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    Chemistry

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    Also known as: 497-19-8, Soda ash, Disodium carbonate, Carbonic acid disodium salt, Sodium carbonate, anhydrous, Calcined soda
    Molecular Formula
    CNa2O3
    Molecular Weight
    105.988  g/mol
    InChI Key
    CDBYLPFSWZWCQE-UHFFFAOYSA-L
    FDA UNII
    45P3261C7T
    Sodium Carbonate
    Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.
    1 2D Structure

    Sodium Carbonate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;carbonate
    2.1.2 InChI
    InChI=1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
    2.1.3 InChI Key
    CDBYLPFSWZWCQE-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C(=O)([O-])[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    45P3261C7T
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Disodium Carbonate, 14c-labeled Cpd

    2. Disodium Carbonate, Heptahydrate

    3. Disodium Carbonate, Monohydrate

    4. Monosodium Carbonate, 14c-labeled Cpd

    5. Monosodium Carbonate, Monohydrate

    6. Sodium Carbonate (2:3), Dihydrate

    7. Sodium Carbonate (4:5)

    8. Sodium Carbonate Decahydrate

    9. Sodium Carbonate, Hydrate

    2.3.2 Depositor-Supplied Synonyms

    1. 497-19-8

    2. Soda Ash

    3. Disodium Carbonate

    4. Carbonic Acid Disodium Salt

    5. Sodium Carbonate, Anhydrous

    6. Calcined Soda

    7. Solvay Soda

    8. Sodium Carbonate Anhydrous

    9. Carbonic Acid, Disodium Salt

    10. Carbonic Acid Sodium Salt (1:2)

    11. Carbonic Acid Sodium Salt

    12. Soda-ash

    13. Natrum Carbonicum

    14. Crystol Carbonate

    15. Natriumkarbonat

    16. Bisodium Carbonate

    17. Na2co3

    18. Anhydrous Sodium Carbonate

    19. Soda Ash Light

    20. Na-x

    21. Sodium Carbonate (anhydrous)

    22. Sodium Salt Of Carbonic Acid

    23. Soda

    24. Sodium Carbonate (2:1)

    25. Sodium Carbonate [nf]

    26. Mfcd00003494

    27. Sodium Carbonate (na2(co3))

    28. Anhydrous Soda

    29. Ins No.500(i)

    30. Chebi:29377

    31. Ins-500(i)

    32. 45p3261c7t

    33. Nsc-156204

    34. E-500(i)

    35. Sodium Carbonate (nf)

    36. Soda (van)

    37. Soda, Calcined

    38. Snowlite I

    39. Light Ash

    40. V Soda

    41. Soda Ash Light 4p

    42. Suprapur 6395

    43. Caswell N0 752

    44. Dynamar L 13890

    45. Disodium;carbonate

    46. Natrium Carbonicum Siccatum

    47. Natrium Carbonicum Calcinatum

    48. Disodium Carbonate (na2co3)

    49. Ccris 7319

    50. Hsdb 5018

    51. V 20n

    52. Einecs 207-838-8

    53. Epa Pesticide Chemical Code 073506

    54. Nsc 156204

    55. Sodium Carbonate, Anhydrous Astm D458

    56. Sodium Carbonate, Acs

    57. Sodium Cabonate

    58. Sodium Carbonat

    59. Carbonate Sodium

    60. Sodium-carbonate

    61. Soda Ash Dense

    62. Unii-45p3261c7t

    63. Sodium Carbonate, Anhydrous Ge Materials D4d5

    64. Dried Sodium Carbonate

    65. Caswell No. 752

    66. Sodium Carbonate Sodium

    67. Sodium Sodium Carbonate

    68. Sodium Carbonate, Dried

    69. Sodium Carbonate, Dense

    70. Disodium Trioxidocarbonate

    71. Schembl25

    72. Sodium Carbonate Solution

    73. Soda Ash [ii]

    74. Carbonic Acid, Sodium Salt

    75. Ec 207-838-8

    76. Sodium Carbonate [ii]

    77. Sodium Carbonate [mi]

    78. Sodium Carbonate Nanoparticles

    79. Sodium Carbonate [fcc]

    80. Chembl186314

    81. Sodium Carbonate [hsdb]

    82. Sodium Carbonate [inci]

    83. Dried Sodium Carbonate (jp17)

    84. Dtxsid1029621

    85. Natrum Carbonicum [hpus]

    86. Sodium Carbonate [vandf]

    87. Sodium Carbonate [mart.]

    88. Anhydrous Soda,99.999%,powder

    89. Sodium Carbonate, Biochemical Grade

    90. Einecs 231-420-4

    91. Dried Sodium Carbonate [jan]

    92. Akos009158235

    93. Sodium Carbonate [orange Book]

    94. Db09460

    95. Sodium Carbonate [ep Monograph]

    96. Sodium Carbonate, Anhydrous, Acs Powder

    97. Carbonate-buffered Saline (5x), Ph 9.0

    98. Sodium Carbonate Anhydrous [mart.]

    99. Carbonate, 0.5m Buffer Solution, Ph 9.4

    100. Carbonate, 0.5m Buffer Solution, Ph 9.5

    101. Carbonate, 0.5m Buffer Solution, Ph 9.6

    102. Db-017706

    103. Sodium Carbonate Anhydrous [usp-rs]

    104. Sodium Carbonate Anhydrous [who-dd]

    105. Sodium Carbonate, Anhydrous, Puratronic(r)

    106. Carbonate, 0.5m Buffer Solution, Ph 10.0

    107. Ft-0645109

    108. S0560

    109. D05283

    110. Sodium Carbonate, 0.05n Standardized Solution

    111. Q190227

    112. Sodium Carbonate, Anhydrous [ep Impurity]

    113. Sodium Carbonate 5% W/v Solution In Water (+/- 0.3%)

    114. Sodium Carbonate, Anhydrous, Granular Trace Metals Grade, 99.99%

    115. Soda Ash, (99% As Sodium Carbonate Or 58% As Sodium Oxide), Technical Grade, Light

    116. Sodium Carbonate Concentrate, 0.1 M Na2co3 In Water, Eluent Concentrate For Ic

    117. Sodium Carbonate, Acculute Standard Volumetric Solution, Final Concentration 0.1n

    118. 1332-57-6

    119. 7542-12-3

    120. Sodium Carbonate Concentrate, Na2co3 72 Mm In Water, Ic Eluent Concentrate (20x) For Metrosep A Supp 7

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 105.988 g/mol
    Molecular Formula CNa2O3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass105.96428242 g/mol
    Monoisotopic Mass105.96428242 g/mol
    Topological Polar Surface Area63.2 Ų
    Heavy Atom Count6
    Formal Charge0
    Complexity18.8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic.

    National Library of Medicine's Medical Subject Headings. Sodium carbonate. Online file (MeSH, 2017). Available from, as of October 23, 2017: https://www.nlm.nih.gov/mesh/2017/mesh_browser/MBrowser.html

    Occasionally, for dermatitides topically as a lotion.

    Troy, D.B. (Ed); Remmington The Science and Practice of Pharmacy. 21 st Edition. Lippincott Williams & Williams, Philadelphia, PA 2005, p. 1089

    Medication (Vet): Has been used as an emetic. In solution to cleanse skin, in eczema, to soften scabs of ringworm.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1596

    Sodium bicarbonate infusion is widely recommended ... for patients who present with self-poisoning from tricyclic antidepressives. Cardiac conduction disorders could also be treated or prevented by means of such an infusion. The scientific basis for these recommendations was investigated by using Medline to search for publications about clinical studies that supported the use of sodium carbonate; 111 articles were scrutinized. Observational studies and case reports mention a rapid improvement in hypotension and cardiac arrhythmias following the administration of sodium bicarbonate. Results from animal experiments are contentious; it is not clear whether alkalinization or the administration of extra sodium causes the effect. Randomized studies in patients have not been carried out. As the toxicity of sodium bicarbonate is low, and its potential benefit appears to be high, /the authors/ recommend its use, despite the lack of scientific evidence. No recommendations concerning dosing, concentration and the length of the therapy can be provided on the basis of the literature.

    PMID:11561485 Vrijlandt PJ et al; Ned Tijdschr Geneeskd 145 (35): 1686-9 (2001)

    For more Therapeutic Uses (Complete) data for Sodium carbonate (8 total), please visit the HSDB record page.

    4.2 Drug Indication

    Used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic.Occasionally, for dermatitides topically as a lotion. Medication (Vet): In solution to cleanse skin, in eczema, to soften scabs of ringworm.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Alkalizing buffering action: Sodium bicarbonate is an alkalinizing agent that dissociates to provide bicarbonate ion. Bicarbonate in excess of that needed to buffer hydrogen ions causes systemic alkalinization and, when excreted, urine alkalinization as well. Oral antacid action: Taken orally, sodium bicarbonate neutralizes stomach acid by the above mechanism.

    5.2 Absorption, Distribution and Excretion

    Absorption

    The uptake of sodium, via exposure to sodium carbonate, is much less than the uptake of sodium via food. Therefore, sodium carbonate is not expected to be systemically available in the body. Furthermore, an oral uptake of sodium carbonate will result in a neutralization in the stomach due to the gastric acid.

    Route of Elimination

    Filtered and reabsorbed by the kidney; less than 1% of filtered bicarbonate is excreted.

    Volume of Distribution

    Distribution occurs naturally and is confined to the systemic circulation.

    The major extracellular buffer in the blood and the interstitial fluid of vertebrates is the bicarbonate buffer system ... . Carbon dioxide from the tissues diffuses rapidly into red blood cells, where it is hydrated with water to form carbonic acid. This reaction is accelerated by carbonic anhydrase, an enzyme present in high concentrations in red blood cells. The carbonic acid formed dissociates into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse into the plasma. Since the ratio of H2CO3 to dissolved CO2 is constant at equilibrium, pH may be expressed in terms of bicarbonate ion concentration and partial pressure of CO2 by means of the Henderson-Hasselbach equation: pH = pk + log [HCO3-]/aPCO2. The blood plasma of /humans/ normally has a pH of 7.40. Should the pH fall below 7.0 or rise above 7.8, irreversible damage may occur. Compensatory mechanisms for acid-base disturbances function to alter the ratio of HCO3 - to PCO2 , returning the pH of the blood to normal. ... The uptake of sodium, via exposure to sodium carbonate, is much less than the uptake of sodium via food. Therefore, sodium carbonate is not expected to be systemically available in the body. Furthermore ... an oral uptake of sodium carbonate will result in a neutralization in the stomach due to the gastric acid.

    OECD; Screening Information Data Set (SIDS) Inital Assessment Report for SIDS Initial Assessment Meeting (SIAM) 15, Sodium carbonate (497-19-8) p.11 (October 2002). Available from, as of October 23, 2017: https://www.inchem.org/pages/sids.html

    5.3 Metabolism/Metabolites

    None.

    5.4 Mechanism of Action

    Carbon dioxide from the tissues diffuses rapidly into red blood cells, where it is hydrated with water to form carbonic acid. This reaction is accelerated by carbonic anhydrase, an enzyme present in high concentrations in red blood cells. The carbonic acid formed dissociates into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse into the plasma. Since the ratio of H2CO3 to dissolved CO2 is constant at equilibrium, pH may be expressed in terms of bicarbonate ion concentration and partial pressure of CO2 by means of the Henderson-Hasselbach equation: pH = pk + log [HCO3-]/aPCO2

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    05-Jan-2021
    25-Oct-2024
    KGS
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    (USD/KGS)    		 Number of Transactions

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