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Also known as: Sennoside g, Pursennid (tn), Sennosides (usp), 66575-30-2, Senna-lax, Sennoside a&b
Molecular Formula
C42H38O20
Molecular Weight
862.7  g/mol
InChI Key
IPQVTOJGNYVQEO-JLDSCGAUSA-N

Sennosides
Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.
1 2D Structure

Sennosides

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
9-[2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25?,26?,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
2.1.3 InChI Key
IPQVTOJGNYVQEO-JLDSCGAUSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
2.1.5 Isomeric SMILES
C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Pursennid

2. Senna Glycoside

3. Sennoside A And B

4. Sennoside A And B, Calcium Salt

5. Sennoside A Calcium

6. Sennoside A Calcium And Sennoside B Calcium

7. Sennoside A+b Calcium

8. Sennoside A, Calcium Salt

9. Sennoside A, Calcium Salt (1:1)

10. Sennoside B Calcium

11. Sennoside B, Calcium Salt

12. Sennosides

13. Sennosides A And B

14. Sennosides A And B Acids

15. Senokot

2.2.2 Depositor-Supplied Synonyms

1. Sennoside G

2. Pursennid (tn)

3. Sennosides (usp)

4. 66575-30-2

5. Senna-lax

6. Sennoside A&b

7. 9-[2-carboxy-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracene-2-carboxylic Acid

8. 517-43-1

9. Sennoside (jan)

10. Sennoside A1

11. Sennoside A1 , Hplc Grade

12. Schembl11140501

13. Chebi:34974

14. (9,9'-bianthracene)-2,2'-dicarboxylic Acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (r*,r*)-

15. Mfcd32068370

16. D02171

17. 135s582

18. Q27116343

19. [9,9'-bianthracene]-2,2'-dicarboxylic Acid, 5,5'-bis(.beta.-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9r,9's)-

20. 5,5'-bis(beta-d-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic Acid

21. 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic Acid

22. 9-[2-carboxy-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9h-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9h-anthracene-2-carboxylic Acid

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 862.7 g/mol
Molecular Formula C42H38O20
XLogP31.2
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count20
Rotatable Bond Count9
Exact Mass862.19564360 g/mol
Monoisotopic Mass862.19564360 g/mol
Topological Polar Surface Area348 Ų
Heavy Atom Count62
Formal Charge0
Complexity1550
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)


API SUPPLIERS

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Alchem International Private Ltd

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Zeon Pharma Industries India Pvt L...

India

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Virtual BoothZeon Pharma is a manufacturer and supplier of APIs & Intermediates.

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Pharm-RX Chemical

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Alchem International Private Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothAlchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

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Alchem International Private Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothAlchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

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Kothari Phytochemicals & Industrie...

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Chemical Resources

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Shashi Phytochemical Industries

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Shashi Phytochemical Industries

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ALPS Pharmaceutical Ind. Co. Ltd.

Japan

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ALPS Pharmaceutical Ind. Co. Ltd.

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ALPS Pharmaceutical Ind. Co. Ltd.

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ALPS Pharmaceutical Ind. Co. Ltd.

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API Reference Price

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PARK","city":"MUMBAI","supplier":"COSMO LIFE SCIENCE","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"TO THE ORDER OF","customerCountry":"EGYPT","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"196.5","totalValueFC":"19136.3","currency":"USD","unitRateINR":15974.84,"date":"25-Jun-2024","totalValueINR":"1597484","totalValueInUsd":"19136.3","indian_port":"Bombay Air","hs_no":"29389090","bill_no":"1928225","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"SHOP NO.3, SHISH MAHAL CHS., R.N.P. PARK, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719772200,"product":"ACID SENNOSIDES HIGH TITRE, BATCH NO:80966\/F, 80967\/F","address":"NO.43\/3 , SHIVAPURA POST,","city":"DODDABALLAPURA, BANGALORE","supplier":"INDENA","supplierCountry":"INDIA","foreign_port":"PARIS - CHARLES DE G","customer":"TO THE ODRER OF","customerCountry":"FRANCE","quantity":"631.30","actualQuantity":"631.3","unit":"KGS","unitRateFc":"16785.8","totalValueFC":"126770.1","currency":"INR","unitRateINR":16785.760003168067,"date":"01-Jul-2024","totalValueINR":"10596850.29","totalValueInUsd":"126770.1","indian_port":"Bangalore Air","hs_no":"29389090","bill_no":"2097935","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"NO.43\/3 , SHIVAPURA POST,, DODDABALLAPURA, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721327400,"product":"DRUG MFD UNDER DRUG MFG LIC NO. RAJ-2415: SENNOSIDES USP (BATCH NO. 556413501001)","address":"301, AVALON APARTMENTS,MEHRAULI","city":"NEW DELHI","supplier":"ALCHEM INTERNATIONAL PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"JOHANNESBURG - JOHAN","customer":"BUYER","customerCountry":"SOUTH AFRICA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"250","totalValueFC":"11922.3","currency":"USD","unitRateINR":19932.02,"date":"19-Jul-2024","totalValueINR":"996601","totalValueInUsd":"11922.3","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"2551552","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"301, AVALON APARTMENTS,MEHRAULI, NEW DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"OTHER GLYCOSIDES NTRL\/RPRDCD BY SYNTHSISANDTHR SLTS ETHRS DRVTVS - SENNOSIDES USP - RODTEP","address":"1, OLD INUDSTRIAL AREA,","city":"ALWAR, RAJASTHAN","supplier":"MANEESH CHEMICALS PVT LTD","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"THE PURCHASING MANAGER","customerCountry":"TAIWAN","quantity":"700.00","actualQuantity":"700","unit":"KGS","unitRateFc":"165.5","totalValueFC":"114244.4","currency":"USD","unitRateINR":13689.510557142858,"date":"23-Aug-2024","totalValueINR":"9582657.39","totalValueInUsd":"114244.4","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"3418464","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"1, OLD INUDSTRIAL AREA,, ALWAR, RAJASTHAN","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731522600,"product":"DRUG MFD UNDER DRUG MFG LIC NO. 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09-Jan-2021
27-Nov-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

sennosides A and B Manufacturers

A sennosides A and B manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of sennosides A and B, including repackagers and relabelers. The FDA regulates sennosides A and B manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. sennosides A and B API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of sennosides A and B manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

sennosides A and B Suppliers

A sennosides A and B supplier is an individual or a company that provides sennosides A and B active pharmaceutical ingredient (API) or sennosides A and B finished formulations upon request. The sennosides A and B suppliers may include sennosides A and B API manufacturers, exporters, distributors and traders.

click here to find a list of sennosides A and B suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

sennosides A and B USDMF

A sennosides A and B DMF (Drug Master File) is a document detailing the whole manufacturing process of sennosides A and B active pharmaceutical ingredient (API) in detail. Different forms of sennosides A and B DMFs exist exist since differing nations have different regulations, such as sennosides A and B USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A sennosides A and B DMF submitted to regulatory agencies in the US is known as a USDMF. sennosides A and B USDMF includes data on sennosides A and B's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The sennosides A and B USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of sennosides A and B suppliers with USDMF on PharmaCompass.

sennosides A and B JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The sennosides A and B Drug Master File in Japan (sennosides A and B JDMF) empowers sennosides A and B API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the sennosides A and B JDMF during the approval evaluation for pharmaceutical products. At the time of sennosides A and B JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of sennosides A and B suppliers with JDMF on PharmaCompass.

sennosides A and B WC

A sennosides A and B written confirmation (sennosides A and B WC) is an official document issued by a regulatory agency to a sennosides A and B manufacturer, verifying that the manufacturing facility of a sennosides A and B active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting sennosides A and B APIs or sennosides A and B finished pharmaceutical products to another nation, regulatory agencies frequently require a sennosides A and B WC (written confirmation) as part of the regulatory process.

click here to find a list of sennosides A and B suppliers with Written Confirmation (WC) on PharmaCompass.

sennosides A and B NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing sennosides A and B as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for sennosides A and B API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture sennosides A and B as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain sennosides A and B and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a sennosides A and B NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of sennosides A and B suppliers with NDC on PharmaCompass.

sennosides A and B GMP

sennosides A and B Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of sennosides A and B GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right sennosides A and B GMP manufacturer or sennosides A and B GMP API supplier for your needs.

sennosides A and B CoA

A sennosides A and B CoA (Certificate of Analysis) is a formal document that attests to sennosides A and B's compliance with sennosides A and B specifications and serves as a tool for batch-level quality control.

sennosides A and B CoA mostly includes findings from lab analyses of a specific batch. For each sennosides A and B CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

sennosides A and B may be tested according to a variety of international standards, such as European Pharmacopoeia (sennosides A and B EP), sennosides A and B JP (Japanese Pharmacopeia) and the US Pharmacopoeia (sennosides A and B USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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