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Saralasin

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FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 FDA Orange Book

1 FDF Dossiers
1 FDA Orange Book

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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Chemistry

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Also known as: Saralasin acetate hydrate, Saralasin acetate [usan], 39698-78-7, Saralasin acetate (usan), Sarenin, Unii-fo21z580m4

Molecular Formula

C₄₄H₇₁N₁₃O₁₃

Molecular Weight

990.1 g/mol

InChI Key

YBZYNINTWCLDQA-UHKVWXOHSA-N

An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.

1 2D Structure

Saralasin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;hydrate

2.1.2 InChI

InChI=1S/C42H65N13O10.C2H4O2.H2O/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65;1-2(3)4;/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47);1H3,(H,3,4);1H2/t24-,28-,29-,30-,31-,33-,34-;;/m0../s1

2.1.3 InChI Key

YBZYNINTWCLDQA-UHKVWXOHSA-N

2.1.4 Canonical SMILES

CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC.CC(=O)O.O

2.1.5 Isomeric SMILES

C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC.CC(=O)O.O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. (sar(1),ala(8))angii

2. (sar1,val5,ala8)angiotensin Ii

3. 1 Sar 8 Ala Angiotensin Ii

4. 1 Sarcosine 8 Alanine Angiotensin Ii

5. 1-sar-8-ala Angiotensin Ii

6. 1-sarcosine-8-alanine Angiotensin Ii

7. Angiotensin Ii, 1-sar-8-ala

8. Angiotensin Ii, 1-sarcosine-8-alanine

9. Angiotensin Ii, Sar(1)-ala(8)-

10. Angiotensin Ii, Sarcosyl(1)-alanine(8)-

11. Anhydrous Saralasin Acetate

12. Hydrated Saralasin Acetate

13. Sar-arg-val-tyr-val-his-pro-ala

14. Saralasin

15. Saralasin Acetate, Anhydrous

16. Saralasin Acetate, Hydrated

2.2.2 Depositor-Supplied Synonyms

1. Saralasin Acetate Hydrate

2. Saralasin Acetate [usan]

3. 39698-78-7

4. Saralasin Acetate (usan)

5. Sarenin

6. Unii-fo21z580m4

7. Sarenin (tn)

8. Saralasin Hydrated Acetate

9. Schembl2200145

10. Chembl1200670

11. Fo21z580m4

12. N-(1-(n-(n-(n-(n-(n2-(n-methylglycyl-l-arginyl)-l-l-valyl)-l-tyrosyl)-l-valyl)-l-histidyl)-l-prolyl)-l-alanine Acetate (salt) Hydrate

13. Saralasin Acetate(34273-10-4 Free Base)

14. D04126

15. Q27278095

16. [sar1, Val5, Ala8]-angiotensin Ii Acetate Salt Hydrate, >=97% (hplc), Powder

17. Angiotensin Ii, 1-(n-methylglycine)-5-l-valine-8-l-alanine-, Acetate (salt) Hydrate

18. N-(1-(n-(n-(n-(n-(n(sup 2)-(n-methylglycyl-l-arginyl)-l-valyl)-l-tyrosyl)-l-valyl)-l-histidyl)-l-prolyl)-l-alanine Acetate (salt) Hydrate

2.3 Create Date

2006-11-22

3 Chemical and Physical Properties

Molecular Formula	C₄₄H₇₁N₁₃O₁₃
Molecular Weight	990.1 g/mol
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	25
Exact Mass	989.52942937 g/mol
Monoisotopic Mass	989.52942937 g/mol
Topological Polar Surface Area	396 Å²
Heavy Atom Count	70
Formal Charge	0
Complexity	1700
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Angiotensin II Type 1 Receptor Blockers

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS. (See all compounds classified as Angiotensin II Type 1 Receptor Blockers.)

FDF Dossiers

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FDA Orange Book

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ABOUT THIS PAGE

Saralasin Manufacturers

A Saralasin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Saralasin, including repackagers and relabelers. The FDA regulates Saralasin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Saralasin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Saralasin Suppliers

A Saralasin supplier is an individual or a company that provides Saralasin active pharmaceutical ingredient (API) or Saralasin finished formulations upon request. The Saralasin suppliers may include Saralasin API manufacturers, exporters, distributors and traders.

Saralasin GMP

Saralasin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Saralasin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Saralasin GMP manufacturer or Saralasin GMP API supplier for your needs.

Saralasin CoA

A Saralasin CoA (Certificate of Analysis) is a formal document that attests to Saralasin's compliance with Saralasin specifications and serves as a tool for batch-level quality control.

Saralasin CoA mostly includes findings from lab analyses of a specific batch. For each Saralasin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Saralasin may be tested according to a variety of international standards, such as European Pharmacopoeia (Saralasin EP), Saralasin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Saralasin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.