/Experimental Therapy/ ... This randomized, double-blind, placebo-controlled intervention study included 725 institutionalized elderly patients (>65 years) from 25 geriatric centers in France. Patients received an oral daily supplement of nutritional doses of trace elements (zinc and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) or a placebo within a 2 x 2 factorial design for 2 years. ... Correction of specific nutrient deficiencies was observed after 6 months of supplementation and was maintained for the first year, during which there was no effect of any treatment on delayed-type hypersensitivity skin response. Antibody titers after influenza vaccine were higher in groups that received trace elements alone or associated with vitamins, whereas the vitamin group had significantly lower antibody titers (P<.05). The number of patients without respiratory tract infections during the study was higher in groups that received trace elements (P = .06). Supplementation with neither trace elements nor vitamins significantly reduced the incidence of urogenital infections. Survival analysis for the 2 years did not show any differences between the 4 groups. CONCLUSIONS: Low-dose supplementation of zinc and selenium provides significant improvement in elderly patients by increasing the humoral response after vaccination and could have considerable public health importance by reducing morbidity from respiratory tract infections.

/Experimental Therapy/ Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow-up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.

Molecular Formula	SSe
Molecular Weight	111.04 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	111.88859 g/mol
Monoisotopic Mass	111.88859 g/mol
Topological Polar Surface Area	32.1 Å²
Heavy Atom Count	2
Formal Charge	0
Complexity	2
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 4
Drug Name	Selenium sulfide
PubMed Health	Selenium Sulfide (On the skin)
Drug Classes	Antiseborrheic, Dermatological Agent
Drug Label	Each mL contains 23 mg of selenium sulfide in a vehicle consisting of: ammonium lauryl sulfate, caprylic capric triglyceride, chromium oxide green, citric acid, cocamidopropyl betaine, D&C yellow #8, diazolidinyl urea, disodium EDTA, FD&C red #40,
Active Ingredient	Selenium sulfide
Dosage Form	Lotion/shampoo
Route	Topical
Strength	2.5%
Market Status	Prescription
Company	Wockhardt; Perrigo New York

2 of 4
Drug Name	Selsun
Active Ingredient	Selenium sulfide
Dosage Form	Lotion/shampoo
Route	Topical
Strength	2.5%
Market Status	Prescription
Company	Chattem

3 of 4
Drug Name	Selenium sulfide
PubMed Health	Selenium Sulfide (On the skin)
Drug Classes	Antiseborrheic, Dermatological Agent
Drug Label	Each mL contains 23 mg of selenium sulfide in a vehicle consisting of: ammonium lauryl sulfate, caprylic capric triglyceride, chromium oxide green, citric acid, cocamidopropyl betaine, D&C yellow #8, diazolidinyl urea, disodium EDTA, FD&C red #40,
Active Ingredient	Selenium sulfide
Dosage Form	Lotion/shampoo
Route	Topical
Strength	2.5%
Market Status	Prescription
Company	Wockhardt; Perrigo New York

4 of 4
Drug Name	Selsun
Active Ingredient	Selenium sulfide
Dosage Form	Lotion/shampoo
Route	Topical
Strength	2.5%
Market Status	Prescription
Company	Chattem

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers

5 USDMF

4 EU WC

5 NDC API

2 VMF

8 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers

7 FDA Orange Book

4 Europe

1 Australia

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1 Evonik

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6 DKSH

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1 Gangwal Healthcare

4 Nanjing Well Pharmaceutical

1 ACG Worldwide

8 Actylis

2 Aeon Procare

1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

12 BASF

1 BioSpectra

13 Corel Pharma Chem

2 Finar

4 Gangwal Chemicals

8 Ideal Cures Pvt Ltd

12 Kerry

4 Kima Chemical

6 Lonza Capsugel

3 Lubrizol Life Science Health

6 Microlex e.U

1 Novo Excipients

2 Pluviaendo

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

4 Roquette

11 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Sigachi Industries

3 The Dow Chemical Company

1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

53 Coating Systems & Additives

26 Topical

24 Controlled & Modified Release

17 Thickeners and Stabilizers

14 Film Formers & Plasticizers

14 Solubilizers

9 Rheology Modifiers

9 Parenteral

7 Fillers, Diluents & Binders

7 Granulation

7 Direct Compression

7 Lubricants & Glidants

6 Surfactant & Foaming Agents

5 Empty Capsules

5 API Stability Enhancers

4 Co-Processed Excipients

4 Vegetarian Capsules

4 Taste Masking

4 Coloring Agents

3 Emulsifying Agents

2 Disintegrants & Superdisintegrants

1 Chewable & Orodispersible Aids

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