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Synopsis

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Chemistry

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Also known as: 98631-95-9, Mst 16, Mst-16, [4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethyl]-2,6-dioxopiperazin-1-yl]methyl 2-methylpropyl carbonate, Perazolin, R1308vh37p
Molecular Formula
C22H34N4O10
Molecular Weight
514.5  g/mol
InChI Key
OCOKWVBYZHBHLU-UHFFFAOYSA-N
FDA UNII
R1308VH37P

Sobuzoxane
Sobuzoxane is the orally available active prodrug of ICRF-154, a bisdioxopiperazine derivative, with cardioprotective and antineoplastic activities. Like other ICRF compounds, sobuzoxane and its active metabolite ICRF-154 interfere with topoisomerase II activity prior to the formation of intermediate cleavable DNA-enzyme complexes during the catalytic cycle resulting in tumor cell growth inhibition. Furthermore, sobuzoxane chelates metal cations thereby limiting the formation of free radical-generating anthracycline-metal complexes and may prevent anthracycline-induced oxidative damage to cardiac and soft tissues.
1 2D Structure

Sobuzoxane

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethyl]-2,6-dioxopiperazin-1-yl]methyl 2-methylpropyl carbonate
2.1.2 InChI
InChI=1S/C22H34N4O10/c1-15(2)11-33-21(31)35-13-25-17(27)7-23(8-18(25)28)5-6-24-9-19(29)26(20(30)10-24)14-36-22(32)34-12-16(3)4/h15-16H,5-14H2,1-4H3
2.1.3 InChI Key
OCOKWVBYZHBHLU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)COC(=O)OCN1C(=O)CN(CC1=O)CCN2CC(=O)N(C(=O)C2)COC(=O)OCC(C)C
2.2 Other Identifiers
2.2.1 UNII
R1308VH37P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethane

2. Mst 16

3. Mst-16

2.3.2 Depositor-Supplied Synonyms

1. 98631-95-9

2. Mst 16

3. Mst-16

4. [4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethyl]-2,6-dioxopiperazin-1-yl]methyl 2-methylpropyl Carbonate

5. Perazolin

6. R1308vh37p

7. Sobuzoxane (jan)

8. Ncgc00015954-02

9. Sobuzoxane [jan]

10. Sobuzoxano

11. Sobuzoxanum

12. Sobuzoxane [inn:jan]

13. Sobuzoxanum [inn-latin]

14. 4,4'-(1,2-ethanediyl)bis(1-iso-butoxycarbonyloxmethyl-2,6-piperazinedione)

15. Sobuzoxano [inn-spanish]

16. Brn 6031322

17. Unii-r1308vh37p

18. Perazolin (tn)

19. Sobuzoxane [mi]

20. Sobuzoxane [inn]

21. Lopac-s-4692

22. 1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane

23. Sobuzoxane [mart.]

24. 4,4'-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione) Bis(isobutyl Carbonate) (ester)

25. Dsstox_cid_25203

26. Dsstox_rid_80747

27. Sobuzoxane [who-dd]

28. Dsstox_gsid_45203

29. Lopac0_001094

30. Schembl18416

31. Mls002153414

32. Chembl1256871

33. Dtxsid5045203

34. Chebi:32136

35. Hms2230c04

36. Hms3263k10

37. Hms3369l07

38. Tox21_110265

39. Tox21_501094

40. Mfcd00866498

41. Zinc22032147

42. Sobuzoxane, >=99% (hplc), Solid

43. Ccg-205171

44. Lp01094

45. Sdccgsbi-0051064.p002

46. Ncgc00015954-01

47. Ncgc00015954-03

48. Ncgc00015954-04

49. Ncgc00094367-01

50. Ncgc00094367-02

51. Ncgc00261779-01

52. Carbonic Acid, 1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-methylpropyl) Ester

53. Smr001230790

54. Cas-98631-95-9

55. Eu-0101094

56. 1-n-trityl-imidazole-2-ylpropionicacid

57. D01404

58. F52515

59. S 4692

60. 631s959

61. A839107

62. Sr-01000075401

63. Sr-01000075401-2

64. Q27287640

65. 4,4'-(1,2-ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)

66. 4,4'-(1,2-ethanediyl)bis(1-isobutoxycarbonyloxymethyl-2,6-piperazinedione)

67. (4,4'-(ethane-1,2-diyl)bis(2,6-dioxopiperazine-4,1-diyl))bis(methylene) Isobutyl Dicarbonate

68. [4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-bis(oxidanylidene)piperazin-1-yl]ethyl]-2,6-bis(oxidanylidene)piperazin-1-yl]methyl 2-methylpropyl Carbonate

69. [4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxo-piperazin-1-yl]ethyl]-2,6-dioxo-piperazin-1-yl]methyl 2-methylpropyl Carbonate

70. Carbonic Acid [4-[2-[4-[[2-methylpropoxy(oxo)methoxy]methyl]-3,5-dioxo-1-piperazinyl]ethyl]-2,6-dioxo-1-piperazinyl]methyl 2-methylpropyl Ester

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 514.5 g/mol
Molecular Formula C22H34N4O10
XLogP32
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count12
Rotatable Bond Count15
Exact Mass514.22749329 g/mol
Monoisotopic Mass514.22749329 g/mol
Topological Polar Surface Area152 Ų
Heavy Atom Count36
Formal Charge0
Complexity743
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)


ABOUT THIS PAGE

Sobuzoxane Manufacturers

A Sobuzoxane manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sobuzoxane, including repackagers and relabelers. The FDA regulates Sobuzoxane manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sobuzoxane API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sobuzoxane Suppliers

A Sobuzoxane supplier is an individual or a company that provides Sobuzoxane active pharmaceutical ingredient (API) or Sobuzoxane finished formulations upon request. The Sobuzoxane suppliers may include Sobuzoxane API manufacturers, exporters, distributors and traders.

click here to find a list of Sobuzoxane suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sobuzoxane JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Sobuzoxane Drug Master File in Japan (Sobuzoxane JDMF) empowers Sobuzoxane API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Sobuzoxane JDMF during the approval evaluation for pharmaceutical products. At the time of Sobuzoxane JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Sobuzoxane suppliers with JDMF on PharmaCompass.

Sobuzoxane GMP

Sobuzoxane Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sobuzoxane GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sobuzoxane GMP manufacturer or Sobuzoxane GMP API supplier for your needs.

Sobuzoxane CoA

A Sobuzoxane CoA (Certificate of Analysis) is a formal document that attests to Sobuzoxane's compliance with Sobuzoxane specifications and serves as a tool for batch-level quality control.

Sobuzoxane CoA mostly includes findings from lab analyses of a specific batch. For each Sobuzoxane CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sobuzoxane may be tested according to a variety of international standards, such as European Pharmacopoeia (Sobuzoxane EP), Sobuzoxane JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sobuzoxane USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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