Find Senicapoc manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 289656-45-7, 2,2-bis(4-fluorophenyl)-2-phenylacetamide, Ica-17043, Senicapoc (usan), Senicapoc [usan], Ts6g201a6q
Molecular Formula
C20H15F2NO
Molecular Weight
323.3  g/mol
InChI Key
SCTZUZTYRMOMKT-UHFFFAOYSA-N
FDA UNII
TS6G201A6Q

Senicapoc
Senicapoc is an orally bioavailable inhibitor of the calcium-activated potassium channel KCa3.1 (Gardos channel; KCNN4; IK-1; SK4), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, senicapoc targets, binds to and inhibits KCa3.1. KCa3.1 regulates membrane potential and calcium signaling in a variety of cells including erythrocytes, activated T and B cells, macrophages, microglia, vascular endothelium, epithelia, and proliferating vascular smooth muscle cells and fibroblasts. The inhibition of KCa3.1 may prevent erythrocyte dehydration in sickle cell disease, reduce fluid secretion, fluid retention and inflammation in the lungs in acute respiratory distress syndrome (ARDS), and reduce inflammation and immune responses in various other diseases such as neuroinflammation in Alzheimer's disease. Senicapoc exhibits good brain penetration.
1 2D Structure

Senicapoc

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,2-bis(4-fluorophenyl)-2-phenylacetamide
2.1.2 InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
2.1.3 InChI Key
SCTZUZTYRMOMKT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
TS6G201A6Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bis(4-fluorophenyl)phenylacetamide

2. Ica 17043

3. Ica-17043

4. Ica17043

2.3.2 Depositor-Supplied Synonyms

1. 289656-45-7

2. 2,2-bis(4-fluorophenyl)-2-phenylacetamide

3. Ica-17043

4. Senicapoc (usan)

5. Senicapoc [usan]

6. Ts6g201a6q

7. Pf-05416266

8. Benzeneacetamide, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-

9. Bis(4-fluorophenyl)phenylacetamide

10. Senicapoc [usan:inn]

11. Ica 17043

12. Unii-ts6g201a6q

13. 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

14. 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide

15. Senicapoc [inn]

16. Senicapoc [mart.]

17. Senicapoc [who-dd]

18. Chembl405821

19. Gtpl2331

20. Schembl1443805

21. Amy2744

22. Dtxsid60276906

23. Hms3741e13

24. Act06676

25. Bcp14507

26. Zinc3816408

27. Bbl102413

28. Bdbm50371391

29. Mfcd09027349

30. Stl556215

31. Akos007930800

32. Cs-0294

33. Db06280

34. 4-methyl-1h-pyrrole-2-carboxylic?acid

35. Hy-50694

36. Ms-20434

37. Db-003217

38. Ft-0660387

39. 2,2-bis(4-fluorophenyl)-2-phenyl-ethanamide

40. C74487

41. D06640

42. 656f457

43. A822267

44. A904983

45. Au-004/43508060

46. Q7450628

47. 4-fluoro-a-(4-fluorophenyl)-a-phenyl-benzeneacetamide

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 323.3 g/mol
Molecular Formula C20H15F2NO
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass323.11217043 g/mol
Monoisotopic Mass323.11217043 g/mol
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in anemia (sickle cell) and asthma.


ABOUT THIS PAGE

Senicapoc Manufacturers

A Senicapoc manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Senicapoc, including repackagers and relabelers. The FDA regulates Senicapoc manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Senicapoc API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Senicapoc Suppliers

A Senicapoc supplier is an individual or a company that provides Senicapoc active pharmaceutical ingredient (API) or Senicapoc finished formulations upon request. The Senicapoc suppliers may include Senicapoc API manufacturers, exporters, distributors and traders.

Senicapoc GMP

Senicapoc Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Senicapoc GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Senicapoc GMP manufacturer or Senicapoc GMP API supplier for your needs.

Senicapoc CoA

A Senicapoc CoA (Certificate of Analysis) is a formal document that attests to Senicapoc's compliance with Senicapoc specifications and serves as a tool for batch-level quality control.

Senicapoc CoA mostly includes findings from lab analyses of a specific batch. For each Senicapoc CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Senicapoc may be tested according to a variety of international standards, such as European Pharmacopoeia (Senicapoc EP), Senicapoc JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Senicapoc USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty