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Chemistry

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Also known as: 26628-22-8, Azide, sodium, Hydrazoic acid sodium salt, Natriumazid, Sodiumazide, Sodium;azide
Molecular Formula
N3Na
Molecular Weight
65.010  g/mol
InChI Key
PXIPVTKHYLBLMZ-UHFFFAOYSA-N
FDA UNII
968JJ8C9DV

Sodium Azide
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
1 2D Structure

Sodium Azide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;azide
2.1.2 InChI
InChI=1S/N3.Na/c1-3-2;/q-1;+1
2.1.3 InChI Key
PXIPVTKHYLBLMZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[N-]=[N+]=[N-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
968JJ8C9DV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azide, Sodium

2. Nan3

2.3.2 Depositor-Supplied Synonyms

1. 26628-22-8

2. Azide, Sodium

3. Hydrazoic Acid Sodium Salt

4. Natriumazid

5. Sodiumazide

6. Sodium;azide

7. Azoture De Sodium

8. Hydrazoic Acid, Sodium Salt

9. Azidosodium

10. Sodium Trinitride

11. Chembl89295

12. 968jj8c9dv

13. Chebi:278547

14. Nemazyd

15. Dsstox_cid_121

16. Dsstox_rid_75383

17. Dsstox_gsid_20121

18. Natriumazid [german]

19. Natriummazide [dutch]

20. Azydek Sodu [polish]

21. Caswell No. 744a

22. Natriummazide

23. Azydek Sodu

24. Nsc 3072

25. Rcra Waste Number P105

26. Azoture De Sodium [french]

27. Sodium, Azoture De

28. Sodium, Azoturo Di

29. Sodium, Azoture De [french]

30. Sodium, Azoturo Di [italian]

31. Cas-26628-22-8

32. Ccris 1261

33. Hsdb 695

34. Nan3

35. Nci-c06462

36. Einecs 247-852-1

37. Un1687

38. Rcra Waste No. P105

39. Epa Pesticide Chemical Code 107701

40. Unii-968jj8c9dv

41. Azido Sodium

42. Sodium Azid

43. Sodium-azide

44. Natrium Azide

45. Ai3-50436

46. Sodium Azid E

47. U-3886

48. Mfcd00003536

49. Azide, 2% Solution

50. Sodium Azide [mi]

51. Ec 247-852-1

52. Sodium Azide [hsdb]

53. Dtxsid8020121

54. Tox21_202461

55. Tox21_300024

56. Sodium Azide [un1687] [poison]

57. Akos015833396

58. Akos015951264

59. Ncgc00090996-01

60. Ncgc00254054-01

61. Ncgc00260010-01

62. S0489

63. Sodium Azide Solution In Water, 10% Wt/volume

64. Q407577

65. J-016500

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 65.010 g/mol
Molecular Formula N3Na
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass64.99899129 g/mol
Monoisotopic Mass64.99899129 g/mol
Topological Polar Surface Area3 Ų
Heavy Atom Count4
Formal Charge0
Complexity15.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Minimum/Potential Fatal Human Dose

... The body of a laboratory assistant, was discovered by his colleagues in the laboratory, seated on a chair located near a digital computer displaying information about sodium azide. Moreover, a half empty 99% sodium azide flask was found near the corpse. ... The elevated sodium azide concentration found in the gastric sample and the amount of gastric content allowed to conclude that sodium azide intake was more than 6 g which was above the lethal dose, i.e. approximately 1 g. ...

PMID:22559996 Le Blanc-Louvry I et al; Forensic Sci Int 221 (1-3): e17-20 (2012)


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Mutagens

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)


5.2 Absorption, Distribution and Excretion

... Sodium azide appeared in rat plasma 5 minutes after a single oral dose at 40 mg/kg and ... by 24 hours, no azide could be detected in either blood or peripheral tissues. A small fraction (7.9 ug) of the administered dose was eliminated in rat urine, but no azide was detected in expired air or feces.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 2-3


When rats were given daily doses of 23 mg/kg sodium azide in their drinking water for 147 days, no azide could be found in their blood.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 3


... For treatment of foot rot /in the bovine hoof/ ... the penetration rate ... of sodium azide /is/ less than 0.05 to 0.24 mm per hr. ... Inclusion of sodium lauryl sulfate in treatments enhanced the penetration rate of ... azide approx 6-fold.

Malecki JC, McCausland IP; Res Vet Sci 3(2): 192-7 (1982)


5.3 Metabolism/Metabolites

... Hepatic biotransformation was considered to be the primary route of detoxification based on in vitro data.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 2-3


5.4 Biological Half-Life

A case of fatal sodium azide poisoning induced by suicidal ingestion was reported. When the patient arrived, her vital signs such as consciousness and blood pressure, were normal. But 25 hours after ingestion, she died from metabolic acidosis, ARDS (acute respiratory distress syndrome) and acute cardiac failure. We detected the azide ion in patient's serum using GCMS method and measured the blood concentration of sodium azide using the GC/NPD method. The half-life period of sodium azide in blood was calculated as about 2.5 hours.

PMID:11806101 Senda T et al; Chudoku Kenkyu 14 (4): 339-42 (2001)


5.5 Mechanism of Action

Sodium azide /is/ an inhibitor of mitochondrial ATPase. ...

Doucet A, Katz AI; Am J Physiol 242 (4): F346-52 (1982)


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08-Aug-2023
08-Aug-2023
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