1. Brandiazin
2. Dermazin
3. Flamazine
4. Flammazine
5. Sicazine
6. Silvadene
7. Silvederma
8. Silver Sulfafdiazine
9. Ssd
10. Ssd Af
11. Sulfadiazine, Silver
12. Sulfafdiazine, Silver
13. Sulfargen
14. Thermazene
1. 22199-08-2
2. Sulfadiazine Silver
3. Flamazine
4. Sulfadiazine Silver Salt
5. Silvadene
6. Dermazin
7. Silver Sulphadiazine
8. Thermazene
9. Sulfadiazine, Silver
10. Dermazine
11. Geben
12. Silver Sulfadiazinate
13. Silvazine
14. Altreet-ag
15. Mfcd00072101
16. Ssd
17. W46jy43ejr
18. Chebi:9142
19. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Monosilver(1+) Salt
20. Silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
21. N(sup 1)-2-pyrimidinylsulfanilamide Monosilver(1+) Salt
22. Silbertone
23. Silver(i) Sulfadiazine
24. Sulfadiazin Silber
25. Dsstox_cid_28572
26. Dsstox_rid_82844
27. Dsstox_gsid_48646
28. Sulfadiazin, Silbersalz
29. Silvadene (tn)
30. Silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide
31. Sulfadiazine, Silver [usan]
32. Cas-22199-08-2
33. Nsc625324
34. Ncgc00183137-01
35. Ncgc00188438-01
36. Unii-w46jy43ejr
37. N1-2-pyrimidinylsulfanilamide Monosilver(1+) Salt
38. Sulfadiazine, Silver (usp)
39. 4-amino-n-(2-pyrimidinyl)benzenesulfonamide Silver Salt
40. Sulfadiazine, Silver [usan:usp]
41. Einecs 244-834-5
42. Sulfadiazinum Argentum
43. Nsc 625324
44. (4-amino-n-pyrimidin-2-ylbenzenesulphonamidato-nn,o1)silver
45. Silver Sulfadiazine Usp
46. Silver, (4-amino-n-(2-pyrimidinyl-.kappa.n1)benzenesulfonamidato-.kappa.o)-
47. Silver, (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,o1)-
48. Silver (i) Sulfadiazine
49. Schembl15633
50. Sulfadiazine Silver (jp17)
51. Silver Sulfadiazine Bulk Powder
52. Chembl1382627
53. Dtxsid4048646
54. Sulfadiazine Silver [jan]
55. (4-amino-n-2-pyrimidinylbenzenesulfonamidato-nn,01)-silver
56. Sulfanilamide, N(sup 1)-2-pyrimidinyl-, Monosilver(1+) Salt
57. Silver Sulfadiazine [vandf]
58. Sulfadiazine Silver [mart.]
59. Tox21_112998
60. Tox21_113471
61. Silver Sulfadiazine [usp-rs]
62. Sulfadiazine Silver [who-dd]
63. Sulfadiazine Silver [who-ip]
64. Sulfadiazine Silver Salt [mi]
65. Akos005111099
66. Ac-3535
67. Db05245
68. Silver Sulfadiazine [green Book]
69. Silver Sulfadiazine [orange Book]
70. As-13863
71. Sy105573
72. Silver Sulfadiazine [usp Monograph]
73. Db-045839
74. Sulfadiazine, Silver [usp Impurity]
75. Ft-0630481
76. S0595
77. Sulfadiazinum Argentum [who-ip Latin]
78. D00433
79. Q420984
80. J-014582
81. Silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide
82. [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide (ag+)
83. 4-amino-n-(2-pyrimidinyl) Benzenesulfonamide Silver Salt
84. Silver(i) ((4-aminophenyl)sulfonyl)(pyrimidin-2-yl)amide
85. Silver(1+) Ion 4-{[(pyrimidin-2-yl)azanidyl]sulfonyl}aniline
86. Benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, Silver(1+) Salt (1:1)
87. 1152234-18-8
1. Soludiazine
2. Suthogen
3. Sulfadiazin-natrium
4. Sulfadiazine Silver
| Molecular Weight | 357.14 g/mol |
|---|---|
| Molecular Formula | C10H9AgN4O2S |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 355.94971 g/mol |
| Monoisotopic Mass | 355.94971 g/mol |
| Topological Polar Surface Area | 95.3 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 327 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 8 | |
|---|---|
| Drug Name | Silvadene |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | King Pharms |
| 2 of 8 | |
|---|---|
| Drug Name | Ssd |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Dr Reddys La |
| 3 of 8 | |
|---|---|
| Drug Name | Ssd af |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | SSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Dr Reddys La |
| 4 of 8 | |
|---|---|
| Drug Name | Thermazene |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | Thermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Thepharmanetwork |
| 5 of 8 | |
|---|---|
| Drug Name | Silvadene |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | King Pharms |
| 6 of 8 | |
|---|---|
| Drug Name | Ssd |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfa... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Dr Reddys La |
| 7 of 8 | |
|---|---|
| Drug Name | Ssd af |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | SSD (1% Silver Sulfadiazine Cream) and SSD AF (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine. The active moiety is contained within an opaque, wh... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Dr Reddys La |
| 8 of 8 | |
|---|---|
| Drug Name | Thermazene |
| PubMed Health | Silver Sulfadiazine (On the skin) |
| Drug Classes | Antibacterial |
| Drug Label | Thermazene (silver sulfadiazine Cream, 1% is a soft, water dispersible cream containing silver sulfadiazine in micronized form for topical application. Each gram of Thermazene contains 10mg of micronized silver sulfadiazine. Thermazene contains 1... |
| Active Ingredient | Silver sulfadiazine |
| Dosage Form | Cream |
| Route | Topical |
| Strength | 1% |
| Market Status | Prescription |
| Company | Thepharmanetwork |
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
D06BA01
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
D - Dermatologicals
D06 - Antibiotics and chemotherapeutics for dermatological use
D06B - Chemotherapeutics for topical use
D06BA - Sulfonamides
D06BA01 - Silver sulfadiazine
Absorption
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
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