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    Chemistry

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    Also known as: 98418-47-4, Metroprolol succinate, Selozok, Toprol xl, Metoprolol (succinate), Seloken-zok
    Molecular Formula
    C34H56N2O10
    Molecular Weight
    652.8  g/mol
    InChI Key
    RGHAZVBIOOEVQX-UHFFFAOYSA-N
    FDA UNII
    TH25PD4CCB
    Metoprolol Succinate
    A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
    1 2D Structure

    Metoprolol Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
    2.1.2 InChI
    InChI=1S/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    RGHAZVBIOOEVQX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    TH25PD4CCB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Beloc Duriles

    2. Beloc-duriles

    3. Betaloc

    4. Betaloc Astra

    5. Betaloc-astra

    6. Betalok

    7. Cgp 2175

    8. Cgp-2175

    9. Cgp2175

    10. H 93 26

    11. H 93-26

    12. H 9326

    13. Lopressor

    14. Metoprolol

    15. Metoprolol Cr Xl

    16. Metoprolol Cr-xl

    17. Metoprolol Tartrate

    18. Seloken

    19. Spesicor

    20. Spesikor

    21. Toprol

    22. Toprol Xl

    23. Toprol-xl

    2.3.2 Depositor-Supplied Synonyms

    1. 98418-47-4

    2. Metroprolol Succinate

    3. Selozok

    4. Toprol Xl

    5. Metoprolol (succinate)

    6. Seloken-zok

    7. H 93/26 Succinate

    8. Toprol-xl

    9. Metoprolol Hemisuccinate

    10. Butanedioic Acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    11. Th25pd4ccb

    12. Spesicor Dos

    13. Seloken Zoc

    14. Beloc- Zok

    15. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, Butanedioate (2:1) (salt)

    16. Metoprolol Succinate [usan]

    17. Unii-th25pd4ccb

    18. Metoprololsuccinate

    19. Metoprolol Succinate [usan:usp]

    20. Toprol Xl (tn)

    21. Metoprolol Succinate Extended-release Tablets

    22. Metoprolol Succinate (usp)

    23. (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

    24. Dsstox_cid_28652

    25. Dsstox_rid_82922

    26. Dsstox_gsid_48726

    27. Schembl40916

    28. Chebi:6905

    29. Chembl2356097

    30. Dtxsid9048726

    31. Metoprolol Succinate [mi]

    32. Hms3886g21

    33. Bcp02473

    34. Metoprolol Succinate [vandf]

    35. Tox21_113155

    36. Hy-17503a

    37. Metoprolol Succinate [mart.]

    38. Mfcd23115896

    39. S5341

    40. Metoprolol Succinate [usp-rs]

    41. Metoprolol Succinate [who-dd]

    42. 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; Succinic Acid

    43. Akos015856332

    44. Bcp9000922

    45. Ccg-270331

    46. Cs-3158

    47. Ks-1241

    48. Ac-26570

    49. Metoprolol Succinate [ep Impurity]

    50. Metoprolol Succinate [orange Book]

    51. Metoprolol Succinate [ep Monograph]

    52. Cas-98418-47-4

    53. Metoprolol Succinate [usp Monograph]

    54. Ft-0628933

    55. Dutoprol Component Metoprolol Succinate

    56. D00635

    57. Metoprolol Succinate Component Of Dutoprol

    58. 418m474

    59. A845856

    60. Q-201401

    61. Q27289962

    62. Metoprolol Succinate, United States Pharmacopeia (usp) Reference Standard

    63. Bis(1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol); Butanedioic Acid

    64. Butanedioic Acid,1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

    65. (+/-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol Succinate (2:1) (salt)

    66. 123245-49-8

    67. 2-propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+/-)-, Butanedioate (2:1) (salt)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 652.8 g/mol
    Molecular Formula C34H56N2O10
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count21
    Exact Mass652.39349599 g/mol
    Monoisotopic Mass652.39349599 g/mol
    Topological Polar Surface Area176 Ų
    Heavy Atom Count46
    Formal Charge0
    Complexity308
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMetoprolol succinate
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

    2 of 4  
    Drug NameToprol-xl
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyAstrazeneca

    3 of 4  
    Drug NameMetoprolol succinate
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Actavis Labs Fl; Reddys; Dr Reddys Labs

    4 of 4  
    Drug NameToprol-xl
    Drug LabelTOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of meto...
    Active IngredientMetoprolol succinate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 25mg tartrate; eq 50mg tartrate; eq 200mg tartrate; eq 100mg tartrate
    Market StatusPrescription
    CompanyAstrazeneca

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic beta-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

    API Reference Price

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REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"360.00","actualQuantity":"360","unit":"KGS","unitRateFc":"50","totalValueFC":"18215","currency":"USD","unitRateINR":"4217.5","date":"10-May-2024","totalValueINR":"1518300","totalValueInUsd":"18215","indian_port":"Hyderabad Air","hs_no":"29221990","bill_no":"3413891","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/. 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REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"135.00","actualQuantity":"135","unit":"KGS","unitRateFc":"71.7","totalValueFC":"9788.8","currency":"USD","unitRateINR":"6082","date":"19-Aug-2024","totalValueINR":"821070","totalValueInUsd":"9788.8","indian_port":"Vizag-EPZ\/SEZ","hs_no":"29221990","bill_no":"5122750","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pellets","supplierPort":"VISAKHAPATNAM SEZ","supplierAddress":"PLOT NO V PHASE-II DUVVADA VISAKHAPATNAM SDNF India","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726165800,"product":"METOPROLOL SUCCINATE","address":"2ND FLOOR, CHINUBHAI CENTRE,","city":"AHMEDABAD, GUJARAT","supplier":"MOEHS IBERICA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1075.00","actualQuantity":"1075","unit":"KGS","unitRateFc":"57","totalValueFC":"62078.4","currency":"USD","unitRateINR":"4839.3","date":"13-Sep-2024","totalValueINR":"5202247.5","totalValueInUsd":"62078.4","indian_port":"JNPT","hs_no":"29420090","bill_no":"5586209","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/. 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    18-Jan-2021
    29-Mar-2025
    KGS
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    Average Price (USD/KGS)

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

    USFDA APPLICATION NUMBER - 19962

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 100MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 200MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 25MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 50MG TARTRATE

    USFDA APPLICATION NUMBER - 210428

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 100MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 25MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 12.5MG;EQ 50MG TARTRATE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21956

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    ABOUT THIS PAGE

    Looking for 123245-49-8 / Metoprolol Succinate API manufacturers, exporters & distributors?

    Metoprolol Succinate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Metoprolol Succinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Metoprolol Succinate manufacturer or Metoprolol Succinate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Metoprolol Succinate manufacturer or Metoprolol Succinate supplier.

    PharmaCompass also assists you with knowing the Metoprolol Succinate API Price utilized in the formulation of products. Metoprolol Succinate API Price is not always fixed or binding as the Metoprolol Succinate Price is obtained through a variety of data sources. The Metoprolol Succinate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Metoprolol Succinate

    Synonyms

    98418-47-4, Metroprolol succinate, Selozok, Toprol xl, Metoprolol (succinate), Seloken-zok

    Cas Number

    123245-49-8

    Unique Ingredient Identifier (UNII)

    TH25PD4CCB

    About Metoprolol Succinate

    A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.

    Seloken ZOC Manufacturers

    A Seloken ZOC manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Seloken ZOC, including repackagers and relabelers. The FDA regulates Seloken ZOC manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Seloken ZOC API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Seloken ZOC manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Seloken ZOC Suppliers

    A Seloken ZOC supplier is an individual or a company that provides Seloken ZOC active pharmaceutical ingredient (API) or Seloken ZOC finished formulations upon request. The Seloken ZOC suppliers may include Seloken ZOC API manufacturers, exporters, distributors and traders.

    click here to find a list of Seloken ZOC suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Seloken ZOC USDMF

    A Seloken ZOC DMF (Drug Master File) is a document detailing the whole manufacturing process of Seloken ZOC active pharmaceutical ingredient (API) in detail. Different forms of Seloken ZOC DMFs exist exist since differing nations have different regulations, such as Seloken ZOC USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Seloken ZOC DMF submitted to regulatory agencies in the US is known as a USDMF. Seloken ZOC USDMF includes data on Seloken ZOC's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Seloken ZOC USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Seloken ZOC suppliers with USDMF on PharmaCompass.

    Seloken ZOC CEP

    A Seloken ZOC CEP of the European Pharmacopoeia monograph is often referred to as a Seloken ZOC Certificate of Suitability (COS). The purpose of a Seloken ZOC CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Seloken ZOC EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Seloken ZOC to their clients by showing that a Seloken ZOC CEP has been issued for it. The manufacturer submits a Seloken ZOC CEP (COS) as part of the market authorization procedure, and it takes on the role of a Seloken ZOC CEP holder for the record. Additionally, the data presented in the Seloken ZOC CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Seloken ZOC DMF.

    A Seloken ZOC CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Seloken ZOC CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Seloken ZOC suppliers with CEP (COS) on PharmaCompass.

    Seloken ZOC WC

    A Seloken ZOC written confirmation (Seloken ZOC WC) is an official document issued by a regulatory agency to a Seloken ZOC manufacturer, verifying that the manufacturing facility of a Seloken ZOC active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Seloken ZOC APIs or Seloken ZOC finished pharmaceutical products to another nation, regulatory agencies frequently require a Seloken ZOC WC (written confirmation) as part of the regulatory process.

    click here to find a list of Seloken ZOC suppliers with Written Confirmation (WC) on PharmaCompass.

    Seloken ZOC NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Seloken ZOC as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Seloken ZOC API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Seloken ZOC as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Seloken ZOC and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Seloken ZOC NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Seloken ZOC suppliers with NDC on PharmaCompass.

    Seloken ZOC GMP

    Seloken ZOC Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Seloken ZOC GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Seloken ZOC GMP manufacturer or Seloken ZOC GMP API supplier for your needs.

    Seloken ZOC CoA

    A Seloken ZOC CoA (Certificate of Analysis) is a formal document that attests to Seloken ZOC's compliance with Seloken ZOC specifications and serves as a tool for batch-level quality control.

    Seloken ZOC CoA mostly includes findings from lab analyses of a specific batch. For each Seloken ZOC CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Seloken ZOC may be tested according to a variety of international standards, such as European Pharmacopoeia (Seloken ZOC EP), Seloken ZOC JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Seloken ZOC USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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