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    Chemistry

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    Also known as: Selenium sulphide, 7446-34-6, Selenium sulfide (ses), Selensulfid, Selensulfid [german], Ccris 554
    Molecular Formula
    SSe
    Molecular Weight
    111.04  g/mol
    InChI Key
    VIDTVPHHDGRGAF-UHFFFAOYSA-N
    Selenium Sulfide
    1 2D Structure

    Selenium Sulfide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 InChI
    InChI=1S/SSe/c1-2
    2.1.2 InChI Key
    VIDTVPHHDGRGAF-UHFFFAOYSA-N
    2.1.3 Canonical SMILES
    S=[Se]
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Selenium Sulphide

    2. 7446-34-6

    3. Selenium Sulfide (ses)

    4. Selensulfid

    5. Selensulfid [german]

    6. Ccris 554

    7. Hsdb 679

    8. Nci-c50033

    9. Unii-j90wfr7zff

    10. Selenium Sulfide Red Powder

    11. Selenosulfide

    12. Abbotselsun

    13. Caspiselenium

    14. Selensulfur

    15. Selenenyl Sulfide

    16. Selenium Sulfide Usp

    17. Ses2

    18. Dtxsid9021265

    19. 446s346

    20. Q27430357

    2.2.2 Other Synonyms

    1. Selsun

    2. Selenium Disulfide

    3. Lenium

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 111.04 g/mol
    Molecular Formula SSe
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass111.88859 g/mol
    Monoisotopic Mass111.88859 g/mol
    Topological Polar Surface Area32.1 Ų
    Heavy Atom Count2
    Formal Charge0
    Complexity2
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameSelenium sulfide
    PubMed HealthSelenium Sulfide (On the skin)
    Drug ClassesAntiseborrheic, Dermatological Agent
    Drug LabelEach mL contains 23 mg of selenium sulfide in a vehicle consisting of: ammonium lauryl sulfate, caprylic capric triglyceride, chromium oxide green, citric acid, cocamidopropyl betaine, D&C yellow #8, diazolidinyl urea, disodium EDTA, FD&C red #40,
    Active IngredientSelenium sulfide
    Dosage FormLotion/shampoo
    RouteTopical
    Strength2.5%
    Market StatusPrescription
    CompanyWockhardt; Perrigo New York

    2 of 4  
    Drug NameSelsun
    Active IngredientSelenium sulfide
    Dosage FormLotion/shampoo
    RouteTopical
    Strength2.5%
    Market StatusPrescription
    CompanyChattem

    3 of 4  
    Drug NameSelenium sulfide
    PubMed HealthSelenium Sulfide (On the skin)
    Drug ClassesAntiseborrheic, Dermatological Agent
    Drug LabelEach mL contains 23 mg of selenium sulfide in a vehicle consisting of: ammonium lauryl sulfate, caprylic capric triglyceride, chromium oxide green, citric acid, cocamidopropyl betaine, D&C yellow #8, diazolidinyl urea, disodium EDTA, FD&C red #40,
    Active IngredientSelenium sulfide
    Dosage FormLotion/shampoo
    RouteTopical
    Strength2.5%
    Market StatusPrescription
    CompanyWockhardt; Perrigo New York

    4 of 4  
    Drug NameSelsun
    Active IngredientSelenium sulfide
    Dosage FormLotion/shampoo
    RouteTopical
    Strength2.5%
    Market StatusPrescription
    CompanyChattem

    4.2 Therapeutic Uses

    /Experimental Therapy/ ... This randomized, double-blind, placebo-controlled intervention study included 725 institutionalized elderly patients (>65 years) from 25 geriatric centers in France. Patients received an oral daily supplement of nutritional doses of trace elements (zinc and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) or a placebo within a 2 x 2 factorial design for 2 years. ... Correction of specific nutrient deficiencies was observed after 6 months of supplementation and was maintained for the first year, during which there was no effect of any treatment on delayed-type hypersensitivity skin response. Antibody titers after influenza vaccine were higher in groups that received trace elements alone or associated with vitamins, whereas the vitamin group had significantly lower antibody titers (P<.05). The number of patients without respiratory tract infections during the study was higher in groups that received trace elements (P = .06). Supplementation with neither trace elements nor vitamins significantly reduced the incidence of urogenital infections. Survival analysis for the 2 years did not show any differences between the 4 groups. CONCLUSIONS: Low-dose supplementation of zinc and selenium provides significant improvement in elderly patients by increasing the humoral response after vaccination and could have considerable public health importance by reducing morbidity from respiratory tract infections.

    PMID:10218756 Girodon F et al; Arch Intern Med 159 (7): 748-54 (1999)

    /Experimental Therapy/ Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow-up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.

    PMID:20735804 Chen C et al; Pediatr Dermatol 27 (5): 459-62 (2010)

    4.3 Drug Warning

    Two cases of new chemicals causing yellow hair shaft discoloration are reported. The chemicals include selenium sulfide 2.5% shampoo and dihydroxyacetone.

    PMID:18664164 Prevost N, English JC III; J Drugs Dermatol 7 (77): 689-91 (2008)

    ... Ingestion is hazardous. If swallowed, avoid oils or alcohol which may promote absorption.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-129

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    D - Dermatologicals

    D01 - Antifungals for dermatological use

    D01A - Antifungals for topical use

    D01AE - Other antifungals for topical use

    D01AE13 - Selenium sulfide

    5.2 Absorption, Distribution and Excretion

    The percutaneous absorption of selenium sulfide was ... studied in /a/ groups who applied the drug to the entire skin for five minutes for eighteen days. Fluorimetric analysis of urinary samples collected on the third and thirteenth days of treatment revealed no significant increase in the excretion of selenium as compared to pretreatment levels. Systemic toxicity was not observed in any of the patients treated. The results suggest that the selenium sulfide is absorbed poorly from the skin...

    PMID:988451 Costa Martins JE et al; Med Cutan Ibero Lat Am 4 (2): 137-41 (1976)

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    [{"dataSource":"API Export","activeIngredients":"SELENIUM SULFIDE","year":"2021","qtr":"Q1","strtotime":1616783400,"product":"LABORATORY CHEMICALS- SELENIUM SULFIDE (INV NO . 1314008901 DTD : 25.03.2021)","address":"23, VADHANI INDUSTRIAL ESTATE,L B S MARG, GHATKOPAR,","city":"MUMBAI, MAHARASHTRA","supplier":"HIMEDIA LABORATORIES","supplierCountry":"INDIA","foreign_port":"COLOMBO","customer":"ANALYTICAL INSTRUMENTS PVT LTD","customerCountry":"SRI LANKA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"399.9","totalValueFC":"197.9","currency":"USD","unitRateINR":28810.639999999999,"date":"27-Mar-2021","totalValueINR":"14405.32","totalValueInUsd":"197.9","indian_port":"BOMBAY AIR","hs_no":"29130090","bill_no":"9708040","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SRI LANKA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"23, VADHANI INDUSTRIAL ESTATE,L B S MARG, GHATKOPAR,, MUMBAI, MAHARASHTRA","customerAddress":""}]
    27-Mar-2021
    27-Mar-2021
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