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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 5 USDMF, 4 JDMF, 2 EU WC, 26 NDC API, 6 Listed Suppliers, $ API Reference Price

15 API Suppliers
5 USDMF
4 JDMF
2 EU WC
26 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

19 FDF Dossiers, 2 Europe, 5 Canada, 2 Australia, 1 South Africa, 9 Listed Dossiers

19 FDF Dossiers
2 Europe
5 Canada
2 Australia
1 South Africa
9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 6 Rochem International Inc, 11 SPI Pharma, 2 Seqens, 11 DKSH, 2 Pharm-RX Chemical, 7 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 13 Gangwal Healthcare, 2 Kewpie Corporation, 9 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 Capital Farma, 4 ACG Worldwide, 11 Actylis, 4 Aeon Procare, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 29 BASF, 1 Bioplus Life Sciences, 2 Clariant, 10 Corel Pharma Chem, 4 DFE Pharma, 2 Finar, 12 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 24 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 16 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 3 Novo Excipients, 2 Pharmatrans-Sanaq, 9 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 31 Roquette, 16 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 10 Sigachi Industries, 3 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 3 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Minakem
6 Rochem International Inc
11 SPI Pharma
2 Seqens
11 DKSH
2 Pharm-RX Chemical
7 Faran Shimi Pharmaceutical
4 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
2 Kewpie Corporation
9 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 Capital Farma
4 ACG Worldwide
11 Actylis
4 Aeon Procare
7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
29 BASF
1 Bioplus Life Sciences
2 Clariant
10 Corel Pharma Chem
4 DFE Pharma
2 Finar
12 Gangwal Chemicals
7 Ideal Cures Pvt Ltd
3 Ingredion Pharma Solutions
24 Kerry
4 Kima Chemical
6 Lonza Capsugel
16 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
3 Novo Excipients
2 Pharmatrans-Sanaq
9 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
31 Roquette
16 Seppic
6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
10 Sigachi Industries
3 The Dow Chemical Company
1 Ulanqab Kema New Material
1 Valens Pharmachem
3 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

75 Fillers, Diluents & Binders, 59 Coating Systems & Additives, 39 Thickeners and Stabilizers, 37 Solubilizers, 36 Direct Compression, 33 Controlled & Modified Release, 26 Parenteral, 25 Topical, 25 Film Formers & Plasticizers, 23 Disintegrants & Superdisintegrants, 22 Lubricants & Glidants, 22 Granulation, 21 Taste Masking, 18 Co-Processed Excipients, 14 Emulsifying Agents, 11 Chewable & Orodispersible Aids, 10 API Stability Enhancers, 9 Empty Capsules, 8 Rheology Modifiers, 6 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

5 NEWS #PharmaBuzz

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GLOBAL SALES INFORMATION

2 Finished Drug Prices

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2 Finished Drug Prices

MARKET PLACE

6 APIs

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6 APIs

REF. STANDARDS & IMPURITIES

2 USP , 7 JP , 11 Others

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2 USP
7 JP
11 Others

ANALYTICAL

3 Analytical Methods

otherMethods
3 Analytical Methods

Sennoside A & B

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 182

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FDF

0INTERMEDIATES

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FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

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PATENTS & EXCLUSIVITIES

US Patents

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Health Canada Patents

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GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

314 RELATED EXCIPIENT COMPANIES

529EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sennoside g, Pursennid (tn), Sennosides (usp), 66575-30-2, Senna-lax, Sennoside a&b

Molecular Formula

C₄₂H₃₈O₂₀

Molecular Weight

862.7 g/mol

InChI Key

IPQVTOJGNYVQEO-JLDSCGAUSA-N

Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.

1 2D Structure

Sennosides

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

9-[2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid

2.1.2 InChI

InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25?,26?,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1

2.1.3 InChI Key

IPQVTOJGNYVQEO-JLDSCGAUSA-N

2.1.4 Canonical SMILES

C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O

2.1.5 Isomeric SMILES

C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Pursennid

2. Senna Glycoside

3. Sennoside A And B

4. Sennoside A And B, Calcium Salt

5. Sennoside A Calcium

6. Sennoside A Calcium And Sennoside B Calcium

7. Sennoside A+b Calcium

8. Sennoside A, Calcium Salt

9. Sennoside A, Calcium Salt (1:1)

10. Sennoside B Calcium

11. Sennoside B, Calcium Salt

12. Sennosides

13. Sennosides A And B

14. Sennosides A And B Acids

15. Senokot

2.2.2 Depositor-Supplied Synonyms

1. Sennoside G

2. Pursennid (tn)

3. Sennosides (usp)

4. 66575-30-2

5. Senna-lax

6. Sennoside A&b

7. 9-[2-carboxy-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9h-anthracene-2-carboxylic Acid

8. 517-43-1

9. Sennoside (jan)

10. Sennoside A1

11. Sennoside A1 , Hplc Grade

12. Schembl11140501

13. Chebi:34974

14. (9,9'-bianthracene)-2,2'-dicarboxylic Acid, 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (r*,r*)-

15. Mfcd32068370

16. D02171

17. 135s582

18. Q27116343

19. [9,9'-bianthracene]-2,2'-dicarboxylic Acid, 5,5'-bis(.beta.-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9r,9's)-

20. 5,5'-bis(beta-d-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic Acid

21. 5,5'-bis(beta-d-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic Acid

22. 9-[2-carboxy-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9h-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9h-anthracene-2-carboxylic Acid

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₄₂H₃₈O₂₀
Molecular Weight	862.7 g/mol
XLogP3	1.2
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	20
Rotatable Bond Count	9
Exact Mass	862.19564360 g/mol
Monoisotopic Mass	862.19564360 g/mol
Topological Polar Surface Area	348 Å²
Heavy Atom Count	62
Formal Charge	0
Complexity	1550
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)

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API Reference Price

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D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00004","unit":"KGS","unitRateFc":"20050000","totalValueFC":"861.7","currency":"USD","unitRateINR":"1810203750","date":"30-Oct-2024","totalValueINR":"72408.15","totalValueInUsd":"861.7","indian_port":"Hyderabad Air","hs_no":"29389090","bill_no":"6422250","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK, MD, US 21704, UNITED STATES OF AMER ICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ACTIVE PHARMA INGREDIENTS

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