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    Chemistry

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    Also known as: Sevelamer hcl, 152751-57-0, 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride, 182683-00-7, Chebi:32127, Bcp21176
    Molecular Formula
    C6H13Cl2NO
    Molecular Weight
    186.08  g/mol
    InChI Key
    KHNXRSIBRKBJDI-UHFFFAOYSA-N
    Sevelamer Hydrochloride
    A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
    1 2D Structure

    Sevelamer Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C3H5ClO.C3H7N.ClH/c4-1-3-2-5-3;1-2-3-4;/h3H,1-2H2;2H,1,3-4H2;1H
    2.1.3 InChI Key
    KHNXRSIBRKBJDI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C=CCN.C1C(O1)CCl.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Carbonate, Sevelamer

    2. Gt335 012

    3. Gt335-012

    4. Gt335012

    5. Hydrochloride, Sevelamer

    6. Renagel

    7. Sevelamer

    8. Sevelamer Carbonate

    2.2.2 Depositor-Supplied Synonyms

    1. Sevelamer Hcl

    2. 152751-57-0

    3. 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride

    4. 182683-00-7

    5. Chebi:32127

    6. Bcp21176

    7. Cga75157

    8. Sevelamer Hydrochloride (jan/usan)

    9. S4129

    10. Akos025149504

    11. Ac-2089

    12. Hs-0082

    13. Db-063954

    14. Ft-0653684

    15. D01983

    16. Ab01568265_01

    17. 2-propen-1-amine Hydrochloride Polymer With (chloromethyl)oxirane

    2.3 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 186.08 g/mol
    Molecular Formula C6H13Cl2NO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass185.0374194 g/mol
    Monoisotopic Mass185.0374194 g/mol
    Topological Polar Surface Area38.6 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity55.1
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Tasermity is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis. Sevelamer hydrochloride should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25 dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Chelating Agents

    Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]
    5.3 ATC Code

    V03AE02

    API Reference Price

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    09-Jan-2021
    31-Aug-2024
    KGS
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    DOSAGE - TABLET;ORAL - 400MG

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