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Silver Sulfadiazine

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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 10 USDMF, 1 JDMF, 4 EU WC, 6 NDC API, 16 Listed Suppliers, $ API Reference Price

23 API Suppliers
10 USDMF
1 JDMF
4 EU WC
6 NDC API
16 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

42 FDF Dossiers, 5 FDA Orange Book, 13 Europe, 3 Canada, 1 Australia, 9 South Africa, 11 Listed Dossiers

42 FDF Dossiers
5 FDA Orange Book
13 Europe
3 Canada
1 Australia
9 South Africa
11 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CREAM;TOPICAL - 1%, CREAM;TOPICAL - 1%

drugProductComposition
CREAM;TOPICAL - 1%
CREAM;TOPICAL - 1%

RELATED EXCIPIENT COMPANIES

1 DKSH, 2 Nanjing Well Pharmaceutical, 5 BASF, 1 Finar, 1 Gangwal Chemicals, 1 Microlex e.U, 1 Nanjing Bold Chemical, 2 Seppic, 1 Valens Pharmachem

relatedExcipients
1 DKSH
2 Nanjing Well Pharmaceutical
5 BASF
1 Finar
1 Gangwal Chemicals
1 Microlex e.U
1 Nanjing Bold Chemical
2 Seppic
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

9 Topical, 6 Solubilizers, 5 Emulsifying Agents, 3 Thickeners and Stabilizers, 2 Film Formers & Plasticizers, 2 Surfactant & Foaming Agents, 2 Parenteral, 1 Granulation, 1 Direct Compression, 1 Lubricants & Glidants

excipientsByApplications
9 Topical
6 Solubilizers
5 Emulsifying Agents
3 Thickeners and Stabilizers
2 Film Formers & Plasticizers
2 Surfactant & Foaming Agents
2 Parenteral
1 Granulation
1 Direct Compression
1 Lubricants & Glidants

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 15 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
15 Finished Drug Prices

MARKET PLACE

18 APIs, 3 FDF Dossiers

marketPlace
18 APIs
3 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 1 JP , 1 Others

otherSolutions
1 USP
1 JP
1 Others

Atman Silver Sulfadiazine

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 359

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

5,783,661

Annual Reports (USD Million)

Finished Drug Prices

15 RELATED EXCIPIENT COMPANIES

32EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 22199-08-2, Sulfadiazine silver, Flamazine, Sulfadiazine silver salt, Silvadene, Dermazin

Molecular Formula

C₁₀H₉AgN₄O₂S

Molecular Weight

357.14 g/mol

InChI Key

UEJSSZHHYBHCEL-UHFFFAOYSA-N

FDA UNII

W46JY43EJR

Antibacterial used topically in burn therapy.

Silver sulfadiazine is a Sulfonamide Antibacterial.

1 2D Structure

Silver Sulfadiazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide

2.1.2 InChI

InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

2.1.3 InChI Key

UEJSSZHHYBHCEL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]

2.2 Other Identifiers

2.2.1 UNII

W46JY43EJR

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Brandiazin

2. Dermazin

3. Flamazine

4. Flammazine

5. Sicazine

6. Silvadene

7. Silvederma

8. Silver Sulfafdiazine

9. Ssd

10. Ssd Af

11. Sulfadiazine, Silver

12. Sulfafdiazine, Silver

13. Sulfargen

14. Thermazene

2.3.2 Depositor-Supplied Synonyms

1. 22199-08-2

2. Sulfadiazine Silver

3. Flamazine

4. Sulfadiazine Silver Salt

5. Silvadene

6. Dermazin

7. Silver Sulphadiazine

8. Thermazene

9. Sulfadiazine, Silver

10. Dermazine

11. Geben

12. Silver Sulfadiazinate

13. Silvazine

14. Altreet-ag

15. Mfcd00072101

16. Ssd

17. W46jy43ejr

18. Chebi:9142

19. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Monosilver(1+) Salt

20. Silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide

21. N(sup 1)-2-pyrimidinylsulfanilamide Monosilver(1+) Salt

22. Silbertone

23. Silver(i) Sulfadiazine

24. Sulfadiazin Silber

25. Dsstox_cid_28572

26. Dsstox_rid_82844

27. Dsstox_gsid_48646

28. Sulfadiazin, Silbersalz

29. Silvadene (tn)

30. Silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide

31. Sulfadiazine, Silver [usan]

32. Cas-22199-08-2

33. Nsc625324

34. Ncgc00183137-01

35. Ncgc00188438-01

36. Unii-w46jy43ejr

37. N1-2-pyrimidinylsulfanilamide Monosilver(1+) Salt

38. Sulfadiazine, Silver (usp)

39. 4-amino-n-(2-pyrimidinyl)benzenesulfonamide Silver Salt

40. Sulfadiazine, Silver [usan:usp]

41. Einecs 244-834-5

42. Sulfadiazinum Argentum

43. Nsc 625324

44. (4-amino-n-pyrimidin-2-ylbenzenesulphonamidato-nn,o1)silver

45. Silver Sulfadiazine Usp

46. Silver, (4-amino-n-(2-pyrimidinyl-.kappa.n1)benzenesulfonamidato-.kappa.o)-

47. Silver, (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,o1)-

48. Silver (i) Sulfadiazine

49. Schembl15633

50. Sulfadiazine Silver (jp17)

51. Silver Sulfadiazine Bulk Powder

52. Chembl1382627

53. Dtxsid4048646

54. Sulfadiazine Silver [jan]

55. (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,01)-silver

56. Sulfanilamide, N(sup 1)-2-pyrimidinyl-, Monosilver(1+) Salt

57. Silver Sulfadiazine [vandf]

58. Sulfadiazine Silver [mart.]

59. Tox21_112998

60. Tox21_113471

61. Silver Sulfadiazine [usp-rs]

62. Sulfadiazine Silver [who-dd]

63. Sulfadiazine Silver [who-ip]

64. Sulfadiazine Silver Salt [mi]

65. Akos005111099

66. Ac-3535

67. Db05245

68. Silver Sulfadiazine [green Book]

69. Silver Sulfadiazine [orange Book]

70. As-13863

71. Sy105573

72. Silver Sulfadiazine [usp Monograph]

73. Db-045839

74. Sulfadiazine, Silver [usp Impurity]

75. Ft-0630481

76. S0595

77. Sulfadiazinum Argentum [who-ip Latin]

78. D00433

79. Q420984

80. J-014582

81. Silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide

82. [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide (ag+)

83. 4-amino-n-(2-pyrimidinyl) Benzenesulfonamide Silver Salt

84. Silver(i) ((4-aminophenyl)sulfonyl)(pyrimidin-2-yl)amide

85. Silver(1+) Ion 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline

86. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Silver(1+) Salt (1:1)

87. 1152234-18-8

2.3.3 Other Synonyms

1. Soludiazine

2. Suthogen

3. Sulfadiazin-natrium

4. Sulfadiazine Silver

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₉AgN₄O₂S
Molecular Weight	357.14 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	355.94971 g/mol
Monoisotopic Mass	355.94971 g/mol
Topological Polar Surface Area	95.3 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	327
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Silvadene
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	King Pharms

2 of 8
Drug Name	Ssd
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Dr Reddys La

3 of 8
Drug Name	Ssd af
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	SSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Dr Reddys La

4 of 8
Drug Name	Thermazene
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	Thermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Thepharmanetwork

5 of 8
Drug Name	Silvadene
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	King Pharms

6 of 8
Drug Name	Ssd
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Dr Reddys La

7 of 8
Drug Name	Ssd af
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	SSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Dr Reddys La

8 of 8
Drug Name	Thermazene
PubMed Health	Silver Sulfadiazine (On the skin)
Drug Classes	Antibacterial
Drug Label	Thermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1...
Active Ingredient	Silver sulfadiazine
Dosage Form	Cream
Route	Topical
Strength	1%
Market Status	Prescription
Company	Thepharmanetwork

4.2 Drug Indication

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.

5.2 MeSH Pharmacological Classification

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

SILVER SULFADIAZINE

5.3.2 FDA UNII

W46JY43EJR

5.3.3 Pharmacological Classes

Sulfonamides [CS]; Sulfonamide Antibacterial [EPC]

5.4 ATC Code

D06BA01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06B - Chemotherapeutics for topical use

D06BA - Sulfonamides

D06BA01 - Silver sulfadiazine

5.5 Absorption, Distribution and Excretion

Absorption

Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.

5.6 Mechanism of Action

Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

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API Reference Price

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DOSAGE - CREAM;TOPICAL - 1%

USFDA APPLICATION NUMBER - 17381

DOSAGE - CREAM;TOPICAL - 1%

USFDA APPLICATION NUMBER - 18578

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9 South Africa

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CREAM;TOPICAL - 1%

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2 Nanjing Well Pharmaceutical

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