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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

30 API Suppliers, 13 USDMF, 2 EU WC, 3 NDC API, 25 Listed Suppliers, $ API Reference Price

30 API Suppliers
13 USDMF
2 EU WC
3 NDC API
25 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

17 Drugs in Development

17 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

56 FDF Dossiers, 32 FDA Orange Book, 6 Europe, 3 South Africa, 15 Listed Dossiers

56 FDF Dossiers
32 FDA Orange Book
6 Europe
3 South Africa
15 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 4 DKSH, 1 Faran Shimi Pharmaceutical, 6 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 1 Aeon Procare, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 1 Clariant, 10 Corel Pharma Chem, 2 DFE Pharma, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 15 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 9 Roquette, 6 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 The Dow Chemical Company, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

43 Coating Systems & Additives, 26 Fillers, Diluents & Binders, 21 Controlled & Modified Release, 14 Lubricants & Glidants, 14 Direct Compression, 13 Thickeners and Stabilizers, 8 Film Formers & Plasticizers, 8 Co-Processed Excipients, 7 Disintegrants & Superdisintegrants, 7 Granulation, 5 Emulsifying Agents, 5 Empty Capsules, 5 Coloring Agents, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Taste Masking, 3 Chewable & Orodispersible Aids, 3 Solubilizers, 2 Topical, 2 Rheology Modifiers, 2 Parenteral, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

4 DATA COMPILATION #PharmaFlow, 40 NEWS #PharmaBuzz

media
4 DATA COMPILATION #PharmaFlow
40 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
6 Finished Drug Prices
5 Annual Reports

MARKET PLACE

9 APIs, 2 FDF Dossiers

marketPlace
9 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

41 US Patents, 3 US Exclusivities

patents
41 US Patents
3 US Exclusivities

REF. STANDARDS & IMPURITIES

3 Others

otherSolutions
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,469

MARKET PLACE

API

FDF

19INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

17DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

5,928

Finished Drug Prices

115 RELATED EXCIPIENT COMPANIES

201EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sacubitril sodium, 149690-05-1, Ahu-377 sodium, Sacubitril (sodium), Mop72gep8z, Sodium;4-[[(2s,4r)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate

Molecular Formula

C₂₄H₂₈NNaO₅

Molecular Weight

433.5 g/mol

InChI Key

RRTBVEJIZWGATF-JKSHRDEXSA-M

FDA UNII

MOP72GEP8Z

1 2D Structure

Sacubitril Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate

2.1.2 InChI

InChI=1S/C24H29NO5.Na/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;+1/p-1/t17-,21+;/m1./s1

2.1.3 InChI Key

RRTBVEJIZWGATF-JKSHRDEXSA-M

2.1.4 Canonical SMILES

CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

MOP72GEP8Z

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Sacubitril Sodium

2. 149690-05-1

3. Ahu-377 Sodium

4. Sacubitril (sodium)

5. Mop72gep8z

6. Sodium;4-[[(2s,4r)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate

7. Unii-mop72gep8z

8. Sacubitril Sodium Salt

9. Sacubitril Sodium [mi]

10. Schembl21239956

11. Dtxsid90164362

12. Hy-15407b

13. (1,1'-biphenyl)-4-pentanoic Acid, Gamma-((3-carboxy-1-oxopropyl)amino)-alpha-methyl-, 4-ethyl Ester, Sodium Salt (1:1), (alphar,gammas)-

14. Cs-0079358

15. A937423

16. Q27284149

17. (1,1'-biphenyl)-4-pentanoic Acid, .gamma.-((3-carboxy-1-oxopropyl)amino)-.alpha.-methyl-, 4-ethyl Ester, Sodium Salt (1:1), (.alpha.r,.gamma.s)-

18. Sodium 4-(((2s,4r)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₈NNaO₅
Molecular Weight	433.5 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	12
Exact Mass	433.18651728 g/mol
Monoisotopic Mass	433.18651728 g/mol
Topological Polar Surface Area	95.5 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	556
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

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USDMF

01

Dr Reddys Laboratories Ltd

India

CPhI India 2024

Booth #RH.E02

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 40307

Submission : 2024-08-28

Status : Active

Type : II

Product Web Link

02

Ami Lifesciences Private Ltd

India

CPhI India 2024

Booth #1.C02

AMI Lifesciences is Driven by Chemistry. Powered by People.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 38140

Submission : 2023-03-17

Status : Active

Type : II

03

Biocon Ltd

India

India

China

BioFlorida Conference

Not Confirmed

Only 10 entries up to this point, click to access all

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EU WC

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NDC API

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Listed Suppliers

01

LGM Pharma

U.S.A

BioFlorida Conference

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Sacubitril Sodium

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

02

Metrochem API Private Limited

India

Pharmtech & Ingredients

Exhibiting

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

About the Company :

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product ...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

03

IOL Chemicals and Pharmaceuticals

India

CPhI India 2024

Booth #1.C01

IOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

About the Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermediates and specialty ch...

With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermediates and specialty chemicals. As an API-based company, IOL Chemicals has substantial manufacturing capacities that provide economies of scale and cost advantages. It also has extensive expertise in specialty chemicals. IOL Chemicals’ API portfolio includes various therapeutic categories such as pain management, anti-diabetic, anti-hypertensive and anti-convulsant. IOL Chemicals is a backward-integrated company that produces all intermediates and key starting materials for ibuprofen.

04

Ami Lifesciences Private Limited

India

CPhI India 2024

Booth #1.C02

AMI Lifesciences is Driven by Chemistry. Powered by People.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

About the Company : Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory thera...

Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory therapeutic areas, Ami offers a wide range of APIs, intermediates, key starting materials, as well as contract bulk manufacturing services. Ami's manufacturing units in Gujarat and Karnataka feature dedicated clean rooms for APIs and adhere to international standards like EU-GMP, WHO-GMP, PMDA, and COFEPRIS. Ami serves as a reliable partner for contract development and manufacturing, offering generic APIs to global pharma companies across more than 60 countries.

05

HRV Global Life Sciences

India

CPhI India 2024

Booth #2.D38

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Sacubitril Sodium

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

Portfolio PDF

Product Web Link

U.S.A

American Pharma Summit

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ABOUT THIS PAGE

Find Sacubitril Sodium manufacturers, exporters & distributors on PharmaCompass

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

30 API Suppliers

13 USDMF

2 EU WC

3 NDC API

25 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

17 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

56 FDF Dossiers

32 FDA Orange Book

6 Europe

3 South Africa

15 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma

4 DKSH

1 Faran Shimi Pharmaceutical

6 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 ACG Worldwide

1 Aeon Procare

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Avesta Pharma

1 Clariant

10 Corel Pharma Chem

2 DFE Pharma

6 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

15 Kerry

3 Kima Chemical

6 Lonza Capsugel

8 Microlex e.U

1 Novo Excipients

1 Pharmatrans-Sanaq

1 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

9 Roquette

6 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

9 Sigachi Industries

2 The Dow Chemical Company

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

43 Coating Systems & Additives

26 Fillers, Diluents & Binders

21 Controlled & Modified Release

14 Lubricants & Glidants

14 Direct Compression

13 Thickeners and Stabilizers

8 Film Formers & Plasticizers

8 Co-Processed Excipients

7 Disintegrants & Superdisintegrants

7 Granulation

5 Emulsifying Agents

5 Empty Capsules

5 Coloring Agents

4 Vegetarian Capsules

4 API Stability Enhancers

4 Taste Masking

3 Chewable & Orodispersible Aids

3 Solubilizers

2 Topical

2 Rheology Modifiers

2 Parenteral

1 Surfactant & Foaming Agents

DIGITAL CONTENT

4 DATA COMPILATION #PharmaFlow

40 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION