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    Chemistry

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    Also known as: Trisodium citrate, 68-04-2, Citrosodine, Natrocitral, Sodium citrate anhydrous, Sodium citrate, anhydrous
    Molecular Formula
    C6H5Na3O7
    Molecular Weight
    258.07  g/mol
    InChI Key
    HRXKRNGNAMMEHJ-UHFFFAOYSA-K
    FDA UNII
    RS7A450LGA
    Sodium Citrate
    Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.
    1 2D Structure

    Sodium Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    trisodium;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    2.1.3 InChI Key
    HRXKRNGNAMMEHJ-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    RS7A450LGA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anhydrous Sodium Citrate

    2. Citra Ph

    3. Monosodium Citrate

    4. Sodium Citrate Dihydrate

    5. Sodium Citrate Monobasic

    6. Sodium Citrate, Anhydrous

    7. Trisodium Citrate Dihydrate

    2.3.2 Depositor-Supplied Synonyms

    1. Trisodium Citrate

    2. 68-04-2

    3. Citrosodine

    4. Natrocitral

    5. Sodium Citrate Anhydrous

    6. Sodium Citrate, Anhydrous

    7. Citric Acid, Trisodium Salt

    8. Trisodium Citrate, Anhydrous

    9. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Trisodium Salt

    10. Anhydrous Sodium Citrate

    11. Citric Acid Trisodium Salt

    12. Sodium 2-hydroxypropane-1,2,3-tricarboxylate

    13. Trisodium Citrate Anhydrous

    14. Fema No. 3026

    15. Trisodium-citrate

    16. Anhydrous Trisodium Citrate

    17. 994-36-5

    18. Sodium Citrate,anhydrous

    19. Rs7a450lga

    20. Ins No.331(iii)

    21. Ins-331(iii)

    22. Chebi:53258

    23. E-331(iii)

    24. Trisodium 2-hydroxypropane-1,2,3-tricarboxylate

    25. Trisodium;2-hydroxypropane-1,2,3-tricarboxylate

    26. Mfcd00012462

    27. Fema No. 3026, Anhydrous-

    28. Citric Acid, Sodium Salt

    29. Citrosodina

    30. Citnatin

    31. Citreme

    32. Citrosodna

    33. Sodium Citrate Hydrous

    34. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Sodium Salt

    35. Ccris 3293

    36. Sodium Citrate (na3c6h5o7)

    37. Hsdb 5201

    38. Einecs 200-675-3

    39. Unii-rs7a450lga

    40. N-1560

    41. Natrii Citras

    42. Tri-sodium Citrate

    43. Trisodium 2-hydroxy-1,2,3-propanetricarboxylate

    44. Sodium Citrate Salt

    45. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Sodium Salt (1:3)

    46. Sodium (iii) Citrate

    47. Sodium Citrate (usp)

    48. Natrii Citras, Dehydrate

    49. Ec 200-675-3

    50. Anticoagulant Sodium Citrate

    51. Chembl1355

    52. Sodium Citrate [mi]

    53. Citrate Concentrated Solution

    54. Dtxsid2026363

    55. Sodium Citrate [who-ip]

    56. 2-hydroxy-1,2,3-propanetricarboxylic Acid, Trisodium Salt

    57. Citric Acid Trisodium Salt, 99%

    58. Natrii Citras [who-ip Latin]

    59. Akos015915009

    60. Citrate Solution, Ph ~3.0, 30 Mm

    61. Db09154

    62. Sodium Citrate Anhydrous [hsdb]

    63. Anhydrous Trisodium Citrate [ii]

    64. Sodium Citrate,anhydrous [vandf]

    65. Ac-15008

    66. E331

    67. Sodium Citrate Dihydrate Usp Fine Granular

    68. Sodium Citrate, Anhydrous [who-ip]

    69. B7298

    70. Ft-0623960

    71. D05855

    72. D77308

    73. Sodium Citrate, 0.5m Buffer Solution, Ph 5.0

    74. Sodium Citrate, 0.5m Buffer Solution, Ph 5.5

    75. Sodium Citrate, 0.5m Buffer Solution, Ph 6.0

    76. Sodium Citrate, 0.5m Buffer Solution, Ph 6.5

    77. Anhydrous Trisodium Citrate [usp Monograph]

    78. Q409728

    79. J-520101

    80. Citric Acid Trisodium Salt, Anhydrous, >=98% (gc)

    81. Citrate Solution, Ph 3.6+/-0.1 (25 C), 27 Mm

    82. Citric Acid Trisodium Salt, Vetec(tm) Reagent Grade, 98%

    83. 2-hydroxy-1,2,3-propanenetricarboxylic Acid Trisodium Salt Dihydrate

    84. Citrate Concentrated Solution, Bioultra, For Molecular Biology, 1 M In H2o

    85. Buffer Solution Ph 5.0 (20 C), Citric Acid ~0.096 M, Sodium Hydroxide ~0.20 M

    86. Citrate Concentrated Solution, Bioreagent, Suitable For Coagulation Assays, 4 % (w/v)

    87. 8055-55-8

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 258.07 g/mol
    Molecular Formula C6H5Na3O7
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass257.97283534 g/mol
    Monoisotopic Mass257.97283534 g/mol
    Topological Polar Surface Area141 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity211
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    ...USED AS AN EXPECTORANT...& SYSTEMIC ALKALIZER. SALINE EXPECTORANTS ARE ESPECIALLY USEFUL WHEN IT IS DESIRED TO LIQUEFY THICK, TENACIOUS SPUTUM. IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE & EXCRETED IN THE URINE; THUS, WHEN GIVEN ORALLY IT IS USEFUL IN ACIDOSIS & TO OVERCOME EXCESSIVE URINARY ACIDITY.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

    SODIUM CITRATE ALSO HAS A DIURETIC...ACTION.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:08

    SODIUM CITRATE ALSO INCREASES THE URINARY EXCRETION OF CALCIUM. THEREFORE, IT HAS BEEN EMPLOYED IN HYPERCALCEMIA & TO FACILITATE ELIMINATION OF LEAD IN POISONING DUE TO THE LATTER AGENT. /SRP: FORMER USE/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

    MEDICATION (VET): ANTICOAGULANT FOR COLLECTION OF BLOOD /SRP: FORMER USE/

    The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1112

    4.2 Drug Warning

    WHEN GIVEN IN EXCESS AMT SODIUM CITRATE MAY PRODUCE ALKALOSIS & MAY CAUSE TETANY OR DEPRESS THE HEART BY DECREASING THE IONIZED CALCIUM LEVEL OF THE BLOOD.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:08

    4.3 Drug Indication

    Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH.

    5.2 MeSH Pharmacological Classification

    Buffers

    A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)

    Food Preservatives

    Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods. (See all compounds classified as Food Preservatives.)

    Anticoagulants

    Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Anti-coagulant [EPC]; Calcium Chelating Activity [MoA]; Calculi Dissolution Agent [EPC]; Decreased Coagulation Factor Activity [PE]; Acidifying Activity [MoA]
    5.4 ATC Code

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05C - Irrigating solutions

    B05CB - Salt solutions

    B05CB02 - Sodium citrate

    5.5 Absorption, Distribution and Excretion

    Absorption

    Tmax of 98-130min.

    Route of Elimination

    Largely eliminated through hepatic metabolism with very little cleared by the kidneys.

    Volume of Distribution

    19-39L.

    Clearance

    Total clearance of 313-1107mL/min.

    IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE & EXCRETED IN THE URINE...

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

    5.6 Metabolism/Metabolites

    Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle.

    IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE...

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

    5.7 Biological Half-Life

    18-54 min

    5.8 Mechanism of Action

    Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine. It also acts as a diuretic and increases the urinary excretion of calcium.

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    01-Jan-2021
    31-Dec-2024
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    ABOUT THIS PAGE

    Looking for 68-04-2 / Sodium Citrate API manufacturers, exporters & distributors?

    Sodium Citrate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Sodium Citrate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Citrate manufacturer or Sodium Citrate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Citrate manufacturer or Sodium Citrate supplier.

    PharmaCompass also assists you with knowing the Sodium Citrate API Price utilized in the formulation of products. Sodium Citrate API Price is not always fixed or binding as the Sodium Citrate Price is obtained through a variety of data sources. The Sodium Citrate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sodium Citrate

    Synonyms

    Trisodium citrate, 68-04-2, Citrosodine, Natrocitral, Sodium citrate anhydrous, Sodium citrate, anhydrous

    Cas Number

    68-04-2

    Unique Ingredient Identifier (UNII)

    RS7A450LGA

    About Sodium Citrate

    Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.

    Sodium Citrate Manufacturers

    A Sodium Citrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Citrate, including repackagers and relabelers. The FDA regulates Sodium Citrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Citrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Sodium Citrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Sodium Citrate Suppliers

    A Sodium Citrate supplier is an individual or a company that provides Sodium Citrate active pharmaceutical ingredient (API) or Sodium Citrate finished formulations upon request. The Sodium Citrate suppliers may include Sodium Citrate API manufacturers, exporters, distributors and traders.

    click here to find a list of Sodium Citrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Sodium Citrate USDMF

    A Sodium Citrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium Citrate active pharmaceutical ingredient (API) in detail. Different forms of Sodium Citrate DMFs exist exist since differing nations have different regulations, such as Sodium Citrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Sodium Citrate DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium Citrate USDMF includes data on Sodium Citrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium Citrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Sodium Citrate suppliers with USDMF on PharmaCompass.

    Sodium Citrate CEP

    A Sodium Citrate CEP of the European Pharmacopoeia monograph is often referred to as a Sodium Citrate Certificate of Suitability (COS). The purpose of a Sodium Citrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Sodium Citrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Sodium Citrate to their clients by showing that a Sodium Citrate CEP has been issued for it. The manufacturer submits a Sodium Citrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Sodium Citrate CEP holder for the record. Additionally, the data presented in the Sodium Citrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Sodium Citrate DMF.

    A Sodium Citrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Sodium Citrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Sodium Citrate suppliers with CEP (COS) on PharmaCompass.

    Sodium Citrate GMP

    Sodium Citrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Sodium Citrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Citrate GMP manufacturer or Sodium Citrate GMP API supplier for your needs.

    Sodium Citrate CoA

    A Sodium Citrate CoA (Certificate of Analysis) is a formal document that attests to Sodium Citrate's compliance with Sodium Citrate specifications and serves as a tool for batch-level quality control.

    Sodium Citrate CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Citrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Sodium Citrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Citrate EP), Sodium Citrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Citrate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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