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Chemistry

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Also known as: 211110-63-3, Gc-1, Qrx-431, Qrx 431, Chembl107400, Gc 1
Molecular Formula
C20H24O4
Molecular Weight
328.4  g/mol
InChI Key
QNAZTOHXCZPOSA-UHFFFAOYSA-N
FDA UNII
XQ31741E9Q

Sobetirome
Sobetirome is a thyroid hormone receptor isoform beta-1 liver-selective analog with antilipidemic and antiatherosclerotic activity. In animal models sobetirome reduced serum lipids, decreased cholesterol levels, and stimulated steps of reverse cholesterol transport, which promotes the reverse transport of cholesterol from atherogenic macrophages back to the liver for excretion. In humans, sobetirome lowered plasma LDL cholesterol and reduced plasma triglycerides, while its liver-selective activity helped avoid the side effects seen with many other thyromimetic agents.
1 2D Structure

Sobetirome

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]acetic acid
2.1.2 InChI
InChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
2.1.3 InChI Key
QNAZTOHXCZPOSA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
XQ31741E9Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3,5-dimethyl-4-(4'-hydoxy-3'-isopropylbenzyl)phenoxy)acetic Acid

2. Gc 1 Compound

3. Gc-1

4. Gc-1 Compound

5. Gc-1 Cpd

6. Qrx 431

7. Qrx-431

8. Qrx431

2.3.2 Depositor-Supplied Synonyms

1. 211110-63-3

2. Gc-1

3. Qrx-431

4. Qrx 431

5. Chembl107400

6. Gc 1

7. Chebi:79988

8. 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic Acid

9. Xq31741e9q

10. 2-[4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]acetic Acid

11. Sobetirome (usan)

12. Sobetirome [usan]

13. {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic Acid

14. Gc 1 Compound

15. Gc-1;qrx-431

16. [4-(4-hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic Acid

17. 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic Acid

18. Acetic Acid, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-

19. 3imy

20. B72

21. Sobetirome [inn]

22. Sobetirome [usan:inn]

23. Sobetirome [who-dd]

24. Schembl282119

25. Unii-xq31741e9q

26. Gtpl2639

27. Dtxsid60891557

28. Gc-1; Qrx-431

29. Bcp23779

30. Bdbm50115668

31. Zinc13475083

32. Akos024458221

33. Cs-0956

34. Db07425

35. Bs-42167

36. Hy-14823

37. Db-066428

38. Ft-0735243

39. A15241

40. D09381

41. A905652

42. Q27088838

43. Gc-1; Gc1; Gc 1; Qrx-431; Qrx 431; Qrx431

44. 3,5-dimethyl-4-(4''-hydroxy-3''-isopropylbenzyl)phenoxyacetic Acid

45. [4-(4-hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic Acid(gc-1)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 328.4 g/mol
Molecular Formula C20H24O4
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass328.16745924 g/mol
Monoisotopic Mass328.16745924 g/mol
Topological Polar Surface Area66.8 Ų
Heavy Atom Count24
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 211110-63-3 / Sobetirome API manufacturers, exporters & distributors?

Sobetirome manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sobetirome API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sobetirome manufacturer or Sobetirome supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sobetirome manufacturer or Sobetirome supplier.

PharmaCompass also assists you with knowing the Sobetirome API Price utilized in the formulation of products. Sobetirome API Price is not always fixed or binding as the Sobetirome Price is obtained through a variety of data sources. The Sobetirome Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sobetirome

Synonyms

211110-63-3, Gc-1, Qrx-431, Qrx 431, Chembl107400, Gc 1

Cas Number

211110-63-3

Unique Ingredient Identifier (UNII)

XQ31741E9Q

About Sobetirome

Sobetirome is a thyroid hormone receptor isoform beta-1 liver-selective analog with antilipidemic and antiatherosclerotic activity. In animal models sobetirome reduced serum lipids, decreased cholesterol levels, and stimulated steps of reverse cholesterol transport, which promotes the reverse transport of cholesterol from atherogenic macrophages back to the liver for excretion. In humans, sobetirome lowered plasma LDL cholesterol and reduced plasma triglycerides, while its liver-selective activity helped avoid the side effects seen with many other thyromimetic agents.

Sobetirome Manufacturers

A Sobetirome manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sobetirome, including repackagers and relabelers. The FDA regulates Sobetirome manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sobetirome API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sobetirome Suppliers

A Sobetirome supplier is an individual or a company that provides Sobetirome active pharmaceutical ingredient (API) or Sobetirome finished formulations upon request. The Sobetirome suppliers may include Sobetirome API manufacturers, exporters, distributors and traders.

Sobetirome GMP

Sobetirome Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sobetirome GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sobetirome GMP manufacturer or Sobetirome GMP API supplier for your needs.

Sobetirome CoA

A Sobetirome CoA (Certificate of Analysis) is a formal document that attests to Sobetirome's compliance with Sobetirome specifications and serves as a tool for batch-level quality control.

Sobetirome CoA mostly includes findings from lab analyses of a specific batch. For each Sobetirome CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sobetirome may be tested according to a variety of international standards, such as European Pharmacopoeia (Sobetirome EP), Sobetirome JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sobetirome USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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