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Inke Salmeterol xinafoate

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Vamsi labs Salmeterol Xinafoate

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Gangwal Healthcare Salmeterol Xinafoate RMB

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Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

40 API Suppliers, 20 USDMF, 16 CEP/COS, 1 JDMF, 11 EU WC, 12 NDC API, 28 Listed Suppliers, $ API Reference Price

40 API Suppliers
20 USDMF
16 CEP/COS
1 JDMF
11 EU WC
12 NDC API
28 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

10 Drugs in Development

10 Drugs in Development

INTERMEDIATES

11 Intermediates Suppliers

11 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

233 FDF Dossiers, 23 FDA Orange Book, 143 Europe, 12 Canada, 1 Australia, 31 South Africa, 23 Listed Dossiers

233 FDF Dossiers
23 FDA Orange Book
143 Europe
12 Canada
1 Australia
31 South Africa
23 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

POWDER;INHALATION - 0.055MG/INH;EQ 0.014MG BASE/INH, POWDER;INHALATION - 0.113MG/INH;EQ 0.014MG BASE/INH, POWDER;INHALATION - 0.232MG/INH;EQ 0.014MG BASE/INH, POWDER;INHALATION - 0.1MG/INH;EQ 0.05MG BASE/INH, POWDER;INHALATION - 0.25MG/INH;EQ 0.05MG BASE/INH, POWDER;INHALATION - 0.5MG/INH;EQ 0.05MG BASE/INH, AEROSOL, METERED;INHALATION - 0.045MG/INH;EQ 0.021MG BASE/INH, AEROSOL, METERED;INHALATION - 0.115MG/INH;EQ 0.021MG BASE/INH, AEROSOL, METERED;INHALATION - 0.23MG/INH;EQ 0.021MG BASE/INH

drugProductComposition
POWDER;INHALATION - 0.055MG/INH;EQ 0.014MG BASE/INH
POWDER;INHALATION - 0.113MG/INH;EQ 0.014MG BASE/INH
POWDER;INHALATION - 0.232MG/INH;EQ 0.014MG BASE/INH
POWDER;INHALATION - 0.1MG/INH;EQ 0.05MG BASE/INH
POWDER;INHALATION - 0.25MG/INH;EQ 0.05MG BASE/INH
POWDER;INHALATION - 0.5MG/INH;EQ 0.05MG BASE/INH
AEROSOL, METERED;INHALATION - 0.045MG/INH;EQ 0.021MG BASE/INH
AEROSOL, METERED;INHALATION - 0.115MG/INH;EQ 0.021MG BASE/INH
AEROSOL, METERED;INHALATION - 0.23MG/INH;EQ 0.021MG BASE/INH

RELATED EXCIPIENT COMPANIES

1 Faran Shimi Pharmaceutical, 3 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 2 BASF, 2 DFE Pharma, 17 Kerry, 2 Microlex e.U, 1 Pluviaendo, 1 Roquette, 2 Sigachi Industries

relatedExcipients
1 Faran Shimi Pharmaceutical
3 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
2 BASF
2 DFE Pharma
17 Kerry
2 Microlex e.U
1 Pluviaendo
1 Roquette
2 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

21 Fillers, Diluents & Binders, 9 Direct Compression, 7 Co-Processed Excipients, 6 Granulation, 1 Coating Systems & Additives, 1 Controlled & Modified Release, 1 Parenteral

excipientsByApplications
21 Fillers, Diluents & Binders
9 Direct Compression
7 Co-Processed Excipients
6 Granulation
1 Coating Systems & Additives
1 Controlled & Modified Release
1 Parenteral

DIGITAL CONTENT

8 DATA COMPILATION #PharmaFlow, 80 NEWS #PharmaBuzz

media
8 DATA COMPILATION #PharmaFlow
80 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 125 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
125 Finished Drug Prices
5 Annual Reports

MARKET PLACE

4 APIs, 2 FDF Dossiers

marketPlace
4 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

247 US Patents, 4 US Exclusivities, 14 Health Canada Patents

patents
247 US Patents
4 US Exclusivities
14 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 6 USP , 7 Others

otherSolutions
3 EDQM
6 USP
7 Others

Inke Salmeterol Xinafoate

Synopsis

ACTIVE PHARMA INGREDIENTS

40

API Suppliers

20

USDMF

16

CEP/COS

CEP/COS Certifications

1

JDMF

11

EU WC

0

KDMF

12

NDC API

0

VMF

28

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 39,700

MARKET PLACE

4

API

2

FDF

11INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

233

FDF Dossiers

23

FDA Orange Book

FDA (Orange Book)

143

Europe

12

Canada

1

Australia

31

South Africa

23

Listed Dossiers

10DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

6

USP

0

JP

7

Others

PATENTS & EXCLUSIVITIES

247

US Patents

4

US Exclusivities

14

Health Canada Patents

DIGITAL CONTENT

8

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

80

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

47,567,777

Annual Reports (USD Million)

8,767

Finished Drug Prices

32 RELATED EXCIPIENT COMPANIES

46EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 94749-08-3, Salmetedur, Arial, Gr 33343x xinafoate, Salmeterol 1-hydroxy-2-naphthoate, Salmeterolo

Molecular Formula

C₃₆H₄₅NO₇

Molecular Weight

603.7 g/mol

InChI Key

XTZNCVSCVHTPAI-UHFFFAOYSA-N

FDA UNII

6EW8Q962A5

Salmeterol Xinafoate

A selective ADRENERGIC BETA-2 RECEPTOR agonist that functions as a BRONCHODILATOR when administered by inhalation. It is used to manage the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

1 2D Structure

Salmeterol Xinafoate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol;1-hydroxynaphthalene-2-carboxylic acid

2.1.2 InChI

InChI=1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14)

2.1.3 InChI Key

XTZNCVSCVHTPAI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

6EW8Q962A5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Salmeterol

2. Serevent

3. Xinafoate, Salmeterol

2.3.2 Depositor-Supplied Synonyms

1. 94749-08-3

2. Salmetedur

3. Arial

4. Gr 33343x Xinafoate

5. Salmeterol 1-hydroxy-2-naphthoate

6. Salmeterolo

7. Salmeterol (xinafoate)

8. 4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphthoate

9. Gr 33343 G

10. 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol;1-hydroxynaphthalene-2-carboxylic Acid

11. Serevent Diskus

12. 6ew8q962a5

13. Gr-33343x

14. Gr-33343 G

15. Ncgc00094372-03

16. Asmerole

17. Betamican

18. Dilamax

19. Inaspir

20. Ultrabeta

21. Beglan

22. Dsstox_cid_25798

23. Dsstox_rid_81137

24. Dsstox_gsid_45798

25. Serevent Inhaler And Disks

26. Salmeterol Xinafoate [usan]

27. Smr000875207

28. Cas-94749-08-3

29. Unii-6ew8q962a5

30. Salmeterol Xinafoate [usan:usp]

31. Serevent (tn)

32. 4-[1-hydroxy-2-[[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(hydroxymethyl)phenol 1-hydroxy-2-naphthoate

33. Salmeterol, 1-hydroxy-2-naphthoate

34. Mfcd00897708

35. Schembl18070

36. (+-)-4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol 1-hydroxy-2-naphthoate (salt)

37. Mls001332577

38. Mls001332578

39. Chebi:9012

40. Lipo-202

41. Chembl1082607

42. Dtxsid1045798

43. Salmeterol Xinafoate (jan/usp)

44. Hms2232i16

45. Hms3263k22

46. Hms3676p13

47. Hms3749i03

48. Hms3885j19

49. Salmeterol Xinafoate [jan]

50. Amy23373

51. Bcp04778

52. Salmeterol Xinafoate [vandf]

53. Tox21_111270

54. Tox21_501100

55. S4296

56. Salmeterol Xinafoate [mart.]

57. Salmeterol Xinafoate [usp-rs]

58. Salmeterol Xinafoate [who-dd]

59. Akos016004957

60. Tox21_111270_1

61. Ccg-270203

62. Cs-1527

63. Ks-1140

64. Lp01100

65. Ncgc00015938-05

66. Ncgc00094372-01

67. Ncgc00094372-02

68. Ncgc00094372-04

69. Ncgc00261785-01

70. 1,3-benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)

71. Hy-17453

72. Salmeterol Xinafoate [ep Impurity]

73. Salmeterol Xinafoate [orange Book]

74. Bcp0726000003

75. Salmeterol Xinafoate [ep Monograph]

76. Advair Component Salmeterol Xinafoate

77. Db-057527

78. Salmeterol Xinafoate [usp Monograph]

79. Eu-0101100

80. Ft-0642283

81. Salmeterol Xinafoate, >=98% (hplc), Solid

82. D00687

83. Lipo-102 Component Salmeterol Xinafoate

84. R10007

85. Salmeterol 1-hydroxy-2-naphthoate [mi]

86. Salmeterol Xinafoate Component Of Advair

87. Advair Hfa Component Salmeterol Xinafoate

88. A916443

89. Sr-01000597359

90. Q-201697

91. Salmeterol Xinafoate Component Of Advair Hfa

92. Sr-01000597359-1

93. Airduo Respiclick Component Salmeterol Xinafoate

94. Q27264747

95. Salmeterol Xinafoate Component Of Airduo Respiclick

96. Salmeterol Xinafoate, European Pharmacopoeia (ep) Reference Standard

97. Salmeterol Xinafoate, United States Pharmacopeia (usp) Reference Standard

98. Salmeterol Xinafoate For System Suitability, European Pharmacopoeia (ep) Reference Standard

99. Salmeterol Xinafoate, Pharmaceutical Secondary Standards; Certified Reference Material

100. (+/-)-4-hydroxy-.alpha.(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-.alpha.,.alpha.'-diol 1-hydroxy-2-naphthoate

101. 1,3-benzenedimethanol, 4-hydroxy-.alpha.(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+/-)-, 1-hydroxy-2-naphthalenecarboxylate

102. 4-(1-hydroxy-2-(6-(4-phenylbutoxy)hexylamino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphthoate

103. 4-hydroxy-?1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic Acid Salt

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₃₆H₄₅NO₇
Molecular Weight	603.7 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	17
Exact Mass	603.31960277 g/mol
Monoisotopic Mass	603.31960277 g/mol
Topological Polar Surface Area	140 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	629
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

beta2-Adrenergic Agonist [EPC]; Adrenergic beta2-Agonists [MoA]

API SUPPLIERS

01

Inke S.A

Spain

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Gangwal Healthcare

India

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Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

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Vamsi Labs

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Axplora- The partner of choice for complex APIs.

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LGM Pharma

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LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Fermion Oy

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Coral Drugs Private Limited

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - POWDER;INHALATION - 0.055MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.055MG/INH;EQ 0.014MG BASE/INH

USFDA APPLICATION NUMBER - 208799

DOSAGE - POWDER;INHALATION - 0.113MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.113MG/INH;EQ 0.014MG BASE/INH

USFDA APPLICATION NUMBER - 208799

DOSAGE - POWDER;INHALATION - 0.232MG/INH;EQ 0...DOSAGE - POWDER;INHALATION - 0.232MG/INH;EQ 0.014MG BASE/INH

USFDA APPLICATION NUMBER - 208799

DOSAGE - POWDER;INHALATION - 0.1MG/INH;EQ 0.0...DOSAGE - POWDER;INHALATION - 0.1MG/INH;EQ 0.05MG BASE/INH

USFDA APPLICATION NUMBER - 21077

DOSAGE - POWDER;INHALATION - 0.25MG/INH;EQ 0....DOSAGE - POWDER;INHALATION - 0.25MG/INH;EQ 0.05MG BASE/INH

USFDA APPLICATION NUMBER - 21077

DOSAGE - POWDER;INHALATION - 0.5MG/INH;EQ 0.0...DOSAGE - POWDER;INHALATION - 0.5MG/INH;EQ 0.05MG BASE/INH

USFDA APPLICATION NUMBER - 21077

DOSAGE - AEROSOL, METERED;INHALATION - 0.045M...DOSAGE - AEROSOL, METERED;INHALATION - 0.045MG/INH;EQ 0.021MG BASE/INH

USFDA APPLICATION NUMBER - 21254

DOSAGE - AEROSOL, METERED;INHALATION - 0.115M...DOSAGE - AEROSOL, METERED;INHALATION - 0.115MG/INH;EQ 0.021MG BASE/INH

USFDA APPLICATION NUMBER - 21254

DOSAGE - AEROSOL, METERED;INHALATION - 0.23MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.23MG/INH;EQ 0.021MG BASE/INH

USFDA APPLICATION NUMBER - 21254

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