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Macsen Selenium

Synopsis

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Chemistry

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Also known as: 7782-49-2, Se, Selane, Selenium hydride, Selenium atom, Elemental selenium

Molecular Formula

Molecular Weight

78.97 g/mol

InChI Key

BUGBHKTXTAQXES-UHFFFAOYSA-N

FDA UNII

V91P54KPAM

Selenium is a nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C.

1 2D Structure

Selenium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

selenium

2.1.2 InChI

InChI=1S/Se

2.1.3 InChI Key

BUGBHKTXTAQXES-UHFFFAOYSA-N

2.1.4 Canonical SMILES

[Se]

2.2 Other Identifiers

2.2.1 UNII

V91P54KPAM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrogen Selenide

2. Hydrogen Selenide, 75se-labeled

3. Selane

2.3.2 Depositor-Supplied Synonyms

1. 7782-49-2

2. Se

3. Selane

4. Selenium Hydride

5. Selenium Atom

6. Elemental Selenium

7. Selenium Elemental

8. Selenium, Elemental

9. Selen

10. Selenium And Compounds

11. Selenium Dihydride

12. Selenium Metallicum

13. Selenium Powder

14. Selenium Compounds

15. Ci 77805

16. Dihydrogen Monoselenide

17. C.i. 77805

18. Mfcd00134090

19. Hydrogen Selenide, Anhydrous

20. H6241uj22b

21. Vandex

22. Gray Selenium

23. Selenium Alloy

24. Selenium Base

25. Selenium Dust

26. Colloidal Selenium

27. Selen [polish]

28. Selenium, Metallic

29. Selenium Homopolymer

30. Selenium, Colloidal

31. Caswell No. 732

32. Selenio

33. Selenium Anhydride

34. Electronic E-2

35. Ccris 4250

36. Hsdb 4493

37. Einecs 231-957-4

38. Un2658

39. Hydrogen Selenide (h2se)

40. Epa Pesticide Chemical Code 072001

41. Selenium Compounds, N.o.s.

42. Selenium Metal

43. Unii-h6241uj22b

44. Selenium And Selenium Compounds

45. Hsdb 548

46. Selenium (powder)

47. Einecs 231-978-9

48. Selenium Shot, 4n

49. Un2202

50. Un3283

51. Selenium (iv) Hydride

52. Hydrogen Selenid

53. B-traxim Se

54. Selenium [mi]

55. Selenium [vandf]

56. Selenium Hydride (seh2)

57. Selenium [mart.]

58. 34se

59. Selenium [who-dd]

60. Unii-v91p54kpam

61. Ec 231-957-4

62. Selenium, Powder, 99+%

63. Selenium Compound, N.o.s.

64. Selenium Powder, -200 Mesh

65. Selenium Powder, -325 Mesh

66. Selsaf 2000

67. Hydrogen Selenide [mi]

68. Selenium, P.a., 99.5%

69. Chembl1235891

70. Dtxsid9021261

71. Chebi:27568

72. Hsdb 6909

73. Selenium Nanopowder In Aq. Media

74. Selenium Metallicum [hpus]

75. Selenium, Elemental [hsdb]

76. Mfcd00011224

77. Db11135

78. Nsc-605850

79. Nsc-605851

80. Nsc-605852

81. N725

82. Q876

83. Selenium, Pellets, < 5mm, >=99.999%

84. E1457

85. Ft-0701285

86. Selenium Ingot/button, ~38mm (1.5in) Dia

87. Selenium And Selenium Compounds [iarc]

88. C01529

89. Selenium Powder [un2658] [keep Away From Food]

90. Selenium Shot, Amorphous, 1-5mm (0.04-0.20in)

91. Selenium, Foil, 25x25mm, Thickness 3mm, 99.95%

92. Hydrogen Selenide, Anhydrous [un2202] [poison Gas]

93. S008000000

94. Selenium, Plasma Standard Solution, Specpure, Se 10g/ml

95. Selenium, Shots, 99.99999% (7n), Diameter 2-4 Mm

96. Selenium, Aas Standard Solution, Specpure?, Se 1000?g/ml

97. Selenium, Pellets, <5 Mm, >=99.99% Trace Metals Basis

98. Selenium, Powder, -100 Mesh, >=99.5% Trace Metals Basis

99. Selenium, Powder, -100 Mesh, 99.99% Trace Metals Basis

100. Selenium, Plasma Standard Solution, Specpure?, Se 1000?g/ml

101. Selenium, Oil Based Standard Solution, Specpure?, Se 1000?g/g

102. Selenium, Plasma Standard Solution, Specpure?, Se 10,000?g/ml

103. Selenium Compound, N.o.s. [un3283] [poison, Keep Away From Food]

104. Selenium, Lump, 3 Mm Max. Lump Size, Weight 100 G, High Purity 99.999%

105. Selenium, Lump, 3 Mm Max. Lump Size, Weight 20 G, High Purity 99.999%

106. Selenium, Lump, 3 Mm Max. Lump Size, Weight 50 G, High Purity 99.999%

107. Selenium, Pellets, <5 Mm Particle Size, >=99.999% Trace Metals Basis

108. Selenium Shot, Amorphous, 2-6mm (0.08-0.2in), Puratronic(r), 99.999% (metals Basis)

109. Selenium, Powder, 250 Max. Part. Size (micron), Purity 99.95%, Weight 100 G

110. Selenium, Powder, 250 Max. Part. Size (micron), Weight 50 G, Purity 99.95%

111. Selenium, Powder, Max. Particle Size 250 Micron, Weight 200 G, Purity 99.95%

112. Selenium, Rod, 99.9999% (6n), Diameter 20 Mm, Length 55 Mm, Approx. 74g

113. Selenium, Rod, 99.99999% (7n), Diameter 20 Mm, Length 55 Mm, Approx. 74 G

114. Se0

115. Selenium Atomic Spectroscopy Standard Concentrate 1.00 G Se, 1.00 G/l, For 1l Standard Solution, Analytical Standard

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	Se
Molecular Weight	78.97 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	0
Exact Mass	79.91652 g/mol
Monoisotopic Mass	79.91652 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	1
Formal Charge	0
Complexity	0
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

/Experimental Therapy/ ... Se-methylselenocysteine (SeMSC), a naturally occurring organic Se product, is considered as one of the most effective chemopreventive selenocompounds. ... Compared with SeMSC, elemental Se at nano size (Nano-Se) possessed equal efficacy in increasing the activities of glutathione peroxidase, thioredoxin reductase, and glutathione S-transferase, but had much lower toxicity as indicated by median lethal dose, acute liver injury, survival rate, and short-term toxicity. /These/ results suggest that Nano-Se can serve as a potential chemopreventive agent with reduced risk of Se toxicity.

PMID:17728283 Zhang J et al; Toxicol Sci 101 (1): 22-31 (2008)

4.2 Drug Indication

For the supplementation of total parenteral nutrition to prevent hyposelenemia.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Selenium is incorporated into many different selenoproteins which serve various functions throughout the body.

5.2 ATC Code

D - Dermatologicals

D11 - Other dermatological preparations

D11A - Other dermatological preparations

D11AC - Medicated shampoos

D11AC03 - Selenium compounds

5.3 Absorption, Distribution and Excretion

Absorption

Oral bioavailability of 90% when given as L-selenomethionine. Tmax of 9.17h.

Route of Elimination

Mainly excreted in urine as 1beta-methylseleno-N-acetyl-d-galactosamine and trimethylselenonium. The amount excreted as 1beta-methylseleno-N-acetyl-d-galactosamine plateaus at doses around 2microg after which the amount excreted as trimethylselenonium increases. Some selenium is also excreted in feces when given orally.

Elemental selenium .. is poorly absorbed.

Norderg, G.F. et al; Handbook on the Toxicology of Metals 3rd ed. Academic Press, Burlington, MA. 2007, p. 789

... The distribution and retention of inhaled selenious acid and selenium metal aerosols ... similar in size and chemical form to selenium aerosols that may be produced during fossil fuel combustion /were examined/. Beagle dogs were given 10 to 61 ug Se/kg of body weight by inhalation. Aerosols generated for the inhalation exposures were also collected and instilled into the upper respiratory tracts or stomachs of additional dogs to measure systemic absorption at these sites. Selenium-75, incorporated into the aerosols, was used to determine the Se content in the whole animal, excreta, and individual tissues as a function of time. Virtually all inhaled selenious acid aerosol was rapidly absorbed into the blood from the lungs, gastrointestinal tract, and the nasal membranes. Selenium metal aerosols were less rapidly absorbed. Selenium that was absorbed into the blood was translocated to the liver, kidney, spleen, and heart. Selenium-75 in these organs had a biological half-life of 30 to 40 days. Approximately 50% of the deposited Se was eliminated with a biological half life of 1.2 days. Urine was the major route of excretion, accounting for 70 to 80% of the excreted Se. The long-term component of the whole-body retention function for both inhaled aerosols had a half-life of about 34 days and accounted for about 20% of the initial Se dose. ... Although absorption of selenious acid into blood following inhalation was more rapid than absorption of selenium metal, once absorbed the disposition of both compounds was similar. 6845362

PMID:6845362 Weissman SH et al; Toxicol Appl Pharmacol 67 (3): 331-7 (1983)

5.4 Metabolism/Metabolites

Selenium supplements are typically available in the form of sodium selenite which is metabolized to selenide through either glutathione conjugation and subsequent reduction by glutathione reductase enzymes or reduction by thioredoxin reductases. Selenide is further metabolized to selenocystein by cysteine synthases and to selenophosphate by selenophosphate synthases. Selenide is also metabolized progressively to methyl-selenol, dimethyl selenide, then trimethylselenonium. Selenocysteine is degraded to methyl-selenol, pyruvate and ammonia by cysteine beta lyase. Selenocystein reacts with oxygen to form selenocysteine selenoxide which spontaneously degrades to methylselenic acid, pyruvate and ammonia. Methylselenic acid can be converted to methylselenol via conjugation with thiol groups on proteins like glutathione.

Selenium compounds are in part reduced in the body to elemental selenium... Much is metabolized to dimethyl selenide which is excreted by the lungs, imparting a garlic-like odor.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 209

5.5 Biological Half-Life

Half life was observed to increase with chronic dosing time. For day 1-2 half life was 1.7 days. For day 2-3 half life was 3 days. For day 3-14 half life was 11.1 days.

Whole body: 140 days; [TDR, p. 1075]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 1075

The distribution and retention of inhaled selenious acid and selenium metal aerosols which were similar in size and chemical form to selenium aerosols that may be produced during fossil fuel combustion /was studied/. Beagle dogs were given 10 to 61 ug Se/kg of body weight by inhalation. ... Approximately 50% of the deposited Se was eliminated with a biological half life of 1.2 days. ... The long-term component of the whole-body retention function for both inhaled aerosols had a half-life of about 34 days and accounted for about 20% of the initial Se dose.

PMID:6845362 Weissman SH et al; Toxicol Appl Pharmacol 67 (3): 331-7 (1983)

5.6 Mechanism of Action

Selenium is first metabolized to selenophosphate and selenocysteine. Selenium incorporation is genetically encoded through the RNA sequence UGA. This sequence is recognized by RNA ste loop structures called selenocysteine inserting sequences (SECIS). These structures require the binding of SECIS binding proteins (SBP-2) to recognize selenocystiene. The specialized tRNA is first bound to a serine residue which is then enzymatically processed to a selylcysteyl-tRNA by selenocystiene sythase using selenophosphate as a selenium donor. Other unidentified proteins are required as part of the binding of this tRNA to the ribosome. Selenoproteins appear to be necessary for life as mice with the specialized tRNA gene knocked out exhibited early embryonic lethality. The most important selenoproteins seem to be the glutathione peroxidases and thioredoxin reductases which are part of the body's defenses againts reactive oxygen species (ROS). The importance of selenium in these anti-oxidant proteins has been implicated in the reduction of atherosclerosis by preventing the oxidation of low density lipoprotein. Selenium supplementation is also being investigated in the prevention of cancer and has been suggested to be beneficial to immune function.

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Macsen Labs

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THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704652200,"product":"SELENIUM COMPOUND N.O.S.L-SELENOMETHIONINE USP B\/N P2311KB112MFG DT.NOV 2023 EXP DT.OCT 2026","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"LOS ANGELES","customer":"TO THE ORDER OF","customerCountry":"UNITED STATES","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"705","totalValueFC":"27588.7","currency":"USD","unitRateINR":57323.574999999997,"date":"08-Jan-2024","totalValueINR":"2292943","totalValueInUsd":"27588.7","indian_port":"Bombay Air","hs_no":"29319090","bill_no":"6608750","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709663400,"product":"SELENIUM COMPOUND N.O.S.L-SELENOMETHIONINE USP BATCH NO-P2402KB024 MFG-FEB 2024,EXP-JAN 2027","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"LOS ANGELES","customer":"TO THE ORDER OF","customerCountry":"UNITED STATES","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"680","totalValueFC":"26915.3","currency":"USD","unitRateINR":55873.394999999997,"date":"06-Mar-2024","totalValueINR":"2234935.8","totalValueInUsd":"26915.3","indian_port":"Bombay Air","hs_no":"29319090","bill_no":"8098618","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710873000,"product":"SELENIUM COMPOUND, N.O.S L-SELENOMETHIONINE USP B\/NO:P2403KB030MFG DT:MAR 2024 EXP DT:FEB 2027","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"LOS ANGELES","customer":"TO THE ORDER OF","customerCountry":"UNITED STATES","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"680","totalValueFC":"66182.1","currency":"USD","unitRateINR":54954.809999999998,"date":"20-Mar-2024","totalValueINR":"5495481","totalValueInUsd":"66182.1","indian_port":"Bombay Air","hs_no":"29319090","bill_no":"8495548","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711564200,"product":"SELENIUM COMPOUND, N.O.S. (L-SELENOMETHIONINE USP)","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"ROTTERDAM","customer":"N\/A","customerCountry":"NETHERLANDS","quantity":"504.00","actualQuantity":"504","unit":"KGS","unitRateFc":"325","totalValueFC":"161998.3","currency":"USD","unitRateINR":26689.799603174604,"date":"28-Mar-2024","totalValueINR":"13451659","totalValueInUsd":"161998.3","indian_port":"JNPT","hs_no":"29319090","bill_no":"8708539","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715020200,"product":"L-SELENOMETHIONINE SELENIUM 0.5% MD 60 MESH BATCH NO-N24125","address":"N0. 991, SWAMY NARAYANA APTS,","city":"6TH BLOCK, VIDYARANYAPURA BANGALORE","supplier":"NOVEL NUTRIENTSS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"VIENNA","customer":"CHEMOPHARMA GMBH","customerCountry":"AUSTRIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"112","totalValueFC":"1169.4","currency":"USD","unitRateINR":9747.1620000000003,"date":"07-May-2024","totalValueINR":"97471.62","totalValueInUsd":"1169.4","indian_port":"Bangalore Air","hs_no":"29319090","bill_no":"9684551","productDescription":"API","marketType":"REGULATED MARKET","country":"AUSTRIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0. 991, SWAMY NARAYANA APTS,, 6TH BLOCK, VIDYARANYAPURA BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723746600,"product":"SELENIUM COMPOUND,N.O.S.,L-SELENOMETHIONINE HAZARD CLASS 6.1 UN NUMBER 3283 BTNO:P2406KB079, MRG:JUN2024 EXP 05\/27","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"BRUSSELS","customer":"TO THE ORDER OF","customerCountry":"BELGIUM","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"930","totalValueFC":"2520.5","currency":"USD","unitRateINR":70471.333333333328,"date":"16-Aug-2024","totalValueINR":"211414","totalValueInUsd":"2520.5","indian_port":"Bombay Air","hs_no":"29319090","bill_no":"3263225","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724697000,"product":"SELENIUM COMPOUND, N.O.S.L-SELENOMETHIONINE USP B\/N:P2407KB091MFG DT: JUL 2024 EXP DT: JUN 2027","address":"PLOT NO. : T-100, MIDC-TARAPUR,","city":"DIST - THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. 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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

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Europe

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Excipients by Applications

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Fillers, Diluents & Binders

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Lubricants & Glidants

Disintegrants & Superdisintegrants

Co-Processed Excipients

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Topical

Chewable & Orodispersible Aids

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EXCIPIENTS

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ABOUT THIS PAGE

Selenium Manufacturers

A Selenium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Selenium, including repackagers and relabelers. The FDA regulates Selenium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Selenium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Selenium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Selenium Suppliers

A Selenium supplier is an individual or a company that provides Selenium active pharmaceutical ingredient (API) or Selenium finished formulations upon request. The Selenium suppliers may include Selenium API manufacturers, exporters, distributors and traders.

click here to find a list of Selenium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Selenium USDMF

A Selenium DMF (Drug Master File) is a document detailing the whole manufacturing process of Selenium active pharmaceutical ingredient (API) in detail. Different forms of Selenium DMFs exist exist since differing nations have different regulations, such as Selenium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Selenium DMF submitted to regulatory agencies in the US is known as a USDMF. Selenium USDMF includes data on Selenium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Selenium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Selenium suppliers with USDMF on PharmaCompass.

Selenium GMP

Selenium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Selenium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Selenium GMP manufacturer or Selenium GMP API supplier for your needs.

Selenium CoA

A Selenium CoA (Certificate of Analysis) is a formal document that attests to Selenium's compliance with Selenium specifications and serves as a tool for batch-level quality control.

Selenium CoA mostly includes findings from lab analyses of a specific batch. For each Selenium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Selenium may be tested according to a variety of international standards, such as European Pharmacopoeia (Selenium EP), Selenium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Selenium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

11 API Suppliers

4 USDMF

7 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

115 FDF Dossiers

3 Europe

92 South Africa

20 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

89 Fillers, Diluents & Binders

60 Coating Systems & Additives

40 Direct Compression

35 Thickeners and Stabilizers

34 Controlled & Modified Release

33 Solubilizers

28 Taste Masking

28 Parenteral

27 Granulation

24 Lubricants & Glidants

22 Disintegrants & Superdisintegrants

21 Co-Processed Excipients

18 Film Formers & Plasticizers

17 Topical

16 Chewable & Orodispersible Aids

12 Emulsifying Agents

9 API Stability Enhancers

9 Empty Capsules

7 Rheology Modifiers