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Chemistry

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Also known as: 1224844-38-5, Ink-128, Mln0128, Ink 128, Ink128, Tak-228
Molecular Formula
C15H15N7O
Molecular Weight
309.33  g/mol
InChI Key
GYLDXIAOMVERTK-UHFFFAOYSA-N
FDA UNII
JGH0DF1U03

Sapanisertib
Sapanisertib is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.
1 2D Structure

Sapanisertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
2.1.2 InChI
InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
2.1.3 InChI Key
GYLDXIAOMVERTK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N
2.2 Other Identifiers
2.2.1 UNII
JGH0DF1U03
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-benzoxazolamine, 5-(4-amino-1-(1-methylethyl)-1h-pyrazolo(3,4-d)pyrimidin-3-yl)-

2. 3-(2-amino-1,3-benzoxazol-5-yl)-1-isopropyl-1h-pyrazolo(3,4-d)pyrimidin-4-amine

3. Cb-228

4. Ink128

5. Mln-0128

6. Mln0128

7. Tak-228

2.3.2 Depositor-Supplied Synonyms

1. 1224844-38-5

2. Ink-128

3. Mln0128

4. Ink 128

5. Ink128

6. Tak-228

7. Mln-0128

8. Ink 128 (mln0128)

9. 5-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine

10. Sapanisertib (mln0128)

11. Jgh0df1u03

12. 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

13. 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine

14. 5-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]-pyrimidin-3-yl)benzo[d]oxazol-2-amine

15. 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine

16. Sapanisertib [inn]

17. Unii-jgh0df1u03

18. 1h-pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-

19. 1h-pyrazolo(3,4-d)pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-

20. Cb-228

21. Sapanisertib; Ink128

22. Sapanisertib (usan/inn)

23. Sapanisertib [usan:inn]

24. Sapanisertib [usan]

25. Mls006011012

26. Sapanisertib [who-dd]

27. Gtpl7933

28. Schembl7902875

29. Chembl3545097

30. Chebi:91450

31. Ex-a951

32. Ink-128/ink128

33. Bdbm315477

34. Dtxsid401022538

35. Hms3656h12

36. Hms3672c21

37. Ink-128;sapanisertib;mln0128

38. Ink-0128

39. Mfcd22124893

40. Nsc764658

41. Nsc768435

42. Nsc780880

43. S2811

44. Zinc73069271

45. Akos025149512

46. Us10172858, Table 1.1

47. Bcp9000789

48. Ccg-265002

49. Cs-0557

50. Db11836

51. Nsc-764658

52. Nsc-768435

53. Nsc-780880

54. Sb16566

55. 2-benzoxazolamine, 5-(4-amino-1-(1-methylethyl)-1h-pyrazolo(3,4-d)pyrimidin-3-yl)-

56. 3-(2-amino-1,3-benzoxazol-5-yl)-1-isopropyl-1h-pyrazolo(3,4-d)pyrimidin-4-amine

57. Us10172858, Table 1.22

58. Ncgc00346654-01

59. Ncgc00346654-10

60. Ac-26848

61. As-16294

62. Bs170924

63. Hy-13328

64. Smr004702810

65. Bcp0726000086

66. A8551

67. Ft-0700125

68. Sw220210-1

69. D11183

70. Ink-128,cas:1224844-38-5

71. J-004811

72. Q27078072

73. 3-(2-aminobenzo[d]oxazol-5-yl)-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine

74. 5-(4-amino-1-isopropyl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine

75. 3-(2-amino-1,3-benzoxazol-5-yl)-1-(propan-2-yl)-1h-pyrazolo(3,4-d)pyrimidin-4-amine

76. Fe5

2.4 Create Date
2010-05-17
3 Chemical and Physical Properties
Molecular Weight 309.33 g/mol
Molecular Formula C15H15N7O
XLogP31.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass309.13380813 g/mol
Monoisotopic Mass309.13380813 g/mol
Topological Polar Surface Area122 Ų
Heavy Atom Count23
Formal Charge0
Complexity436
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 1224844-38-5 / Sapanisertib API manufacturers, exporters & distributors?

Sapanisertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sapanisertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sapanisertib manufacturer or Sapanisertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sapanisertib manufacturer or Sapanisertib supplier.

PharmaCompass also assists you with knowing the Sapanisertib API Price utilized in the formulation of products. Sapanisertib API Price is not always fixed or binding as the Sapanisertib Price is obtained through a variety of data sources. The Sapanisertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sapanisertib

Synonyms

1224844-38-5, Ink-128, Mln0128, Ink 128, Ink128, Tak-228

Cas Number

1224844-38-5

Unique Ingredient Identifier (UNII)

JGH0DF1U03

About Sapanisertib

Sapanisertib is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.

Sapanisertib Manufacturers

A Sapanisertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sapanisertib, including repackagers and relabelers. The FDA regulates Sapanisertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sapanisertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sapanisertib Suppliers

A Sapanisertib supplier is an individual or a company that provides Sapanisertib active pharmaceutical ingredient (API) or Sapanisertib finished formulations upon request. The Sapanisertib suppliers may include Sapanisertib API manufacturers, exporters, distributors and traders.

Sapanisertib GMP

Sapanisertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sapanisertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sapanisertib GMP manufacturer or Sapanisertib GMP API supplier for your needs.

Sapanisertib CoA

A Sapanisertib CoA (Certificate of Analysis) is a formal document that attests to Sapanisertib's compliance with Sapanisertib specifications and serves as a tool for batch-level quality control.

Sapanisertib CoA mostly includes findings from lab analyses of a specific batch. For each Sapanisertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sapanisertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Sapanisertib EP), Sapanisertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sapanisertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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