Transo-Pharm USA LLC

U.S.A

SupplySide West 2024

Not Confirmed

TransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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U.S.A

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Ruxolitinib

About the Company : Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout...

Transo-Pharm, a fully licensed and certified distributor, specializes in pharmaceutical components for the health and veterinary industries. It offers support to clients throughout the entire API life cycle, from product development through sales. Transo-Pharm serves as a sourcing and regulatory marketing agent for API manufacturers. It aids clients in establishing DMFs and provides GMP consulting. With a dedicated regulatory department, a warehouse, proprietary IPs for API processes, and partnerships with laboratories, Transo-Pharm offers a wide range of services. It operates from its offices in Shanghai, Hong Kong, Singapore, and the US.

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04

LGM Pharma

U.S.A

BioFlorida Conference

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

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Ruxolitinib Phosphate

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

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05

Metrochem API Private Limited

India

Pharmtech & Ingredients

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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India

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Ruxolitinib Phosphate

About the Company :

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product ...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

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06

Inabata France S.A.S

France

SupplySide West 2024

Not Confirmed

IKF/Pharmasynthese have been with fine chemicals market and APIs performance for more than 40 years.

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France

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Ruxolitinib

About the Company : Established in 1990, Inabata France, a part of the Inabata Group, used to export chemical and pharmaceutical products to Japan. In 2006, it acquired Pharmasynthèse. Today, Inabata...

Established in 1990, Inabata France, a part of the Inabata Group, used to export chemical and pharmaceutical products to Japan. In 2006, it acquired Pharmasynthèse. Today, Inabata-Pharmasynthèse offers a wide range of services, including sourcing, manufacturing, and the development of raw materials for the pharmaceutical and cosmetic industries. It supplies these ingredients to Europe, Japan, and other countries. With expertise in fine chemical production, Inabata-Pharmasynthèse conducts manufacturing operations, ranging from pilot to commercial quantities, at its GMP-certified facility at St. Pierre-Les-Elbeuf in France.

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07

Seqens

France

SupplySide West 2024

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

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France

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Ruxolitinib Phosphate

About the Company : Since its inception in 2003, Seqens has grown to become a global leader in pharmaceutical solutions and specialty ingredients. Seqens supports its customers in developing, scaling ...

Since its inception in 2003, Seqens has grown to become a global leader in pharmaceutical solutions and specialty ingredients. Seqens supports its customers in developing, scaling up and manufacturing drug substances from the pre-clinical phase to the commercial phase. It offers a large portfolio of APIs and proprietary products. Seqens also develops custom solutions and ingredients for the most demanding industries, such as healthcare, electronics and cosmetics. Its unique range of technologies enables it to manufacture complex molecules for small- and large-scale demands. It operates 24 industrial plants and 10 R&D centres across the globe.

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08

Faran Shimi Pharmaceutical

Iran

SupplySide West 2024

Not Confirmed

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

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Iran

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Ruxolitinib Phosphate

About the Company : Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs)...

Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs) and finished dosage forms. For the past three years, the company focused on extracting alkaloid opiates, controlled substances, and narcotics. The APIs are widely used by major pharmaceutical companies nationwide and exported to the Middle East. All production adheres to local GMP standards in an SOP-driven environment with modern systems and utilities, ensuring the highest quality and safety.

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09

Shandong Chenghui Shuangda Pharmace...

China

SupplySide West 2024

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Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

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China

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Ruxolitinib Phosphate

About the Company : Shandong Chenghui Shuangda Pharmaceutical Co., Ltd. is specialized in R&D and production of APIs and advanced intermediates. With 22 years of production experience,the company has ...

Shandong Chenghui Shuangda Pharmaceutical Co., Ltd. is specialized in R&D and production of APIs and advanced intermediates. With 22 years of production experience,the company has 6 workshops and 9 production lines which has 100t/month production capacity.The company is committed to maintain the standards with continuous improvements to the current standards throughout the product lifecycle.The main products include local anesthetic drugs, antiviral drugs, cardiovascular and cerebrovascular drugs, antitumor drugs, gastrointestinal drugs, diabetic drugs, veterinary drugs, and CDMO products.

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10

Aarti Pharmalabs

India

CPhI India 2024

Aarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

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India

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Ruxolitinib

About the Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cyto...

Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cytotoxic & oncology products. It has 2 R&D centers & 3 cGMP plants successfully audited by the USFDA, EUGMP, EDQM, KFDA & COFEPRIS. It offers CDMO services for generic APIs & NCEs, intermediates & key building blocks.Note: None of the products will be supplied to countries in which this could be in conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

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API Reference Price

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RUXO-20210308) (FOR R&D PURPOSED ONLY)","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"CHONGQING HUAPONT PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"45000","totalValueFC":"4528.3","currency":"USD","unitRateINR":"3415500","date":"16-Dec-2021","totalValueINR":"341550","totalValueInUsd":"4528.3","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"6698982","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1644517800,"product":"RUXOLITINIB PHOSPHATE","address":"CIPLA HOUSE, PENINSULA BUSINESS,PA RK,GANPATRAO KADAM MARG,LOWER","city":"PAREL MUMBAI MAHARASHTRA,MAHARASHTR","supplier":"CHONGQING HUAPONT PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"NA","customer":"CIPLA","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"45000","totalValueFC":"11369","currency":"USD","unitRateINR":"3408750","date":"11-Feb-2022","totalValueINR":"852187.5","totalValueInUsd":"11369","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"7446114","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"CIPLA HOUSE, PENINSULA BUSINESS,PA RK,GANPATRAO KADAM MARG,LOWER"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1647369000,"product":"RUXOLITINIB (3R)-3-CYCLOPENTYL-3-(4-1H-PYRROLO2,3-DPYRIMIDIN-4-YL-1H-PYRAZOL-1-YL)PROPANENITRILE; PHOSPHORIC ACID)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"MEDCHEMEXPRESS LLC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"15","unit":"GMS","unitRateFc":"366.7","totalValueFC":"5531.1","currency":"USD","unitRateINR":"28105","date":"16-Mar-2022","totalValueINR":"421575","totalValueInUsd":"5531.1","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1003677","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"1 DEERPARK DR STE Q PRINCETON, NJ 08852","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649442600,"product":"RUXOLITINIB PHOSPHATE ( R & D) PART NO.1092939-17-7","address":"PLOT NO F GANESH INDUSTRIAL ESTATE ,BAVLA MORAIYA ROAD","city":"AHMEDABAD,GUJARAT","supplier":"HABO HONG KONG CO. LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"SYNZEAL RESEARCH PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"43.5","totalValueFC":"454.3","currency":"USD","unitRateINR":"3427.4","date":"09-Apr-2022","totalValueINR":"34274.3","totalValueInUsd":"454.3","indian_port":"AHMEDABAD AIR","hs_no":"29339990","bill_no":"8213536","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO F GANESH INDUSTRIAL ESTATE ,BAVLA MORAIYA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650479400,"product":"RUXOLITINIB (R & D) PART NO.941678-49-5","address":"PLOT NO F GANESH INDUSTRIAL ESTATE ,BAVLA MORAIYA ROAD","city":"AHMEDABAD,GUJARAT","supplier":"HABO HONG KONG CO. LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"SYNZEAL RESEARCH PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"50","totalValueFC":"530.9","currency":"USD","unitRateINR":"4005.7","date":"21-Apr-2022","totalValueINR":"40056.49","totalValueInUsd":"530.9","indian_port":"AHMEDABAD AIR","hs_no":"29339990","bill_no":"8359006","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO F GANESH INDUSTRIAL ESTATE ,BAVLA MORAIYA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1652985000,"product":"RUXOLITINIB (PHOSPHATE)","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"MEDCHEMEXPRESS LLC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"557.2","totalValueFC":"2833.3","currency":"USD","unitRateINR":"43794","date":"20-May-2022","totalValueINR":"218970","totalValueInUsd":"2833.3","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1002030","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"18 WILKINSON WAY, PRINCETON, NJ 08540 UNITED STATES","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1659119400,"product":"RUXOLITINIB (PHOSPHATE","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"MEDCHEMEXPRESS LLC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"557.2","totalValueFC":"2836.1","currency":"USD","unitRateINR":"45103.4","date":"30-Jul-2022","totalValueINR":"225517","totalValueInUsd":"2836.1","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1003068","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"18 WILKINSON WAY, PRINCETON, NJ 08540 UNITED STATES","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697653800,"product":"RUXOLITINIB PHOSPHATE INN","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"14000","totalValueFC":"21232.3","currency":"USD","unitRateINR":"1178100","date":"19-Oct-2023","totalValueINR":"1767150","totalValueInUsd":"21232.3","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"8378913","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO:2 TONGHAI SI ROAD YANGKOU CHEMICAL INDUSTRIAL PARK RUDONG COASTAL ECONOMIC DEVELOPMENT ZONE CHINA China","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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INTERMEDIATES SUPPLIERS

01

Shandong Chenghui Shuangda Pharmace...

China

SupplySide West 2024

Not Confirmed

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

1-(1-ethoxyethyl)-4-(4,4,5,5- tetramethyl-1,3,2-di...

CAS Number : 1029716-44-6

End Use API : Ruxolitinib Phosphate

Shandong Chenghui Shuangda Pharmaceutical

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02

Shandong Chenghui Shuangda Pharmace...

China

SupplySide West 2024

Not Confirmed

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

3-Cyclopentylacrylonitrile

CAS Number : 591769-05-0

End Use API : Ruxolitinib Phosphate

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

Digital Content

03

Shandong Chenghui Shuangda Pharmace...

China

SupplySide West 2024

Not Confirmed

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

(4-(1-(2-Cyano-1- cyclopentylethyl)-1h-pyrazol-4-y...

CAS Number : 1236033-05-8

End Use API : Ruxolitinib Phosphate

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

Digital Content

04

Hangzhou Allsino Chemicals

China

SupplySide West 2024

Not Confirmed

Allsino Pharma excels in R&D & manufacturing of RSMs, GMP intermediates, & APIs; ISO-certified, GMP-compliant, accredited by NMPA.

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dio...

CAS Number : 1029716-44-6

End Use API : Ruxolitinib Phosphate

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Product Web Link

Digital Content

05

Hangzhou Allsino Chemicals

China

SupplySide West 2024

Not Confirmed

Allsino Pharma excels in R&D & manufacturing of RSMs, GMP intermediates, & APIs; ISO-certified, GMP-compliant, accredited by NMPA.

4-Chloro-7H-pyrrolo-[2,3-d]pyrimidine

CAS Number : 3680-69-1

End Use API : Ruxolitinib Phosphate

Allsino Company Banner

Product Web Link

Digital Content

06

Hangzhou Allsino Chemicals

China

SupplySide West 2024

Not Confirmed

Allsino Pharma excels in R&D & manufacturing of RSMs, GMP intermediates, & APIs; ISO-certified, GMP-compliant, accredited by NMPA.

4-Methyl-7-H-pyrrolo[2,3-d]pyrimidine

CAS Number : 945950-37-8

End Use API : Ruxolitinib Phosphate

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Digital Content

07

Almelo

India

SupplySide West 2024

Not Confirmed

08

Chengda Pharmaceuticals

China

SupplySide West 2024

Not Confirmed

09

Hangzhou Longshine Bio-Tech Co.,LTD

China

SupplySide West 2024

Not Confirmed

10

Hangzhou Longshine Bio-Tech Co.,LTD

China

SupplySide West 2024

Not Confirmed

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Health Canada Patents

01

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

02

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

03

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

04

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

05

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

06

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

07

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

08

Gowling WLG (Canada) LLP

Ruxolitinib Phosphate

SupplySide West 2024

Not Confirmed

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