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Chemistry

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Also known as: 1609452-30-3, Sel120, Sel-120, Se-120-34a, Sdm3m518pj, Sel120-34a (monohydrochloride)
Molecular Formula
C15H19Br2ClN4
Molecular Weight
450.6  g/mol
InChI Key
GQXLWUCQESKBSC-UHFFFAOYSA-N
FDA UNII
SDM3M518PJ

RVU120
CDK8/19 Inhibitor SEL 120 is an orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor SEL 120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation.
1 2D Structure

RVU120

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6,7-dibromo-5-methyl-2-piperazin-1-yl-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride
2.1.2 InChI
InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4-18-5-8-20;/h18H,2-8H2,1H3;1H
2.1.3 InChI Key
GQXLWUCQESKBSC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C2C3=C(CCCN3C(=N2)N4CCNCC4)C(=C1Br)Br.Cl
2.2 Other Identifiers
2.2.1 UNII
SDM3M518PJ
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1609452-30-3

2. Sel120

3. Sel-120

4. Se-120-34a

5. Sdm3m518pj

6. Sel120-34a (monohydrochloride)

7. 1609452-30-3 (hcl)

8. 7,8-dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4h-imidazo[4,5,1-ij]quinoline Hydrochloride

9. 4h-imidazo(4,5,1-ij)quinoline, 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-, Hydrochloride (1:1)

10. 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4himidazo(4,5,1-ij)quinoline Hydrochloride

11. Unii-sdm3m518pj

12. Chembl4578881

13. Schembl17106021

14. S8840

15. Akos037648926

16. Ex-a2929-1

17. Hy-111388a

18. 7,8-dibromo-9-methyl-2-(piperazin-1-yl)-5,6-dihydro-4h-imidazo[4,5,1-ij]quinoline Hydrochloride

19. Bs-16042

20. Imidazo[4,5,1-ij]quinoline Hydrochloride

21. Cs-0041061

22. A17086

23. D80736

24. Sel120(sel120-34,sel120-34a)

25. 7,8-dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4h-

26. Sel120-34a Monohydrochloride (1609522-33-9 Free Base)

27. 6,7-dibromo-5-methyl-2-piperazin-1-yl-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride

2.4 Create Date
2014-05-26
3 Chemical and Physical Properties
Molecular Weight 450.6 g/mol
Molecular Formula C15H19Br2ClN4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass449.96445 g/mol
Monoisotopic Mass447.96650 g/mol
Topological Polar Surface Area33.1 Ų
Heavy Atom Count22
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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ABOUT THIS PAGE

RVU120 Manufacturers

A RVU120 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of RVU120, including repackagers and relabelers. The FDA regulates RVU120 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. RVU120 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

RVU120 Suppliers

A RVU120 supplier is an individual or a company that provides RVU120 active pharmaceutical ingredient (API) or RVU120 finished formulations upon request. The RVU120 suppliers may include RVU120 API manufacturers, exporters, distributors and traders.

RVU120 GMP

RVU120 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of RVU120 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right RVU120 GMP manufacturer or RVU120 GMP API supplier for your needs.

RVU120 CoA

A RVU120 CoA (Certificate of Analysis) is a formal document that attests to RVU120's compliance with RVU120 specifications and serves as a tool for batch-level quality control.

RVU120 CoA mostly includes findings from lab analyses of a specific batch. For each RVU120 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

RVU120 may be tested according to a variety of international standards, such as European Pharmacopoeia (RVU120 EP), RVU120 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (RVU120 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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