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ACTIVE PHARMA INGREDIENTS

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Silybin a,b (mixture), 802918-57-6, Silybin (a+b), (2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one, Legalon, Silibin

Molecular Formula

C₂₅H₂₂O₁₀

Molecular Weight

482.4 g/mol

InChI Key

SEBFKMXJBCUCAI-DBMPWETRSA-N

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

1 2D Structure

Silymarin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

2.1.2 InChI

InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1

2.1.3 InChI Key

SEBFKMXJBCUCAI-DBMPWETRSA-N

2.1.4 Canonical SMILES

COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

2.1.5 Isomeric SMILES

COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 2,3 Dehydrosilybin

2. 2,3-dehydrosilybin

3. Alepa Forte

4. Alepa-forte

5. Ardeyhepan

6. Cefasilymarin

7. Durasilymarin

8. Hepa Loges

9. Hepa Merz Sil

10. Hepa-loges

11. Hepa-merz Sil

12. Hepabesch

13. Hepar Pasc

14. Hepar-pasc

15. Heparsyx

16. Heplant

17. Lagosa

18. Legalon Forte

19. Silibin

20. Silibinin

21. Silibinin A

22. Silibinin B

23. Silybin A

24. Silybin B

25. Silybinin

26. Carsil

27. Karsil

28. Legalon

29. Silimarin

30. Silymarin

2.2.2 Depositor-Supplied Synonyms

1. Silybin A,b (mixture)

2. 802918-57-6

3. Silybin (a+b)

4. (2r,3r)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

5. Legalon

6. Silibin

7. Silliver

8. Silybine

9. Silymarin

10. Chembl9509

11. Silibinin A-silibinin B Mixt.

12. Schembl14270800

13. Schembl22398934

14. Hy-n0779a

15. Cs-0138778

16. S0508

17. E80721

18. Silybin (mixture Of Silybin A And B) 100 Microg/ml In Acetonitrile

19. (2r,3r)-2,3-dihydro-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydro-1,4-benzodioxin-6-yl]-4h-1-benzopyran-4-one

20. 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine

2.3 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₂₂O₁₀
Molecular Weight	482.4 g/mol
XLogP3	2.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	4
Exact Mass	482.12129689 g/mol
Monoisotopic Mass	482.12129689 g/mol
Topological Polar Surface Area	155 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	750
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

Protective Agents

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)

4.2 ATC Code

A - Alimentary tract and metabolism

A05 - Bile and liver therapy

A05B - Liver therapy, lipotropics

A05BA - Liver therapy

A05BA03 - Silymarin

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API Reference Price

[{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1638729000,"product":"SILYMARIN(NOT FOR MEDICINAL USE)","address":"28 RAGUNAIKULU STREET,PARK TOWN","city":"CHENNAI,TAMIL NADU","supplier":"NINGBO HI-TECH BIOCHEMICALS","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"AADISHWAR EXCIPIENTS PVT ","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"22.8","totalValueFC":"46376.5","currency":"USD","unitRateINR":"1749","date":"06-Dec-2021","totalValueINR":"3498004.82","totalValueInUsd":"46376.5","indian_port":"BANGALORE ICD","hs_no":"29339990","bill_no":"6552918","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"N\/A","supplierAddress":"","customerAddress":"28 RAGUNAIKULU STREET,PARK TOWN"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649874600,"product":"SILYMARIN E.P \/ I.P.","address":"5 C SHREE LAXMI INDUSTRAIAL ESTATE ,NEW LINK ROAD ANDHERI W","city":"MUMBAI,MAHARASHTRA","supplier":"INDENA","supplierCountry":"ITALY","foreign_port":"NA","customer":"G.C. CHEMIE PHARMIE LIMITED","customerCountry":"INDIA","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"99.8","totalValueFC":"33486.1","currency":"EUR","unitRateINR":"8421.6","date":"14-Apr-2022","totalValueINR":"2526490.85","totalValueInUsd":"33486.1","indian_port":"BOMBAY AIR","hs_no":"29329990","bill_no":"8274174","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"5 C SHREE LAXMI INDUSTRAIAL ESTATE ,NEW LINK ROAD ANDHERI W"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1660242600,"product":"SILYMARIN 70% UV (NOT FOR MEDICINAL USE)","address":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,","city":"CHENNAI,TAMIL NADU","supplier":"NINGBO HI-TECH BIOCHEMICALS","supplierCountry":"CHINA","foreign_port":"NA","customer":"D.K. ENTERPRISES","customerCountry":"INDIA","quantity":"1500.00","actualQuantity":"1500","unit":"KGS","unitRateFc":"24.8","totalValueFC":"37586.9","currency":"USD","unitRateINR":"1993.8","date":"12-Aug-2022","totalValueINR":"2990683.45","totalValueInUsd":"37586.9","indian_port":"MADRAS SEA","hs_no":"29329990","bill_no":"9979880","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"NA","supplierAddress":"","customerAddress":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672597800,"product":"SILYMARIN 80% (BATCH NO. 20220402W)","address":"A-1\/2,MAHENDRU ENCLAVE G T KARNAL ROAD","city":"DELHI,DELHI","supplier":"HANGZHOU XUANDA BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"NA","customer":"CORAL ORGANICALS","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"29.5","totalValueFC":"18087.6","currency":"USD","unitRateINR":"2464.7","date":"02-Jan-2023","totalValueINR":"1478835","totalValueInUsd":"18087.6","indian_port":"DELHI TKD ICD","hs_no":"29321990","bill_no":"3998136","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A-1\/2,MAHENDRU ENCLAVE G T KARNAL ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1684261800,"product":"SILYMARIN 70 UV NOT FOR MEDICINAL USE","address":"PHULE NAGAR, NRC COLONY, MOHANE","city":"THANE","supplier":"A WELL INGREDIENTS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"D K ENTERPRISES","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"23.8","totalValueFC":"47866.3","currency":"USD","unitRateINR":"1969.3","date":"17-May-2023","totalValueINR":"3938639","totalValueInUsd":"47866.3","indian_port":"MADRAS SEA","hs_no":"29329990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"China","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"","customerAddress":"PHULE NAGAR, NRC COLONY, MOHANE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688149800,"product":"SILYMARIN 70% UV (NOT FOR MEDICINAL USE)","address":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,","city":"CHENNAI,TAMIL NADU","supplier":"AWELL INGREDIENTS CO ","supplierCountry":"CHINA","foreign_port":"NA","customer":"D.K. ENTERPRISES","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"23.9","totalValueFC":"48417.4","currency":"USD","unitRateINR":"1990","date":"01-Jul-2023","totalValueINR":"3979402.602","totalValueInUsd":"48417.4","indian_port":"MADRAS SEA","hs_no":"29329990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"NA","supplierAddress":"","customerAddress":"NO.28, RAGHUNAYAKULU STREET,,PARKT OWN,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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APIs

Silybin API needed in India [ENA21615]

A company that focuses on development and manufacturing of various intermediates and active pharmaceutical ingredients is looking for suppliers of Silybin (1 kg & 100 kg) API for both development & commercial purposes. The suppliers must support this enquiry with CoA.

02 Jan 2025

Silybin (63 kg) API needed in India [ENA21376]

A company that focuses on research, development and manufacturing of OSDs & injectables is looking for suppliers of Silybin (63 kg) API for commercial purposes. The suppliers must support this enquiry with CEP, EUDMF & CoA.

10 Dec 2024

Silymarin (1.2 MT - 1.4 MT/ annum) API needed in India [ENA21083]

A company that focuses on the development and manufacturing of various nutraceutical products is looking for suppliers of Silymarin (1.2 MT - 1.4 MT/ annum) API for commercial purposes. The suppliers must support this enquiry with CEP, GMP & CoA.

11 Nov 2024

Silymarin (5 kg) API needed in India [ENA18399]

A pharmaceutical manufacturing company that deals in beta-lactam, non-beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Silymarin (5 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.

19 Oct 2023

Silymarin (500 g) API needed in South Korea [ENA16957]

A pharmaceutical company that focuses on research, development, manufacturing and commercialization of biologics, chemicals, OTC drugs & medical devices is looking for suppliers of Silymarin (500 g) API for development purposes. The suppliers must support this enquiry with CoA.

24 Apr 2023

Silymarin (5 kg) API needed in India [ENA13208]

A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Silymarin (5 kg) API for commercial purpose. The suppliers must support this enquiry with CoA.

05 Apr 2022

Silymarin (1 kg) API needed in Pakistan [ENA07990]

Chemsco, an indenting agent based in Pakistan is looking for suppliers of Silymarin (1 kg) API for research purposes. Interested suppliers can contact them via their email: mahwash@chemsco.com.

21 Jul 2020

Various APIs needed in India [ENA07962]

Sangauss, a group company engaged in API trading business supplying to various formulation units in India is looking for suppliers of Various APIs. Interested suppliers can contact them via their email: aushem@sangaussindia.com. 1. Aceclofenac (350 kg) 2. Azithromycin (250 kg) 3. Ciprofloxacin (250 kg) 4. Deflazacort (100 kg) 5. Diclofenac (150 kg) 6. Levocetirizine (30 kg) 7. Dextromethorphan (50 kg) 8. Montelukast (50 kg) 9. Nimesulide (500 kg) 10. Ofloxacin (200 kg) 11. Omeprazole Pellets (300 kg) 12. Ornidazole (200 kg) 13. Paracetamol (4 MT) 14. Rabeprazole + Domperidone (500 kg) 15. Pantoprazole + Domperidone (350 kg) 16. Silymarin 70-80% (50 kg) 17. Pregabalin (150 kg) 18. Omeprazole + Domperidone (450 kg) 19. Phenylephrine HCl (15 kg)

20 Jul 2020

Silymarin API needed in India [ENA02833]

Meditrex Pharma, a company committed to developing the latest and different Healthcare solutions is looking for suppliers of Silymarin API. Interested suppliers can contact Hiren Dhameliya via Email: dhamelhiren@yahoo.in or Tel: 8128668350 with COA and quotation.

04 Dec 2018

IP grade Piracetam, Silymerine and other APIs needed in India [ENA01894]

Pramukh labs- a leading and growing pharmaceutical trading company based in India are looking for the suppliers of the following APIs: 1) IP grade Piracetam- 50g 2) Silymarin- 100g 3) Iron (III) Hydroxides Polymaltose Complex 33%- 100g 4) IP grade Ferric Ammonium Citrate- 50g 5) Ferric Ascorbate- 50g 6) Triprolidine HCl Interested suppliers must support this enquiry with the Certificate of Analysis (COA) and must contact Pramukh Labs via E-mail: purchase@pramukhlabs.com or Tel: 02752 240444/ 96879 49444/9687945444.

13 Sep 2018

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FDF DOSSIERS

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA17718]

Multiprofile Hospital For Active Treatment - Privomay Eood is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 28-August-2023. 1. Omeprazole (20 mg) Capsules. The required quantity is 5,600 units. 2. Silymarin (90 mg) Capsules. The required quantity is 4,000 units.

01 Aug 2023

Tender// Various Finished Dosage Formulations needed in Macedonia [ENA17561]

University Clinic for infectious diseases and febrille conditions –Skopje is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 14-August-2023. 1. Silymarin (100 mg) Hard Capsules. The required quantity is 20,000 units. 2. Ceftriaxone (2 g) Injections. The required quantity is 30,000 units.

15 Jul 2023

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA17362]

Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov Ad is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 18-July-2023. 1. Piracetam (200 mg/ ml in 5 ml) Injections. The required quantity is 44,000 units. 2. Silymarin (90 mg) Hard Capsules. The required quantity is 27,000 units.

21 Jun 2023

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA17270]

University Multiprofessional Hospital For Active Treatment - Burgas Ad is looking for suppliers of Various Finished Dosage Formulations for commercial purposes. The deadline is 10-July-2023. 1. Diazepam (10 mg) Tablets. The required quantity is 70,000 units. 2. Silymarin (90 mg) Capsules. The required quantity is 39,000 units.

09 Jun 2023

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA17208]

State Psychiatric Hospital "Dr. Georgi Kisyov" is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 27-June-2023. 1. Silymarin (90 mg) Capsules. The required quantity is 28,800 units. 2. Haloperidol (5 mg) Injections. The required quantity is 30,000 units. 3. Chlorpromazine (50 mg) Injections. The required quantity is 23,000 units.

01 Jun 2023

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA16606]

Multiprofile Hospital For Active Treatment - Tutrakan Eood is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 10-Apr-2023. 1. Nadroparin (3800 IU) Solution for Injections. The required quantity is 11,000 units. 2. Dexamethasone (4 mg/ml in 1 ml) Solution for Injections. The required quantity is 10,000 units. 3. Silymarin (110 mg) Capsules. The required quantity is 4,500 units. 4. Bromhexine (8 mg) Tablets. The required quantity is 4,000 units.

15 Mar 2023

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA15615]

Multiprofile Hospital For Active Treatment Dr. Teodosi Vitanov Ltd is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 4-Jan-2023. 1. Paracetamol (500 mg) Tablets. The required quantity is 4,600 units. 2. Silymarin (22.5 mg) Tablets. The required quantity is 1,360 units. 3. Vinpocetine (5 mg) Tablets. The required quantity is 720 units. 4. Spironolactone (50 mg) Tablets. The required quantity is 600 units.

22 Nov 2022

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA14205]

University Multiprofessional Hospital For Active Treatment - Prof. Dr. Stoyan Kirkovich Ad is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 08-Aug-2022. 1. Famotidine (20 mg) Powder and solvent for solution for Injections. The required quantity is 110,000 units. 2. Silymarin (90 mg) Capsules. The required quantity is 55,000 units. 3. Ascorbic Acid (100 mg/ ml in 5 ml) Solution for Injections. The required quantity is 180,000 units. 4. Dexamethasone (4 mg/ ml in 1 ml) Solution for Injections. The required quantity is 80,000 units.

04 Jul 2022

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA14051]

Mnogoprofilna Bolnitsa Za Aktivno Lechenie - Dr Bratan Shukerov Ad is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 19-Jul-2022. 1. Omeprazole (40 mg) Powder for Solution for Infusions. The required quantity is 30,000 units. 2. Silymarin (90 mg) Hard Capsules. The required quantity is 22,000 units.

21 Jun 2022

Tender// Various Finished Dosage Formulations needed in Bulgaria [ENA11477]

KOTS - V. Tarnovo is looking for supplies of Various Finished Dosage Formulations for commercial purpose. The deadline is 19-Oct-2021. 1. Metamizole Sodium (500 mg/ 2 ml) Ampoules. The required quantity is 15,000,000 units. 2. Paracetamol (10 mg/ ml in 100 ml) Injections. The required quantity is 1,000,000 units. 3. Piracetam (3 g) Ampoules. The required quantity is 600,000 units. 4. Citicoline (1000 mg in 4 ml) Ampoules. The required quantity is 120,000 units. 5. Famotidine (20 mg) Tablets. The required quantity is 40,000 units. 6. Silymarin (90 mg) Capsules. The required quantity is 90,000 units. 7. S-adenosylmethionine (500 mg) Tablets. The required quantity is 150,000 units.

23 Sep 2021

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Aozeal Certified Standards

U.S.A

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02

Cfm Oskar Tropitzsch GmbH

Germany

BIO Partnering at JPM

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Cfm Oskar Tropitzsch GmbH

Germany

BIO Partnering at JPM

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USP

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ABOUT THIS PAGE

Silymarin Manufacturers

A Silymarin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Silymarin, including repackagers and relabelers. The FDA regulates Silymarin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Silymarin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Silymarin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Silymarin Suppliers

A Silymarin supplier is an individual or a company that provides Silymarin active pharmaceutical ingredient (API) or Silymarin finished formulations upon request. The Silymarin suppliers may include Silymarin API manufacturers, exporters, distributors and traders.

click here to find a list of Silymarin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Silymarin GMP

Silymarin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Silymarin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Silymarin GMP manufacturer or Silymarin GMP API supplier for your needs.

Silymarin CoA

A Silymarin CoA (Certificate of Analysis) is a formal document that attests to Silymarin's compliance with Silymarin specifications and serves as a tool for batch-level quality control.

Silymarin CoA mostly includes findings from lab analyses of a specific batch. For each Silymarin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Silymarin may be tested according to a variety of international standards, such as European Pharmacopoeia (Silymarin EP), Silymarin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Silymarin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers

4 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

20 FDF Dossiers

9 Europe

6 South Africa

5 Listed Dossiers

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2 NEWS #PharmaBuzz

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9 APIs

13 FDF Dossiers

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1 USP

4 Others

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API REF. PRICE (USD/KG)

$ 33

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