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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Ar-67, 220913-32-6, Db-67, Ar67, Db 67; silatecan, Db 67
Molecular Formula
C26H30N2O5Si
Molecular Weight
478.6  g/mol
InChI Key
XUSKJHCMMWAAHV-SANMLTNESA-N
FDA UNII
3YEA04NV6H

Silatecan
Silatecan AR-67 is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. 7-tert-butyldimethylsilyl-10-hydroxycamptothecin binds to and stabilizes the topoisomerase I-DNA covalent complex. This inhibits the religation of topoisomerase I-mediated single-stranded DNA breaks and produces lethal double-stranded DNA breaks when encountered by the DNA replication machinery, thereby inhibiting DNA replication and inducing apoptosis. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. Modifications on the E ring of camptothecin prevent binding of human serum albumin, which prefers the inactive carboxylate form, thereby enhancing the stability of the active lactone structure and resulting in prolonged agent activity. In addition, this agent sensitizes tumor cells toward radiation treatment.
1 2D Structure

Silatecan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(19S)-10-[tert-butyl(dimethyl)silyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
2.1.2 InChI
InChI=1S/C26H30N2O5Si/c1-7-26(32)18-11-20-21-16(12-28(20)23(30)17(18)13-33-24(26)31)22(34(5,6)25(2,3)4)15-10-14(29)8-9-19(15)27-21/h8-11,29,32H,7,12-13H2,1-6H3/t26-/m0/s1
2.1.3 InChI Key
XUSKJHCMMWAAHV-SANMLTNESA-N
2.1.4 Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=CC(=C5)O)N=C4C3=C2)[Si](C)(C)C(C)(C)C)O
2.1.5 Isomeric SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=CC(=C5)O)N=C4C3=C2)[Si](C)(C)C(C)(C)C)O
2.2 Other Identifiers
2.2.1 UNII
3YEA04NV6H
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)- Dione, 11-((1,1-dimethylethyl)dimethylsilyl)-4-ethyl-4,9- Dihydroxy-, (4s)-

2. 7-t-butyldimethylsilyl-10-hydroxycamptothecin

3. 7-tert-butyldimethylsilyl-10-hydroxycamptothecin

4. Ar 67 Cpd

5. Ar-67 Cpd

6. Db 67

7. Db-67

2.3.2 Depositor-Supplied Synonyms

1. Ar-67

2. 220913-32-6

3. Db-67

4. Ar67

5. Db 67; Silatecan

6. Db 67

7. Nsc-708298

8. 3yea04nv6h

9. Db67

10. (s)-11-(tert-butyldimethylsilyl)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

11. (20s)-7-t-butyldimethylsilyl-10-hydroxycamptothecin

12. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 11-((1,1-dimethylethyl)dimethylsilyl)-4-ethyl-4,9-dihydroxy-, (4s)-

13. Nci60_038363

14. Ar 67 Cpd

15. Ar-67 Cpd

16. Unii-3yea04nv6h

17. Chembl412309

18. Gtpl8919

19. Schembl1266162

20. Dtxsid00176592

21. Ar 67

22. Nsc708298

23. Zinc170020689

24. Compound 14 [pmid:11052802]

25. Db12384

26. Nsc 708298

27. Q27074492

28. (20s)-7-tert-butyldimethysilyl-10-hydroxycamptothecin

29. (19s)-10-[tert-butyl(dimethyl)silyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

30. 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)dione, 11-[(1,1-dimethylethyl)dimethylsilyl]-4-ethyl-4,9-dihydroxy-, (4s)-

2.4 Create Date
2006-06-05
3 Chemical and Physical Properties
Molecular Weight 478.6 g/mol
Molecular Formula C26H30N2O5Si
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass478.19239860 g/mol
Monoisotopic Mass478.19239860 g/mol
Topological Polar Surface Area100 Ų
Heavy Atom Count34
Formal Charge0
Complexity982
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Silatecan Manufacturers

A Silatecan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Silatecan, including repackagers and relabelers. The FDA regulates Silatecan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Silatecan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Silatecan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Silatecan Suppliers

A Silatecan supplier is an individual or a company that provides Silatecan active pharmaceutical ingredient (API) or Silatecan finished formulations upon request. The Silatecan suppliers may include Silatecan API manufacturers, exporters, distributors and traders.

click here to find a list of Silatecan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Silatecan GMP

Silatecan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Silatecan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Silatecan GMP manufacturer or Silatecan GMP API supplier for your needs.

Silatecan CoA

A Silatecan CoA (Certificate of Analysis) is a formal document that attests to Silatecan's compliance with Silatecan specifications and serves as a tool for batch-level quality control.

Silatecan CoA mostly includes findings from lab analyses of a specific batch. For each Silatecan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Silatecan may be tested according to a variety of international standards, such as European Pharmacopoeia (Silatecan EP), Silatecan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Silatecan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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