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Chemistry

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Also known as: 888478-45-3, Rx-5902, P-p68 inhibitor rx-5902, Zu8om8v5wf, 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide, 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
Molecular Formula
C22H24FN5O4
Molecular Weight
441.5  g/mol
InChI Key
KAKPGJJRYRYSTP-UHFFFAOYSA-N
FDA UNII
ZU8OM8V5WF

RX-5902
P-p68 Inhibitor RX-5902 is an orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence.
1 2D Structure

RX-5902

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
2.1.2 InChI
InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29)
2.1.3 InChI Key
KAKPGJJRYRYSTP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC(=CC(=C1)N2CCN(CC2)C(=O)NC3=NC4=C(C=CC(=C4)F)N=C3OC)OC
2.2 Other Identifiers
2.2.1 UNII
ZU8OM8V5WF
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(3,5-dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl)piperazine

2. Rx-5902

2.3.2 Depositor-Supplied Synonyms

1. 888478-45-3

2. Rx-5902

3. P-p68 Inhibitor Rx-5902

4. Zu8om8v5wf

5. 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide

6. 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide

7. 1-(3,5-dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl) Piperazine

8. 1-piperazinecarboxamide, 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxy-2-quinoxalinyl)-

9. Unii-zu8om8v5wf

10. Schembl1137972

11. Chembl1278118

12. Rx-5902 (supinoxin)

13. Ex-a4696

14. Nsc779374

15. Nsc793148

16. Nsc-779374

17. Nsc-793148

18. Sb19791

19. Hy-123611

20. Cs-0083830

21. 1-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 441.5 g/mol
Molecular Formula C22H24FN5O4
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass441.18123243 g/mol
Monoisotopic Mass441.18123243 g/mol
Topological Polar Surface Area89 Ų
Heavy Atom Count32
Formal Charge0
Complexity611
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 888478-45-3 / RX-5902 API manufacturers, exporters & distributors?

RX-5902 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of RX-5902 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right RX-5902 manufacturer or RX-5902 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred RX-5902 manufacturer or RX-5902 supplier.

PharmaCompass also assists you with knowing the RX-5902 API Price utilized in the formulation of products. RX-5902 API Price is not always fixed or binding as the RX-5902 Price is obtained through a variety of data sources. The RX-5902 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

RX-5902

Synonyms

888478-45-3, P-p68 inhibitor rx-5902, Zu8om8v5wf, 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide, 4-(3,5-dimethoxyphenyl)-n-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide, 1-(3,5-dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl) piperazine

Cas Number

888478-45-3

Unique Ingredient Identifier (UNII)

ZU8OM8V5WF

About RX-5902

P-p68 Inhibitor RX-5902 is an orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence.

RX-5902 Manufacturers

A RX-5902 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of RX-5902, including repackagers and relabelers. The FDA regulates RX-5902 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. RX-5902 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

RX-5902 Suppliers

A RX-5902 supplier is an individual or a company that provides RX-5902 active pharmaceutical ingredient (API) or RX-5902 finished formulations upon request. The RX-5902 suppliers may include RX-5902 API manufacturers, exporters, distributors and traders.

RX-5902 GMP

RX-5902 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of RX-5902 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right RX-5902 GMP manufacturer or RX-5902 GMP API supplier for your needs.

RX-5902 CoA

A RX-5902 CoA (Certificate of Analysis) is a formal document that attests to RX-5902's compliance with RX-5902 specifications and serves as a tool for batch-level quality control.

RX-5902 CoA mostly includes findings from lab analyses of a specific batch. For each RX-5902 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

RX-5902 may be tested according to a variety of international standards, such as European Pharmacopoeia (RX-5902 EP), RX-5902 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (RX-5902 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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