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Chemistry

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Also known as: Onilcamotide [inn], Unii-uqe6kp7t0d, Uqe6kp7t0d, Rhoc peptide vaccine rv001v, Rv001, Rv-001
Molecular Formula
C96H177N39O24S
Molecular Weight
2293.7  g/mol
InChI Key
BSLDVUIBJUKAAR-GXARRZNISA-N

RV001
Onilcamotide is a cancer vaccine composed of an immunogenic peptide derived from the Ras homolog family member C (RhoC; Rho-related GTP-binding protein RhoC) that is emulsified in the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, onilcamotide may stimulate the host immune system to mount a humoral and cytotoxic T-lymphocyte (CTL) response against tumor cells expressing RhoC, which results in tumor cell lysis. RhoC, a tumor-associated antigen (TAA) that is overexpressed in a variety of tumor cell types, is associated with increased metastatic potential.
1 2D Structure

RV001

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
2.1.2 InChI
InChI=1S/C96H177N39O24S/c1-12-50(8)72(88(155)131-64(91(158)159)42-48(4)5)133-86(153)66-30-22-40-135(66)90(157)65(46-160)121-70(140)45-118-76(143)54(25-17-35-112-92(102)103)122-79(146)58(27-19-37-114-94(106)107)125-80(147)59(28-20-38-115-95(108)109)124-78(145)55(23-13-15-33-97)126-85(152)63(43-68(101)138)130-82(149)56(24-14-16-34-98)123-81(148)60(29-21-39-116-96(110)111)128-87(154)71(49(6)7)132-83(150)61(31-32-67(100)137)127-84(151)62(41-47(2)3)120-69(139)44-117-75(142)52(10)119-77(144)57(26-18-36-113-93(104)105)129-89(156)73(53(11)136)134-74(141)51(9)99/h47-66,71-73,136,160H,12-46,97-99H2,1-11H3,(H2,100,137)(H2,101,138)(H,117,142)(H,118,143)(H,119,144)(H,120,139)(H,121,140)(H,122,146)(H,123,148)(H,124,145)(H,125,147)(H,126,152)(H,127,151)(H,128,154)(H,129,156)(H,130,149)(H,131,155)(H,132,150)(H,133,153)(H,134,141)(H,158,159)(H4,102,103,112)(H4,104,105,113)(H4,106,107,114)(H4,108,109,115)(H4,110,111,116)/t50-,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,71-,72-,73-/m0/s1
2.1.3 InChI Key
BSLDVUIBJUKAAR-GXARRZNISA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C1CCCN1C(=O)C(CS)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)O)NC(=O)C(C)N
2.1.5 Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. R 1507

2. R-1507

3. R-1507 Monoclonal Antibody

4. R1507

5. Ro-4858696

6. Ro-4858696-000

7. Ro-4858696000

8. Ro4858696

9. Ro4858696-000

10. Rv-001

11. Rv001

12. Tepezza

13. Teprotumumab

14. Teprotumumab-trbw

2.2.2 Depositor-Supplied Synonyms

1. Onilcamotide [inn]

2. Unii-uqe6kp7t0d

3. Uqe6kp7t0d

4. Rhoc Peptide Vaccine Rv001v

5. Rv001

6. Rv-001

7. Ala-thr-arg-ala-gly-leu-gln-val-arg-lys-asn-lys-arg-arg-arg-gly-cys-pro-ile-leu

8. 1164096-85-8

9. L-alanyl-l-threonyl-l-arginyl-l-alanylglycyl-l-leucyl-l-glutaminyl-l-valyl-l-arginyl-l-lysyl-l-asparaginyl-l-lysyl-l-arginyl-l-arginyl-l-arginylglycyl-l-cysteinyl-l-prolyl-l-isoleucyl-l-leucine

10. L-leucine, L-alanyl-l-threonyl-l-arginyl-l-alanylglycyl-l-leucyl-l-glutaminyl-l-valyl-l-arginyl-l-lysyl-l-asparaginyl-l-lysyl-l-arginyl-l-arginyl-l-arginylglycyl-l-cysteinyl-l-prolyl-l-isoleucyl-

2.3 Create Date
2021-02-25
3 Chemical and Physical Properties
Molecular Weight 2293.7 g/mol
Molecular Formula C96H177N39O24S
XLogP3-11.3
Hydrogen Bond Donor Count41
Hydrogen Bond Acceptor Count33
Rotatable Bond Count85
Exact Mass2293.3582937 g/mol
Monoisotopic Mass2292.3549388 g/mol
Topological Polar Surface Area1080 Ų
Heavy Atom Count160
Formal Charge0
Complexity4890
Isotope Atom Count0
Defined Atom Stereocenter Count20
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

RV001 Manufacturers

A RV001 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of RV001, including repackagers and relabelers. The FDA regulates RV001 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. RV001 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

RV001 Suppliers

A RV001 supplier is an individual or a company that provides RV001 active pharmaceutical ingredient (API) or RV001 finished formulations upon request. The RV001 suppliers may include RV001 API manufacturers, exporters, distributors and traders.

RV001 GMP

RV001 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of RV001 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right RV001 GMP manufacturer or RV001 GMP API supplier for your needs.

RV001 CoA

A RV001 CoA (Certificate of Analysis) is a formal document that attests to RV001's compliance with RV001 specifications and serves as a tool for batch-level quality control.

RV001 CoA mostly includes findings from lab analyses of a specific batch. For each RV001 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

RV001 may be tested according to a variety of international standards, such as European Pharmacopoeia (RV001 EP), RV001 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (RV001 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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