Find Savolitinib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Volitinib, 1313725-88-0, Azd-6094, Hmpl-504, Azd6094, Savolitinib [inn]
Molecular Formula
C17H15N9
Molecular Weight
345.4  g/mol
InChI Key
XYDNMOZJKOGZLS-NSHDSACASA-N
FDA UNII
2A2DA6857R

Savolitinib
Savolitinib is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.
1 2D Structure

Savolitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine
2.1.2 InChI
InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
2.1.3 InChI Key
XYDNMOZJKOGZLS-NSHDSACASA-N
2.1.4 Canonical SMILES
CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
2.1.5 Isomeric SMILES
C[C@@H](C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
2.2 Other Identifiers
2.2.1 UNII
2A2DA6857R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1h-pyrazol-4-yl)-1h-(1,2,3)triazolo(4,5-b)pyrazine

2. Azd6094

3. Hmpl-504

4. Volitinib

2.3.2 Depositor-Supplied Synonyms

1. Volitinib

2. 1313725-88-0

3. Azd-6094

4. Hmpl-504

5. Azd6094

6. Savolitinib [inn]

7. Hmpl504

8. (s)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1h-pyrazol-4-yl)-1h-[1,2,3]triazolo[4,5-b]pyrazine

9. Chembl3334567

10. 2a2da6857r

11. 1h-1,2,3-triazolo(4,5-b)pyrazine, 1-((1s)-1-imidazo(1,2-a)pyridin-6-ylethyl)-6-(1-methyl-1h-pyrazol-4-yl)-

12. 3-[(1s)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine

13. Orpathys

14. Unii-2a2da6857r

15. Azd6094, Hmpl-504

16. Volitinib(savolitinib)

17. Azd-6094volitinib

18. Savolitinib (usan/inn)

19. Savolitinib [usan:inn]

20. Savolitinib [usan]

21. Savolitinib [who-dd]

22. Gtpl9918

23. Hmpl 504

24. Schembl12489208

25. Ex-a845

26. Dtxsid801111016

27. Azd 6094

28. Bdbm50023342

29. Mfcd28359096

30. Nsc782121

31. Nsc800966

32. S7674

33. Akos030526403

34. Savolitinib(azd6094, Hmpl-504)

35. Zinc149738712

36. Ccg-267976

37. Db12048

38. Nsc-782121

39. Nsc-800966

40. Compound 28 [pmid: 25148209]

41. Ncgc00475727-01

42. Ac-35267

43. As-35250

44. Bv160378

45. Hy-15959

46. Savolitinib;volitinib;hmpl-504;azd-6094

47. A14419

48. D11139

49. J-690125

50. Q27254463

51. (3e)-5-chloro-3-[(5-{3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl}-2-furyl)methylene]-1,3-dihydro-2h-indol-2-one Hydrochloride

52. 1-((s)-1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1h-pyrazol-4-yl)-1h-(1,2,3)-triazolo(4,5-b)pyrazine

53. 4-{1-[(1s)-1-{imidazo[1,2-a]pyridin-6-yl}ethyl]-1h-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1-methyl-1h-pyrazole

2.4 Create Date
2012-11-30
3 Chemical and Physical Properties
Molecular Weight 345.4 g/mol
Molecular Formula C17H15N9
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass345.14504152 g/mol
Monoisotopic Mass345.14504152 g/mol
Topological Polar Surface Area91.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of lung cancer


Treatment of renal neoplasms


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

Global Sales Information

Do you need Business Intel? Ask us

ABOUT THIS PAGE

Savolitinib Manufacturers

A Savolitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Savolitinib, including repackagers and relabelers. The FDA regulates Savolitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Savolitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Savolitinib Suppliers

A Savolitinib supplier is an individual or a company that provides Savolitinib active pharmaceutical ingredient (API) or Savolitinib finished formulations upon request. The Savolitinib suppliers may include Savolitinib API manufacturers, exporters, distributors and traders.

Savolitinib GMP

Savolitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Savolitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Savolitinib GMP manufacturer or Savolitinib GMP API supplier for your needs.

Savolitinib CoA

A Savolitinib CoA (Certificate of Analysis) is a formal document that attests to Savolitinib's compliance with Savolitinib specifications and serves as a tool for batch-level quality control.

Savolitinib CoA mostly includes findings from lab analyses of a specific batch. For each Savolitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Savolitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Savolitinib EP), Savolitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Savolitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty