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    Chemistry

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    Also known as: 7647-14-5, Salt, Table salt, Halite, Saline, Rock salt
    Molecular Formula
    ClNa
    Molecular Weight
    58.44  g/mol
    InChI Key
    FAPWRFPIFSIZLT-UHFFFAOYSA-M
    FDA UNII
    451W47IQ8X
    Sodium Chloride
    A ubiquitous sodium salt that is commonly used to season food.
    1 2D Structure

    Sodium Chloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;chloride
    2.1.2 InChI
    InChI=1S/ClH.Na/h1H;/q;+1/p-1
    2.1.3 InChI Key
    FAPWRFPIFSIZLT-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    [Na+].[Cl-]
    2.2 Other Identifiers
    2.2.1 UNII
    451W47IQ8X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Sodium Chloride, (22)na

    2. Sodium Chloride, (24)nacl

    2.3.2 Depositor-Supplied Synonyms

    1. 7647-14-5

    2. Salt

    3. Table Salt

    4. Halite

    5. Saline

    6. Rock Salt

    7. Common Salt

    8. Dendritis

    9. Purex

    10. Sodium Chloric

    11. Iodized Salt

    12. Top Flake

    13. Sodium Chloride (nacl)

    14. Hyposaline

    15. Sodium Monochloride

    16. Flexivial

    17. Gingivyl

    18. Slow Sodium

    19. Sea Salt

    20. Nacl

    21. Ss Salt

    22. Sodiumchloride

    23. Natriumchlorid

    24. Adsorbanac

    25. Hypersal

    26. Sodium;chloride

    27. Trisodium Trichloride

    28. White Crystal

    29. H.g. Blending

    30. Salt (ingredient)

    31. Colyte

    32. Isotonic Saline

    33. Sodium Chloride (na4cl4)

    34. Caswell No. 754

    35. Normal Saline

    36. Natrum Muriaticum

    37. Extra Fine 200 Salt

    38. Extra Fine 325 Salt

    39. Sodium Chloride Brine, Purified

    40. Arm-a-vial

    41. Ccris 982

    42. Dendritic Salt

    43. Hsdb 6368

    44. Epa Pesticide Chemical Code 013905

    45. 14762-51-7

    46. Sodium Chloride Solution

    47. Mfcd00003477

    48. Nsc-77364

    49. Sodium Chloride, Hypertonic

    50. Ls-1700

    51. 10% Sodium Chloride Injection

    52. Chebi:26710

    53. 451w47iq8x

    54. Ayr

    55. Buffer Solution, Tisab

    56. Sodium Chloride, Ultra Dry

    57. Sodium Chloride Solution, 5 M

    58. Natriumchlorid [german]

    59. Broncho Saline

    60. Sodium, Reference Standard Solution

    61. Halite (nacl)

    62. Sodium Chloride, Acs Reagent, >=99.0%

    63. Sodium-36 Chloride

    64. Einecs 231-598-3

    65. Nsc 77364

    66. Sodium Chloride Physiological Solution, Bioultra, Tablet

    67. Sodium Chloride (na36cl)

    68. Sodium Chloride [usp:jan]

    69. Isotonic

    70. Kochsalz

    71. Mafiron

    72. Rocksalt

    73. Titrisol

    74. Cloruro Sodico

    75. Sodium-chloride

    76. Solsel

    77. Unii-451w47iq8x

    78. Natrii Chloridum

    79. Saline Solution

    80. Sea Water

    81. Watesal A

    82. Uzushio Biryuu M

    83. Chlorure De Sodium

    84. Adsorbanac (tn)

    85. Brinewate Superfine

    86. Sodium Chloride In Plastic Container

    87. Sodium Chloride Salt

    88. Canners 999

    89. Sodium Chloride Acs

    90. Nacl Solution, 1m

    91. 0.9% Saline

    92. Sodium Chloride 3% In Plastic Container

    93. Sodium Chloride 5% In Plastic Container

    94. Suprasel Nitrite

    95. 0.9% Saline Solution

    96. Saline, Sodium Chloride

    97. Sodium Chloride, Tablet

    98. Sodium Chloride (8ci)

    99. Sodium Chloride 0.9% In Plastic Container

    100. Mono-sodium Chloride Salt

    101. 0.9% Nacl

    102. Sodium Chloride 0.45% In Plastic Container

    103. Sodium Chloride 23.4% In Plastic Container

    104. Sodium Chloride, Isotonic

    105. Unii-vr5y7pdt5w

    106. Salt (6ci,7ci)

    107. Vr5y7pdt5w

    108. Special Salt 100/95

    109. Nacl 0.9%

    110. Wln: Na G

    111. Ec 231-598-3

    112. Sodium Chloride [ii]

    113. Sodium Chloride [mi]

    114. Sodium Chloride 0.9% In Sterile Plastic Container

    115. Sodium Chloride, Acs Reagent

    116. B1655 [langual]

    117. Sodium Chloride [jan]

    118. Rns60 Component Saline

    119. Sodium Chloride (jp17/usp)

    120. Sodium Chloride [hsdb]

    121. Sodium Chloride [inci]

    122. Sodium Chloride Solution, 1 M

    123. Sodium Chloride Solution, 2 M

    124. Sodium Chloride, Optical Grade

    125. Sodium Chloride [vandf]

    126. Sodium Chloride Anhydrous

    127. Bacteriostatic Sodium Chloride 0.9% In Plastic Container

    128. Chembl1200574

    129. Dtxsid3021271

    130. Natrum Muriaticum [hpus]

    131. Rns-60 Component Saline

    132. Sodium Chloride Biochemical Grade

    133. 7647-14-5 (solid)

    134. Sodium Chloride [usp-rs]

    135. Sodium Chloride [who-dd]

    136. Sodium Chloride [who-ip]

    137. Sodium Chloride, Anhydrous

    138. Sodium Chloride Solution, 0.1 M

    139. Sodium Chloride Solution, 0.85%

    140. Sodium Chloride Solution, Isotonic

    141. Nsc77364

    142. Sodium Chloride, Ar, >=99.9%

    143. Sodium Chloride, Lr, >=99.5%

    144. Sodium Chloride, Spectroscopy Grade

    145. Str02627

    146. Sodium Chloride, Manac Incorporated

    147. Sodium Chloride [green Book]

    148. Sodium Chloride, >=99%, Ar Grade

    149. Sodium Chloride [orange Book]

    150. Akos024438089

    151. Akos024457457

    152. Sodium Chloride [ep Monograph]

    153. Sodium Chloride, Bacteriostatic

    154. 10% Sodium Chloride Solution In Water

    155. Db09153

    156. Sodium Chloride [usp Monograph]

    157. Sodium Chloride Saturated Solution 26%

    158. Sodium Chloride, Technical Grade, 95%

    159. Sodium Chloride, Technical Grade, 97%

    160. Natrii Chloridum [who-ip Latin]

    161. Sodium Chloride, Ph. Eur., Usp Grade

    162. Sodium Chloride, P.a., 99-100.5%

    163. 32343-72-9

    164. Chloride Standard Solution, 1 Mg/ml Cl-

    165. Sodium Chloride, Nist(r) Srm(r) 919b

    166. Sodium Chloride, Reagentplus(r), >=99%

    167. Sodium Chloride, Usp, 99.0-100.5%

    168. Sodium Chloride, Usp, 99.0-101.0%

    169. B7288

    170. Ft-0645114

    171. Q2314

    172. S0572

    173. Sodium Chloride, 0.1n Standardized Solution

    174. Sodium Chloride, Bioxtra, >=99.5% (at)

    175. Sodium Chloride, Saj First Grade, >=99.0%

    176. Sodium Chloride, Tested According To Ph.eur.

    177. D02056

    178. Sodium Chloride, 99.999% Trace Metals Basis

    179. Sodium Chloride, Jis Special Grade, >=99.5%

    180. Sodium Chloride, Trace Metals Grade, 99.99%

    181. Isotopic Standard For Chlorine, Nist Srm 975a

    182. Sodium Chloride, 5m Aqueous Solution, Autoclaved

    183. Sodium Chloride, Vetec(tm) Reagent Grade, 99%

    184. Sodanylium And Hydrochloric Acid, Ion(1-) (1:1)

    185. Sodium Chloride, 5m Aqueous Solution, Rnase Free

    186. Sodium Chloride, Puriss. P.a., >=99.5% (at)

    187. Sodium Chloride, Nist(r) Srm(r) 2201, Ion-selective

    188. Sodium Chloride Crystal Optic Disc, 13mm X 2mm, Unpolished

    189. Sodium Chloride Crystal Optic Disc, 25mm X 5mm, Unpolished

    190. Sodium Chloride Crystal Optic Disc, 32mm X 3mm, Unpolished

    191. Sodium Chloride, 5m Aqueous Solution, Ph 8.0, Autoclaved

    192. Sodium Chloride Crystal Optic Disc, 13mm X 1mm, Polished Both Sides

    193. Sodium Chloride Crystal Optic Disc, 13mm X 2mm, Polished Both Sides

    194. Sodium Chloride Crystal Optic Disc, 22mm X 4mm, Polished Both Sides

    195. Sodium Chloride Crystal Optic Disc, 25mm X 2mm, Polished Both Sides

    196. Sodium Chloride Crystal Optic Disc, 25mm X 4mm, Polished Both Sides

    197. Sodium Chloride Crystal Optic Disc, 32mm X 3mm, Polished Both Sides

    198. Sodium Chloride Crystal Optic Disc, 38mm X 6mm, Polished Both Sides

    199. Sodium Chloride, Bioultra, For Molecular Biology, >=99.5% (at)

    200. Sodium Chloride, Puriss. P.a., >=99.5% (at), Powder Or Crystals

    201. Sodium Chloride, Reagent Grade, >=98%, +80 Mesh Particle Size

    202. Sodium Chloride, United States Pharmacopeia (usp) Reference Standard

    203. Sodium Standard For Aas, Ready-to-use, Traceable To Bam, In H2o

    204. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm, Unpolished

    205. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm, Unpolished

    206. Sodium Chloride Crystal Optic Rectangle, 41mm X 23mm X 6mm, Unpolished

    207. Sodium Chloride Solution, Bioultra, For Molecular Biology, ~5 M In H2o

    208. Sodium Chloride Solution, Technical, ~26% (saturated In Water At 20c, At)

    209. Sodium Chloride, Anhydrous, Beads, -10 Mesh, 99.99% Trace Metals Basis

    210. Sodium Chloride, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis

    211. Sodium Chloride, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.5%

    212. Sodium Chloride, Random Crystals, Optical Grade, 99.98% Trace Metals Basis

    213. Sodium Chloride Crystal Optic Disc, 32mm X 3mm (drilled), Polished Both Sides

    214. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm (drilled), Polished Both Sides

    215. Sodium Chloride Crystal Optic Rectangle, 30mm X 15mm X 4mm, Polished Both Sides

    216. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm, Polished Both Sides

    217. Sodium Chloride Solution, 0.9% In Water, Bioxtra, Suitable For Cell Culture

    218. Sodium Chloride, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), >=99%

    219. Sodium Chloride, Anhydrous, Redi-dri(tm), Free-flowing, Acs Reagent, >=99%

    220. Sodium Chloride, Bioperformance Certified, >=99% (titration), Cell Culture Tested

    221. Sodium Chloride, Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.0-100.5%

    222. Sodium Chloride, Pharmaceutical Secondary Standard; Certified Reference Material

    223. Sodium Chloride, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.5%

    224. Sodium Atomic Spectroscopy Standard Concentrate 1.00 G Na, 1.00 G/l, For 1 L Standard Solution, Analytical Standard

    225. Sodium Atomic Spectroscopy Standard Concentrate 10.00 G Na, 10.00 G/l, For 1 L Standard Solution, Analytical Standard

    226. Sodium Chloride Crystal Optic Rectangle, 38.5mm X 19.5mm X 4mm (drilled), Polished Both Sides

    227. Sodium Chloride Solution, 5 M In H2o, Bioreagent, For Molecular Biology, Suitable For Cell Culture

    228. Sodium Chloride, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Plant Cell Culture, >=99%

    229. Sodium Chloride, Certified Reference Material For Titrimetry, Certified By Bam, According To Iso 17025, >=99.5%

    230. Sodium Chloride, For Molecular Biology, Dnase, Rnase, And Protease, None Detected, >=98% (titration)

    231. Sodium Chloride, Pharmagrade, Usp, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production.

    232. Sodium Chloride, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 99.0-100.5% (calc. To The Dried Substance), <=0.00002% Al

    233. Sodium Standard Solution, Suitable For Atomic Absorption Spectrometry, 1000 Ppm Na, 1 Mg/ml Na

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 58.44 g/mol
    Molecular Formula ClNa
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass57.9586220 g/mol
    Monoisotopic Mass57.9586220 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count2
    Formal Charge0
    Complexity2
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameBroncho saline
    PubMed HealthSodium Chloride (By breathing)
    Drug ClassesAntiasthma, Respiratory Agent
    Drug Label14.6% Sodium Chloride Injection, USP Additive Solution is a sterile, nonpyrogenic, concentrated solution for intravenous administration ONLY AFTER DILUTION to replenish electrolytes. The preparations contain either 2.92 or 5.84 g of sodium chloride (...
    Active IngredientSodium chloride
    Dosage FormAerosol, metered
    RouteInhalation
    Strength0.9%
    Market StatusOver the Counter
    CompanyBlairex

    2 of 6  
    Drug NameSodium chloride
    PubMed HealthSodium Chloride
    Drug ClassesAntiasthma, Osmotherapy Agent, Parenteral Electrolyte, Sodium, Respiratory Agent, Sodium Supplement
    Active IngredientSodium chloride
    Dosage FormInjectable
    Routeinjection
    Strength10ml
    Market StatusPrescription
    CompanyTaro Pharms Ireland

    3 of 6  
    Drug NameSodium chloride in plastic container
    Active IngredientSodium chloride
    Dosage FormInjectable
    RouteInjection
    Strength2.5meq/ml
    Market StatusPrescription
    CompanyHospira

    4 of 6  
    Drug NameBroncho saline
    PubMed HealthSodium Chloride (By breathing)
    Drug ClassesAntiasthma, Respiratory Agent
    Drug Label14.6% Sodium Chloride Injection, USP Additive Solution is a sterile, nonpyrogenic, concentrated solution for intravenous administration ONLY AFTER DILUTION to replenish electrolytes. The preparations contain either 2.92 or 5.84 g of sodium chloride (...
    Active IngredientSodium chloride
    Dosage FormAerosol, metered
    RouteInhalation
    Strength0.9%
    Market StatusOver the Counter
    CompanyBlairex

    5 of 6  
    Drug NameSodium chloride
    PubMed HealthSodium Chloride
    Drug ClassesAntiasthma, Osmotherapy Agent, Parenteral Electrolyte, Sodium, Respiratory Agent, Sodium Supplement
    Active IngredientSodium chloride
    Dosage FormInjectable
    Routeinjection
    Strength10ml
    Market StatusPrescription
    CompanyTaro Pharms Ireland

    6 of 6  
    Drug NameSodium chloride in plastic container
    Active IngredientSodium chloride
    Dosage FormInjectable
    RouteInjection
    Strength2.5meq/ml
    Market StatusPrescription
    CompanyHospira

    4.2 Therapeutic Uses

    Sodium chloride injections are used as a source of sodium chloride and water for hydration. Sodium chloride is used in the prevention or treatment of deficiencies of sodium and chloride ions and in the prevention of muscle cramps and heat prostration resulting from excessive perspiration during exposure to high temperature. Sodium chloride is also used to treat deficiencies of sodium and chloride caused by excessive diuresis or excessive salt restriction.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758

    0.45% Sodium chloride injection is used principally as a hydrating solution and may be used to assess renal function status, since more water is provided than is required for excretion of salt. 0.45% Sodium chloride injection is also used in the management of hyperosmolar diabetes.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758

    0.9% Sodium chloride injection is used for extracellular fluid replacement and in the management of metabolic alkalosis in the presence of fluid loss and mild sodium depletion. 0.9% Sodium chloride injection (normal saline) is also used as a priming fluid for hemodialysis procedures and to initiate and terminate blood transfusions.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758

    Hypertonic (i.e., 3%, 5%) sodium chloride injection is used in the management of severe sodium chloride depletion when rapid electrolyte restoration is essential. Severe sodium chloride depletion may occur in the presence of heart failure or renal impairment, or during surgery or postoperatively. In these conditions, chloride loss often exceeds sodium loss. Hypertonic sodium chloride injections are also used in the management of hyponatremia and hypochloremia resulting from administration of sodium-free fluids during fluid and electrolyte therapy; in the management of extreme dilution of extracellular fluid following excessive water intake (e.g., that resulting from multiple enemas or perfusion of irrigating solutions into open venous sinuses during transurethral prostatic resections); and in the emergency treatment of severe sodium chloride depletion resulting from excess sweating, vomiting, diarrhea, and other conditions.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2758

    For more Therapeutic Uses (Complete) data for SODIUM CHLORIDE (13 total), please visit the HSDB record page.

    4.3 Drug Warning

    Bacteriostatic sodium chloride injection containing benzyl alcohol as a preservative (antimicrobial agent) should not be used for diluting or reconstituting drugs for administration in neonates nor should it be used to flush intravascular catheters in neonates. Several deaths have been reported in neonates weighing less than 2.5 kg in whom bacteriostatic sodium chloride for injection containing 0.9% benzyl alcohol was used for flushing IV catheters; some of these neonates received additional benzyl alcohol when bacteriostatic sodium chloride injection was used to dilute or reconstitute drugs. The deaths were usually preceded by a syndrome that included metabolic acidosis, CNS depression, respiratory distress progressing to gasping respiration, hypotension, renal failure, and, occasionally, seizures and intracranial hemorrhage. High concentrations of benzyl alcohol, benzoic acid, and hippuric acid (a metabolite) were present in blood and urine in these neonates. Benzyl alcohol toxicity apparently was caused by administration of relatively large daily doses (99-404 mg/kg daily) of the preservative in proportion to the neonate's weight. Although these neonates had biochemical evidence of benzyl alcohol toxicity, they also had serious underlying conditions.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759

    Sodium chloride is contraindicated in patients with conditions in which administration of sodium and chloride is detrimental. Sodium chloride 3 and 5% injections are also contraindicated in the presence of increased, normal, or only slightly decreased serum electrolyte concentrations.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759

    Sodium chloride should be used with extreme caution, if at all, in patients with congestive heart failure or other edematous or sodium-retaining conditions, in patients with severe renal insufficiency, in patients with liver cirrhosis, and in patients receiving corticosteroids or corticotropin; particular caution is necessary in geriatric or postoperative patients. IV administration of sodium chloride may cause fluid and/or solute overload resulting in dilution of serum electrolytes, overhydration, congestive conditions, or pulmonary edema. The risk of dilutional conditions is inversely proportional to the electrolyte concentration administered, and the risk of solute overload and resultant congestive conditions with peripheral and/or pulmonary edema is directly proportional to the electrolyte concentration administered. The manufacturers warn that excessive IV administration of sodium chloride may result in hypokalemia.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759

    Changes in fluid balance, electrolyte concentrations, and acid-base balance should be evaluated clinically and via periodic laboratory determinations during prolonged therapy with sodium chloride and in patients whose condition warrants such evaluation. Substantial changes may require additional electrolyte supplements or other appropriate therapy. Additional electrolyte supplementation may also be required in patients with substantial electrolyte losses resulting from conditions such as protracted nasogastric suctioning, vomiting, diarrhea, or GI fistula drainage.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2759

    For more Drug Warnings (Complete) data for SODIUM CHLORIDE (12 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    The estimated fatal dose of sodium chloride is approximately 0.75 to 3.00 g/kg.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057

    An estimated dose of more than 400 mEq/kg resulted in brain injury and death in a 2 year old child given a salt water solution to induce emesis.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057

    4.5 Drug Indication

    This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Increased Large Intestinal Motility [PE]
    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12C - Other mineral supplements

    A12CA - Sodium

    A12CA01 - Sodium chloride

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05C - Irrigating solutions

    B05CB - Salt solutions

    B05CB01 - Sodium chloride

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05X - I.v. solution additives

    B05XA - Electrolyte solutions

    B05XA03 - Sodium chloride

    S - Sensory organs

    S01 - Ophthalmologicals

    S01X - Other ophthalmologicals

    S01XA - Other ophthalmologicals

    S01XA03 - Sodium chloride, hypertonic

    5.4 Absorption, Distribution and Excretion

    Absorption

    Absorption of sodium in the small intestine plays an important role in the absorption of chloride, amino acids, glucose, and water. Chloride, in the form of hydrochloric acid (HCl), is also an important component of gastric juice, which aids the digestion and absorption of many nutrients.

    Route of Elimination

    Substantially excreted by the kidneys.

    Volume of Distribution

    The volume of distribution is 0.64 L/kg.

    The primary route of sodium excretion is the urine; additional excretion occurs in sweat and feces. The kidney filters sodium a the glomerulus, but 60% to 70% is reabsorbed in the proximal tubules along with bicarbonate and water. Another 25% to 30% is reabsorbed in the loop of Henle, along with chloride and water. In the distal tubules, aldosterone modulates the reabsorption of sodium and, indirectly, chloride. The renal threshold for sodium is 110 to 130 mEq/L. Less than 1% of the filtered sodium is excreted in the urine.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057

    Sodium is rapidly absorbed from the GI tract; it is also absorbed from rectal enemas. Intestinal wall absorption occurs via the Na+, K+-adenosine triphosphatase system that is augmented by aldosterone and desoxycorticosterone acetate. Sodium is not bound by plasma proteins. The volume of distribution is 0.64 L/kg.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1057

    In one study using radiolabeled 20% sodium chloride injection, most of the drug concentrated in the decidua and the fetal part of the placenta following intra-amniotic injection. Following intra-amniotic administration of 20% sodium chloride injection, some of the drug diffuses into the maternal blood.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 3323

    Atrichial sweat glands ... are the organs by which considerable body water and electrolytes, mainly sodium chloride, are lost.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 8:69

    For more Absorption, Distribution and Excretion (Complete) data for SODIUM CHLORIDE (6 total), please visit the HSDB record page.

    5.5 Metabolism/Metabolites

    The salt that is taken in to gastro intestinal tract remains for the most part unabsorbed as the liquid contents pass through the stomach and small bowel. On reaching the colon this salt, together with the water is taken in to the blood. As excesses are absorbed the kidney is constantly excreting sodium chloride, so that the chloride level in the blood and tissues remains fairly constant.Further more, if the chloride intake ceases, the kidney ceases to excrete chlorides. Body maintains an equilibrium retaining the 300gm of salt dissolved in the blood and fluid elements of the tissue dissociated into sodium ions and chloride ions.

    5.6 Biological Half-Life

    17 minutes

    5.7 Mechanism of Action

    Sodium and chloride major electrolytes of the fluid compartment outside of cells (i.e., extracellular) work together to control extracellular volume and blood pressure. Disturbances in sodium concentrations in the extracellular fluid are associated with disorders of water balance.

    Intra-amniotic instillation of 20% sodium chloride injection induces abortion and fetal death. Although the mechanism has not been conclusively determined, some studies indicate that the drug's abortifacient activity may be mediated by prostaglandins released from decidual cells damaged by hypertonic solutions of sodium chloride. Hypertonic sodium chloride-induced uterine contractions are usually sufficient to cause evacuation of both the fetus and placenta; however, abortion may be incomplete in 25-40% of patients. /20% injection/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 3323

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REDDY\\'S LABORATORIES","supplierCountry":"INDIA","foreign_port":"VISAKHAPATNAM SEZ","customer":"DR. REDDY\\'S LABORATORIES","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.005","unit":"KGS","unitRateFc":"41","totalValueFC":"0.2","currency":"USD","unitRateINR":"3478","date":"07-Nov-2024","totalValueINR":"17.39","totalValueInUsd":"0.2","indian_port":"Vizag-EPZ\/SEZ","hs_no":"29339990","bill_no":"6549430","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"VISAKHAPATNAM SEZ","supplierAddress":"FTO -7, PLOT NO.P1 TO P9 V.S.E.Z., DUVVADA, VISAKHAPATNAM SDNF India","customerAddress":"H.NO. 8-2-337, BESIDE TV9 OFFICE,,"}]
    11-Jan-2021
    18-Dec-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 900MG/100ML

    USFDA APPLICATION NUMBER - 16366

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    DOSAGE - SOLUTION;INJECTION - 225MG/25ML (9MG...DOSAGE - SOLUTION;INJECTION - 225MG/25ML (9MG/ML)

    USFDA APPLICATION NUMBER - 16677

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    DOSAGE - SOLUTION;INJECTION - 450MG/50ML (9MG...DOSAGE - SOLUTION;INJECTION - 450MG/50ML (9MG/ML)

    USFDA APPLICATION NUMBER - 16677

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    DOSAGE - SOLUTION;INJECTION - 900MG/100ML

    USFDA APPLICATION NUMBER - 16677

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;30...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;30MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 16682

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    DOSAGE - SOLUTION;IRRIGATION - 900MG/100ML

    USFDA APPLICATION NUMBER - 16733

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;3.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;3.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 17512

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    DOSAGE - SOLUTION;IRRIGATION - 900MG/100ML

    USFDA APPLICATION NUMBER - 17514

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;900...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;900MG/100ML

    USFDA APPLICATION NUMBER - 17585

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;225...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;225MG/100ML

    USFDA APPLICATION NUMBER - 17606

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;450...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;450MG/100ML

    USFDA APPLICATION NUMBER - 17607

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5G...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5GM/100ML;30MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 17608

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;300...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;300MG/100ML

    USFDA APPLICATION NUMBER - 17799

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    DOSAGE - INJECTABLE;INJECTION - 450MG/100ML

    USFDA APPLICATION NUMBER - 18016

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    DOSAGE - INJECTABLE;INJECTION - 450MG/100ML

    USFDA APPLICATION NUMBER - 18090

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149MG/100ML;450MG/100ML

    USFDA APPLICATION NUMBER - 18362

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;224...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;224MG/100ML;450MG/100ML

    USFDA APPLICATION NUMBER - 18362

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298MG/100ML;450MG/100ML

    USFDA APPLICATION NUMBER - 18362

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74....DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74.5MG/100ML;450MG/100ML

    USFDA APPLICATION NUMBER - 18362

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149MG/100ML;225MG/100ML

    USFDA APPLICATION NUMBER - 18365

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298MG/100ML;225MG/100ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18365

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74....DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74.5MG/100ML;225MG/100ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18365

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    DOSAGE - SOLUTION;IRRIGATION - 0.154MG/ML;0.9...DOSAGE - SOLUTION;IRRIGATION - 0.154MG/ML;0.92MG/ML;0.184MG/ML;0.2MG/ML;0.38MG/ML;2.1MG/ML;7.14MG/ML;0.42MG/ML

    USFDA APPLICATION NUMBER - 18469

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    DOSAGE - SOLUTION;INJECTION - 180MG/20ML (9MG...DOSAGE - SOLUTION;INJECTION - 180MG/20ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18800

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    DOSAGE - SOLUTION;INJECTION - 270MG/30ML (9MG...DOSAGE - SOLUTION;INJECTION - 270MG/30ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18800

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    DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/...DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18800

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    DOSAGE - SOLUTION;INJECTION - 180MG/20ML (9MG...DOSAGE - SOLUTION;INJECTION - 180MG/20ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INJECTION - 18MG/2ML (9MG/M...DOSAGE - SOLUTION;INJECTION - 18MG/2ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INJECTION - 27MG/3ML (9MG/M...DOSAGE - SOLUTION;INJECTION - 27MG/3ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INJECTION - 450MG/50ML (9MG...DOSAGE - SOLUTION;INJECTION - 450MG/50ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INJECTION - 45MG/5ML (9MG/M...DOSAGE - SOLUTION;INJECTION - 45MG/5ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/...DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/ML)

    USFDA APPLICATION NUMBER - 18803

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;1.5GM/100ML;15.2MG/100ML;567MG/100ML;392MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;2.5GM/100ML;15.2MG/100ML;567MG/100ML;392MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;4.25GM/100ML;15.2MG/100ML;567MG/100ML;392MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 18883

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    DOSAGE - SOLUTION;IRRIGATION - 20MG/100ML;30M...DOSAGE - SOLUTION;IRRIGATION - 20MG/100ML;30MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 19416

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    DOSAGE - INJECTABLE;INJECTION - 450MG/100ML

    USFDA APPLICATION NUMBER - 19635

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    DOSAGE - INJECTABLE;INJECTION - 900MG/100ML

    USFDA APPLICATION NUMBER - 19635

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    DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/...DOSAGE - SOLUTION;INJECTION - 90MG/10ML (9MG/ML)

    USFDA APPLICATION NUMBER - 19635

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5G...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5GM/100ML;104MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 19685

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5G...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5GM/100ML;179MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 19685

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5G...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5GM/100ML;254MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 19685

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    DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5G...DOSAGE - INJECTABLE;INJECTION - 20MG/100ML;5GM/100ML;328MG/100ML;600MG/100ML;310MG/100ML

    USFDA APPLICATION NUMBER - 19685

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;149MG/100ML;900MG/100ML

    USFDA APPLICATION NUMBER - 19691

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;224...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;224MG/100ML;900MG/100ML

    USFDA APPLICATION NUMBER - 19691

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298...DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;298MG/100ML;900MG/100ML

    USFDA APPLICATION NUMBER - 19691

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    DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74....DOSAGE - INJECTABLE;INJECTION - 5GM/100ML;74.5MG/100ML;900MG/100ML

    USFDA APPLICATION NUMBER - 19691

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    DOSAGE - FOR SOLUTION;ORAL - 420GM/BOT;1.48GM...DOSAGE - FOR SOLUTION;ORAL - 420GM/BOT;1.48GM/BOT;5.72GM/BOT;11.2GM/BOT

    USFDA APPLICATION NUMBER - 19797

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20163

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20163

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 25.7MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20163

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20171

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20171

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.4MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20171

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;1.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20183

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;2.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20183

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;3.5GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20183

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    DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/10...DOSAGE - SOLUTION;INTRAPERITONEAL - 18.3MG/100ML;4.25GM/100ML;5.08MG/100ML;538MG/100ML;448MG/100ML

    USFDA APPLICATION NUMBER - 20183

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    DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML;3.05GM/1000ML;0.314GM/1000ML ;3.09GM/1000ML;6.34GM/1000ML;0.187GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 207026

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;3....DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;6.95GM/1000ML;0.187GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 207026

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    DOSAGE - SOLUTION;IRRIGATION - 0.48MG/ML;0.3M...DOSAGE - SOLUTION;IRRIGATION - 0.48MG/ML;0.3MG/ML;0.75MG/ML;3.9MG/ML;6.4MG/ML;1.7MG/ML

    USFDA APPLICATION NUMBER - 20742

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    DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML;20GM/1000ML;5.4GM/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;7.07GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML;20GM/1000ML;5.4GM/1000ML;3.05GM/1000ML;0.314GM/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 3.68GM/1000ML;20GM/1000ML;5.4GM/1000ML;3.05GM/1000ML;N/A/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - 5.15GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 5.15GM/1000ML;20GM/1000ML;5.4GM/1000ML;2.03GM/1000ML;0.157GM/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - 5.15GM/1000ML...DOSAGE - INJECTABLE;INJECTION - 5.15GM/1000ML;N/A/1000ML;5.4GM/1000ML;2.03GM/1000ML;N/A/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20...DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20GM/1000ML;5.4GM/1000ML;2.03GM/1000ML;0.157GM/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20...DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20GM/1000ML;5.4GM/1000ML;2.44GM/1000ML;0.314GM/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20...DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20GM/1000ML;5.4GM/1000ML;3.05GM/1000ML;0.157GM/1000ML;2.21GM/1000ML;7.07GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20...DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;20GM/1000ML;5.4GM/1000ML;3.05GM/1000ML;0.314GM/1000ML;2.21GM/1000ML;7.07GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;N/...DOSAGE - INJECTABLE;INJECTION - N/A/1000ML;N/A/1000ML;5.4GM/1000ML;2.44GM/1000ML;N/A/1000ML;3.09GM/1000ML;6.46GM/1000ML (5000ML)

    USFDA APPLICATION NUMBER - 21703

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    ABOUT THIS PAGE

    Looking for 7647-14-5 / Sodium Chloride API manufacturers, exporters & distributors?

    Sodium Chloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Sodium Chloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Chloride manufacturer or Sodium Chloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Chloride manufacturer or Sodium Chloride supplier.

    PharmaCompass also assists you with knowing the Sodium Chloride API Price utilized in the formulation of products. Sodium Chloride API Price is not always fixed or binding as the Sodium Chloride Price is obtained through a variety of data sources. The Sodium Chloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sodium Chloride

    Synonyms

    7647-14-5, Salt, Table salt, Halite, Saline, Rock salt

    Cas Number

    7647-14-5

    Unique Ingredient Identifier (UNII)

    451W47IQ8X

    About Sodium Chloride

    A ubiquitous sodium salt that is commonly used to season food.

    Sodium Chloride Manufacturers

    A Sodium Chloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Chloride, including repackagers and relabelers. The FDA regulates Sodium Chloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Chloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Sodium Chloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Sodium Chloride Suppliers

    A Sodium Chloride supplier is an individual or a company that provides Sodium Chloride active pharmaceutical ingredient (API) or Sodium Chloride finished formulations upon request. The Sodium Chloride suppliers may include Sodium Chloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Sodium Chloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Sodium Chloride USDMF

    A Sodium Chloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium Chloride active pharmaceutical ingredient (API) in detail. Different forms of Sodium Chloride DMFs exist exist since differing nations have different regulations, such as Sodium Chloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Sodium Chloride DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium Chloride USDMF includes data on Sodium Chloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium Chloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Sodium Chloride suppliers with USDMF on PharmaCompass.

    Sodium Chloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Sodium Chloride Drug Master File in Japan (Sodium Chloride JDMF) empowers Sodium Chloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Sodium Chloride JDMF during the approval evaluation for pharmaceutical products. At the time of Sodium Chloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Sodium Chloride suppliers with JDMF on PharmaCompass.

    Sodium Chloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Sodium Chloride Drug Master File in Korea (Sodium Chloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Sodium Chloride. The MFDS reviews the Sodium Chloride KDMF as part of the drug registration process and uses the information provided in the Sodium Chloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Sodium Chloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Sodium Chloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Sodium Chloride suppliers with KDMF on PharmaCompass.

    Sodium Chloride CEP

    A Sodium Chloride CEP of the European Pharmacopoeia monograph is often referred to as a Sodium Chloride Certificate of Suitability (COS). The purpose of a Sodium Chloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Sodium Chloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Sodium Chloride to their clients by showing that a Sodium Chloride CEP has been issued for it. The manufacturer submits a Sodium Chloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Sodium Chloride CEP holder for the record. Additionally, the data presented in the Sodium Chloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Sodium Chloride DMF.

    A Sodium Chloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Sodium Chloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Sodium Chloride suppliers with CEP (COS) on PharmaCompass.

    Sodium Chloride WC

    A Sodium Chloride written confirmation (Sodium Chloride WC) is an official document issued by a regulatory agency to a Sodium Chloride manufacturer, verifying that the manufacturing facility of a Sodium Chloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Sodium Chloride APIs or Sodium Chloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Sodium Chloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Sodium Chloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Sodium Chloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sodium Chloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Sodium Chloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Sodium Chloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Sodium Chloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sodium Chloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Sodium Chloride suppliers with NDC on PharmaCompass.

    Sodium Chloride GMP

    Sodium Chloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Sodium Chloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Chloride GMP manufacturer or Sodium Chloride GMP API supplier for your needs.

    Sodium Chloride CoA

    A Sodium Chloride CoA (Certificate of Analysis) is a formal document that attests to Sodium Chloride's compliance with Sodium Chloride specifications and serves as a tool for batch-level quality control.

    Sodium Chloride CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Chloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Sodium Chloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Chloride EP), Sodium Chloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Chloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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