Find Sitravatinib manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 1123837-84-2, Mgcd516, Mg-516, Mgcd-516, Sitravatinib [inn], Cwg62q1vtb
Molecular Formula
C33H29F2N5O4S
Molecular Weight
629.7  g/mol
InChI Key
WLAVZAAODLTUSW-UHFFFAOYSA-N
FDA UNII
CWG62Q1VTB

Sitravatinib
Sitravatinib is an orally bioavailable, receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Upon administration, sitravatinib binds to and inhibits the activity of several RTKs including hepatocyte growth factor receptor (HGFR; c-Met; MET), tyrosine-protein kinase receptor UFO (AXL receptor tyrosine kinase; AXL), mast/stem cell growth factor receptor (SCFR; c-kit; KIT), the receptor tyrosine kinase MER, discoidin domain receptor 2 (DDR2), vascular endothelial growth factor receptor (VEGFR) types 1 (VEGFR-1; FLT1), 2 (VEGFR-2; KDR; Flk-1) and 3 (VEGFR-3), members of the platelet-derived growth factor receptor (PDGFR) family, RET (rearranged during transfection), tropomyosin-related kinases (TRK) and members of the ephrin (Eph) family of receptor tyrosine kinases. This may result in both the inhibition of signal transduction pathways mediated by these RTKs and the reduction of tumor cell proliferation in cancer cell types that overexpress these RTKs.
1 2D Structure

Sitravatinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-N'-[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
2.1.2 InChI
InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)
2.1.3 InChI Key
WLAVZAAODLTUSW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COCCNCC1=CN=C(C=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
2.2 Other Identifiers
2.2.1 UNII
CWG62Q1VTB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Mgcd516

2.3.2 Depositor-Supplied Synonyms

1. 1123837-84-2

2. Mgcd516

3. Mg-516

4. Mgcd-516

5. Sitravatinib [inn]

6. Cwg62q1vtb

7. Sitravatinib (mgcd516)

8. Mg-91516

9. Mg516

10. 1-n'-[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

11. N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

12. 1,1-cyclopropanedicarboxamide, N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)-2-pyridinyl)thieno(3,2-b)pyridin-7-yl)oxy)phenyl)-n'-(4-fluorophenyl)-

13. 1,1-cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-n'-(4- Fluorophenyl)-

14. N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno(3,2-b)pyridin-7-yl)oxy)phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

15. Unii-cwg62q1vtb

16. Sitravatinib (usan/inn)

17. Sitravatinib [usan:inn]

18. Sitravatinib [usan]

19. Schembl172015

20. Sitravatinib [who-dd]

21. Gcd516

22. Gtpl9920

23. Chembl3989926

24. Mgcd516;mg516

25. Gcd-516

26. Dtxsid801100124

27. Bcp29099

28. Ex-a2588

29. Bdbm50467574

30. Nsc788203

31. S8573

32. Zinc164334830

33. Ccg-270287

34. Cs-5652

35. Db15036

36. Nsc-788203

37. Sb17195

38. Ncgc00483926-01

39. Ac-36164

40. Bs-14332

41. Bs166446

42. Hy-16961

43. D11140

44. D83649

45. A910305

46. Q27275860

47. Mgcd516;mgcd-516;mgcd 516;mg516;mg 516;mg-516

48. 1609655-67-5

2.4 Create Date
2009-04-13
3 Chemical and Physical Properties
Molecular Weight 629.7 g/mol
Molecular Formula C33H29F2N5O4S
XLogP35.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count12
Exact Mass629.19083192 g/mol
Monoisotopic Mass629.19083192 g/mol
Topological Polar Surface Area143 Ų
Heavy Atom Count45
Formal Charge0
Complexity1000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Sitravatinib Manufacturers

A Sitravatinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sitravatinib, including repackagers and relabelers. The FDA regulates Sitravatinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sitravatinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sitravatinib Suppliers

A Sitravatinib supplier is an individual or a company that provides Sitravatinib active pharmaceutical ingredient (API) or Sitravatinib finished formulations upon request. The Sitravatinib suppliers may include Sitravatinib API manufacturers, exporters, distributors and traders.

Sitravatinib GMP

Sitravatinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sitravatinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sitravatinib GMP manufacturer or Sitravatinib GMP API supplier for your needs.

Sitravatinib CoA

A Sitravatinib CoA (Certificate of Analysis) is a formal document that attests to Sitravatinib's compliance with Sitravatinib specifications and serves as a tool for batch-level quality control.

Sitravatinib CoA mostly includes findings from lab analyses of a specific batch. For each Sitravatinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sitravatinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Sitravatinib EP), Sitravatinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sitravatinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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