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Chemistry

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Also known as: Ltx-315, Ruxotemitide, 1345407-05-7, Kkwwkkwdipk-nh2, Ltx 315, Kkwwkkw-.beta.-phenyl-fk-nh2
Molecular Formula
C78H106N18O9
Molecular Weight
1439.8  g/mol
InChI Key
GGAKLYWEFZCVIT-TVEKFXMRSA-N
FDA UNII
75FBL12IZ7

Ruxotemitide
Ruxotemitide is a peptide derived from human lactoferrin, with potential lytic and immunostimulating activities. Upon transdermal injection directly into the tumor, ruxotemitide may bind to the tumor cell membranes and subsequently lyse tumor cells, thereby inducing tumor cell necrosis. In turn, presentation of the tumor antigens to the immune system may induce systemic innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural killer T (NKT) cells. This may trigger an immune response against tumor associated antigens on tumors distant from the primary tumor. Human lactoferrin, a 692 amino acid glycoprotein, belongs to the transferrin family of metal-binding proteins.
1 2D Structure

Ruxotemitide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2,6-diamino-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3,3-diphenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]hexanamide
2.1.2 InChI
InChI=1S/C78H106N18O9/c79-38-18-13-30-57(84)71(98)90-62(35-15-20-40-81)73(100)93-66(44-52-47-87-59-32-11-8-28-55(52)59)76(103)95-65(43-51-46-86-58-31-10-7-27-54(51)58)75(102)92-63(36-16-21-41-82)72(99)91-64(37-17-22-42-83)74(101)94-67(45-53-48-88-60-33-12-9-29-56(53)60)77(104)96-69(78(105)89-61(70(85)97)34-14-19-39-80)68(49-23-3-1-4-24-49)50-25-5-2-6-26-50/h1-12,23-29,31-33,46-48,57,61-69,86-88H,13-22,30,34-45,79-84H2,(H2,85,97)(H,89,105)(H,90,98)(H,91,99)(H,92,102)(H,93,100)(H,94,101)(H,95,103)(H,96,104)/t57-,61-,62-,63-,64-,65-,66-,67-,69-/m0/s1
2.1.3 InChI Key
GGAKLYWEFZCVIT-TVEKFXMRSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CNC8=CC=CC=C87)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N
2.1.5 Isomeric SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CNC8=CC=CC=C87)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N
2.2 Other Identifiers
2.2.1 UNII
75FBL12IZ7
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ltx-315

2.3.2 Depositor-Supplied Synonyms

1. Ltx-315

2. Ruxotemitide

3. 1345407-05-7

4. Kkwwkkwdipk-nh2

5. Ltx 315

6. Kkwwkkw-.beta.-phenyl-fk-nh2

7. 75fbl12iz7

8. Ruxotemitide [inn]

9. Unii-75fbl12iz7

10. Ltx315

11. Chembl4297628

12. Ltx 315 [who-dd]

13. K-k-w-w-k-k-w-dip-k-nh2

14. S8199

15. Ccg-270681

16. Cs-6979

17. Db12748

18. Bs-15278

19. Hy-19894

20. D84062

21. Q27266383

22. (s)-2,6-diamino-n-((5s,8s,11s,14s,17s,20s,23s,26s)-11,20,23-tris((1h-indol-3-yl)methyl)-1,30-diamino-14,17-bis(4-aminobutyl)-8-benzhydryl-5-carbamoyl-7,10,13,16,19,22,25-heptaoxo-6,9,12,15,18,21,24-heptaazatriacontan-26-yl)hexanamide

23. L-lysinamide, L-lysyl-l-lysyl-l-tryptophyl-l-tryptophyl-l-lysyl-l-lysyl-l-tryptophyl-.beta.-phenyl-l-phenylalanyl-

2.4 Create Date
2010-07-06
3 Chemical and Physical Properties
Molecular Weight 1439.8 g/mol
Molecular Formula C78H106N18O9
XLogP33.6
Hydrogen Bond Donor Count18
Hydrogen Bond Acceptor Count15
Rotatable Bond Count46
Exact Mass1438.83901703 g/mol
Monoisotopic Mass1438.83901703 g/mol
Topological Polar Surface Area479 Ų
Heavy Atom Count105
Formal Charge0
Complexity2670
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1345407-05-7 / Ruxotemitide API manufacturers, exporters & distributors?

Ruxotemitide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ruxotemitide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ruxotemitide manufacturer or Ruxotemitide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ruxotemitide manufacturer or Ruxotemitide supplier.

PharmaCompass also assists you with knowing the Ruxotemitide API Price utilized in the formulation of products. Ruxotemitide API Price is not always fixed or binding as the Ruxotemitide Price is obtained through a variety of data sources. The Ruxotemitide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ruxotemitide

Synonyms

Ltx-315, 1345407-05-7, Kkwwkkwdipk-nh2, Ltx 315, Kkwwkkw-.beta.-phenyl-fk-nh2, 75fbl12iz7

Cas Number

1345407-05-7

Unique Ingredient Identifier (UNII)

75FBL12IZ7

About Ruxotemitide

Ruxotemitide is a peptide derived from human lactoferrin, with potential lytic and immunostimulating activities. Upon transdermal injection directly into the tumor, ruxotemitide may bind to the tumor cell membranes and subsequently lyse tumor cells, thereby inducing tumor cell necrosis. In turn, presentation of the tumor antigens to the immune system may induce systemic innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural killer T (NKT) cells. This may trigger an immune response against tumor associated antigens on tumors distant from the primary tumor. Human lactoferrin, a 692 amino acid glycoprotein, belongs to the transferrin family of metal-binding proteins.

Ruxotemitide Manufacturers

A Ruxotemitide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ruxotemitide, including repackagers and relabelers. The FDA regulates Ruxotemitide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ruxotemitide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ruxotemitide Suppliers

A Ruxotemitide supplier is an individual or a company that provides Ruxotemitide active pharmaceutical ingredient (API) or Ruxotemitide finished formulations upon request. The Ruxotemitide suppliers may include Ruxotemitide API manufacturers, exporters, distributors and traders.

Ruxotemitide GMP

Ruxotemitide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ruxotemitide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ruxotemitide GMP manufacturer or Ruxotemitide GMP API supplier for your needs.

Ruxotemitide CoA

A Ruxotemitide CoA (Certificate of Analysis) is a formal document that attests to Ruxotemitide's compliance with Ruxotemitide specifications and serves as a tool for batch-level quality control.

Ruxotemitide CoA mostly includes findings from lab analyses of a specific batch. For each Ruxotemitide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ruxotemitide may be tested according to a variety of international standards, such as European Pharmacopoeia (Ruxotemitide EP), Ruxotemitide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ruxotemitide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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