Find Sibofimloc manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Regulatory FDF Prices

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MARKET PLACE

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API

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FDF

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

Chemistry

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Also known as: 1616113-45-1, Antibiotic-202, Vrt-1353385, Sibofimloc [inn], Sibofimloc [usan], Eb8018
Molecular Formula
C35H39NO11
Molecular Weight
649.7  g/mol
InChI Key
SFHMWDMKUYVSQJ-VECBPBMLSA-N
FDA UNII
00OF00QZC4

Sibofimloc
Sibofimloc is under investigation in clinical trial NCT03943446 (TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD)).
1 2D Structure

Sibofimloc

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone
2.1.2 InChI
InChI=1S/C35H39NO11/c1-18(39)36-12-10-35(11-13-36)23-14-19(4-8-25-29(40)33(44)31(42)27(16-37)46-25)2-6-21(23)22-7-3-20(15-24(22)35)5-9-26-30(41)34(45)32(43)28(17-38)47-26/h2-3,6-7,14-15,25-34,37-38,40-45H,10-13,16-17H2,1H3/t25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m1/s1
2.1.3 InChI Key
SFHMWDMKUYVSQJ-VECBPBMLSA-N
2.1.4 Canonical SMILES
CC(=O)N1CCC2(CC1)C3=C(C=CC(=C3)C#CC4C(C(C(C(O4)CO)O)O)O)C5=C2C=C(C=C5)C#CC6C(C(C(C(O6)CO)O)O)O
2.1.5 Isomeric SMILES
CC(=O)N1CCC2(CC1)C3=C(C=CC(=C3)C#C[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C5=C2C=C(C=C5)C#C[C@@H]6[C@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O
2.2 Other Identifiers
2.2.1 UNII
00OF00QZC4
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1616113-45-1

2. Antibiotic-202

3. Vrt-1353385

4. Sibofimloc [inn]

5. Sibofimloc [usan]

6. Eb8018

7. 00of00qzc4

8. 1-[2,7-bis[2-[(2r,3s,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone

9. 1-[2,7-bis[2-[(2r,3s,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone

10. Eb-8018

11. 1-(2,7-bis(2,6-anhydro-7,8-dideoxy-d-glycero-d-manno-oct-7-ynitol-8-yl)spiro(fluorene-9,4'-piperidin)-1'-yl)ethan-1-one

12. 1-[2,7-bis({2-[(2r,3s,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl})spiro[fluorene-9,4'-piperidine]-1'-yl]ethan-1-one

13. 8,8'-(1'-acetylspiro(9h-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-d-glycero-d-manno-oct-7-ynitol)

14. D-glycero-d-manno-oct-7-ynitol, 8,8'-(1'-acetylspiro(9h-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-

15. Antibiotic 202

16. Sibofimloc (usan/inn)

17. Unii-00of00qzc4

18. Chembl4594305

19. Schembl15836795

20. Ex-a750

21. Antibiotic-202;vrt-1353385

22. Mfcd28144726

23. Who 10950

24. Zinc209678340

25. Cs-5487

26. Ac-35872

27. Da-43714

28. Hy-12820

29. B5896

30. D11825

31. J-690221

2.4 Create Date
2014-08-04
3 Chemical and Physical Properties
Molecular Weight 649.7 g/mol
Molecular Formula C35H39NO11
XLogP3-0.8
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass649.25231106 g/mol
Monoisotopic Mass649.25231106 g/mol
Topological Polar Surface Area201 Ų
Heavy Atom Count47
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1616113-45-1 / Sibofimloc API manufacturers, exporters & distributors?

Sibofimloc manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sibofimloc API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sibofimloc manufacturer or Sibofimloc supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sibofimloc manufacturer or Sibofimloc supplier.

PharmaCompass also assists you with knowing the Sibofimloc API Price utilized in the formulation of products. Sibofimloc API Price is not always fixed or binding as the Sibofimloc Price is obtained through a variety of data sources. The Sibofimloc Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sibofimloc

Synonyms

1616113-45-1, Antibiotic-202, Vrt-1353385, Sibofimloc [inn], Sibofimloc [usan], Eb8018

Cas Number

1616113-45-1

Unique Ingredient Identifier (UNII)

00OF00QZC4

About Sibofimloc

Sibofimloc is under investigation in clinical trial NCT03943446 (TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD)).

Sibofimloc Manufacturers

A Sibofimloc manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sibofimloc, including repackagers and relabelers. The FDA regulates Sibofimloc manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sibofimloc API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sibofimloc Suppliers

A Sibofimloc supplier is an individual or a company that provides Sibofimloc active pharmaceutical ingredient (API) or Sibofimloc finished formulations upon request. The Sibofimloc suppliers may include Sibofimloc API manufacturers, exporters, distributors and traders.

click here to find a list of Sibofimloc suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sibofimloc NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sibofimloc as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sibofimloc API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sibofimloc as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sibofimloc and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sibofimloc NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sibofimloc suppliers with NDC on PharmaCompass.

Sibofimloc GMP

Sibofimloc Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sibofimloc GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sibofimloc GMP manufacturer or Sibofimloc GMP API supplier for your needs.

Sibofimloc CoA

A Sibofimloc CoA (Certificate of Analysis) is a formal document that attests to Sibofimloc's compliance with Sibofimloc specifications and serves as a tool for batch-level quality control.

Sibofimloc CoA mostly includes findings from lab analyses of a specific batch. For each Sibofimloc CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sibofimloc may be tested according to a variety of international standards, such as European Pharmacopoeia (Sibofimloc EP), Sibofimloc JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sibofimloc USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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