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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

29 API Suppliers, 19 USDMF, 8 EU WC, 11 KDMF, 8 NDC API, 15 Listed Suppliers, $ API Reference Price

29 API Suppliers
19 USDMF
8 EU WC
11 KDMF
8 NDC API
15 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

66 FDF Dossiers, 35 FDA Orange Book, 10 Europe, 4 Canada, 1 South Africa, 16 Listed Dossiers

66 FDF Dossiers
35 FDA Orange Book
10 Europe
4 Canada
1 South Africa
16 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 3 Rochem International Inc, 14 SPI Pharma, 13 DKSH, 2 Pharm-RX Chemical, 2 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 8 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 3 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 1 Bioplus Life Sciences, 10 Corel Pharma Chem, 2 DFE Pharma, 1 Finar, 9 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 19 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 1 NEWEDGE Overseas, 3 Novo Excipients, 3 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 14 Roquette, 7 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Vasa Pharmachem

relatedExcipients
1 Minakem
3 Rochem International Inc
14 SPI Pharma
13 DKSH
2 Pharm-RX Chemical
2 Faran Shimi Pharmaceutical
4 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
8 Gangwal Healthcare
3 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 ACG Worldwide
3 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
10 BASF
1 Bioplus Life Sciences
10 Corel Pharma Chem
2 DFE Pharma
1 Finar
9 Gangwal Chemicals
7 Ideal Cures Pvt Ltd
1 Ingredion Pharma Solutions
19 Kerry
3 Kima Chemical
6 Lonza Capsugel
8 Microlex e.U
1 NEWEDGE Overseas
3 Novo Excipients
3 Pharmatrans-Sanaq
2 Pluviaendo
2 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
14 Roquette
7 Seppic
3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
9 Sigachi Industries
2 The Dow Chemical Company
1 Ulanqab Kema New Material
1 Valens Pharmachem
1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Coating Systems & Additives, 46 Fillers, Diluents & Binders, 30 Direct Compression, 24 Controlled & Modified Release, 21 Thickeners and Stabilizers, 21 Disintegrants & Superdisintegrants, 16 Chewable & Orodispersible Aids, 16 Lubricants & Glidants, 15 Granulation, 14 Taste Masking, 13 Film Formers & Plasticizers, 12 Co-Processed Excipients, 10 Parenteral, 8 Solubilizers, 8 Topical, 7 API Stability Enhancers, 5 Empty Capsules, 5 Coloring Agents, 5 Emulsifying Agents, 4 Rheology Modifiers, 4 Vegetarian Capsules

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 20 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
20 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
2 Annual Reports

MARKET PLACE

12 APIs, 4 FDF Dossiers

marketPlace
12 APIs
4 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 US Patents, 3 Health Canada Patents

patents
3 US Patents
3 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 104

MARKET PLACE

API

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

372,965,336

Annual Reports (USD Million)

627

Finished Drug Prices

193 RELATED EXCIPIENT COMPANIES

338EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 845273-93-0, 2-propen-1-amine polymer with (chloromethyl)oxirane carbonate, Carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine, Sevelamercarbonate, Gt-335-012, Chembl1201799

Molecular Formula

C₇H₁₄ClNO₄

Molecular Weight

211.64 g/mol

InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

1 2D Structure

Sevelamer Carbonate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

2.1.2 InChI

InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)

2.1.3 InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C=CCN.C1C(O1)CCl.C(=O)(O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Carbonate, Sevelamer

2. Gt335 012

3. Gt335-012

4. Gt335012

5. Hydrochloride, Sevelamer

6. Renagel

7. Sevelamer

8. Sevelamer Hydrochloride

2.2.2 Depositor-Supplied Synonyms

1. 845273-93-0

2. 2-propen-1-amine Polymer With (chloromethyl)oxirane Carbonate

3. Carbonic Acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

4. Sevelamercarbonate

5. Gt-335-012

6. Chembl1201799

7. Bcp13411

8. Ex-a4743

9. Akos037515475

10. Hs-0081

11. Gt335-012

12. Gt335 012;gt335-012;gt335012;carbonate, Sevelamer

2.3 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₇H₁₄ClNO₄
Molecular Weight	211.64 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	211.0611356 g/mol
Monoisotopic Mass	211.0611356 g/mol
Topological Polar Surface Area	96.1 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	81.4
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Indication

Renvela is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Renvela is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus 1. 78 mmol/l.

Renvela should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.

Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Sevelamer carbonate Winthrop is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus > 1. 78 mmol/L.

Sevelamer carbonate Winthrop should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]

5.3 ATC Code

V03AE02

API SUPPLIERS

01

Century Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Century has been an API manufacturer for over 30 years & is the partner of choice for multipurpose custom manufacturing projects.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

EUROAPI

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Attending

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

Contact Supplier

France

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF

VMF ROW

AUDIT

03

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Ami Lifesciences Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

AMI Lifesciences is Driven by Chemistry. Powered by People.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC

NDC KDMF VMF Others AUDIT

05

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU

AUDIT

06

USV Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

USV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Portfolio PDF

07

Solara Active Pharma Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

08

Waterstone Pharmaceuticals Inc.

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

09

Sun Pharmaceutical Industries Limi...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

10

CHEMO IBERICA SA

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

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USDMF

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EU WC

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KDMF

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NDC API

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API Reference Price

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REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"5695.72","actualQuantity":"5695.72","unit":"KGS","unitRateFc":"76.5","totalValueFC":"440769","currency":"USD","unitRateINR":"6491","date":"27-Aug-2024","totalValueINR":"36971060.91","totalValueInUsd":"440769","indian_port":"Reddy r-SEZ\/Srikakulam","hs_no":"29339990","bill_no":"5274400","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"No 36 Hoping Street Louchu SDNF Taiwan","customerAddress":"H.NO. 8-2-337, BESIDE TV9 OFFICE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727980200,"product":"SEVELAMER CARBONATE","address":"H.NO. 8-2-337,BESIDE TV9 OFFICE","city":"HYDERABAD ANDHRA PRADESH","supplier":"FORMOSA LABORATORIES","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"DR. 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REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"6929.91","actualQuantity":"6929.91","unit":"KGS","unitRateFc":"75","totalValueFC":"525455.2","currency":"USD","unitRateINR":"6371.3","date":"25-Oct-2024","totalValueINR":"44152189.09","totalValueInUsd":"525455.2","indian_port":"Reddy r-SEZ\/Srikakulam","hs_no":"29339990","bill_no":"6330563","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"No 36 Hoping St Taoyuan SDNF Taiwan","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ABOUT THIS PAGE

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

29 API Suppliers

19 USDMF

8 EU WC

11 KDMF

8 NDC API

15 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

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66 FDF Dossiers

35 FDA Orange Book

10 Europe

4 Canada

1 South Africa

16 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

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46 Fillers, Diluents & Binders

30 Direct Compression

24 Controlled & Modified Release

21 Thickeners and Stabilizers

21 Disintegrants & Superdisintegrants

16 Chewable & Orodispersible Aids

16 Lubricants & Glidants

15 Granulation

14 Taste Masking