List of Suppliers of sacubitril valsartan sodium hydrate intermediates listed on PharmaCompass.com

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Also known as: Sacubitril valsartan sodium hydrate, Sacubitril mixture with valsartan, Wb8ft61183, Lcz 696, Sacubitril valsartan sodium hydrate (jan), Sacubitril valsartan sodium hydrate [jan]
Molecular Formula
C96H120N12Na6O21
Molecular Weight
1916.0  g/mol
InChI Key
ZASXKEGREHRXDL-CAWNUZPDSA-H
FDA UNII
WB8FT61183

Sacubitril-Valsartan
Sacubitril/Valsartan is a combination of sacubitril and valsartan with natriuretic and anti-hypertensive properties. Upon administration, sacubitril is metabolized by esterases to its active metabolite, LBQ657 (sacubitrilat), which inhibits neprilysin, a neutral endopeptidase that cleaves natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides including as angiotensin I and II, and endothelin-1. Inhibition of neprilysin leads to increased concentrations of endogenous natriuretic peptides, which function to activate downstream receptors that promote vasodilation, natriuresis and diuresis, while simultaneously increasing the concentration of vasoconstricting peptides such as angiotensin II. Co-administration with valsartan, an angiotensin II receptor blocker, prevents the vasoconstrictive effects of neprilysin inhibition and promotes a decrease in vascular resistance and blood pressure.
1 2D Structure

Sacubitril-Valsartan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
hexasodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;(2S)-3-methyl-2-[pentanoyl-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]amino]butanoate;pentahydrate
2.1.2 InChI
InChI=1S/2C24H29N5O3.2C24H29NO5.6Na.5H2O/c2*1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;;;;;;;;;;;/h2*6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H2,25,26,27,28,31,32);2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);;;;;;;5*1H2/q;;;;6*+1;;;;;/p-6/t2*22-;2*17-,21+;;;;;;;;;;;/m0011.........../s1
2.1.3 InChI Key
ZASXKEGREHRXDL-CAWNUZPDSA-H
2.1.4 Canonical SMILES
CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)C(C(C)C)C(=O)[O-].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)C(C(C)C)C(=O)[O-].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
2.1.5 Isomeric SMILES
CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)[C@@H](C(C)C)C(=O)[O-].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)[C@@H](C(C)C)C(=O)[O-].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
WB8FT61183
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate

2. Lcz 696

3. Lcz-696

4. Lcz696

5. Sacubitril And Valsartan Drug Combination

6. Sacubitril And Valsartan Sodium Anhydrous Drug Combination

7. Sacubitril And Valsartan Sodium Hydrate Drug Combination

8. Sacubitril Valsartan Drug Combination

9. Sacubitril Valsartan Sodium Anhydrous

10. Sacubitril Valsartan Sodium Hydrate

11. Sacubitril-valsartan

12. Sacubitril-valsartan Sodium Anhydrous Drug Combination

13. Sacubitril-valsartan Sodium Hydrate Drug Combination

14. Trisodium (3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate) Hemipentahydrate

2.3.2 Depositor-Supplied Synonyms

1. Sacubitril Valsartan Sodium Hydrate

2. Sacubitril Mixture With Valsartan

3. Wb8ft61183

4. Lcz 696

5. Sacubitril Valsartan Sodium Hydrate (jan)

6. Sacubitril Valsartan Sodium Hydrate [jan]

7. Entresto (tn)

8. Unii-wb8ft61183

9. Valsartan Mixture With Ahu-377

10. Ex-a2849

11. Mfcd29477717

12. 3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate

13. Ac-29037

14. Sucabitril Valsartan Sodium Hydrate

15. Trisodium (3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate) Hemipentahydrate

16. D10226

17. Valsartan Ahu-377 Sodium Hemipentahydrate

18. Q27292546

19. L-valine, N-(1-oxopentyl)-n-((2'-(2h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, Compd. With .alpha.-ethyl (.alpha.r,.gamma.s)-.gamma.-((3-carboxy-1-oxopropyl)amino)-.alpha.-methyl(1,1'-biphenyl)-4-pentanoate, Sodium Salt, Hydrate (2:2:6:5)

20. L-valine, N-(1-oxopentyl)-n-((2'-(2h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, Compd. With Alpha-ethyl(alphar,gammas)-gamma-((3-carboxy-1-oxopropyl)amino)-alpha-methyl(1,1'-biphenyl)-4-pentanoate, Sodium Salt, Hydrate (2:2:6:5)

2.4 Create Date
2013-05-27
3 Chemical and Physical Properties
Molecular Weight 1916.0 g/mol
Molecular Formula C96H120N12Na6O21
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count29
Rotatable Bond Count40
Exact Mass1915.8110694 g/mol
Monoisotopic Mass1914.8077146 g/mol
Topological Polar Surface Area396 Ų
Heavy Atom Count135
Formal Charge0
Complexity1140
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count15
4 Drug and Medication Information
4.1 Drug Indication

Entresto is indicated in adult patients for treatment of symptomatic chronic heart failure with reduced ejection fraction.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Angiotensin Receptor Antagonists

Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR. (See all compounds classified as Angiotensin Receptor Antagonists.)


5.2 ATC Code

C09DX04


API SUPPLIERS

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01

Dr. Reddy\'s Laboratories

India

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Polpharma

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Faran Shimi Pharmaceutical

Iran

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Virupaksha Organics

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Ami Lifesciences Private Limited

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Aptra Synthesis

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HRV Global Life Sciences

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Zhuhai Rundu Pharmaceutical

China

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Zhuhai Rundu Pharmaceutical

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HONOUR LAB LTD

India

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HONOUR LAB LTD

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Zhejiang Tianyu Pharmaceutical Co....

China

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Zhejiang Tianyu Pharmaceutical Co....

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Sacubitril/Valsartan IH

Date of Issue : 2022-07-28

Valid Till : 2025-11-30

Written Confirmation Number : WC-0390

Address of the Firm : CTO-SEZ-Process Unit-01, Sector No 28 to 34, 36 to 37, 40, 50 to 53 & 03, Survey...

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Sacubitril Valsartan Trisodium salt Hemipentahydrate IH

Date of Issue : 2022-08-11

Valid Till : 2025-06-26

Written Confirmation Number : WC-0054

Address of the Firm : Block No. 82/B, ECP Road, At & Post. Karakhadi, Tal-Padra, City Karakhadi -39145...

AMI Lifesciences

03

ASC 2024
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Sacubitril-Valsartan IH

Date of Issue : 2022-06-17

Valid Till : 2025-07-02

Written Confirmation Number : WC-0082

Address of the Firm : API Division Kharakhadi, Plot No. 842-843, Kharakhadi, Padra Vadodara-391 450, G...

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Sacubitril And Valsartan IH

Date of Issue : 2019-05-06

Valid Till : 2022-05-05

Written Confirmation Number : WC-362

Address of the Firm : Unit-III Plot No.4 Hetero Infrastructure SEZ N.Narasapuram Village, Nakkapally m...

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Sacubitril And Valsartan IH

Date of Issue : 2019-07-26

Valid Till : 2022-08-08

Written Confirmation Number : WC-0383

Address of the Firm : Sy. No.455/A, 455/AA, 455/E & 455/EE Chandampet Village Shankarampet Mandal Meda...

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RXXDY'XXLABXXATOXXES XXA.","customerCountry":"ISRAEL","quantity":"402.00","actualQuantity":"402","unit":"KGS","unitRateFc":"1261.4","totalValueFC":"501752.5","currency":"USD","unitRateINR":104194.05970149254,"date":"22-Jun-2024","totalValueINR":"41886012","totalValueInUsd":"501752.5","indian_port":"Reddy r-SEZ\/Srikakulam","hs_no":"29332990","bill_no":"4000464","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ISRAEL","selfForZScoreResived":"Pharma Grade","supplierPort":"Reddy r-SEZ\/Srikakulam","supplierAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE, HYDERABAD ANDHRA PRADESH","customerAddress":""}]
03-Feb-2021
22-Jun-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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